JP2012530113A5 - - Google Patents

Download PDF

Info

Publication number
JP2012530113A5
JP2012530113A5 JP2012515500A JP2012515500A JP2012530113A5 JP 2012530113 A5 JP2012530113 A5 JP 2012530113A5 JP 2012515500 A JP2012515500 A JP 2012515500A JP 2012515500 A JP2012515500 A JP 2012515500A JP 2012530113 A5 JP2012530113 A5 JP 2012530113A5
Authority
JP
Japan
Prior art keywords
group
formula
branched
linear
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012515500A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012530113A (ja
Filing date
Publication date
Priority claimed from EP09305562A external-priority patent/EP2270021A1/en
Application filed filed Critical
Publication of JP2012530113A publication Critical patent/JP2012530113A/ja
Publication of JP2012530113A5 publication Critical patent/JP2012530113A5/ja
Pending legal-status Critical Current

Links

JP2012515500A 2009-06-18 2010-06-17 より良好な生物学的利用能を示すホスホネート誘導体の合成のためのホスホネートシントン Pending JP2012530113A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09305562.2 2009-06-18
EP09305562A EP2270021A1 (en) 2009-06-18 2009-06-18 Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability
PCT/EP2010/058567 WO2010146127A1 (en) 2009-06-18 2010-06-17 Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability

Publications (2)

Publication Number Publication Date
JP2012530113A JP2012530113A (ja) 2012-11-29
JP2012530113A5 true JP2012530113A5 (https=) 2013-08-01

Family

ID=41171101

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012515500A Pending JP2012530113A (ja) 2009-06-18 2010-06-17 より良好な生物学的利用能を示すホスホネート誘導体の合成のためのホスホネートシントン

Country Status (6)

Country Link
US (1) US8785629B2 (https=)
EP (2) EP2270021A1 (https=)
JP (1) JP2012530113A (https=)
CA (1) CA2764827C (https=)
ES (1) ES2601849T3 (https=)
WO (1) WO2010146127A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012034719A1 (en) * 2010-09-14 2012-03-22 Centre National De La Recherche Scientifique Novel antiviral acyclic nucleoside phosphonates
WO2021177339A1 (ja) * 2020-03-04 2021-09-10 富士フイルム和光純薬株式会社 ホスホン酸エステルの製造方法、リン酸エステルの製造方法
JP2024526730A (ja) * 2021-07-15 2024-07-19 アルナイラム ファーマシューティカルズ， インコーポレイテッド ２，６－ジアミノプリン及び２－アミノアデニンのコンジュゲートをオリゴヌクレオチドに導入するための簡便な化学的アプローチ

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6814978A (https=) 1967-10-30 1969-05-02
BR6914868D0 (pt) * 1969-01-23 1973-03-20 & Co Inc Merck Processos quimicos
JPS6069089A (ja) 1983-09-26 1985-04-19 Nissan Chem Ind Ltd ジヒドロピリジン−５−ホスホネ−ト誘導体およびその製造法
ATE131825T1 (de) * 1990-06-13 1996-01-15 Arnold Glazier Phosphorylierte prodrugs
EP0521622B1 (en) 1991-07-03 1997-08-13 PHARMACIA & UPJOHN COMPANY Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories
ZA941088B (en) * 1993-02-19 1995-09-27 Symphar Sa Substituted ketophosphonates the processes for their preparation and pharmaceutical compositions containing them
DE4343599A1 (de) 1993-12-21 1995-06-22 Bayer Ag Verwendung von Phosphonsäureestern zur Behandlung von Hirnleistungsstörungen und Depressionen
US5635449A (en) * 1995-04-07 1997-06-03 American Cyanamid Company Arylthioalkyl- and arylthioalkenylphosphonic acids and derivatives thereof useful as herbicidal agents
IT1281498B1 (it) * 1995-06-07 1998-02-18 Sardinian Antiviral Research C Pirazolo - derivati ad attivita' antitumorale, processo per la loro preparazione e composizioni farmaceutiche che li contengono , e
ES2218660T3 (es) * 1996-01-16 2004-11-16 Bristol-Myers Squibb Company Inhibidores aromaticos conformacionalmente restringidos de la proteina de transferencia de trigliceridos microsomales y procedimiento.
IT1290444B1 (it) 1997-03-27 1998-12-03 Boehringer Mannheim Italia Coniugati di bis-fosfonati con funzionalita' alchilanti aventi attivita' antitumorale
DE60038038T2 (de) * 1999-12-03 2009-02-12 The Regents of The University of California at San Diego, La Jolla Phosphonatverbindungen
AU2003231765B9 (en) 2002-04-26 2010-01-28 Gilead Sciences, Inc. Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds and the compounds as such
WO2004026315A1 (en) 2002-09-19 2004-04-01 Ilex Oncology Research, Sarl Substituted ketophosphonate compounds having bone anabolic activity
US20040157804A1 (en) * 2002-10-16 2004-08-12 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
JP2010535701A (ja) * 2003-04-25 2010-11-25 ギリアード サイエンシーズ， インコーポレイテッド 抗癌ホスホネートアナログ
CN1882327A (zh) 2003-11-19 2006-12-20 症变治疗公司 含磷的新的拟甲状腺素药
US20080261923A1 (en) * 2004-08-04 2008-10-23 Etzkorn Felicia A Alkene Mimics
WO2008096002A1 (en) 2007-02-08 2008-08-14 Tibotec Pharmaceuticals Ltd. Hcv inhibiting macrocyclic phosphonates and amidophosphates

Similar Documents

Publication Publication Date Title
RU2010126906A (ru) Способ получения производного индолинона
RU2014117188A (ru) Способ получения производных 4,4-дифтор-3,4-дигидроизохинолина
JP2006508903A5 (https=)
DK1678119T3 (da) Fremgangsmåde til fremstilling af 2-dihalogenacyl-3-amino-acrylsyreestere og 3-dihalogenmethyl-pyrazol-4-carboxylsyreestere
JP2012046478A5 (ja) 化合物
JP2008514418A5 (https=)
JP2016510070A5 (https=)
JP2012520865A5 (https=)
JP2004505965A5 (https=)
JP2009538336A5 (https=)
JP2006512410A5 (https=)
JP2012528811A5 (https=)
JP2019182850A5 (https=)
JP2009541414A5 (https=)
JP2012530113A5 (https=)
JP5372771B2 (ja) プロセス
JP2010512379A5 (https=)
JP2004536153A5 (https=)
JP2002179691A5 (https=)
WO2005070875A1 (ja) アミン類の製造方法
JP2015506916A5 (https=)
JP2014009330A5 (https=)
JP2007045816A5 (ja) カルバゾール誘導体、発光素子用材料として用いられるアントラセン誘導体の作製方法
JP2012517339A5 (https=)
JP2010138088A (ja) フルオレン誘導体の製造方法