JP2012532839A5 - - Google Patents
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- Publication number
- JP2012532839A5 JP2012532839A5 JP2012518924A JP2012518924A JP2012532839A5 JP 2012532839 A5 JP2012532839 A5 JP 2012532839A5 JP 2012518924 A JP2012518924 A JP 2012518924A JP 2012518924 A JP2012518924 A JP 2012518924A JP 2012532839 A5 JP2012532839 A5 JP 2012532839A5
- Authority
- JP
- Japan
- Prior art keywords
- lipid
- amphiphile
- anionic
- cationic
- liposome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09165106A EP2277508B1 (en) | 2009-07-09 | 2009-07-09 | Emulation of lipoprotein structures |
| EP09165106.7 | 2009-07-09 | ||
| EP09171102 | 2009-09-23 | ||
| EP09171102.8 | 2009-09-23 | ||
| PCT/EP2010/059487 WO2011003834A1 (en) | 2009-07-09 | 2010-07-02 | Amphoteric liposomes comprising imino lipids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012532839A JP2012532839A (ja) | 2012-12-20 |
| JP2012532839A5 true JP2012532839A5 (https=) | 2014-08-14 |
| JP5851399B2 JP5851399B2 (ja) | 2016-02-03 |
Family
ID=42555953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012518924A Active JP5851399B2 (ja) | 2009-07-09 | 2010-07-02 | イミノ脂質を含む両性リポソーム |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US20120237589A1 (https=) |
| EP (2) | EP2451440B2 (https=) |
| JP (1) | JP5851399B2 (https=) |
| KR (1) | KR101954912B1 (https=) |
| CN (2) | CN102481256B (https=) |
| AU (1) | AU2010270337B2 (https=) |
| BR (2) | BR112012000255B1 (https=) |
| CA (1) | CA2765694C (https=) |
| DK (1) | DK2823810T3 (https=) |
| ES (1) | ES2527220T5 (https=) |
| IL (1) | IL216996A0 (https=) |
| SG (1) | SG177590A1 (https=) |
| WO (1) | WO2011003834A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE037082T2 (hu) | 2008-11-10 | 2018-08-28 | Arbutus Biopharma Corp | Új lipidek és készítmények terápiás hatóanyagok szállítására |
| DK2823810T3 (da) † | 2009-07-09 | 2019-05-27 | Novosom Verwaltungs Gmbh | Amfotere liposomer, der omfatter iminolipider |
| ES2762224T3 (es) * | 2011-05-12 | 2020-05-22 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Liposomas que comprenden lípidos conjugados con polímero y usos relacionados |
| EP3354644A1 (en) | 2011-06-08 | 2018-08-01 | Translate Bio, Inc. | Cleavable lipids |
| WO2016125163A1 (en) | 2015-02-04 | 2016-08-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | LIPID ASSEMBLIES AND USES THEREOF AND SOME pH AND ELECTROSTATIC MODULATING LIPIDS TO BE USED IN SAID ASSEMBLIES |
| JP6820912B2 (ja) * | 2016-03-28 | 2021-01-27 | 富士フイルム株式会社 | 製剤、製剤用部材およびそれらの製造方法 |
| CN109414451B (zh) * | 2016-05-16 | 2022-08-12 | 德克萨斯大学系统董事会 | 用于作为纳米粒递送tRNA的组合物及其使用方法 |
| CN110283223B (zh) * | 2018-03-19 | 2022-01-04 | 广州市锐博生物科技有限公司 | 一种阳离子脂质分子及其在核酸递送中的应用 |
| WO2020154594A2 (en) * | 2019-01-25 | 2020-07-30 | Agenovir Corporation | Compositions and methods for treatment of human papillomavirus |
| CN110974954B (zh) * | 2019-12-24 | 2021-03-16 | 珠海丽凡达生物技术有限公司 | 一种用于增强核酸疫苗免疫效果的脂质纳米颗粒及其制备方法 |
| CN118697890A (zh) * | 2021-07-15 | 2024-09-27 | 郑州大学 | 一种高浓度纳米粒凝胶剂及其制备方法 |
| WO2024160826A1 (en) | 2023-01-31 | 2024-08-08 | BioNTech SE | Compositions and methods |
| CN116370437A (zh) * | 2023-05-26 | 2023-07-04 | 北京因诺惟康医药科技有限公司 | 包含胆固醇琥珀酸单酯的核酸脂质纳米颗粒组合物及其用途 |
| TW202527962A (zh) | 2023-10-31 | 2025-07-16 | 德商拜恩技術股份公司 | 粒子、組合物及方法 |
| WO2025176732A1 (en) | 2024-02-20 | 2025-08-28 | BioNTech SE | Compositions and methods |
| WO2025261607A1 (en) | 2024-06-21 | 2025-12-26 | BioNTech SE | Particles, compositions and methods |
| WO2025262460A1 (en) * | 2024-06-21 | 2025-12-26 | BioNTech SE | Lipid compositions for nucleic acid delivery |
| WO2026021698A1 (en) | 2024-07-23 | 2026-01-29 | BioNTech SE | Nucleic acid particle |
| WO2026029597A1 (ko) * | 2024-07-31 | 2026-02-05 | 주식회사 메디치바이오 | 신규한 스테롤 지질 또는 이의 유도체를 함유하는 지질 나노입자 조성물 |
| WO2026027695A1 (en) | 2024-08-01 | 2026-02-05 | BioNTech SE | Compositions and methods |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| US6020317A (en) | 1993-02-19 | 2000-02-01 | Nippon Shinyaku Co. Ltd. | Glycerol derivative, device and pharmaceutical composition |
| US5651981A (en) | 1994-03-29 | 1997-07-29 | Northwestern University | Cationic phospholipids for transfection |
| US5777153A (en) * | 1994-07-08 | 1998-07-07 | Gilead Sciences, Inc. | Cationic lipids |
| DE59507224D1 (de) * | 1994-12-28 | 1999-12-16 | Max Delbrueck Centrum | Neues cholesterolderivat für den liposomalen gentransfer |
| US5965434A (en) | 1994-12-29 | 1999-10-12 | Wolff; Jon A. | Amphipathic PH sensitive compounds and delivery systems for delivering biologically active compounds |
| US6726894B1 (en) | 1995-07-25 | 2004-04-27 | Synvolux Ip B.V. | Transport vehicles for macromolecules |
| US5980935A (en) * | 1996-05-15 | 1999-11-09 | Kirpotin; Dmitri | Cationic lipids and methods of use therefor |
| DE19631189A1 (de) * | 1996-08-02 | 1998-02-05 | Max Delbrueck Centrum | Neuartige kationische Amphiphile für den liposomalen Gentransfer |
| CA2217550A1 (en) * | 1996-10-22 | 1998-04-22 | F. Hoffmann-La Roche Ag | Cationic lipids for gene therapy |
| DE19648625A1 (de) | 1996-11-13 | 1998-05-14 | Soft Gene Gmbh | Mikroprojektil für das Einbringen von Substanzen in Zellen durch ballistischen Transfer |
| CA2289702C (en) | 1997-05-14 | 2008-02-19 | Inex Pharmaceuticals Corp. | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| DE19753182A1 (de) | 1997-11-21 | 1999-07-29 | Claas Junghans | Topologisch fixierte matrixgebundene Nukleinsäure |
| DE19753132C5 (de) | 1997-11-29 | 2010-05-20 | Geze Gmbh | Brandschutzschiebetüranlage |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| US6171862B1 (en) * | 1998-03-31 | 2001-01-09 | The Regents Of The University Of California | Transfection in serum-containing media |
| DE10160151A1 (de) | 2001-01-09 | 2003-06-26 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens |
| CN1396908A (zh) | 2000-01-28 | 2003-02-12 | 宝洁公司 | 美味的精氨酸化合物及其用于心血管健康的应用 |
| DE10109897A1 (de) * | 2001-02-21 | 2002-11-07 | Novosom Ag | Fakultativ kationische Liposomen und Verwendung dieser |
| US7108863B2 (en) * | 2001-03-26 | 2006-09-19 | Alza Corporation | Liposome composition for improved intracellular delivery of a therapeutic agent |
| ATE490267T1 (de) | 2001-06-05 | 2010-12-15 | Curevac Gmbh | Stabilisierte mrna mit erhöhtem g/c-gehalt, kodierend für ein virales antigen |
| TWI257924B (en) * | 2003-09-22 | 2006-07-11 | Lipotek Inc | Cationic lipid for delivery function, and nanoparticle comprising the same |
| JP2007091657A (ja) * | 2005-09-29 | 2007-04-12 | Terumo Corp | アミジン誘導体およびそれを構成成分とする薬物担体 |
| CA2631677C (en) * | 2005-12-01 | 2014-08-12 | Pronai Therapeutics, Inc. | Amphoteric liposome formulation |
| EP2004141A2 (en) | 2006-03-17 | 2008-12-24 | Novosom AG | An efficient method for loading amphoteric liposomes with nucleic acid active substances |
| JP5424885B2 (ja) * | 2006-10-13 | 2014-02-26 | マリーナ バイオテック，インコーポレイテッド | 両性リポソームにおけるまたは両性リポソームに関する改善、両性リポソームを処方する方法および両性リポソームに充填する方法 |
| CA2686735A1 (en) * | 2007-05-04 | 2008-11-13 | Mdrna, Inc. | Amino acid lipids and uses thereof |
| DE102007029471A1 (de) * | 2007-06-20 | 2008-12-24 | Novosom Ag | Neue fakultativ kationische Sterole |
| WO2009031896A2 (en) * | 2007-09-07 | 2009-03-12 | Synvolux Ip B.V. | Improved liposomes and uses thereof |
| CA2702103A1 (en) | 2007-10-12 | 2009-04-16 | Novosom Ag | Improvements in or relating to amphotaric liposomes comprising neutral lipids |
| WO2009086558A1 (en) | 2008-01-02 | 2009-07-09 | Tekmira Pharmaceuticals Corporation | Improved compositions and methods for the delivery of nucleic acids |
| CN102047236A (zh) | 2008-03-18 | 2011-05-04 | 法布里克斯电视有限公司 | 受控速率视频点播服务器 |
| US8389768B2 (en) | 2008-05-19 | 2013-03-05 | The University Of North Carolina At Chapel Hill | Methods and compositions comprising novel cationic lipids |
| DK2823810T3 (da) † | 2009-07-09 | 2019-05-27 | Novosom Verwaltungs Gmbh | Amfotere liposomer, der omfatter iminolipider |
-
2010
- 2010-07-02 DK DK14188521.0T patent/DK2823810T3/da active
- 2010-07-02 EP EP10734065.5A patent/EP2451440B2/en active Active
- 2010-07-02 CA CA2765694A patent/CA2765694C/en active Active
- 2010-07-02 US US13/378,484 patent/US20120237589A1/en not_active Abandoned
- 2010-07-02 KR KR1020127003373A patent/KR101954912B1/ko active Active
- 2010-07-02 BR BR112012000255-4A patent/BR112012000255B1/pt active IP Right Grant
- 2010-07-02 AU AU2010270337A patent/AU2010270337B2/en not_active Ceased
- 2010-07-02 ES ES10734065.5T patent/ES2527220T5/es active Active
- 2010-07-02 CN CN201080031041.7A patent/CN102481256B/zh active Active
- 2010-07-02 JP JP2012518924A patent/JP5851399B2/ja active Active
- 2010-07-02 CN CN201510053094.3A patent/CN104744310A/zh active Pending
- 2010-07-02 EP EP14188521.0A patent/EP2823810B9/en active Active
- 2010-07-02 WO PCT/EP2010/059487 patent/WO2011003834A1/en not_active Ceased
- 2010-07-02 SG SG2012001673A patent/SG177590A1/en unknown
- 2010-07-02 BR BR212012000255U patent/BR212012000255U2/pt not_active Application Discontinuation
-
2011
- 2011-12-15 IL IL216996A patent/IL216996A0/en unknown
-
2016
- 2016-02-22 US US15/050,416 patent/US10039714B2/en active Active
-
2018
- 2018-08-01 US US16/051,728 patent/US20180338919A1/en not_active Abandoned
-
2020
- 2020-05-04 US US16/866,363 patent/US11541010B2/en active Active
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