JP2012532185A5 - - Google Patents
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- Publication number
- JP2012532185A5 JP2012532185A5 JP2012518956A JP2012518956A JP2012532185A5 JP 2012532185 A5 JP2012532185 A5 JP 2012532185A5 JP 2012518956 A JP2012518956 A JP 2012518956A JP 2012518956 A JP2012518956 A JP 2012518956A JP 2012532185 A5 JP2012532185 A5 JP 2012532185A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- therapeutic agent
- asparaginase
- peg
- agent according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 15
- 229920001223 polyethylene glycol Polymers 0.000 claims 15
- 229940124597 therapeutic agent Drugs 0.000 claims 15
- 102100025573 1-alkyl-2-acetylglycerophosphocholine esterase Human genes 0.000 claims 14
- 108010024976 Asparaginase Proteins 0.000 claims 14
- 239000002202 Polyethylene glycol Substances 0.000 claims 14
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 6
- 125000003277 amino group Chemical group 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 4
- 206010020751 Hypersensitivity Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 150000001413 amino acids Chemical group 0.000 claims 3
- 229960001230 asparagine Drugs 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
- 206010061819 Disease recurrence Diseases 0.000 claims 2
- 241000588698 Erwinia Species 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 2
- 230000009610 hypersensitivity Effects 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 206010002199 Anaphylactic shock Diseases 0.000 claims 1
- 102100023927 Asparagine synthetase [glutamine-hydrolyzing] Human genes 0.000 claims 1
- 108010070255 Aspartate-ammonia ligase Proteins 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 208000003455 anaphylaxis Diseases 0.000 claims 1
- 125000003827 glycol group Chemical group 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000009097 single-agent therapy Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22332009P | 2009-07-06 | 2009-07-06 | |
| US61/223,320 | 2009-07-06 | ||
| PCT/EP2010/054156 WO2011003633A1 (en) | 2009-07-06 | 2010-03-30 | Pegylated l-asparaginase |
| EPPCT/EP2010/054156 | 2010-03-30 | ||
| PCT/EP2010/059599 WO2011003886A1 (en) | 2009-07-06 | 2010-07-06 | Pegylated l-asparaginase |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012532185A JP2012532185A (ja) | 2012-12-13 |
| JP2012532185A5 true JP2012532185A5 (OSRAM) | 2013-08-22 |
| JP6014956B2 JP6014956B2 (ja) | 2016-10-26 |
Family
ID=42232655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012518956A Active JP6014956B2 (ja) | 2009-07-06 | 2010-07-06 | ペグ化されたｌ−アスパラギナーゼ |
Country Status (25)
| Country | Link |
|---|---|
| US (6) | US20120100121A1 (OSRAM) |
| JP (1) | JP6014956B2 (OSRAM) |
| KR (1) | KR101731999B1 (OSRAM) |
| CN (1) | CN102573917B (OSRAM) |
| AU (1) | AU2010270294B2 (OSRAM) |
| BR (1) | BR112012000367A2 (OSRAM) |
| CA (1) | CA2767149C (OSRAM) |
| CO (1) | CO6612174A2 (OSRAM) |
| DK (1) | DK2451486T4 (OSRAM) |
| EA (1) | EA021168B1 (OSRAM) |
| ES (1) | ES2636476T5 (OSRAM) |
| FI (1) | FI2451486T4 (OSRAM) |
| HU (1) | HUE035771T2 (OSRAM) |
| IL (1) | IL217392A (OSRAM) |
| IN (1) | IN2012DN00958A (OSRAM) |
| LT (1) | LT2451486T (OSRAM) |
| MA (1) | MA33503B1 (OSRAM) |
| MX (1) | MX2012000424A (OSRAM) |
| MY (1) | MY180758A (OSRAM) |
| NZ (1) | NZ597912A (OSRAM) |
| PE (2) | PE20120501A1 (OSRAM) |
| PT (1) | PT2451486T (OSRAM) |
| SG (1) | SG176984A1 (OSRAM) |
| UA (1) | UA104634C2 (OSRAM) |
| WO (2) | WO2011003633A1 (OSRAM) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE531779C2 (sv) * | 2007-11-26 | 2009-08-04 | Promimic Ab | Framställning av kalciumfosfatpartiklar i nanostorlek som pulver eller beläggning via bifunktionella prekursorer |
| WO2011003633A1 (en) | 2009-07-06 | 2011-01-13 | Alize Pharma Ii | Pegylated l-asparaginase |
| WO2015033344A1 (en) | 2013-09-05 | 2015-03-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods and kits for inhibiting pathogenicity of group a streptococcus (gas) or group g streptococcus (ggs) |
| US20160213759A1 (en) * | 2013-09-10 | 2016-07-28 | Board Of Regents, The University Of Texas System | Therapeutic asparaginases |
| CN104046600B (zh) * | 2013-12-30 | 2019-04-05 | 江苏众红生物工程创药研究院有限公司 | 多臂聚乙二醇修饰剂的新用途及其在修饰门冬酰胺酶中的应用 |
| BR102014000585B1 (pt) | 2014-01-10 | 2021-01-12 | Coppe/Ufrj-Instituto Alberto Luiz Coimbra De Pós-Graduação | l-asparaginase recombinante de zymomonas |
| US9808011B2 (en) | 2014-12-15 | 2017-11-07 | Biovectra Inc. | Pentacyclic triterpene compounds and uses thereof |
| CN105802948B (zh) * | 2014-12-29 | 2020-06-09 | 江苏众红生物工程创药研究院有限公司 | 聚乙二醇定点修饰的门冬酰胺酶及其制备方法与应用 |
| US10947598B2 (en) | 2015-09-29 | 2021-03-16 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for determining the metabolic status of lymphomas |
| CN109153711B (zh) * | 2016-03-01 | 2022-04-26 | 伊利诺伊大学理事会 | 具有降低的l-谷氨酰胺酶活性和增强的稳定性的l-天冬酰胺酶变体和融合蛋白 |
| JP7109427B2 (ja) | 2016-06-01 | 2022-07-29 | セルヴィエ アイピー ユーケー リミテッド | ポリアルキレンオキシド－アスパラギナーゼの製剤ならびにその製造法および使用法 |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12186296B1 (en) | 2016-07-22 | 2025-01-07 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12478604B1 (en) | 2016-07-22 | 2025-11-25 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| WO2018085493A1 (en) * | 2016-11-04 | 2018-05-11 | Georgia State University Research Foundation, Inc. | Endotoxin free asparaginase |
| EP3418383A1 (en) * | 2017-06-21 | 2018-12-26 | XL-protein GmbH | Modified l-asparaginase |
| US10174302B1 (en) | 2017-06-21 | 2019-01-08 | Xl-Protein Gmbh | Modified L-asparaginase |
| MX2019015502A (es) * | 2017-06-21 | 2020-07-28 | Jazz Pharmaceuticals Ireland Ltd | L-asparaginasa modificada. |
| JP7358347B2 (ja) | 2017-10-27 | 2023-10-10 | フェネックス インク． | 組み換えＥ．ｃｏｌｉアスパラギナーゼの製造のための方法 |
| JP7784804B2 (ja) * | 2017-10-27 | 2025-12-12 | フェネックス インク． | 組み換えｅｒｗｉｎｉａアスパラギナーゼの製造のための方法 |
| CN111818937A (zh) * | 2017-11-30 | 2020-10-23 | 爵士制药爱尔兰有限公司 | 使用天冬酰胺酶的治疗方法 |
| EP3781197B1 (en) * | 2018-04-19 | 2025-09-10 | Elanco US Inc. | Variant asparaginase polypeptides for medical use |
| US20210299233A1 (en) | 2018-07-12 | 2021-09-30 | The Children's Medical Center Corporation | Method for treating cancer |
| MX2021007654A (es) * | 2018-12-24 | 2021-09-21 | Gennova Biopharmaceuticals Ltd | Una composicion liofilizada de pegaspargasa. |
| AU2020231916B2 (en) | 2019-03-01 | 2025-08-28 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
| GB201912020D0 (en) * | 2019-08-21 | 2019-10-02 | Porton Biopharma Ltd | Therapeutic Conjugate |
| BR112022007677A2 (pt) | 2019-10-25 | 2022-10-25 | Jazz Pharmaceuticals Ireland Ltd | L-asparaginase recombinante |
| KR102269634B1 (ko) * | 2019-10-31 | 2021-06-25 | 대상 주식회사 | ansB 유전자 불활성화에 의해 아미노산 생산능력이 향상된 균주 |
| IL303948A (en) | 2020-12-23 | 2023-08-01 | Jazz Pharmaceuticals Ireland Ltd | Methods of purifying charge-shielded fusion proteins |
| CN114854729B (zh) * | 2021-02-03 | 2025-09-02 | 重庆派金生物科技有限公司 | 定向化学偶联门冬酰胺酶突变体及其制备方法和应用 |
| WO2022211829A1 (en) | 2021-03-30 | 2022-10-06 | Jazz Pharmaceuticals Ireland Ltd. | Dosing of recombinant l-asparaginase |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| EP4551216A1 (en) | 2022-07-04 | 2025-05-14 | Institut National de la Santé et de la Recherche Médicale | Use of a l-asparaginase in combination with a ferroptosis inducer for the treatment of extranodal natural killer/t-cell lymphoma |
| WO2024015529A2 (en) | 2022-07-14 | 2024-01-18 | Jazz Pharmaceuticals Ireland Ltd. | Combination therapies involving l-asparaginase |
| WO2024211977A1 (pt) * | 2023-04-12 | 2024-10-17 | Biobreyer Pesquisa E Desenvolvimento Científico Ltda | Processo de peguilação sítio específica de lasparaginase contendo cisteínas de superfície, produto obtido por processo e uso |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US5286637A (en) | 1989-08-07 | 1994-02-15 | Debiopharm, S.A. | Biologically active drug polymer derivatives and method for preparing same |
| US5766897A (en) | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| GB9017002D0 (en) | 1990-08-02 | 1990-09-19 | Health Lab Service Board | Improved method for the purification of erwina l-asparaginase |
| US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
| US5359030A (en) | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
| US5681811A (en) | 1993-05-10 | 1997-10-28 | Protein Delivery, Inc. | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
| US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| US5776746A (en) | 1996-05-01 | 1998-07-07 | Genitope Corporation | Gene amplification methods |
| US6309633B1 (en) | 1999-06-19 | 2001-10-30 | Nobex Corporation | Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same |
| US20020065397A1 (en) | 2000-10-12 | 2002-05-30 | Joseph Roberts | Protecting therapeutic compositions from host-mediated inactivation |
| US6913915B2 (en) * | 2001-08-02 | 2005-07-05 | Phoenix Pharmacologics, Inc. | PEG-modified uricase |
| WO2003018742A2 (en) * | 2001-08-22 | 2003-03-06 | Gosudarstvennoe Uchrezhdenie Nauchno-Issledovatelsky Institut Biomeditsinskoy Khimii Im. Orekhovicha Rossiiskoy Akademii Meditsinskikh Nauk | Recombinant l-asparaginase erwinia caratovora |
| EP1608688B1 (en) | 2003-03-14 | 2013-02-27 | BioGeneriX AG | Branched water-soluble polymers and their conjugates |
| WO2007103290A2 (en) | 2006-03-03 | 2007-09-13 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Materials and methods directed to asparagine synthetase and asparaginase therapies |
| WO2007123006A1 (ja) | 2006-04-21 | 2007-11-01 | Konica Minolta Holdings, Inc. | ガスバリアフィルム、有機エレクトロルミネッセンス用樹脂基材、それを用いた有機エレクトロルミネッセンス素子及びガスバリアフィルムの製造方法 |
| ES2519466T3 (es) * | 2007-03-09 | 2014-11-07 | Novozymes A/S | Asparaginasas termoestables |
| WO2011003633A1 (en) | 2009-07-06 | 2011-01-13 | Alize Pharma Ii | Pegylated l-asparaginase |
| EP3389720A1 (en) | 2015-12-18 | 2018-10-24 | The General Hospital Corporation | Polyacetal polymers, conjugates, particles and uses thereof |
-
2010
- 2010-03-30 WO PCT/EP2010/054156 patent/WO2011003633A1/en not_active Ceased
- 2010-07-06 EA EA201270134A patent/EA021168B1/ru not_active IP Right Cessation
- 2010-07-06 BR BR112012000367A patent/BR112012000367A2/pt not_active Application Discontinuation
- 2010-07-06 PE PE2012000023A patent/PE20120501A1/es not_active Application Discontinuation
- 2010-07-06 LT LTEP10730170.7T patent/LT2451486T/lt unknown
- 2010-07-06 MY MYPI2012000054A patent/MY180758A/en unknown
- 2010-07-06 MA MA34598A patent/MA33503B1/fr unknown
- 2010-07-06 PE PE2016001555A patent/PE20161325A1/es unknown
- 2010-07-06 SG SG2011096013A patent/SG176984A1/en unknown
- 2010-07-06 HU HUE10730170A patent/HUE035771T2/en unknown
- 2010-07-06 KR KR1020127003202A patent/KR101731999B1/ko active Active
- 2010-07-06 ES ES10730170T patent/ES2636476T5/es active Active
- 2010-07-06 UA UAA201201135A patent/UA104634C2/ru unknown
- 2010-07-06 JP JP2012518956A patent/JP6014956B2/ja active Active
- 2010-07-06 CN CN201080030392.6A patent/CN102573917B/zh active Active
- 2010-07-06 FI FIEP10730170.7T patent/FI2451486T4/fi active
- 2010-07-06 PT PT107301707T patent/PT2451486T/pt unknown
- 2010-07-06 MX MX2012000424A patent/MX2012000424A/es active IP Right Grant
- 2010-07-06 CA CA2767149A patent/CA2767149C/en active Active
- 2010-07-06 AU AU2010270294A patent/AU2010270294B2/en active Active
- 2010-07-06 NZ NZ597912A patent/NZ597912A/en unknown
- 2010-07-06 WO PCT/EP2010/059599 patent/WO2011003886A1/en not_active Ceased
- 2010-07-06 US US13/382,276 patent/US20120100121A1/en not_active Abandoned
- 2010-07-06 DK DK10730170.7T patent/DK2451486T4/da active
-
2012
- 2012-01-05 IL IL217392A patent/IL217392A/en active IP Right Grant
- 2012-02-02 IN IN958DEN2012 patent/IN2012DN00958A/en unknown
- 2012-02-06 CO CO12020409A patent/CO6612174A2/es unknown
-
2015
- 2015-08-05 US US14/819,305 patent/US9920311B2/en not_active Ceased
-
2018
- 2018-02-01 US US15/886,216 patent/US20180346900A1/en not_active Abandoned
-
2020
- 2020-03-18 US US16/822,764 patent/USRE49736E1/en active Active
- 2020-05-18 US US16/877,324 patent/US11046946B2/en active Active
-
2021
- 2021-06-03 US US17/338,508 patent/US12441992B2/en active Active
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