JP2012532188A5 - - Google Patents
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- Publication number
- JP2012532188A5 JP2012532188A5 JP2012519078A JP2012519078A JP2012532188A5 JP 2012532188 A5 JP2012532188 A5 JP 2012532188A5 JP 2012519078 A JP2012519078 A JP 2012519078A JP 2012519078 A JP2012519078 A JP 2012519078A JP 2012532188 A5 JP2012532188 A5 JP 2012532188A5
- Authority
- JP
- Japan
- Prior art keywords
- degarelix
- solvent
- salt
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010052004 acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide Proteins 0.000 claims 16
- MEUCPCLKGZSHTA-XYAYPHGZSA-N degarelix Chemical compound C([C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CC=1C=CC(NC(=O)[C@H]2NC(=O)NC(=O)C2)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(NC(N)=O)C=C1 MEUCPCLKGZSHTA-XYAYPHGZSA-N 0.000 claims 16
- 229960002272 degarelix Drugs 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 16
- 239000002904 solvent Substances 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 238000009472 formulation Methods 0.000 claims 7
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 2
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09251738 | 2009-07-06 | ||
| EP09251738.2 | 2009-07-06 | ||
| US23581609P | 2009-08-21 | 2009-08-21 | |
| US61/235,816 | 2009-08-21 | ||
| PCT/IB2010/001785 WO2011004260A2 (en) | 2009-07-06 | 2010-07-05 | Composition for the treatment of benign prostate hyperplasia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012532188A JP2012532188A (ja) | 2012-12-13 |
| JP2012532188A5 true JP2012532188A5 (enExample) | 2013-08-22 |
Family
ID=41112615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012519078A Pending JP2012532188A (ja) | 2009-07-06 | 2010-07-05 | 良性前立腺肥大症を治療するための組成物 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20110039787A1 (enExample) |
| EP (1) | EP2451469B1 (enExample) |
| JP (1) | JP2012532188A (enExample) |
| KR (1) | KR20120038956A (enExample) |
| CN (1) | CN102470159A (enExample) |
| AR (1) | AR081439A1 (enExample) |
| AU (1) | AU2010269958A1 (enExample) |
| BR (1) | BR112012000185A2 (enExample) |
| CA (1) | CA2766008A1 (enExample) |
| IL (1) | IL216987A0 (enExample) |
| MX (1) | MX2012000315A (enExample) |
| NZ (1) | NZ597060A (enExample) |
| RU (1) | RU2011152514A (enExample) |
| SA (1) | SA110310575B1 (enExample) |
| TW (1) | TW201105344A (enExample) |
| UY (1) | UY32769A (enExample) |
| WO (1) | WO2011004260A2 (enExample) |
| ZA (1) | ZA201109513B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0117057D0 (en) * | 2001-07-12 | 2001-09-05 | Ferring Bv | Pharmaceutical composition |
| JOP20090061B1 (ar) | 2008-02-11 | 2021-08-17 | Ferring Int Center Sa | طريقة معالجة سرطان البروستاتا بمضادات الهرمونات التناسلية GnRH |
| WO2010125468A1 (en) * | 2009-05-01 | 2010-11-04 | Ferring International Center Sa | Composition for the treatment of prostate cancer |
| US20110039787A1 (en) * | 2009-07-06 | 2011-02-17 | Ferring International Center S.A. | Compositions, kits and methods for treating benign prostate hyperplasia |
| EP2447276A1 (en) | 2010-10-27 | 2012-05-02 | Ferring B.V. | Process for the manufacture of Degarelix and its intermediates |
| PL2632934T3 (pl) | 2010-10-27 | 2017-06-30 | Ferring B.V. | Sposób wytwarzania degareliksu i jego związków pośrednich |
| JO3755B1 (ar) | 2011-01-26 | 2021-01-31 | Ferring Bv | تركيبات تستوستيرون |
| WO2013104745A1 (en) * | 2012-01-13 | 2013-07-18 | Ferring Bv | Pharmaceutical composition |
| WO2013178788A2 (en) | 2012-06-01 | 2013-12-05 | Ferring B.V. | Manufacture of degarelix |
| HUP1400294A2 (hu) | 2014-06-13 | 2015-12-28 | Skillpharm Kft | Clopidogrel új alkalmazása |
| US12274680B2 (en) | 2022-09-13 | 2025-04-15 | II George William Creasy | Treatment of benign prostatic hypertrophy with capsinoids |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| JP2719233B2 (ja) * | 1991-04-25 | 1998-02-25 | デゲンギ，ロマノ | 黄体形成ホルモン放出ホルモン拮抗ペプチド |
| SI9300468A (en) * | 1992-10-14 | 1994-06-30 | Hoffmann La Roche | Injectable composition for the sustained release of biologically active compounds |
| US5506207A (en) * | 1994-03-18 | 1996-04-09 | The Salk Institute For Biological Studies | GNRH antagonists XIII |
| US5595760A (en) * | 1994-09-02 | 1997-01-21 | Delab | Sustained release of peptides from pharmaceutical compositions |
| US5860957A (en) * | 1997-02-07 | 1999-01-19 | Sarcos, Inc. | Multipathway electronically-controlled drug delivery system |
| US5821230A (en) * | 1997-04-11 | 1998-10-13 | Ferring Bv | GnRH antagonist decapeptides |
| US5925730A (en) * | 1997-04-11 | 1999-07-20 | Ferring Bv | GnRH antagonists |
| FR2776520B1 (fr) * | 1998-03-25 | 2000-05-05 | Sod Conseils Rech Applic | Nouvelles compositions pharmaceutiques destinees a la liberation prolongee de peptides et leur procede de preparation |
| GB0117057D0 (en) * | 2001-07-12 | 2001-09-05 | Ferring Bv | Pharmaceutical composition |
| AR042815A1 (es) * | 2002-12-26 | 2005-07-06 | Alza Corp | Dispositivo de suministro de agente activo que tiene miembros compuestos |
| EP1674082A1 (de) * | 2004-12-22 | 2006-06-28 | Zentaris GmbH | Verfahren zur Herstellung von sterilen Suspensionen oder Lyophilisaten schwerlöslicher basischer Peptidkomplexe, diese enthaltende pharmazeutische Formulierungen sowie ihre Verwendung als Arzneimittel |
| GB0506759D0 (en) * | 2005-04-02 | 2005-05-11 | Medical Res Council | Combination treatment methods |
| EP1891964A1 (en) * | 2006-08-08 | 2008-02-27 | AEterna Zentaris GmbH | Application of initial doses of LHRH analogues and maintenance doses of LHRH antagonists for the treatment of hormone-dependent cancers and corresponding pharmaceutical kits |
| EP1967202A1 (en) * | 2007-03-05 | 2008-09-10 | AEterna Zentaris GmbH | Use of LHRH Antagonists for the Treatment of Lower Urinary Tract Symptoms, in particular Overactive Bladder and/or Detrusor Overactivity |
| JOP20090061B1 (ar) * | 2008-02-11 | 2021-08-17 | Ferring Int Center Sa | طريقة معالجة سرطان البروستاتا بمضادات الهرمونات التناسلية GnRH |
| EP2257324B1 (en) * | 2008-02-11 | 2016-07-27 | Safety Syringes, Inc. | Syringe with safety needle guard and clip to prevent release of guard during reconstitution process |
| WO2010125468A1 (en) * | 2009-05-01 | 2010-11-04 | Ferring International Center Sa | Composition for the treatment of prostate cancer |
| TW201043221A (en) * | 2009-05-06 | 2010-12-16 | Ferring Int Ct Sa | Kit and method for preparation of a Degarelix solution |
| US20110039787A1 (en) * | 2009-07-06 | 2011-02-17 | Ferring International Center S.A. | Compositions, kits and methods for treating benign prostate hyperplasia |
| PL2632934T3 (pl) * | 2010-10-27 | 2017-06-30 | Ferring B.V. | Sposób wytwarzania degareliksu i jego związków pośrednich |
| EP2447276A1 (en) * | 2010-10-27 | 2012-05-02 | Ferring B.V. | Process for the manufacture of Degarelix and its intermediates |
| JO3755B1 (ar) * | 2011-01-26 | 2021-01-31 | Ferring Bv | تركيبات تستوستيرون |
| ES2655172T3 (es) * | 2011-07-15 | 2018-02-19 | Ferring B.V. | Procedimiento para preparación temporal de una colonoscopia en la que se administra una composición de picosulfato |
-
2010
- 2010-07-02 US US12/829,467 patent/US20110039787A1/en not_active Abandoned
- 2010-07-05 TW TW099122050A patent/TW201105344A/zh unknown
- 2010-07-05 MX MX2012000315A patent/MX2012000315A/es active IP Right Grant
- 2010-07-05 RU RU2011152514/15A patent/RU2011152514A/ru unknown
- 2010-07-05 WO PCT/IB2010/001785 patent/WO2011004260A2/en not_active Ceased
- 2010-07-05 CA CA2766008A patent/CA2766008A1/en not_active Abandoned
- 2010-07-05 CN CN2010800295366A patent/CN102470159A/zh active Pending
- 2010-07-05 NZ NZ597060A patent/NZ597060A/xx not_active IP Right Cessation
- 2010-07-05 AU AU2010269958A patent/AU2010269958A1/en not_active Abandoned
- 2010-07-05 JP JP2012519078A patent/JP2012532188A/ja active Pending
- 2010-07-05 BR BR112012000185A patent/BR112012000185A2/pt not_active IP Right Cessation
- 2010-07-05 US US13/381,762 patent/US20120172302A1/en not_active Abandoned
- 2010-07-05 KR KR1020127000337A patent/KR20120038956A/ko not_active Withdrawn
- 2010-07-05 EP EP10740272.9A patent/EP2451469B1/en not_active Not-in-force
- 2010-07-06 SA SA110310575A patent/SA110310575B1/ar unknown
- 2010-07-06 AR ARP100102410A patent/AR081439A1/es unknown
- 2010-07-07 UY UY0001032769A patent/UY32769A/es not_active Application Discontinuation
-
2011
- 2011-12-15 IL IL216987A patent/IL216987A0/en unknown
- 2011-12-22 ZA ZA2011/09513A patent/ZA201109513B/en unknown
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