JP2013144679A5 - - Google Patents
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- Publication number
- JP2013144679A5 JP2013144679A5 JP2013017346A JP2013017346A JP2013144679A5 JP 2013144679 A5 JP2013144679 A5 JP 2013144679A5 JP 2013017346 A JP2013017346 A JP 2013017346A JP 2013017346 A JP2013017346 A JP 2013017346A JP 2013144679 A5 JP2013144679 A5 JP 2013144679A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- amino
- benzimidazol
- pyrazol
- methanone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013017346A JP5732081B2 (ja) | 2009-08-07 | 2013-01-31 | アミノピラゾール誘導体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009184822 | 2009-08-07 | ||
| JP2009184822 | 2009-08-07 | ||
| JP2013017346A JP5732081B2 (ja) | 2009-08-07 | 2013-01-31 | アミノピラゾール誘導体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011525936A Division JP5225470B2 (ja) | 2009-08-07 | 2010-08-05 | アミノピラゾール誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013144679A JP2013144679A (ja) | 2013-07-25 |
| JP2013144679A5 true JP2013144679A5 (enExample) | 2013-09-26 |
| JP5732081B2 JP5732081B2 (ja) | 2015-06-10 |
Family
ID=43544423
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011525936A Expired - Fee Related JP5225470B2 (ja) | 2009-08-07 | 2010-08-05 | アミノピラゾール誘導体 |
| JP2013017346A Expired - Fee Related JP5732081B2 (ja) | 2009-08-07 | 2013-01-31 | アミノピラゾール誘導体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011525936A Expired - Fee Related JP5225470B2 (ja) | 2009-08-07 | 2010-08-05 | アミノピラゾール誘導体 |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US8829199B2 (enExample) |
| EP (1) | EP2471786B1 (enExample) |
| JP (2) | JP5225470B2 (enExample) |
| KR (1) | KR101529767B1 (enExample) |
| CN (1) | CN102574836B (enExample) |
| AR (1) | AR084370A1 (enExample) |
| AU (1) | AU2010279930B2 (enExample) |
| BR (1) | BR112012008094A2 (enExample) |
| CA (1) | CA2770195C (enExample) |
| CL (1) | CL2012000324A1 (enExample) |
| CY (1) | CY1117142T1 (enExample) |
| DK (1) | DK2471786T3 (enExample) |
| ES (1) | ES2561659T3 (enExample) |
| HR (1) | HRP20151258T1 (enExample) |
| HU (1) | HUE028584T2 (enExample) |
| IL (1) | IL217912A (enExample) |
| IN (1) | IN2012DN01249A (enExample) |
| MX (1) | MX2012001653A (enExample) |
| MY (1) | MY163531A (enExample) |
| PE (1) | PE20120795A1 (enExample) |
| PH (1) | PH12012500252A1 (enExample) |
| PL (1) | PL2471786T3 (enExample) |
| PT (1) | PT2471786E (enExample) |
| RU (1) | RU2580543C9 (enExample) |
| SI (1) | SI2471786T1 (enExample) |
| TW (1) | TWI464160B (enExample) |
| WO (1) | WO2011016528A1 (enExample) |
| ZA (1) | ZA201200895B (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2770195C (en) | 2009-08-07 | 2015-10-13 | Chugai Seiyaku Kabushiki Kaisha | Aminopyrazole derivative |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| EP2817294B1 (en) | 2012-02-20 | 2017-12-27 | Rhodia Operations | Process for production of dfmb derivatives |
| HUE042374T2 (hu) | 2012-06-13 | 2019-06-28 | Incyte Holdings Corp | Szubsztituált triciklusos vegyületek mint FGFR inhibitorok |
| NZ703495A (en) | 2012-07-11 | 2018-02-23 | Blueprint Medicines Corp | Inhibitors of the fibroblast growth factor receptor |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| EP2902489B9 (en) * | 2012-09-27 | 2018-02-07 | Chugai Seiyaku Kabushiki Kaisha | Fgfr3 fusion gene and pharmaceutical drug targeting same |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| AR094812A1 (es) | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
| HUE036571T2 (hu) | 2013-04-19 | 2018-07-30 | Incyte Holdings Corp | Biciklusos heterociklusok mint FGFR inhibitorok |
| CN103224479B (zh) * | 2013-04-26 | 2014-10-15 | 温州大学 | 一种2-芳基苯并呋喃类化合物的合成方法 |
| TWI637744B (zh) * | 2013-07-31 | 2018-10-11 | 中外製藥股份有限公司 | 含有胺基吡唑衍生物之醫藥製劑 |
| HUE059037T2 (hu) | 2013-10-25 | 2022-10-28 | Blueprint Medicines Corp | Fibroblaszt növekedési faktor receptor gátlók |
| CN105722834B (zh) * | 2013-12-13 | 2017-12-22 | 豪夫迈·罗氏有限公司 | 酪氨酸蛋白激酶抑制剂 |
| CN105814035B (zh) * | 2013-12-13 | 2018-02-02 | 豪夫迈·罗氏有限公司 | 布鲁顿氏酪氨酸激酶抑制剂 |
| MX374758B (es) * | 2013-12-13 | 2025-03-06 | Hoffmann La Roche | Inhibidores de tirosina cinasa de bruton. |
| WO2015099127A1 (ja) | 2013-12-27 | 2015-07-02 | 中外製薬株式会社 | Ｆｇｆｒゲートキーパー変異遺伝子およびそれを標的とする医薬 |
| WO2015108992A1 (en) | 2014-01-15 | 2015-07-23 | Blueprint Medicines Corporation | Heterobicyclic compounds and their use as fgfr4 receptor inhibitors |
| EP3125936B1 (en) | 2014-03-31 | 2019-05-08 | Debiopharm International SA | Fgfr fusions |
| CA2953004C (en) * | 2014-07-08 | 2023-02-21 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
| KR102344105B1 (ko) | 2014-08-18 | 2021-12-29 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 모노시클릭 피리딘 유도체의 염 및 이의 결정 |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MX388991B (es) | 2015-02-20 | 2025-03-20 | Incyte Corp | Heterociclos biciclicos como inhibidores de receptores del factor de crecimiento fibroblastico (fgfr) |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| CN107205996A (zh) | 2015-03-25 | 2017-09-26 | 国立癌症研究中心 | 胆管癌治疗剂 |
| US10479780B2 (en) | 2015-06-17 | 2019-11-19 | Chugai Seiyaku Kabushiki Kaisha | Aminopyrazole derivatives |
| CN108026588A (zh) | 2015-07-24 | 2018-05-11 | 德彪药业国际股份公司 | Fgfr表达以及对fgfr抑制剂的敏感性 |
| US10214515B2 (en) | 2015-08-20 | 2019-02-26 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Substituted pyrazoles as inhibitors of fibroblast growth factor receptor |
| RU2730503C2 (ru) | 2015-12-17 | 2020-08-24 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Терапевтическое средство для лечения рака молочной железы |
| WO2017157332A1 (zh) * | 2016-03-18 | 2017-09-21 | 江苏恒瑞医药股份有限公司 | 芳香酰胺类衍生物、其制备方法及其在医药上的应用 |
| WO2018049233A1 (en) | 2016-09-08 | 2018-03-15 | Nicolas Stransky | Inhibitors of the fibroblast growth factor receptor in combination with cyclin-dependent kinase inhibitors |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| AU2019241625A1 (en) | 2018-03-28 | 2020-09-03 | Eisai R&D Management Co., Ltd. | Therapeutic agent for hepatocellular carcinoma |
| EP3788047B1 (en) | 2018-05-04 | 2024-09-04 | Incyte Corporation | Solid forms of an fgfr inhibitor and processes for preparing the same |
| BR112020022373A2 (pt) | 2018-05-04 | 2021-02-02 | Incyte Corporation | sais de um inibidor de fgfr |
| GB201810092D0 (en) | 2018-06-20 | 2018-08-08 | Ctxt Pty Ltd | Compounds |
| CN110950848B (zh) * | 2018-09-27 | 2024-03-26 | 徐诺药业 | 新型氨基吡唑类衍生物的合成与应用 |
| CN112996529B (zh) | 2018-10-02 | 2025-09-02 | 迪斯克医药公司 | Matriptase 2抑制剂及其用途 |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| CN110092791B (zh) * | 2019-05-17 | 2020-04-03 | 河南大学 | 5,6-吲哚并二恶烷类衍生物及其制备方法和应用 |
| PL3986890T3 (pl) | 2019-06-18 | 2024-03-11 | Pfizer Inc. | Pochodne benzizoksazolosulfonamidu |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CN112358435B (zh) * | 2019-10-12 | 2023-01-10 | 中国医学科学院医药生物技术研究所 | 取代芳并杂环类化合物、制备方法和抑制ulk1及抗肿瘤用途 |
| KR20220100879A (ko) | 2019-10-14 | 2022-07-18 | 인사이트 코포레이션 | Fgfr 저해제로서의 이환식 헤테로사이클 |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| KR20220131900A (ko) | 2019-12-04 | 2022-09-29 | 인사이트 코포레이션 | Fgfr 억제제의 유도체 |
| WO2021113479A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| JP2023529867A (ja) | 2020-06-05 | 2023-07-12 | キネート バイオファーマ インク． | 線維芽細胞増殖因子受容体キナーゼの阻害剤 |
| WO2022221170A1 (en) | 2021-04-12 | 2022-10-20 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| TW202313611A (zh) | 2021-06-09 | 2023-04-01 | 美商英塞特公司 | 作為ｆｇｆｒ抑制劑之三環雜環 |
| EP4352060A1 (en) | 2021-06-09 | 2024-04-17 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| TW202333686A (zh) * | 2021-12-08 | 2023-09-01 | 美商奇奈特生物製藥公司 | 以fgfr激酶抑制劑治療癌症 |
| EP4450494A1 (en) | 2023-04-20 | 2024-10-23 | Consejo Superior De Investigaciones Científicas | Indole derivatives as histone deacetylase (hdac) inhibitors for the treatment of cancer |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0674624T3 (da) | 1992-12-17 | 1999-09-13 | Pfizer | Pyrazoler med CRF-antagonistisk aktivitet |
| US6316466B1 (en) * | 1998-05-05 | 2001-11-13 | Syntex (U.S.A.) Llc | Pyrazole derivatives P-38 MAP kinase inhibitors |
| ATE292118T1 (de) | 1998-05-05 | 2005-04-15 | Hoffmann La Roche | Pyrazolderivative als p-38 map kinase inhibitoren |
| US6534535B1 (en) * | 1999-08-12 | 2003-03-18 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| JP2003050945A (ja) | 2001-08-06 | 2003-02-21 | Takashi Hashimoto | 連動型広告配信システム及び広告配信サーバの動作方法 |
| FR2831537B1 (fr) * | 2001-10-26 | 2008-02-29 | Aventis Pharma Sa | Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation |
| BR0213562A (pt) | 2001-10-26 | 2004-08-31 | Aventis Pharma Inc | Benzimidazóis e análogos e seu uso como inibidores de cinases de proteìna |
| FR2854159B1 (fr) | 2003-04-25 | 2008-01-11 | Aventis Pharma Sa | Nouveaux derives de l'indole, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de kdr |
| PT2298743E (pt) * | 2003-06-26 | 2012-12-04 | Novartis Ag | Inibidores de p38 quinase a base de heterociclo de 5 elementos |
| JP2008545776A (ja) | 2005-06-11 | 2008-12-18 | ヴァーナリス アールアンドディー リミテッド | 癌および自己免疫疾患の治療における使用のためのピラゾール−置換ベンズイミダゾール誘導体 |
| EP1968579A1 (en) | 2005-12-30 | 2008-09-17 | Astex Therapeutics Limited | Pharmaceutical compounds |
| FR2903406B1 (fr) | 2006-07-04 | 2012-08-10 | Aventis Pharma Sa | Derives de pyrazolylbenzimidazole,compositions les contenant et utilisation |
| RU2011106357A (ru) * | 2008-07-23 | 2012-08-27 | Ф.Хоффманн-Ля Рош Аг (Ch) | Гетероциклические антивирусные соединения |
| WO2010010017A1 (en) * | 2008-07-23 | 2010-01-28 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| CA2770195C (en) | 2009-08-07 | 2015-10-13 | Chugai Seiyaku Kabushiki Kaisha | Aminopyrazole derivative |
-
2010
- 2010-08-05 CA CA2770195A patent/CA2770195C/en not_active Expired - Fee Related
- 2010-08-05 MY MYPI2012000478A patent/MY163531A/en unknown
- 2010-08-05 AR ARP100102875A patent/AR084370A1/es active IP Right Grant
- 2010-08-05 BR BR112012008094-6A patent/BR112012008094A2/pt not_active Application Discontinuation
- 2010-08-05 TW TW099126056A patent/TWI464160B/zh not_active IP Right Cessation
- 2010-08-05 JP JP2011525936A patent/JP5225470B2/ja not_active Expired - Fee Related
- 2010-08-05 RU RU2012108164/04A patent/RU2580543C9/ru active
- 2010-08-05 PT PT108065277T patent/PT2471786E/pt unknown
- 2010-08-05 PL PL10806527T patent/PL2471786T3/pl unknown
- 2010-08-05 MX MX2012001653A patent/MX2012001653A/es active IP Right Grant
- 2010-08-05 CN CN201080045256.4A patent/CN102574836B/zh not_active Expired - Fee Related
- 2010-08-05 KR KR1020127005218A patent/KR101529767B1/ko not_active Expired - Fee Related
- 2010-08-05 AU AU2010279930A patent/AU2010279930B2/en not_active Ceased
- 2010-08-05 EP EP10806527.7A patent/EP2471786B1/en active Active
- 2010-08-05 US US13/389,146 patent/US8829199B2/en active Active
- 2010-08-05 DK DK10806527.7T patent/DK2471786T3/en active
- 2010-08-05 PH PH1/2012/500252A patent/PH12012500252A1/en unknown
- 2010-08-05 HR HRP20151258TT patent/HRP20151258T1/hr unknown
- 2010-08-05 HU HUE10806527A patent/HUE028584T2/en unknown
- 2010-08-05 ES ES10806527.7T patent/ES2561659T3/es active Active
- 2010-08-05 IN IN1249DEN2012 patent/IN2012DN01249A/en unknown
- 2010-08-05 SI SI201031114T patent/SI2471786T1/sl unknown
- 2010-08-05 PE PE2012000181A patent/PE20120795A1/es active IP Right Grant
- 2010-08-05 WO PCT/JP2010/063315 patent/WO2011016528A1/ja not_active Ceased
-
2012
- 2012-02-02 IL IL217912A patent/IL217912A/en active IP Right Grant
- 2012-02-06 ZA ZA2012/00895A patent/ZA201200895B/en unknown
- 2012-02-07 CL CL2012000324A patent/CL2012000324A1/es unknown
-
2013
- 2013-01-31 JP JP2013017346A patent/JP5732081B2/ja not_active Expired - Fee Related
-
2014
- 2014-06-06 US US14/297,790 patent/US9102692B2/en active Active
-
2016
- 2016-01-18 CY CY20161100044T patent/CY1117142T1/el unknown
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