JP2012533407A - Ｌ−ラクチドのコポリマーを含む破壊靱性を改良した埋込型医療機器 - Google Patents
Ｌ−ラクチドのコポリマーを含む破壊靱性を改良した埋込型医療機器 Download PDFInfo
- Publication number
- JP2012533407A JP2012533407A JP2012521677A JP2012521677A JP2012533407A JP 2012533407 A JP2012533407 A JP 2012533407A JP 2012521677 A JP2012521677 A JP 2012521677A JP 2012521677 A JP2012521677 A JP 2012521677A JP 2012533407 A JP2012533407 A JP 2012533407A
- Authority
- JP
- Japan
- Prior art keywords
- lactide
- copolymer
- mol
- poly
- implantable medical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001577 copolymer Polymers 0.000 title claims abstract description 53
- JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 title claims abstract description 18
- 229920000642 polymer Polymers 0.000 claims description 67
- 239000000178 monomer Substances 0.000 claims description 28
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 14
- 239000002667 nucleating agent Substances 0.000 claims description 12
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 claims description 12
- 229920001434 poly(D-lactide) Polymers 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 238000000137 annealing Methods 0.000 claims description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 claims description 6
- VPVXHAANQNHFSF-UHFFFAOYSA-N 1,4-dioxan-2-one Chemical compound O=C1COCCO1 VPVXHAANQNHFSF-UHFFFAOYSA-N 0.000 claims description 5
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical class CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims description 5
- -1 citrate ester Chemical class 0.000 claims description 4
- KMZHZAAOEWVPSE-UHFFFAOYSA-N 2,3-dihydroxypropyl acetate Chemical compound CC(=O)OCC(O)CO KMZHZAAOEWVPSE-UHFFFAOYSA-N 0.000 claims description 3
- MQIUGAXCHLFZKX-UHFFFAOYSA-N Di-n-octyl phthalate Natural products CCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCC MQIUGAXCHLFZKX-UHFFFAOYSA-N 0.000 claims description 3
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 3
- 239000005977 Ethylene Substances 0.000 claims description 3
- UYXTWWCETRIEDR-UHFFFAOYSA-N Tributyrin Chemical compound CCCC(=O)OCC(OC(=O)CCC)COC(=O)CCC UYXTWWCETRIEDR-UHFFFAOYSA-N 0.000 claims description 3
- WURBFLDFSFBTLW-UHFFFAOYSA-N benzil Chemical group C=1C=CC=CC=1C(=O)C(=O)C1=CC=CC=C1 WURBFLDFSFBTLW-UHFFFAOYSA-N 0.000 claims description 3
- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 claims description 3
- DGVMNQYBHPSIJS-UHFFFAOYSA-N dimagnesium;2,2,6,6-tetraoxido-1,3,5,7-tetraoxa-2,4,6-trisilaspiro[3.3]heptane;hydrate Chemical compound O.[Mg+2].[Mg+2].O1[Si]([O-])([O-])O[Si]21O[Si]([O-])([O-])O2 DGVMNQYBHPSIJS-UHFFFAOYSA-N 0.000 claims description 3
- GRGBENNNGZARRZ-UHFFFAOYSA-N dodecanedihydrazide Chemical compound NNC(=O)CCCCCCCCCCC(=O)NN GRGBENNNGZARRZ-UHFFFAOYSA-N 0.000 claims description 3
- 229940116333 ethyl lactate Drugs 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 3
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 3
- 239000000454 talc Substances 0.000 claims description 3
- 229910052623 talc Inorganic materials 0.000 claims description 3
- XZZNDPSIHUTMOC-UHFFFAOYSA-N triphenyl phosphate Chemical compound C=1C=CC=CC=1OP(OC=1C=CC=CC=1)(=O)OC1=CC=CC=C1 XZZNDPSIHUTMOC-UHFFFAOYSA-N 0.000 claims description 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- 239000000194 fatty acid Substances 0.000 claims description 2
- 229930195729 fatty acid Natural products 0.000 claims description 2
- 150000004665 fatty acids Chemical class 0.000 claims description 2
- 150000003903 lactic acid esters Chemical class 0.000 claims description 2
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 description 11
- 238000006243 chemical reaction Methods 0.000 description 10
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 10
- 230000002792 vascular Effects 0.000 description 10
- 239000013078 crystal Substances 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 229920001432 poly(L-lactide) Polymers 0.000 description 8
- 230000008569 process Effects 0.000 description 8
- 238000002425 crystallisation Methods 0.000 description 7
- 230000008025 crystallization Effects 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 229920000747 poly(lactic acid) Polymers 0.000 description 6
- 229920005603 alternating copolymer Polymers 0.000 description 5
- 238000006065 biodegradation reaction Methods 0.000 description 5
- 229920001400 block copolymer Polymers 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 229920001519 homopolymer Polymers 0.000 description 5
- 235000014655 lactic acid Nutrition 0.000 description 5
- 239000004310 lactic acid Substances 0.000 description 5
- 230000006911 nucleation Effects 0.000 description 5
- 238000010899 nucleation Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 230000000295 complement effect Effects 0.000 description 4
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 4
- 238000001125 extrusion Methods 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 229940065514 poly(lactide) Drugs 0.000 description 4
- 238000006116 polymerization reaction Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
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- 150000003384 small molecules Chemical class 0.000 description 3
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- 229940124597 therapeutic agent Drugs 0.000 description 3
- 206010051113 Arterial restenosis Diseases 0.000 description 2
- 208000014882 Carotid artery disease Diseases 0.000 description 2
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 2
- 210000000013 bile duct Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003999 initiator Substances 0.000 description 2
- 238000010907 mechanical stirring Methods 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 229920005604 random copolymer Polymers 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- 206010002329 Aneurysm Diseases 0.000 description 1
- 206010056375 Bile duct obstruction Diseases 0.000 description 1
- 206010008635 Cholestasis Diseases 0.000 description 1
- 101100453790 Drosophila melanogaster Kebab gene Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000016222 Pancreatic disease Diseases 0.000 description 1
- 208000005764 Peripheral Arterial Disease Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 208000004608 Ureteral Obstruction Diseases 0.000 description 1
- 206010070693 Vascular dissection Diseases 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 229920000249 biocompatible polymer Polymers 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
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- 230000000747 cardiac effect Effects 0.000 description 1
- 208000037876 carotid Atherosclerosis Diseases 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000000412 dendrimer Substances 0.000 description 1
- 210000001787 dendrite Anatomy 0.000 description 1
- 229920000736 dendritic polymer Polymers 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
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- 210000003709 heart valve Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
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- 235000015231 kebab Nutrition 0.000 description 1
- 208000030175 lameness Diseases 0.000 description 1
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- 239000004014 plasticizer Substances 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
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- 229920006126 semicrystalline polymer Polymers 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000005070 sphincter Anatomy 0.000 description 1
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- 230000002194 synthesizing effect Effects 0.000 description 1
- KSBAEPSJVUENNK-UHFFFAOYSA-L tin(ii) 2-ethylhexanoate Chemical compound [Sn+2].CCCCC(CC)C([O-])=O.CCCCC(CC)C([O-])=O KSBAEPSJVUENNK-UHFFFAOYSA-L 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
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- 210000003437 trachea Anatomy 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/506,881 US8119704B2 (en) | 2009-07-21 | 2009-07-21 | Implantable medical device comprising copolymer of L-lactide with improved fracture toughness |
| US12/506,881 | 2009-07-21 | ||
| PCT/US2010/041996 WO2011011241A2 (en) | 2009-07-21 | 2010-07-14 | Implantable medical device comprising copolymer of l-lactide with improved fracture toughness |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012533407A true JP2012533407A (ja) | 2012-12-27 |
| JP2012533407A5 JP2012533407A5 (enExample) | 2013-08-29 |
Family
ID=42731899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012521677A Pending JP2012533407A (ja) | 2009-07-21 | 2010-07-14 | Ｌ−ラクチドのコポリマーを含む破壊靱性を改良した埋込型医療機器 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8119704B2 (enExample) |
| EP (1) | EP2456479B1 (enExample) |
| JP (1) | JP2012533407A (enExample) |
| WO (1) | WO2011011241A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014527485A (ja) * | 2011-08-11 | 2014-10-16 | アボット カーディオヴァスキュラー システムズ インコーポレイテッド | 溶融加工のための生体再吸収性ポリマーの水分の制御及び可塑化 |
| US9744259B2 (en) | 2006-06-01 | 2017-08-29 | Abbott Cardiovascular Systems Inc. | Implantable medical devices fabricated from branched polymers |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8952123B1 (en) * | 2006-08-02 | 2015-02-10 | Abbott Cardiovascular Systems Inc. | Dioxanone-based copolymers for implantable devices |
| US20130150943A1 (en) * | 2007-01-19 | 2013-06-13 | Elixir Medical Corporation | Biodegradable endoprostheses and methods for their fabrication |
| US8814930B2 (en) * | 2007-01-19 | 2014-08-26 | Elixir Medical Corporation | Biodegradable endoprosthesis and methods for their fabrication |
| EP2367505B1 (en) | 2008-09-29 | 2020-08-12 | Edwards Lifesciences CardiAQ LLC | Heart valve |
| EP2845569A1 (en) | 2008-10-01 | 2015-03-11 | Cardiaq Valve Technologies, Inc. | Delivery system for vascular implant |
| WO2010121076A2 (en) | 2009-04-15 | 2010-10-21 | Cardiaq Valve Technologies, Inc. | Vascular implant and delivery system |
| US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
| US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
| US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
| KR101316069B1 (ko) | 2011-08-25 | 2013-10-11 | 한국과학기술연구원 | 유연한 폴리락티드 입체이성질 복합체의 제조방법 및 이의 방법에 의해 제조된 화합물 |
| US9345573B2 (en) | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
| US10583002B2 (en) | 2013-03-11 | 2020-03-10 | Neovasc Tiara Inc. | Prosthetic valve with anti-pivoting mechanism |
| US9681951B2 (en) | 2013-03-14 | 2017-06-20 | Edwards Lifesciences Cardiaq Llc | Prosthesis with outer skirt and anchors |
| US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
| CN103387756B (zh) * | 2013-07-30 | 2015-07-08 | 浙江微度医疗器械有限公司 | 一种羟基磷灰石的改性方法和应用 |
| US9480588B2 (en) | 2014-08-15 | 2016-11-01 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
| US9259339B1 (en) | 2014-08-15 | 2016-02-16 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
| US9730819B2 (en) | 2014-08-15 | 2017-08-15 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
| US9855156B2 (en) * | 2014-08-15 | 2018-01-02 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
| US11622872B2 (en) | 2016-05-16 | 2023-04-11 | Elixir Medical Corporation | Uncaging stent |
| ES2873887T3 (es) | 2016-05-16 | 2021-11-04 | Elixir Medical Corp | Liberación de stent |
| CN107011641A (zh) * | 2017-05-11 | 2017-08-04 | 广州飞胜高分子材料有限公司 | 一种用于3d打印的低温支架复合材料及其加工方法 |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH03205059A (ja) * | 1989-09-27 | 1991-09-06 | Bristol Myers Squibb Co | 生分解ステント |
| JP2005525911A (ja) * | 2002-05-20 | 2005-09-02 | オーバス メディカル テクノロジーズ インク． | 移植可能な薬物溶出医療用デバイス |
| JP2007046050A (ja) * | 2005-07-15 | 2007-02-22 | National Institute Of Advanced Industrial & Technology | 医療用樹脂組成物とその製造方法および成形体 |
| JP2007512094A (ja) * | 2003-11-20 | 2007-05-17 | アドヴァンスド カーディオヴァスキュラー システムズ， インコーポレイテッド | 乳酸のポリマーを含む埋め込み型用具用コーティングおよびこのコーティングの製造方法 |
| JP2008012912A (ja) * | 2006-05-25 | 2008-01-24 | Cordis Corp | フープの選定された領域に、改変された分子構造を有するポリマーステント、および、それの製造方法 |
| JP2008110204A (ja) * | 2006-10-06 | 2008-05-15 | Cordis Corp | 分解を促進するための複合構造を有する生体吸収性装置 |
| WO2008089434A2 (en) * | 2007-01-19 | 2008-07-24 | Elixir Medical Corporation | Biodegradable endoprostheses and methods for their fabrication |
| JP2008539002A (ja) * | 2005-04-29 | 2008-11-13 | アボット カーディオヴァスキュラー システムズ インコーポレイテッド | 非晶質ポリ（ｄ，ｌ−ラクチド）被膜 |
| WO2009045808A2 (en) * | 2007-09-28 | 2009-04-09 | Abbott Cardiovascular Systems Inc. | Implantable medical devices fabricated from block copolymers |
| WO2009055426A2 (en) * | 2007-10-23 | 2009-04-30 | Abbott Cardiovascular Systems Inc. | Random amorphous terpolymer containing lactide and glycolide |
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| US9744259B2 (en) | 2006-06-01 | 2017-08-29 | Abbott Cardiovascular Systems Inc. | Implantable medical devices fabricated from branched polymers |
| US9931431B2 (en) | 2006-06-01 | 2018-04-03 | Abbott Cardiovascular Systems Inc. | Implantable medical devices fabricated from branched polymers |
| JP2014527485A (ja) * | 2011-08-11 | 2014-10-16 | アボット カーディオヴァスキュラー システムズ インコーポレイテッド | 溶融加工のための生体再吸収性ポリマーの水分の制御及び可塑化 |
| US10213949B2 (en) | 2011-08-11 | 2019-02-26 | Abbott Cardiovascular Systems Inc. | Controlling moisture in and plasticization of bioresorbable polymer for melt processing |
Also Published As
| Publication number | Publication date |
|---|---|
| US20110022163A1 (en) | 2011-01-27 |
| WO2011011241A3 (en) | 2011-05-05 |
| EP2456479A2 (en) | 2012-05-30 |
| US8119704B2 (en) | 2012-02-21 |
| EP2456479B1 (en) | 2013-05-15 |
| WO2011011241A2 (en) | 2011-01-27 |
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