JP2012533308A5 - - Google Patents
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- Publication number
- JP2012533308A5 JP2012533308A5 JP2012520829A JP2012520829A JP2012533308A5 JP 2012533308 A5 JP2012533308 A5 JP 2012533308A5 JP 2012520829 A JP2012520829 A JP 2012520829A JP 2012520829 A JP2012520829 A JP 2012520829A JP 2012533308 A5 JP2012533308 A5 JP 2012533308A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- concentration
- extract
- rrna
- rna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22610609P | 2009-07-16 | 2009-07-16 | |
| US22602509P | 2009-07-16 | 2009-07-16 | |
| US61/226,025 | 2009-07-16 | ||
| US61/226,106 | 2009-07-16 | ||
| PCT/US2010/042365 WO2011009104A1 (en) | 2009-07-16 | 2010-07-16 | Nucleic acid analysis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015246006A Division JP2016116512A (ja) | 2009-07-16 | 2015-12-17 | 核酸分析 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012533308A JP2012533308A (ja) | 2012-12-27 |
| JP2012533308A5 true JP2012533308A5 (https=) | 2013-08-29 |
| JP5909444B2 JP5909444B2 (ja) | 2016-04-26 |
Family
ID=43449850
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012520829A Active JP5909444B2 (ja) | 2009-07-16 | 2010-07-16 | 核酸分析 |
| JP2015246006A Pending JP2016116512A (ja) | 2009-07-16 | 2015-12-17 | 核酸分析 |
| JP2017086218A Pending JP2017131244A (ja) | 2009-07-16 | 2017-04-25 | 核酸分析 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015246006A Pending JP2016116512A (ja) | 2009-07-16 | 2015-12-17 | 核酸分析 |
| JP2017086218A Pending JP2017131244A (ja) | 2009-07-16 | 2017-04-25 | 核酸分析 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20110195426A1 (https=) |
| EP (1) | EP2454588B1 (https=) |
| JP (3) | JP5909444B2 (https=) |
| KR (2) | KR20180029105A (https=) |
| CN (2) | CN105779436A (https=) |
| AU (1) | AU2010273928A1 (https=) |
| BR (1) | BR112012001077A2 (https=) |
| CA (1) | CA2768371A1 (https=) |
| DK (1) | DK2454588T3 (https=) |
| ES (1) | ES2547715T3 (https=) |
| IN (1) | IN2012DN00866A (https=) |
| SG (2) | SG177677A1 (https=) |
| WO (1) | WO2011009104A1 (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3517151T3 (da) * | 2006-03-09 | 2021-07-12 | Aethlon Medical Inc | Ekstrakorporal fjernelse af mikrovesikulære partikler |
| US11266736B2 (en) | 2008-04-17 | 2022-03-08 | Vin De Bona Trading Company Pte Ltd | Method of painting micro vesicles |
| EP2475988B1 (en) | 2009-09-09 | 2018-11-14 | The General Hospital Corporation | Use of microvesicles in analyzing nucleic acid profiles |
| US20130029339A1 (en) | 2009-09-09 | 2013-01-31 | The General Hospital Corporation | Use of microvesicles in analyzing kras mutations |
| WO2011156763A1 (en) * | 2010-06-11 | 2011-12-15 | Hitachi Chemical Co., Ltd. | Methods for characterizing kidney function |
| WO2012031008A2 (en) | 2010-08-31 | 2012-03-08 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
| CA2817111C (en) * | 2010-11-10 | 2019-03-05 | Exosome Diagnostics, Inc. | Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom |
| CA2821355A1 (en) * | 2011-01-31 | 2012-08-09 | Esoterix Genetic Laboratories, Llc | Methods for enriching microparticles or nucleic acids using binding molecules |
| CA2835641C (en) * | 2011-05-11 | 2019-05-28 | Exosome Diagnostics, Inc. | Nucleic acid extraction from heterogeneous biological materials |
| JP5823031B2 (ja) | 2011-06-10 | 2015-11-25 | 日立化成株式会社 | 小胞捕捉デバイスおよびそれを用いるための方法 |
| EP3492606B1 (en) | 2011-08-22 | 2023-10-04 | Exosome Diagnostics, Inc. | Urine biomarkers |
| US10174361B2 (en) * | 2011-11-10 | 2019-01-08 | Exosome Diagnostics, Inc. | Cerebrospinal fluid assay |
| CN104995311A (zh) | 2012-08-30 | 2015-10-21 | 外来体诊断公司 | 用于核酸测定的对照 |
| WO2014055775A1 (en) | 2012-10-03 | 2014-04-10 | Exosome Diagnostics, Inc. | Use of microvesicles in diagnosis, prognosis, and treatment of medical diseases and conditions |
| WO2014055687A1 (en) * | 2012-10-05 | 2014-04-10 | Hitachi Chemical Co., Ltd. | Urine exosome mrnas and methods of using same to detect diabetic nephropathy |
| DK2906717T3 (en) | 2012-10-11 | 2019-04-01 | Vin De Bona Trading Company Pte Ltd | PROCEDURE FOR PAINTING MICROVESICS |
| WO2014159662A1 (en) * | 2013-03-13 | 2014-10-02 | University Of Miami | Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids |
| US12558316B2 (en) | 2013-03-13 | 2026-02-24 | University Of Miami | Methods and compositions for the treatment of epidermolysis bullosa |
| WO2014182330A1 (en) | 2013-05-06 | 2014-11-13 | Hitachi Chemical Company Ltd | Devices and methods for capturing target molecules |
| CA2920429C (en) | 2013-08-06 | 2021-11-16 | Exosome Diagnostics, Inc. | Urine biomarker cohorts, gene expression signatures, and methods of use thereof |
| ES2923942T3 (es) * | 2013-11-06 | 2022-10-03 | Us Health | Procedimiento para el subtipado de tipos de linfoma por medio de perfiles de expresión |
| EP3077528B1 (en) * | 2013-12-02 | 2018-08-22 | Albert-Ludwigs-Universität Freiburg | Process for the diagnosis of cancer by using exosomes |
| EP3125907A4 (en) | 2014-04-01 | 2017-11-29 | Cornell University | Use of double-stranded dna in exosomes: a novel biomarker in cancer detection |
| EP3134524A4 (en) * | 2014-04-22 | 2017-11-29 | Trovagene, Inc. | Concentrating nucleic acids in urine |
| CN104031915A (zh) * | 2014-06-17 | 2014-09-10 | 复旦大学附属肿瘤医院 | 用于结直肠癌预后的基因片段及其应用 |
| US10266895B2 (en) | 2014-11-05 | 2019-04-23 | Hitachi Chemical Company Ltd. | Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease |
| EP3218521B1 (en) | 2014-11-12 | 2019-12-25 | Hitachi Chemical Co., Ltd. | Method for diagnosing organ injury |
| WO2016172598A1 (en) * | 2015-04-22 | 2016-10-27 | The Broad Institute Inc. | Exosomes and uses thereof |
| GB2539497A (en) | 2015-06-19 | 2016-12-21 | Airbus Operations Ltd | A Rotational Joint For An Aircraft Folding Wing |
| DE112016003948T5 (de) | 2015-08-31 | 2018-05-09 | City Of Sapporo | Molekulare verfahren zum beurteilen einer urothelialen erkrankung |
| WO2017181161A1 (en) | 2016-04-15 | 2017-10-19 | Predicine, Inc. | Systems and methods for detecting genetic alterations |
| CN109642229A (zh) * | 2016-05-13 | 2019-04-16 | 外来体诊断公司 | 从生物液体分离细胞外囊泡和共分离无细胞dna的自动和手动方法 |
| US11174503B2 (en) | 2016-09-21 | 2021-11-16 | Predicine, Inc. | Systems and methods for combined detection of genetic alterations |
| US11891664B2 (en) | 2017-05-17 | 2024-02-06 | Exosome Diagnostics, Inc. | Methods of detecting renal transplant rejection using microvesicle nucleic acid biomarkers |
| CN111133106A (zh) | 2017-07-12 | 2020-05-08 | 外来体诊断公司 | 用于分离和富集生物流体来源的细胞外囊泡的方法及其使用方法 |
| JP7069587B2 (ja) * | 2017-07-31 | 2022-05-18 | 東ソー株式会社 | 分析機器の洗浄方法 |
| WO2019116234A1 (en) * | 2017-12-12 | 2019-06-20 | Nestec S.A. | Methods for determining microbiome ribosomal rna composition changes |
| JP7444386B2 (ja) * | 2018-06-07 | 2024-03-06 | 株式会社Lsiメディエンス | ヒト尿からのマイクロベシクルの分離方法及び分析方法 |
| WO2020106853A1 (en) | 2018-11-20 | 2020-05-28 | Exosome Diagnostics, Inc. | Compositions and methods for internal controls of microvesicle isolations |
| CN109856259A (zh) * | 2018-12-29 | 2019-06-07 | 南通大学附属医院 | 一种血清胰腺癌外泌体特异蛋白及其再验证过程 |
| CN111593093B (zh) * | 2020-03-09 | 2022-03-04 | 中山大学 | 一种获取adar蛋白细胞内高效结合的底物序列的方法及底物序列和应用 |
| WO2021243206A1 (en) | 2020-05-29 | 2021-12-02 | Exosome Diagnostics, Inc. | Use of microvesicle signature for the diagnosis and treatment of kidney transplant rejection |
| CN116057185A (zh) | 2020-08-15 | 2023-05-02 | 雷杰纳荣制药公司 | 治疗具有编码降钙素受体(calcr)的变体核酸分子的受试者的肥胖症 |
| EP4370712A1 (en) | 2021-07-16 | 2024-05-22 | Exosome Diagnostics, Inc. | Methods of detecting sjögren's syndrome using salivary exosomes |
| AU2023221644A1 (en) | 2022-02-18 | 2024-09-12 | Bio-Techne Corporation | Use of microvesicle signatures in the identification and treatment of renal disorders |
| CN114480656B (zh) * | 2022-03-07 | 2023-12-26 | 温州医科大学附属眼视光医院 | Slc12a3和/或slc12a9在作为葡萄膜黑色素瘤治疗和预后检测指标中的应用 |
| WO2024054572A1 (en) | 2022-09-07 | 2024-03-14 | Exosome Diagnostics, Inc. | Methods of detecting sjögren's syndrome using salivary exosomes |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639611A (en) | 1988-12-12 | 1997-06-17 | City Of Hope | Allele specific polymerase chain reaction |
| US5219727A (en) | 1989-08-21 | 1993-06-15 | Hoffmann-Laroche Inc. | Quantitation of nucleic acids using the polymerase chain reaction |
| US5840867A (en) | 1991-02-21 | 1998-11-24 | Gilead Sciences, Inc. | Aptamer analogs specific for biomolecules |
| CA2074214C (en) | 1991-07-23 | 2000-02-22 | Will Bloch | Improvements in the in situ pcr |
| US5582981A (en) | 1991-08-14 | 1996-12-10 | Gilead Sciences, Inc. | Method for identifying an oligonucleotide aptamer specific for a target |
| US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| US5639606A (en) | 1993-04-06 | 1997-06-17 | The University Of Rochester | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
| US5556773A (en) | 1993-08-06 | 1996-09-17 | Yourno; Joseph | Method and apparatus for nested polymerase chain reaction (PCR) with single closed reaction tubes |
| DE69739909D1 (de) * | 1996-03-26 | 2010-07-29 | Michael S Kopreski | Methoden aus plasma oder serum extrahierte extrazelluraere rna zur diagnoseüberwachung oder evaluation von krebs verwenden |
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| US6994960B1 (en) | 1997-05-28 | 2006-02-07 | The Walter And Eliza Hall Institute Of Medical Research | Nucleic acid diagnostics based on mass spectrometry or mass separation and base specific cleavage |
| US6004755A (en) | 1998-04-07 | 1999-12-21 | Incyte Pharmaceuticals, Inc. | Quantitative microarray hybridizaton assays |
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| CA2733672C (en) * | 2007-08-16 | 2018-09-11 | The Royal Institution For The Advancement Of Learning/Mcgill University | Tumor cell-derived microvesicles |
| AU2008295394B2 (en) * | 2007-09-05 | 2014-04-24 | Laurentian University | Method of using tumour RNA integrity to measure response to chemotherapy in cancer patients |
| EP2610342B1 (en) * | 2007-09-14 | 2016-05-04 | The Ohio State University Research Foundation | MiRNA Expression in Human Peripheral Blood Microvesicles and uses Thereof |
| KR101810799B1 (ko) * | 2008-02-01 | 2017-12-19 | 더 제너럴 하스피탈 코포레이션 | 의학적 질환 및 병태의 진단, 예후, 및 치료에 있어서 미세소포체의 용도 |
-
2010
- 2010-07-16 WO PCT/US2010/042365 patent/WO2011009104A1/en not_active Ceased
- 2010-07-16 AU AU2010273928A patent/AU2010273928A1/en not_active Abandoned
- 2010-07-16 CN CN201610128465.4A patent/CN105779436A/zh active Pending
- 2010-07-16 KR KR1020187006847A patent/KR20180029105A/ko not_active Ceased
- 2010-07-16 ES ES10800649.5T patent/ES2547715T3/es active Active
- 2010-07-16 EP EP10800649.5A patent/EP2454588B1/en active Active
- 2010-07-16 JP JP2012520829A patent/JP5909444B2/ja active Active
- 2010-07-16 DK DK10800649.5T patent/DK2454588T3/en active
- 2010-07-16 SG SG2012003141A patent/SG177677A1/en unknown
- 2010-07-16 BR BR112012001077-8A patent/BR112012001077A2/pt not_active IP Right Cessation
- 2010-07-16 KR KR1020127003940A patent/KR20120037992A/ko not_active Ceased
- 2010-07-16 CA CA2768371A patent/CA2768371A1/en not_active Abandoned
- 2010-07-16 US US12/838,413 patent/US20110195426A1/en not_active Abandoned
- 2010-07-16 CN CN201080041496.7A patent/CN102498397B/zh active Active
- 2010-07-16 IN IN866DEN2012 patent/IN2012DN00866A/en unknown
- 2010-07-16 SG SG2014014617A patent/SG2014014617A/en unknown
-
2015
- 2015-12-17 JP JP2015246006A patent/JP2016116512A/ja active Pending
-
2016
- 2016-07-11 US US15/206,747 patent/US20160348095A1/en not_active Abandoned
- 2016-12-09 US US15/374,766 patent/US20170114389A1/en not_active Abandoned
-
2017
- 2017-04-25 JP JP2017086218A patent/JP2017131244A/ja active Pending
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