JP2013144154A - 多層構造の粒子、繊維糸、およびスプレーを生産するためのシステムおよび方法ならびにそれらを施すための方法 - Google Patents
多層構造の粒子、繊維糸、およびスプレーを生産するためのシステムおよび方法ならびにそれらを施すための方法 Download PDFInfo
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Abstract
【解決手段】治療薬、造影剤、および他の薬剤成分などの、少なくとも1つのカプセル封入された、および/または閉じ込められた薬剤を含むカプセルおよび粒子は、電気流体力学的プロセスにより形成されうる。より具体的には、賦形剤、カプセル、粒子、ベクター、または担体内にカプセル封入された薬剤は、治療および/または撮像の悪影響を最小限に抑えつつ悪性癌の治療および/または撮像を最大化することが可能である。
【選択図】図1
Description
定義
(実施例1)
この実施例は、溶液のpHを安定させるためにリン酸塩などの塩の存在下でウシ血清アルブミン(BSA)の溶液からなる殻調製剤の修正形態を用いたタンパク質溶液のカプセル封入を説明するものである。共焦点蛍光顕微鏡(CFM)およびBSAを蛍光標識とともに使用し、カプセルの視覚化を行った。約2mgの蛍光タンパク質をリン酸緩衝生理食塩水(PBS)約1mLに溶解したが、これは、この水溶液の塩基特性を約7.4に等しいpHに安定させるタイプの緩衝液であった。
実施例1で蛍光BSAをカプセル封入するために使用されるゾルゲル法およびプロセス変数は、アミノ基転移酵素をカプセル封入するようにわずかに修正された。この酵素は、以下の反応を触媒するために使用された。
D,Lグルタミン+グリオキシル酸L−グルタミン(左は未反応)+α−ケト誘導体(D−グルタミンから)+グリシン
DNAマーカーとして3.1 LACZを有する粒子
約1wt%のイソプロパノールを含有する約10mMのビス−トリスプロパン緩衝水溶液中の3.1 LACZと約2mMのCaCl2とを混合することにより治療薬溶液を調製した。3.1 LACZの最終濃度は、700μg/mLであった。
PDsred2−NUCのカプセル封入
この実施例の化合物は、図5に示されている2ジェットシステムにより形成された。PDsred2−NUCと約1wt%のイソプロパノールを含有する約10mMのビス−トリスプロパン水溶液と約2mMのCaCl2とを混合することにより最初にコア流体溶液を調製した。コア流体溶液中のPDsred2−NUCの最終濃度は、約22.5μg/mLであった。
緑色蛍光タンパク質のカプセル封入
緑色蛍光タンパク質、略してGFPと約1wt%のイソプロパノールと約2mMのCaCl2を含有する約10mMのビス−トリスプロパン水溶液とを混合することによりコア流体溶液を調製した。コア流体溶液中のGFPの最終濃度は、約30μg/mLであった。
葉酸官能基を含むドキソルビシンによる粒子
塩酸ドキソルビシン、略してDOXOをジクロロメタン中に溶解することにより、治療薬溶液を調製する。治療薬溶液中のDOXOの濃度は、約1,000μg/mLである。
ドキソルビシンのカプセル封入
約1wt%のイソプロパノールを含有する約10mMのビス−トリスプロパン水溶液中の塩酸ドキソルビシン、略してDOXOと約2mMのCaCl2を混合することによりコア流体溶液を調製した。コア流体溶液中のDOXOの最終濃度は、約1,000μg/mLであった。
コバルトナノ粒子のカプセル封入
コバルトナノ粒子、略してNP−Coの水溶液と約1wt%のイソプロパノールおよび約2mMのCaCl2を含有する10mMのビス−トリスプロパン水溶液とを混合することによりコア流体溶液を調製した。コア流体溶液中のNP−Coの最終濃度は、約1,000から約500μg/mLの範囲内であった。
EGF官能基を含むドキソルビシンによる粒子
塩酸ドキソルビシン、略してDOXOをジクロロメタン中に溶解することにより、治療薬溶液を調製する。治療薬溶液中のDOXOの濃度は、約1,000μg/mLである。
DNAマーカーとしてルシフェラーゼを有する粒子
約1wt%のイソプロパノールを含有する10mMのビス−トリスプロパン緩衝水溶液中のルシフェラーゼと約2mMのCaCl2とを混合することにより治療薬溶液を調製する。ルシフェラーゼの最終濃度は、334.5μg/mLである。
DNAマーカーとしてTKレニラルシフェラーゼを有する粒子
約1wt%のイソプロパノールを含有する約10mMのビス−トリスプロパン緩衝水溶液中のTKレニラルシフェラーゼと約2mMのCaCl2とを混合することにより治療薬溶液を調製した。TKレニラルシフェラーゼの最終濃度は、約334.5μg/mLであった。
EGFおよびミトコンドリア局在化ベクターを含むカプセルへのコバルトナノ粒子のカプセル封入
コバルトナノ粒子、略してNP−Coの水溶液と約1.0wt%のイソプロパノールおよび約2mMのCaCl2を含有する10mMのビス−トリスプロパン水溶液とを混合することによりコア流体溶液を調製する。コア流体溶液中のNP−Coの最終濃度は、約1,000から約500μg/mLの範囲内である。
殻上にCD19官能基を含むカプセル内へのクロランブシルのカプセル封入
約1wt%のイソプロパノール、約2mMのCaCl2、およびDMSOを含有する約10mMのビス−トリスプロパン水溶液中にクロランブシルを溶解することによりコア流体溶液を調製した。コア流体溶液中のクロランブシルの最終濃度は、約2,000から約500μg/mLの範囲内であった。
CD20官能基を含むカプセル内へのクロランブシルのカプセル封入
約1.0wt%のイソプロパノール、約2.0mMのCaCl2、およびDMSOを含有する約10mMのビス−トリスプロパン水溶液中にクロランブシルを溶解することによりコア流体溶液を調製した。コア流体溶液中のクロランブシルの最終濃度は、約2,000から約500μg/mLの範囲内であった。
CD19およびCD20官能基を含むカプセル内へのクロランブシルおよび硫酸ヒドロキシクロロキンのカプセル封入
約1.0wt%のイソプロパノール、2mMのCaCl2、およびDMSOを含有する約10mMのビス−トリスプロパン水溶液中にクロランブシルおよび硫酸ヒドロキシクロロキン、略してHCQを溶解することによりコア流体溶液を調製した。コア流体溶液中のクロランブシルおよびHCQの最終濃度は、約2,000から約500μg/mLの範囲内であった。
CD19官能基およびゴルジ複合体局在化ベクターを含むカプセル内へのクロランブシルのカプセル封入
約1wt%のイソプロパノール、約2mMのCaCl2、およびDMSOを含有する約10mMのビス−トリスプロパン水溶液中にクロランブシルを溶解することによりコア流体溶液を調製する。コア流体溶液中のクロランブシルの最終濃度は、約2,000から約500μg/mLの範囲内である。
ヨウ素125およびEGF官能基を含む粒子
ヨウ素125をジクロロメタン中に溶解することにより、治療薬溶液を調製する。治療薬溶液中のヨウ素125の濃度は、約1,000μg/mLである。
Ga/Feナノ粒子および上皮成長因子受容体を含むカプセル内へのクロランブシルのカプセル封入
約1.0wt%のイソプロパノール、約2.0mMのCaCl2、およびDMSOを含有する10mMのビス−トリスプロパン水溶液中にクロランブシルを溶解することによりコア流体溶液を調製する。コア流体溶液中のクロランブシルの最終濃度は、約2,000から約500μg/mLの範囲内である。
Ga/B/Feナノ粒子および上皮増殖因子受容体を含むカプセル内へのクロランブシルのカプセル封入
約1.0wt%のイソプロパノール、約2.0mMのCaCl2、およびDMSOを含有する約10.0mMのビス−トリスプロパン水溶液中にクロランブシルを溶解することによりコア流体溶液を調製する。コア流体溶液中のクロランブシルの最終濃度は、約2,000から約500μg/mLの範囲内である。
葉酸官能基を含むパクリタキセルによる粒子
パクリタキセルをジクロロメタン中に溶解することにより、治療薬溶液を調製する。治療薬溶液中のパクリタキセルの濃度は、約1,000μg/mLである。
葉酸官能基を含むパクリタキセルによるカプセル
DMSO中のパクリタキセルと約10wt%のγ−シクロデキストリンとを約1wt%のイソプロパノールおよび約2mMのCaCl2を含有する約10mMのビス−トリスプロパン水溶液中で混合することによりコア流体溶液を調製する。コア流体溶液中のパクリタキセルの最終濃度は、約20μg/mLである。
パクリタキセルによる粒子
パクリタキセルをジクロロメタン中で混合することにより、治療薬溶液を調製する。治療薬溶液中のパクリタキセルの濃度は、約1,000μg/mLである。
パクリタキセルのカプセル封入
DMSO中のパクリタキセルと約10wt%のγ−シクロデキストリンとを約1wt%のイソプロパノールおよび約2mMのCaCl2を含有する約10mMのビス−トリスプロパン水溶液中で混合することによりコア流体溶液を調製する。コア流体溶液中のパクリタキセルの最終濃度は、約20μg/mLである。
金ナノ粒子のカプセル封入
金ナノ粒子、略してNP−Auの水溶液と約1wt%のイソプロパノールおよび約2mMのCaCl2を含有する10mMのビス−トリスプロパン水溶液とを混合することによりコア流体溶液を調製する。コア流体溶液中のNP−Auの最終濃度は、約1,000から約500μg/mLの範囲内である。
銀ナノ粒子のカプセル封入
銀ナノ粒子、略してNP−Agの水溶液と約1wt%のイソプロパノールおよび約2mMのCaCl2を含有する10mMのビス−トリスプロパン水溶液とを混合することによりコア流体溶液を調製する。コア流体溶液中のNP−Agの最終濃度は、約1,000から約500μg/mLの範囲内である。
パラジウムナノ粒子のカプセル封入
パラジウムナノ粒子、略してNP−Pdの水溶液と約1wt%のイソプロパノールおよび約2mMのCaCl2を含有する約10mMのビス−トリスプロパン水溶液とを混合することによりコア流体溶液を調製する。コア流体溶液中のNP−Pdの最終濃度は、約1,000から約500μg/mLの範囲内である。
パクリタキセルおよびエストラジオール官能基を含む粒子
パクリタキセルをジクロロメタン中で混合することにより、治療薬溶液を調製する。治療薬溶液中のパクリタキセルの濃度は、約1,000μg/mLである。
パクリタキセルおよびエストラジオール官能基を含むカプセル
DMSO中のパクリタキセルと約10wt%のγ−シクロデキストリンとを約1wt%のイソプロパノールおよび2mMのCaCl2を含有する約10mMのビス−トリスプロパン水溶液中で混合することによりコア流体溶液を調製する。コア流体溶液中のパクリタキセルの最終濃度は、約20μg/mLである。
パクリタキセルおよび上皮成長因子群を含む粒子
パクリタキセルをジクロロメタン中に溶解することにより、治療薬溶液を調製する。治療薬溶液中のパクリタキセルの濃度は約1,000μg/mLである。
パクリタキセルおよび上皮成長因子群を含むカプセル
DMSO中のパクリタキセルと約10wt%のγ−シクロデキストリンとを約1wt%のイソプロパノールおよび2mMのCaCl2を含有する約10mMのビス−トリスプロパン水溶液中で混合することによりコア流体溶液を調製する。コア流体溶液中のパクリタキセルの最終濃度は、約20μg/mLである。
pCMV−Lucプラスミドのカプセル封入
pGL2−Basic Vectorプラスミドの蛍ルシフェラーゼの上流に挿入されたpcDNA3のサイトメガロウイルス(CMV)プロモーターを含むpCMV−Lucプラスミドを含む緩衝液を薬1wt%のイソプロパノールおよび約2mMのCaCl2を含有する10mMのビス−トリスプロパン水溶液と混合することによりコア流体溶液を調製する。コア流体溶液中のpCMV−Lucの最終濃度は、約1から約1000μg/mLの範囲内である。
425 TNF−α DNAおよびウシ血清アルブミンローダミン抱合体のカプセル封入
約1wt%のイソプロパノールと約2mMのCaCl2を含有する約10mMのビス−トリスプロパン水溶液中で、425 TNF−α DNA、およびウシ血清アルブミンローダミン抱合体、またはBSA−ローダミンを混合することによりコア流体溶液を調製した。コア流体溶液中の425 TNF−α DNAおよびBSA−ローダミンの最終濃度は、それぞれ約12.2μg/mLおよび約200μg/mLであった。
テモゾロミドのカプセル封入
テモゾロミド、略してTMZを約0.1Mの緩衝酢酸溶液中でコア流体溶液を調製した。コア流体溶液中のTMZの最終濃度は、約10μMである。
TNF−αタンパク質およびウシ血清アルブミンフルオレセイン抱合体のカプセル封入
約1wt%のイソプロパノールと約2mMのCaCl2を含有する約10mMのビス−トリスプロパン水溶液中で、TNF−αタンパク質、およびウシ血清アルブミンフルオレセイン抱合体、またはBSA−fluor 594を混合することによりコア流体溶液を調製した。コア流体溶液中のTNF−αタンパク質およびBSA−fluorの最終濃度は、それぞれ約345μg/mLおよび約200μg/mLであった。
20 流体
100 2流体流の流れ
104 内部流体
106 外部流体
108 テイラーコーン構造
110 先端部
112 捕集体
200 カプセル
202 コア領域
204 殻領域
206 ドメイン
208 非生物的または官能基
300 上昇流EHDシステム
302 注射器ポンプ
304 注射器ポンプ
306 流体槽
308 殻流体
310 管
312 捕集板
314 電圧源
316 電極
318 コア流体供給管
320 殻流体供給管
322 開放端
324 殻流体
326 円錐状ジェット領域ゾーン
328 プルーム
408 殻流体
414 エクストラクタ
416 オリフィス
418 導電体
422 開放端
424 殻流体流
510 管
524 殻流体流
532 管
536 角度
610 管
626 捕集体ゾーン
632 導管
640 殻流体入口ポート
642 ケース
644 コア流体入口
710 管
714 壁
716 殻流体
718 ギャップ
720 ギャップ
810 管
812 円筒状ケース
814 棒
816 殻流体
910、916 同軸管
912 殻流体
914 コア流体
916 第3の管または導管
1002 管
1004 管
1006 多孔質体
1008 外壁
1102 リザーバ
1104 槽
1106 オリフィス
1108 外壁
1302 エレクトロスプレーノズル
1304 雲
1306 入口
1308 出口ポート
1310 対向電極
1312 殻形成反応体積
1314 高電圧DC源
1316 AC電極
1318 AC電圧源
Claims (83)
- 少なくとも1つのカプセル封入された薬剤を有するカプセルを形成する方法であって、
コア流体を中空管の内部に供給する段階と、
殻流体流を供給する段階と、
前記中空管の外壁への殻流体流を発生する段階と、
前記中空管の先端部に2流体帯電ジェットを形成するように前記コア流体および前記殻流体に電位を加える段階と、
コア領域および殻領域を有するカプセルを中空管の先端部に形成する段階とを含む方法。 - 前記コア流体は、約0.005mL/時から約5mL/時までの範囲内の流量で供給される請求項1に記載の方法。
- 前記コア流体の流量は、約0.025mL/hである請求項2に記載の方法。
- 前記殻流体は、約0.005mL/時から約5mL/時までの範囲内の流量で供給される請求項1に記載の方法。
- 前記殻流体の流量は、約0.75mL/hである請求項4に記載の方法。
- 捕集電極を備える段階と、
前記形成されたカプセルを前記捕集電極の表面上に堆積する段階とをさらに含む請求項1に記載の方法。 - 前記電位は、正の電気的バイアスである請求項1に記載の方法。
- 前記正の電気的バイアスは、約5kVから約18kVの範囲内の電圧を有する請求項7に記載の方法。
- 前記捕集電極の電位は、グラウンド電位である請求項6に記載の方法。
- 前記電位が前記2流体帯電ジェットと捕集電極との間の電位にバイアスされるようにエクストラクタ本体を備える段階をさらに含む請求項6に記載の方法。
- 前記カプセルの前記殻領域内にマグネタイト粒子の少なくとも1つの化学種を分散させる段階をさらに含む請求項1に記載の方法。
- 前記マグネタイト粒子種は、Fe3O4である請求項11に記載の方法。
- マグネタイト粒子の前記少なくとも1つの化学種は、約1nmから約300nmの範囲内のサイズを有する請求項11に記載の方法。
- 前記カプセルの前記殻領域内に感光ナノ粒子の少なくとも1つの化学種を分散させる段階をさらに含む請求項1に記載の方法。
- 感光ナノ粒子の前記化学種は、銀、金、パラジウム、およびこれらの組み合わせからなる群から選択された化合物である請求項14に記載の方法。
- 前記感光ナノ粒子種は、約1nmから約50nmの範囲内のサイズを有する請求項14に記載の方法。
- さらに、前記カプセルの前記殻の外周上に官能基を分散させる段階を含む請求項1に記載の方法。
- 前記官能基は、ヒドロキシル基、アミノ基、カルボキシル基、カルボン酸無水物基、メルカプト基、ヒドロシリコン基、チオ基、カルボン酸基、アミン基、およびこれらの組み合わせからなる群から選択された物質である請求項17に記載の方法。
- 前記官能基は、膵臓癌細胞に化学的または物理的に付着する能力を有する請求項17に記載の方法。
- 前記官能基は、キナーゼ受容体、線維芽細胞増殖因子受容体、EGF、TGF、VEGF−A、ウロキナーゼ受容体、インターロイキン−4受容体、レチノイン酸受容体、ヘパリン結合EGF様増殖因子、HB−EGF、アンフィレグリン、エピレグリン、ニューレグリン、およびこれらの機能的に同等の物質からなる群から選択された1つまたは複数の化合物である請求項19に記載の方法。
- 前記官能基は、約0wt%から約1wt%の範囲内の含有量を有する請求項20に記載の方法。
- 前記官能基は、グリオーマ細胞に化学的または物理的に付着する能力を有する請求項17に記載の方法。
- 前記官能基は、上皮成長因子およびその機能的に同等の物質である請求項22に記載の方法。
- 前記官能基は、約0wt%から約0.02wt%の範囲内の含有量をカプセル上に有する請求項23に記載の方法。
- 前記官能基は、乳癌細胞に化学的または物理的に付着する能力を有する請求項17に記載の方法。
- 前記官能基は、エストロゲンおよびその機能的に同等の物質である請求項25に記載の方法。
- 前記官能基は、約0.02wt%から約0.4wt%の範囲内の含有量をカプセル上に有する請求項26に記載の方法。
- 前記官能基は、リンパ腫、骨髄腫、および白血病癌細胞の少なくとも一つに化学的または物理的に付着する能力を有する請求項17に記載の方法。
- 前記官能基は、VEGR−2、トスツモマブ、CD20受容体、CD5、CD7、CD13、CD19、CD22、CD33、CD52、CD61に結合できる抗体、抗ミエロペルオキシダーゼ、およびその機能的に同等な物質からなる群から選択された1つまたは複数の化合物である請求項28に記載の方法。
- 前記官能基は、約0.0wt%から約1.0wt%の範囲内の含有量をカプセルの殻上に有する請求項29に記載の方法。
- 前記殻流体は、少なくとも1つの生体適合性ポリマーである請求項1に記載の方法。
- 前記少なくとも1つの生体適合性ポリマーは、ポリ(乳酸)、ポリ(乳酸−コ−グリコール酸)、キトサン、メタクリル酸アルキル、ポリカプロラクトン、デンプン、ポリエチレングリコール、およびこれらの組み合わせから得られるコポリマーからなる群から選択されたポリマーである請求項31に記載の方法。
- 前記コア流体は、治療薬および造影剤のうちの少なくとも1つである請求項1に記載の方法。
- 前記治療薬は、核酸、二本鎖DNA、一本鎖DNA、二本鎖RNA、一本鎖RNA、ペプチド核酸(PNA)、アンチセンスDNA、アンチセンスRNA、低分子干渉RNA、タンパク質、脂質、炭水化物、およびこれらの組み合わせからなる群から選択された1つまたは複数の生物由来物質である請求項33に記載の方法。
- 前記治療薬は、少なくとも1つの生体由来物質である請求項33に記載の方法。
- 前記治療薬は、何らかの病気を患っている患者を治療するのに適している請求項33に記載の方法。
- 前記患者は、乳癌、神経膠腫、リンパ腫、白血病、前立腺癌、膵臓癌、癌腫、肉腫、中皮腫、神経膠腫、胚細胞腫、および絨毛癌からなる群から選択された少なくとも1つの病気を患っている請求項36に記載の方法。
- 前記造影剤は、患者の悪性癌を発見するのに適している請求項33に記載の方法。
- 請求項1に記載の方法により生産される少なくとも1つのカプセル封入された薬剤を入れたカプセル。
- 前記カプセル封入された薬剤は、治療薬および造影剤のうちの少なくとも1つである請求項39に記載のカプセル。
- 前記カプセルは、殻領域とコア領域とを備える請求項39に記載のカプセル。
- 磁気ナノ粒子が、前記殻領域内に分散される請求項41に記載のカプセル。
- 前記官能基は、前記殻領域の外面上に分散される請求項41に記載のカプセル。
- 前記官能基は、標的細胞に化学的または物理的に付着する親和性を有する請求項43に記載のカプセル。
- 前記標的細胞は、乳癌、神経膠腫、リンパ腫、白血病、前立腺癌、膵臓癌、癌腫、肉腫、中皮腫、神経膠腫、胚細胞腫、および絨毛癌からなる群から選択された悪性癌細胞である請求項44に記載のカプセル。
- 前記殻領域は、細孔を備える請求項41に記載のカプセル。
- 前記細孔は、約0.5nmから約2.0nmの範囲内のサイズを有する請求項46に記載のカプセル。
- 前記治療薬は、化学療法薬、放射性同位体、および化学療法増強薬のうちの少なくとも1つである請求項39に記載のカプセル。
- 前記治療薬は、抗炎症性化合物、抗アレルギー剤、グルココルチコイド、抗感染症薬、抗生物質、抗真菌剤、抗ウイルス薬、粘液溶解薬、防腐薬、血管収縮薬、創傷治癒剤、局部麻酔薬、ペプチド、およびタンパク質からなる群から選択された1つの化合物である請求項39に記載のカプセル。
- 前記官能基は、細胞内標的を対象とする能力を有する請求項17に記載のカプセル。
- 前記細胞内標的は、小胞体、ミトコンドリア、ゴルジ体、液胞、核、エアロソーム、中心小体、繊毛、グリオキシゾーム、リソソーム、メラノソーム、筋細線維、核小体、ペルオキシソーム、アクチン、チュブリン、原形質膜、およびリボソーム、ベシクルからなる群から選択された1つまたは複数の構成要素である請求項50に記載のカプセル。
- カプセルであって、
コア領域と、
約0.5nmから約2.0nmの範囲内のサイズを有する細孔を備えるような殻領域と、
少なくとも1つの閉じ込められた、および/またはカプセル封入された薬剤と、
前記殻領域の表面上に分散された官能基とを含むカプセル。 - 前記カプセル封入された、および/または閉じ込められた薬剤は、治療薬および造影剤のうちの少なくとも1つである請求項52に記載のカプセル。
- 磁気ナノ粒子が、前記殻領域内に分散される請求項52に記載のカプセル。
- 前記官能基は、標的細胞に化学的または物理的に付着する親和性を有する請求項52に記載のカプセル。
- 前記標的細胞は、乳癌、神経膠腫、リンパ腫、白血病、前立腺癌、膵臓癌、癌腫、肉腫、中皮腫、神経膠腫、胚細胞腫、および絨毛癌からなる群から選択された悪性癌細胞である請求項55に記載のカプセル。
- 前記治療薬は、化学療法薬、放射性同位体、および化学療法増強薬のうちの少なくとも1つである請求項53に記載のカプセル。
- 前記治療薬は、抗炎症性化合物、抗アレルギー剤、グルココルチコイド、抗感染症薬、抗生物質、抗真菌剤、抗ウイルス薬、粘液溶解薬、防腐薬、血管収縮薬、創傷治癒剤、局部麻酔薬、ペプチド、およびタンパク質からなる群から選択された1つの化合物である請求項57に記載のカプセル。
- 前記官能基は、細胞内標的を対象とする能力を有する請求項52に記載のカプセル。
- 前記細胞内標的は、小胞体、ミトコンドリア、ゴルジ体、液胞、核、エアロソーム、中心小体、繊毛、グリオキシゾーム、リソソーム、メラノソーム、筋細線維、核小体、ペルオキシソーム、アクチン、チュブリン、原形質膜、およびリボソーム、ベシクルからなる群から選択された1つまたは複数の構成要素である請求項52に記載のカプセル。
- 少なくとも1つのカプセル封入された薬剤を有するカプセルを形成するための電気流体力学システムであって、
コア流体を受け入れるように構成された内部を備える中空管と、
前記中空管を取り囲む流体源と、
前記コア流体を前記中空管の前記内部に供給するように配列されたコア流体供給管と、
前記殻流体を前記殻流体源に供給するように配列された殻流体供給管と、
前記コア流体および前記殻流体に電位を加えて、前記流体に少なくとも2流体帯電流体を含むジェットを形成させる電位源とを備える電気流体力学システム。 - 流体槽の上に配置された捕集電極をさらに備える請求項61に記載のシステム。
- 前記流体槽と前記捕集電極との間に配置されたエクストラクタ本体をさらに備える請求項62に記載のシステム。
- 前記カプセル封入された薬剤は、治療薬および造影剤のうちの少なくとも1つである請求項61に記載のシステム。
- コア流体リザーバをさらに備える請求項61に記載のシステム。
- 殻流体リザーバをさらに備える請求項61に記載のシステム。
- 前記流体源は、流体槽である請求項61に記載のシステム。
- 前記流体源は、多孔質材である請求項61に記載のシステム。
- 前記多孔質材は、スポンジである請求項68に記載のシステム。
- 前記流体源は、複数の管を備える請求項61に記載のシステム。
- 少なくとも1つのカプセル封入された薬剤を有するカプセルを形成するためのシステムであって、
複数の中空管と、
前記複数の中空管を取り囲むケースと、
コア流体を前記複数の中空管の前記内部に供給するように配列されたコア流体供給管と、
殻流体を供給するように配列された殻流体供給管と、
前記コア流体および前記殻流体に電位を加えて、前記流体に少なくとも2流体帯電流体を有するジェットを形成させる電位源とを備えるシステム。 - 前記複数の中空管のうちの少なくとも1つは、前記ケース内に円周配列される請求項71に記載のシステム。
- 前記殻供給管は、前記殻流体を前記複数の中空管の間の空間に供給するように構成され、配列される請求項72に記載のシステム。
- 前記複数の中空管は、少なくとも2枚の板を備える前記ケース内に直線状に配列される請求項71に記載のシステム。
- 前記殻供給管は、前記殻流体を前記複数の中空管の間の空間に供給するように構成され、配列される請求項74に記載のシステム。
- 上昇流電気流体力学的作用を行わせるように配列された請求項71に記載のシステム。
- 下降流電気流体力学的作用を行わせるように配列された請求項71に記載のシステム。
- 捕集電極をさらに備える請求項71に記載のシステム。
- 前記システムはエクストラクタ本体をさらに備える請求項71に記載のシステム。
- 前記カプセル封入された薬剤は、治療薬および造影剤のうちの少なくとも1つである請求項71に記載のシステム。
- コア流体リザーバをさらに備える請求項71に記載のシステム。
- 殻流体リザーバをさらに備える請求項71に記載のシステム。
- 前記ケースは、前記殻流体を受け入れ、また送達するように構成される請求項71に記載のシステム。
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JP2013077492A Pending JP2013144154A (ja) | 2006-05-03 | 2013-04-03 | 多層構造の粒子、繊維糸、およびスプレーを生産するためのシステムおよび方法ならびにそれらを施すための方法 |
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EP (2) | EP2724718A1 (ja) |
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JP6356614B2 (ja) | 2012-02-17 | 2018-07-11 | ユニバーシティ・オブ・ジョージア・リサーチ・ファウンデイション・インコーポレイテッド | 薬剤のミトコンドリア輸送のためのナノ粒子 |
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WO2014149279A1 (en) * | 2013-03-15 | 2014-09-25 | The George Washington University, A Congressionally Chartered Not-For-Profit Corporation | Biomimetic biphasic 3d nanocomposite scaffold for osteochondral regeneration |
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CN107614123B (zh) * | 2015-05-14 | 2019-08-30 | 国立大学法人东京农工大学 | 液体射流射出装置和液体射流射出方法 |
HU231076B1 (hu) * | 2015-07-31 | 2020-06-29 | Szegedi Tudományegyetem | Hatóanyagoknak a központi idegrendszerben történő szabályozott leadására alkalmas nanokompozit, eljárás annak előállítására és alkalmazása |
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- 2007-05-03 CN CN201210213588XA patent/CN102871986A/zh active Pending
- 2007-05-03 JP JP2009510081A patent/JP5334841B2/ja not_active Expired - Fee Related
- 2007-05-03 BR BRPI0709753-0A patent/BRPI0709753A2/pt not_active IP Right Cessation
- 2007-05-03 AU AU2007247964A patent/AU2007247964B2/en not_active Ceased
- 2007-05-03 EP EP13162348.0A patent/EP2724718A1/en not_active Withdrawn
- 2007-05-03 CA CA002650937A patent/CA2650937A1/en not_active Abandoned
- 2007-05-03 WO PCT/US2007/068173 patent/WO2007131128A2/en active Application Filing
- 2007-05-03 EP EP07783225A patent/EP2012937A4/en not_active Withdrawn
- 2007-05-03 CN CN2007800237104A patent/CN101479051B/zh not_active Expired - Fee Related
- 2007-05-03 CN CN201310270432.XA patent/CN103393621B/zh active Active
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2012
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2013
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JP2004531301A (ja) * | 2001-03-22 | 2004-10-14 | バテル メモリアル インスティチュート | 溶解可能な製剤の製造 |
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CN103393621B (zh) | 2018-06-01 |
EP2012937A2 (en) | 2009-01-14 |
US20070296099A1 (en) | 2007-12-27 |
CN101479051B (zh) | 2013-07-10 |
JP5334841B2 (ja) | 2013-11-06 |
CN103393621A (zh) | 2013-11-20 |
BRPI0709753A2 (pt) | 2012-08-21 |
AU2007247964B2 (en) | 2012-01-19 |
WO2007131128A2 (en) | 2007-11-15 |
CA2650937A1 (en) | 2007-11-15 |
WO2007131128A3 (en) | 2008-03-20 |
CN101479051A (zh) | 2009-07-08 |
US8297959B2 (en) | 2012-10-30 |
US20130017148A1 (en) | 2013-01-17 |
JP2009536084A (ja) | 2009-10-08 |
AU2007247964A1 (en) | 2007-11-15 |
US20080187487A1 (en) | 2008-08-07 |
EP2724718A1 (en) | 2014-04-30 |
EP2012937A4 (en) | 2013-03-13 |
CN102871986A (zh) | 2013-01-16 |
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