JP2012533601A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012533601A5 JP2012533601A5 JP2012521032A JP2012521032A JP2012533601A5 JP 2012533601 A5 JP2012533601 A5 JP 2012533601A5 JP 2012521032 A JP2012521032 A JP 2012521032A JP 2012521032 A JP2012521032 A JP 2012521032A JP 2012533601 A5 JP2012533601 A5 JP 2012533601A5
- Authority
- JP
- Japan
- Prior art keywords
- aza
- bicyclo
- yloxy
- octane
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052736 halogen Inorganic materials 0.000 claims description 25
- 150000002367 halogens Chemical class 0.000 claims description 25
- 125000004122 cyclic group Chemical group 0.000 claims description 22
- 229910052757 nitrogen Inorganic materials 0.000 claims description 22
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 22
- 125000000217 alkyl group Chemical group 0.000 claims description 20
- 150000001875 compounds Chemical class 0.000 claims description 19
- 229910052717 sulfur Chemical group 0.000 claims description 13
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 11
- 125000003545 alkoxy group Chemical group 0.000 claims description 11
- 125000003118 aryl group Chemical group 0.000 claims description 11
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 11
- 125000001188 haloalkyl group Chemical group 0.000 claims description 11
- 125000005842 heteroatom Chemical group 0.000 claims description 11
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 11
- 229910052760 oxygen Inorganic materials 0.000 claims description 11
- 239000001301 oxygen Chemical group 0.000 claims description 11
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 11
- 125000001424 substituent group Chemical group 0.000 claims description 11
- 239000011593 sulfur Chemical group 0.000 claims description 11
- 125000004434 sulfur atom Chemical group 0.000 claims description 11
- 125000004438 haloalkoxy group Chemical group 0.000 claims description 8
- 125000002950 monocyclic group Chemical group 0.000 claims description 8
- 125000003367 polycyclic group Chemical group 0.000 claims description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 125000002947 alkylene group Chemical group 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 229920006395 saturated elastomer Polymers 0.000 claims description 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 4
- 239000012458 free base Substances 0.000 claims description 4
- 150000003839 salts Chemical group 0.000 claims description 4
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 125000006413 ring segment Chemical group 0.000 claims description 3
- -1 6-p-tolyl-pyridin-3-yloxy Chemical group 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- OAELZAVJUGTVJK-SJCJKPOMSA-N (2s,3r)-2-methyl-3-[6-(5-methylthiophen-2-yl)pyridazin-3-yl]oxy-1-azabicyclo[2.2.2]octane Chemical compound O([C@H]1[C@@H](N2CCC1CC2)C)C(N=N1)=CC=C1C1=CC=C(C)S1 OAELZAVJUGTVJK-SJCJKPOMSA-N 0.000 claims 1
- BOOUVSNRSCUOIL-INIZCTEOSA-N (3r)-3-(5-phenylpyrimidin-2-yl)oxy-1-azabicyclo[2.2.2]octane Chemical compound O([C@@H]1C2CCN(C1)CC2)C(N=C1)=NC=C1C1=CC=CC=C1 BOOUVSNRSCUOIL-INIZCTEOSA-N 0.000 claims 1
- UOXAHMAZBMSBFV-SFHVURJKSA-N (3r)-3-(6-phenylpyridin-3-yl)oxy-1-azabicyclo[2.2.2]octane Chemical compound O([C@@H]1C2CCN(C1)CC2)C(C=N1)=CC=C1C1=CC=CC=C1 UOXAHMAZBMSBFV-SFHVURJKSA-N 0.000 claims 1
- IVSYTOZBFVMTEM-KRWDZBQOSA-N (3r)-3-[5-(2-fluoro-4-methylphenyl)pyrimidin-2-yl]oxy-1-azabicyclo[2.2.2]octane Chemical compound FC1=CC(C)=CC=C1C(C=N1)=CN=C1O[C@@H]1C(CC2)CCN2C1 IVSYTOZBFVMTEM-KRWDZBQOSA-N 0.000 claims 1
- FJSAFINTVSTUNP-SFHVURJKSA-N (3r)-3-[5-(3,4-dimethylphenyl)pyrimidin-2-yl]oxy-1-azabicyclo[2.2.2]octane Chemical compound C1=C(C)C(C)=CC=C1C(C=N1)=CN=C1O[C@@H]1C(CC2)CCN2C1 FJSAFINTVSTUNP-SFHVURJKSA-N 0.000 claims 1
- IADFRBKHIWFHFV-KRWDZBQOSA-N (3r)-3-[5-(4-methylphenyl)pyrimidin-2-yl]oxy-1-azabicyclo[2.2.2]octane Chemical compound C1=CC(C)=CC=C1C(C=N1)=CN=C1O[C@@H]1C(CC2)CCN2C1 IADFRBKHIWFHFV-KRWDZBQOSA-N 0.000 claims 1
- QUVNZVHUMJPPGC-KRWDZBQOSA-N (3r)-3-[6-(2,5-difluoro-4-methylphenyl)pyridazin-3-yl]oxy-1-azabicyclo[2.2.2]octane Chemical compound C1=C(F)C(C)=CC(F)=C1C(N=N1)=CC=C1O[C@@H]1C(CC2)CCN2C1 QUVNZVHUMJPPGC-KRWDZBQOSA-N 0.000 claims 1
- OWGWNCCDDZYCGR-SFHVURJKSA-N (3r)-3-[6-(2-fluoro-4,5-dimethylphenyl)pyridazin-3-yl]oxy-1-azabicyclo[2.2.2]octane Chemical compound C1=C(C)C(C)=CC(F)=C1C(N=N1)=CC=C1O[C@@H]1C(CC2)CCN2C1 OWGWNCCDDZYCGR-SFHVURJKSA-N 0.000 claims 1
- GDJTWWGJXFJUTQ-KRWDZBQOSA-N (3r)-3-[6-(2-fluoro-4-methylphenyl)pyridazin-3-yl]oxy-1-azabicyclo[2.2.2]octane Chemical compound FC1=CC(C)=CC=C1C(N=N1)=CC=C1O[C@@H]1C(CC2)CCN2C1 GDJTWWGJXFJUTQ-KRWDZBQOSA-N 0.000 claims 1
- RIZMSQYMRPTCFN-SFHVURJKSA-N (3r)-3-[6-(3,4-dimethylphenyl)pyridazin-3-yl]oxy-1-azabicyclo[2.2.2]octane Chemical compound C1=C(C)C(C)=CC=C1C(N=N1)=CC=C1O[C@@H]1C(CC2)CCN2C1 RIZMSQYMRPTCFN-SFHVURJKSA-N 0.000 claims 1
- PLYXOZYCJHNCBB-FQEVSTJZSA-N (3r)-3-[6-(3,4-dimethylphenyl)pyridin-3-yl]oxy-1-azabicyclo[2.2.2]octane Chemical compound C1=C(C)C(C)=CC=C1C(N=C1)=CC=C1O[C@@H]1C(CC2)CCN2C1 PLYXOZYCJHNCBB-FQEVSTJZSA-N 0.000 claims 1
- TYNXKNLHFFRJPQ-KRWDZBQOSA-N (3r)-3-[6-(4-methylphenyl)pyridazin-3-yl]oxy-1-azabicyclo[2.2.2]octane Chemical compound C1=CC(C)=CC=C1C(N=N1)=CC=C1O[C@@H]1C(CC2)CCN2C1 TYNXKNLHFFRJPQ-KRWDZBQOSA-N 0.000 claims 1
- NPDLTEZXGWRMLQ-IBGZPJMESA-N (3r)-3-[6-(4-methylphenyl)pyridin-3-yl]oxy-1-azabicyclo[2.2.2]octane Chemical compound C1=CC(C)=CC=C1C(N=C1)=CC=C1O[C@@H]1C(CC2)CCN2C1 NPDLTEZXGWRMLQ-IBGZPJMESA-N 0.000 claims 1
- JXZOJYUTJFMJQV-UHFFFAOYSA-N 2,3-dimethyl-5-[6-[(2-methyl-1-azabicyclo[2.2.2]octan-3-yl)oxy]pyridazin-3-yl]-1h-indole Chemical compound C1CC2CCN1C(C)C2OC1=CC=C(C=2C=C3C(C)=C(C)NC3=CC=2)N=N1 JXZOJYUTJFMJQV-UHFFFAOYSA-N 0.000 claims 1
- XHUPABDGSDCFMH-BFUOFWGJSA-N 5-[2-[[(2r,3s)-2-methyl-1-azabicyclo[2.2.2]octan-3-yl]oxy]pyrimidin-5-yl]-1h-indole Chemical compound C1CC2CCN1[C@H](C)[C@H]2OC1=NC=C(C=2C=C3C=CNC3=CC=2)C=N1 XHUPABDGSDCFMH-BFUOFWGJSA-N 0.000 claims 1
- XHUPABDGSDCFMH-DJJJIMSYSA-N 5-[2-[[(2s,3r)-2-methyl-1-azabicyclo[2.2.2]octan-3-yl]oxy]pyrimidin-5-yl]-1h-indole Chemical compound C1CC2CCN1[C@@H](C)[C@@H]2OC1=NC=C(C=2C=C3C=CNC3=CC=2)C=N1 XHUPABDGSDCFMH-DJJJIMSYSA-N 0.000 claims 1
- ZQXZZBNDHQVUEX-UHFFFAOYSA-N 5-[5-[(2-methyl-1-azabicyclo[2.2.2]octan-3-yl)oxy]pyridin-2-yl]-1h-indole Chemical compound C1CC2CCN1C(C)C2OC1=CC=C(C=2C=C3C=CNC3=CC=2)N=C1 ZQXZZBNDHQVUEX-UHFFFAOYSA-N 0.000 claims 1
- WFMNAESJUUOVOL-ZUOKHONESA-N 5-[6-[[(2r,3s)-2-methyl-1-azabicyclo[2.2.2]octan-3-yl]oxy]pyridazin-3-yl]-1h-indole Chemical compound C1CC2CCN1[C@H](C)[C@H]2OC1=CC=C(C=2C=C3C=CNC3=CC=2)N=N1 WFMNAESJUUOVOL-ZUOKHONESA-N 0.000 claims 1
- WFMNAESJUUOVOL-RBZFPXEDSA-N 5-[6-[[(2s,3r)-2-methyl-1-azabicyclo[2.2.2]octan-3-yl]oxy]pyridazin-3-yl]-1h-indole Chemical compound C1CC2CCN1[C@@H](C)[C@@H]2OC1=CC=C(C=2C=C3C=CNC3=CC=2)N=N1 WFMNAESJUUOVOL-RBZFPXEDSA-N 0.000 claims 1
- 206010003591 Ataxia Diseases 0.000 claims 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22795109P | 2009-07-23 | 2009-07-23 | |
| US61/227,951 | 2009-07-23 | ||
| PCT/EP2010/060571 WO2011009890A2 (en) | 2009-07-23 | 2010-07-21 | Use of azabicycloalkyl derivatives or pyrrolidine-2-one derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015117200A Division JP2015212277A (ja) | 2009-07-23 | 2015-06-10 | 運動失調症の処置または予防のための、アザビシクロアルキル誘導体またはピロリジン−２−オン誘導体の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012533601A JP2012533601A (ja) | 2012-12-27 |
| JP2012533601A5 true JP2012533601A5 (OSRAM) | 2015-07-30 |
Family
ID=43127649
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012521032A Pending JP2012533601A (ja) | 2009-07-23 | 2010-07-21 | 運動失調症の処置または予防のための、アザビシクロアルキル誘導体またはピロリジン−２−オン誘導体の使用 |
| JP2015117200A Pending JP2015212277A (ja) | 2009-07-23 | 2015-06-10 | 運動失調症の処置または予防のための、アザビシクロアルキル誘導体またはピロリジン−２−オン誘導体の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015117200A Pending JP2015212277A (ja) | 2009-07-23 | 2015-06-10 | 運動失調症の処置または予防のための、アザビシクロアルキル誘導体またはピロリジン−２−オン誘導体の使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20120157464A1 (OSRAM) |
| EP (2) | EP2959902A1 (OSRAM) |
| JP (2) | JP2012533601A (OSRAM) |
| CN (1) | CN102573842A (OSRAM) |
| WO (1) | WO2011009890A2 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6262265A (ja) * | 1985-09-13 | 1987-03-18 | Hitachi Ltd | 復水器自動検査補修システム |
| JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
| CA2830458A1 (en) * | 2011-03-18 | 2012-09-27 | Novartis Ag | Combinations of alpha 7 nicotinic acetylcholine receptor activators and mglur5 antagonists for use in dopamine induced dyskinesia in parkinson's disease |
| WO2013010679A1 (en) | 2011-07-15 | 2013-01-24 | Novartis Ag | Salts of aza-bicyclic di-aryl ethers and methods to make them or their precursors |
| JOP20130273B1 (ar) | 2012-09-11 | 2021-08-17 | Genzyme Corp | مثبطات انزيم (سينثاز) غلوكوسيل سيراميد |
| BR112015016994A8 (pt) * | 2013-01-15 | 2018-01-23 | Novartis Ag | uso de agonistas do receptor alfa 7 nicotínico de acetilcolina |
| US20150313884A1 (en) | 2013-01-15 | 2015-11-05 | Novartis Ag | Use of alpha 7 nicotinic acetylcholine receptor agonists |
| WO2014111837A1 (en) * | 2013-01-15 | 2014-07-24 | Novartis Ag | Use of alpha 7 nicotinic acetylcholine receptor agonists |
| PL3027600T3 (pl) * | 2013-07-31 | 2022-08-08 | Novartis Ag | 1,4-dwupodstawione pochodne pirydazyny i ich zastosowanie do leczenia stanów związanych z niedoborem smn |
| IL295255A (en) | 2020-02-03 | 2022-10-01 | Genzyme Corp | Methods for treating neurological symptoms associated with lysosomal storage diseases |
| MX2023001014A (es) | 2020-07-24 | 2023-03-01 | Genzyme Corp | Composiciones farmaceuticas que comprenden venglustat. |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0010955D0 (en) * | 2000-05-05 | 2000-06-28 | Novartis Ag | Organic compounds |
| GB0128996D0 (en) | 2001-12-04 | 2002-01-23 | Novartis Ag | Organic compounds |
| SE0201943D0 (sv) | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | New use |
| RU2323217C2 (ru) * | 2002-08-14 | 2008-04-27 | Ньюросерч А/С | Новые хинуклидиновые производные и их применение |
| EP1531820A1 (en) * | 2002-08-30 | 2005-05-25 | Memory Pharmaceuticals Corporation | Anabaseine derivatives useful in the treatment of neurodegenerative diseases |
| BR0203527A (pt) | 2002-09-03 | 2004-05-25 | Kluber Lubrication Lubrificant | Fluìdo transmissor de calor e seu respectivo processo de obtenção |
| GB0220581D0 (en) * | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
| CA2549965A1 (en) | 2003-10-31 | 2005-05-19 | Astrazeneca Ab | Alkynes iii |
| WO2005044267A1 (en) | 2003-10-31 | 2005-05-19 | Astrazeneca Ab | Alkynes ii |
| CA2549967A1 (en) | 2003-10-31 | 2005-05-19 | Astrazeneca Ab | Alkynes i |
| US20070060588A1 (en) * | 2003-12-22 | 2007-03-15 | Jianguo Ji | Fused bicycloheterocycle substituted quinuclidine derivatives |
| US7071143B2 (en) | 2004-01-28 | 2006-07-04 | Eastman Kodak Company | Direct thermographic materials with improved protective layers |
| GB0412019D0 (en) | 2004-05-28 | 2004-06-30 | Novartis Ag | Organic compounds |
| PE20060437A1 (es) * | 2004-06-18 | 2006-06-08 | Novartis Ag | COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR |
| GB0415746D0 (en) * | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
| ATE441792T1 (de) | 2005-04-25 | 2009-09-15 | Hoerbiger & Co | Betätigungssteuereinrichtung für die lamellen einer hydraulischen doppelkupplung |
| GB0521508D0 (en) * | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
| GB0525673D0 (en) * | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| GB0525672D0 (en) * | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| AU2006329007A1 (en) | 2005-12-20 | 2007-06-28 | Novartis Ag | Nicotinic acid derivatives as modulators of metabotropic glutamate receptors |
| WO2007085036A1 (en) | 2006-01-26 | 2007-08-02 | Medizinische Universität Wien | Treatment of friedreich' s ataxia |
| AU2007219009B2 (en) | 2006-02-22 | 2012-12-20 | Apotex Technologies Inc. | The use of deferiprone and methods to treat and/or prevent Friedreich Ataxia resulting from intracellular mishandling of iron |
| CL2008000119A1 (es) * | 2007-01-16 | 2008-05-16 | Wyeth Corp | Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia. |
| MX2010003156A (es) * | 2007-10-04 | 2010-04-01 | Hoffmann La Roche | Derivados de aril amida substituida con tetrazol y usos de los mismos. |
| JP2011516489A (ja) * | 2008-03-31 | 2011-05-26 | ユニバーシティ・オブ・サウス・フロリダ | 疾患誘発性運動失調症および非運動失調性平衡異常の治療法 |
-
2010
- 2010-07-21 WO PCT/EP2010/060571 patent/WO2011009890A2/en not_active Ceased
- 2010-07-21 JP JP2012521032A patent/JP2012533601A/ja active Pending
- 2010-07-21 EP EP15176482.6A patent/EP2959902A1/en not_active Withdrawn
- 2010-07-21 EP EP10734744A patent/EP2456438A2/en not_active Ceased
- 2010-07-21 CN CN2010800335791A patent/CN102573842A/zh active Pending
- 2010-07-21 US US13/383,690 patent/US20120157464A1/en not_active Abandoned
-
2015
- 2015-06-10 JP JP2015117200A patent/JP2015212277A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012533601A5 (OSRAM) | ||
| JP2017509586A5 (OSRAM) | ||
| JP2019512478A5 (OSRAM) | ||
| JP2017502092A5 (OSRAM) | ||
| JP2010509356A5 (OSRAM) | ||
| JP2010509375A5 (OSRAM) | ||
| RU2011124304A (ru) | Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе | |
| JP2015537020A5 (OSRAM) | ||
| JP2008195730A5 (OSRAM) | ||
| JP2014527974A5 (OSRAM) | ||
| JP2013533253A5 (OSRAM) | ||
| JP2017515844A5 (OSRAM) | ||
| JP2014515406A5 (OSRAM) | ||
| JP2017528467A5 (OSRAM) | ||
| JP2016508130A5 (OSRAM) | ||
| JP2013510120A5 (OSRAM) | ||
| NZ590987A (en) | Quinuclidine carbonate derivatives and medicinal composition thereof | |
| RU2013130253A (ru) | 7-деазапуриновые регуляторы метилтрансферазы гистонов и способы их применения | |
| JP2010511721A5 (OSRAM) | ||
| JP2010138190A5 (OSRAM) | ||
| EA201071094A1 (ru) | Тризамещенные 1,2,4-триазолы в качестве модуляторов никотиновых ацетилхолиновых рецепторов | |
| RU2012123154A (ru) | Способы лечения синдрома фибромиалгии | |
| UY29389A1 (es) | Derivados sustituidos del ácido1-((4-((((3,3-dimetil-2-oxo-2,3-dihidro-1h-indol-1-il)carbonil)amino)metil)piperidin-1-il)metil)ciclobutanocarboxílico, sales farmaceuticamente aceptables, composiciones que los contienen y aplicaciones. | |
| JP2011513410A5 (OSRAM) | ||
| HRP20130040T1 (hr) | 4-piridinon spojevi i njihova uporaba kod karcinoma |