JP2012530061A5 - - Google Patents
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- JP2012530061A5 JP2012530061A5 JP2012515167A JP2012515167A JP2012530061A5 JP 2012530061 A5 JP2012530061 A5 JP 2012530061A5 JP 2012515167 A JP2012515167 A JP 2012515167A JP 2012515167 A JP2012515167 A JP 2012515167A JP 2012530061 A5 JP2012530061 A5 JP 2012530061A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- pharmaceutical composition
- substituted
- composition according
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 241000700605 Viruses Species 0.000 claims description 40
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 20
- 150000001875 compounds Chemical class 0.000 claims description 18
- 229910052739 hydrogen Inorganic materials 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 16
- 201000010099 disease Diseases 0.000 claims description 16
- 239000001257 hydrogen Substances 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 12
- 150000002431 hydrogen Chemical class 0.000 claims description 9
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 8
- 125000002252 acyl group Chemical group 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 5
- 201000009182 Chikungunya Diseases 0.000 claims description 4
- 241001502567 Chikungunya virus Species 0.000 claims description 4
- 201000003075 Crimean-Congo hemorrhagic fever Diseases 0.000 claims description 4
- LXBIFEVIBLOUGU-UHFFFAOYSA-N Deoxymannojirimycin Natural products OCC1NCC(O)C(O)C1O LXBIFEVIBLOUGU-UHFFFAOYSA-N 0.000 claims description 4
- 206010014611 Encephalitis venezuelan equine Diseases 0.000 claims description 4
- 206010066919 Epidemic polyarthritis Diseases 0.000 claims description 4
- 206010061192 Haemorrhagic fever Diseases 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 4
- -1 N- {4'-azido-2'-nitrophenyl} -6-aminohexyl Chemical group 0.000 claims description 4
- FTSCEGKYKXESFF-LXTVHRRPSA-N N-nonyldeoxynojirimycin Chemical compound CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO FTSCEGKYKXESFF-LXTVHRRPSA-N 0.000 claims description 4
- 206010037660 Pyrexia Diseases 0.000 claims description 4
- 208000000705 Rift Valley Fever Diseases 0.000 claims description 4
- 241000713124 Rift Valley fever virus Species 0.000 claims description 4
- 208000002687 Venezuelan Equine Encephalomyelitis Diseases 0.000 claims description 4
- 201000009145 Venezuelan equine encephalitis Diseases 0.000 claims description 4
- 241000710959 Venezuelan equine encephalitis virus Species 0.000 claims description 4
- 125000003435 aroyl group Chemical group 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- LXBIFEVIBLOUGU-JGWLITMVSA-N duvoglustat Chemical compound OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O LXBIFEVIBLOUGU-JGWLITMVSA-N 0.000 claims description 4
- 125000001188 haloalkyl group Chemical group 0.000 claims description 4
- 241000710929 Alphavirus Species 0.000 claims description 2
- 208000006825 Eastern Equine Encephalomyelitis Diseases 0.000 claims description 2
- 201000005804 Eastern equine encephalitis Diseases 0.000 claims description 2
- 241000710945 Eastern equine encephalitis virus Species 0.000 claims description 2
- 206010014587 Encephalitis eastern equine Diseases 0.000 claims description 2
- 206010014614 Encephalitis western equine Diseases 0.000 claims description 2
- 208000035751 Epidemic nephropathy Diseases 0.000 claims description 2
- 208000000832 Equine Encephalomyelitis Diseases 0.000 claims description 2
- 241000608292 Mayaro virus Species 0.000 claims description 2
- 241000150452 Orthohantavirus Species 0.000 claims description 2
- 241000150350 Peribunyaviridae Species 0.000 claims description 2
- 201000000239 Phlebotomus fever Diseases 0.000 claims description 2
- 241000710942 Ross River virus Species 0.000 claims description 2
- 201000007009 Ross river fever Diseases 0.000 claims description 2
- 241000710799 Rubella virus Species 0.000 claims description 2
- 241000710961 Semliki Forest virus Species 0.000 claims description 2
- 241000150278 Seoul orthohantavirus Species 0.000 claims description 2
- 241000710960 Sindbis virus Species 0.000 claims description 2
- 241000710924 Togaviridae Species 0.000 claims description 2
- 208000005466 Western Equine Encephalomyelitis Diseases 0.000 claims description 2
- 201000005806 Western equine encephalitis Diseases 0.000 claims description 2
- 241000710951 Western equine encephalitis virus Species 0.000 claims description 2
- 230000002612 cardiopulmonary effect Effects 0.000 claims description 2
- 206010014599 encephalitis Diseases 0.000 claims description 2
- 230000002988 nephrogenic effect Effects 0.000 claims description 2
- 201000005404 rubella Diseases 0.000 claims description 2
- 230000035900 sweating Effects 0.000 claims description 2
- 208000011580 syndromic disease Diseases 0.000 claims description 2
- 230000009385 viral infection Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 37
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 241000150489 Andes orthohantavirus Species 0.000 claims 1
- 241000150288 Sin Nombre orthohantavirus Species 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18661409P | 2009-06-12 | 2009-06-12 | |
| US61/186,614 | 2009-06-12 | ||
| PCT/US2010/038247 WO2010144759A1 (en) | 2009-06-12 | 2010-06-11 | Iminosugars and methods of treating bunyaviral and togaviral diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012530061A JP2012530061A (ja) | 2012-11-29 |
| JP2012530061A5 true JP2012530061A5 (enExample) | 2014-04-10 |
| JP5634510B2 JP5634510B2 (ja) | 2014-12-03 |
Family
ID=43306958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012515167A Expired - Fee Related JP5634510B2 (ja) | 2009-06-12 | 2010-06-11 | イミノ糖ならびにブニヤウイルスおよびトガウイルス疾患を治療する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8426445B2 (enExample) |
| EP (1) | EP2440205B1 (enExample) |
| JP (1) | JP5634510B2 (enExample) |
| KR (1) | KR101463661B1 (enExample) |
| CN (1) | CN102639133B (enExample) |
| CA (1) | CA2765086C (enExample) |
| ES (1) | ES2524361T3 (enExample) |
| WO (1) | WO2010144759A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2398321B1 (en) | 2009-02-23 | 2015-11-25 | United Therapeutics Corporation | Iminosugars and methods of treating viral diseases |
| ES2524361T3 (es) * | 2009-06-12 | 2014-12-05 | United Therapeutics Corporation | Iminoazúcares para su uso en el tratamiento de enfermedades por bunyavirus y togavirus |
| CN104703597A (zh) | 2012-06-06 | 2015-06-10 | 尤尼特尔滤过性微生物学有限责任公司 | 新型亚氨基糖及它们的应用 |
| CN102875450B (zh) * | 2012-10-25 | 2015-04-08 | 上海丝绸集团股份有限公司 | 一种从桑叶中提取制备1-脱氧野尻霉素的工艺方法 |
| CN105246478A (zh) * | 2013-03-15 | 2016-01-13 | 优尼特尔病毒学公司 | 抗菌化合物 |
| AP2016009125A0 (en) | 2013-09-16 | 2016-04-30 | Emergent Virology Llc | Deoxynojirimycin derivatives and methods of their using |
| CN104357583B (zh) * | 2014-10-31 | 2016-11-09 | 中国检验检疫科学研究院 | 巴马哈森林病毒的实时荧光rt-pcr检测试剂盒和方法 |
| US10428022B2 (en) | 2014-11-05 | 2019-10-01 | Emergent Virology Llc | Iminosugars useful for the treatment of viral diseases |
| CN114681472B (zh) * | 2019-03-13 | 2023-06-30 | 中国人民解放军军事科学院军事医学研究院 | 氨基葡萄糖及其衍生物作为抗病毒药物的应用 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1555654A (en) * | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
| NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| DE2834122A1 (de) | 1978-08-03 | 1980-02-14 | Bayer Ag | Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose |
| DE2839309A1 (de) * | 1978-09-09 | 1980-03-27 | Bayer Ag | 3,4,5-trihydroxypiperidin-derivate |
| DE2853573A1 (de) * | 1978-12-12 | 1980-07-03 | Bayer Ag | Herstellung von n-substituierten derivaten des l-desoxynojirimycins |
| DE3038901A1 (de) | 1980-10-15 | 1982-05-06 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins |
| DE3611841A1 (de) * | 1986-04-09 | 1987-10-15 | Bayer Ag | Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten |
| US5043273A (en) * | 1989-08-17 | 1991-08-27 | Monsanto Company | Phosphorylated glycosidase inhibitor prodrugs |
| US5103008A (en) * | 1989-08-17 | 1992-04-07 | Monsanto Company | Compound, N-butyl-deoxynojirimycin-6-phosphate |
| US4994572A (en) | 1989-10-12 | 1991-02-19 | Monsanto Company | Synthesis of nojirimycin derivatives |
| US5030638A (en) * | 1990-02-26 | 1991-07-09 | G. D. Searle & Co. | Method of antiviral enhancement |
| US5200523A (en) * | 1990-10-10 | 1993-04-06 | Monsanto Company | Synthesis of nojirimycin derivatives |
| US5206251A (en) * | 1992-04-01 | 1993-04-27 | G. D. Searle & Co. | 2- and 3- amino and azido derivatives of 1,5-iminosugars |
| US5399567A (en) * | 1993-05-13 | 1995-03-21 | Monsanto Company | Method of treating cholera |
| WO1995022975A1 (en) | 1994-02-25 | 1995-08-31 | G.D. Searle & Co. | Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus |
| BR9813508A (pt) * | 1997-12-11 | 2000-10-03 | Univ Oxford | Inibição de replicação viral associada com membrana |
| EP1714676A3 (en) | 1998-02-12 | 2006-11-15 | G.D. Searle LLC. | Use of N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections |
| US6689759B1 (en) * | 1998-02-12 | 2004-02-10 | G. D. Searle & Co. | Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy |
| TR200002323T2 (tr) | 1998-02-12 | 2000-12-21 | G.D. Searle & Co. | Hepatit virüs enfeksiyonlarının tedavi edilmesi için N-ikameli-1,5-dideoksi 1,5-imino-D-glusitol bileşiklerinin kullanımı |
| US6610703B1 (en) * | 1998-12-10 | 2003-08-26 | G.D. Searle & Co. | Method for treatment of glycolipid storage diseases |
| GB9828474D0 (en) * | 1998-12-24 | 1999-02-17 | British Aerospace | Surface topology inspection |
| ATE402701T1 (de) * | 1999-02-12 | 2008-08-15 | United Therapeutics Corp | N-(8,8,8-trifluorooctyl)-1,5-dideoxy-1,5-imino- - glucitol zur behandlung von hepatitis-virus- infektionen |
| GB0100889D0 (en) * | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
| ATE234626T1 (de) * | 1999-07-26 | 2003-04-15 | Searle & Co | Verwendung von langkettigen n-alkyl derivaten von deoxynojirimycin mit glucocerebrosidase enzyme zur herstellung eines medikaments zur behandlung von mit glykolipiden akkumulation zusammenhängenden krankheiten |
| US7256005B2 (en) * | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
| WO2004069190A2 (en) * | 2003-01-31 | 2004-08-19 | Mount Sinai School Of Medicine Of New York University | Combination therapy for treating protein deficiency disorders |
| US7446098B2 (en) | 2003-02-18 | 2008-11-04 | Mount Sinai School Of Medicine Of New York University | Combination therapy for treating protein deficiencies |
| US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| US20060211752A1 (en) | 2004-03-16 | 2006-09-21 | Kohn Leonard D | Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression |
| US20050256168A1 (en) * | 2004-04-28 | 2005-11-17 | Block Timothy M | Compositions for oral administration for the treatment of interferon-responsive disorders |
| US7524829B2 (en) * | 2004-11-01 | 2009-04-28 | Avi Biopharma, Inc. | Antisense antiviral compounds and methods for treating a filovirus infection |
| GB0501352D0 (en) | 2005-01-21 | 2005-03-02 | Slingsby Jason H | Use of glycosylation modulators in combination with membrane fusion inhibitors for treatment of infections caused by viruses bearing glycosylated envelope |
| EP1863527A2 (en) * | 2005-03-16 | 2007-12-12 | University of Oxford | Mannose immunogens for hiv-1 |
| ES2572148T3 (es) * | 2005-05-17 | 2016-05-30 | Amicus Therapeutics Inc | Un método para el tratamiento de la enfermedad de Pompe usando 1-desoxinojirimicina y derivados |
| EP1909812A4 (en) * | 2005-07-27 | 2009-11-25 | Univ Florida | SMALL CONNECTIONS FOR THE CORRECTION OF PROTEIN MISFAIRINGS AND USES THEREOF |
| AU2006272586A1 (en) * | 2005-07-27 | 2007-02-01 | University Of Florida Research Foundation, Inc. | Use of heat shock to treat ocular disease |
| US20070244184A1 (en) * | 2006-01-09 | 2007-10-18 | Simon Fraser University | Glycosidase inhibitors and methods of synthesizing same |
| CA2650311A1 (en) * | 2006-04-24 | 2007-11-01 | Academisch Medisch Centrum | Improved treatment of cystic fibrosis |
| WO2007140184A2 (en) * | 2006-05-24 | 2007-12-06 | United Therapeutics Corporation | Deoxynojirimycin and d-arabinitol analogs and methods of using |
| EP2356990A3 (en) | 2006-08-02 | 2011-10-19 | University of Oxford | Liposome treatment of viral infections |
| JP2010510171A (ja) * | 2006-08-21 | 2010-04-02 | ユナイテッド セラピューティクス コーポレーション | ウイルス感染症の治療のための併用療法 |
| WO2008068548A1 (en) | 2006-12-08 | 2008-06-12 | Institut Necker | Use of inhibitors of the glycosylation process for the prevention and treatment of genetic diseases |
| WO2009118658A2 (en) * | 2008-03-26 | 2009-10-01 | University Of Oxford | Endoplasmic reticulum targeting liposomes |
| US9040488B2 (en) * | 2008-09-02 | 2015-05-26 | Baruch S. Blumberg Institute | Imino sugar derivatives demonstrate potent antiviral activity and reduced toxicity |
| US8703744B2 (en) * | 2009-03-27 | 2014-04-22 | The Chancellor, Masters And Scholars Of The University Of Oxford | Cholesterol level lowering liposomes |
| ES2524361T3 (es) * | 2009-06-12 | 2014-12-05 | United Therapeutics Corporation | Iminoazúcares para su uso en el tratamiento de enfermedades por bunyavirus y togavirus |
-
2010
- 2010-06-11 ES ES10786885.3T patent/ES2524361T3/es active Active
- 2010-06-11 EP EP10786885.3A patent/EP2440205B1/en not_active Not-in-force
- 2010-06-11 KR KR1020127000433A patent/KR101463661B1/ko not_active Expired - Fee Related
- 2010-06-11 CA CA2765086A patent/CA2765086C/en not_active Expired - Fee Related
- 2010-06-11 JP JP2012515167A patent/JP5634510B2/ja not_active Expired - Fee Related
- 2010-06-11 CN CN201080033499.6A patent/CN102639133B/zh not_active Expired - Fee Related
- 2010-06-11 US US12/813,882 patent/US8426445B2/en not_active Expired - Fee Related
- 2010-06-11 WO PCT/US2010/038247 patent/WO2010144759A1/en not_active Ceased
-
2013
- 2013-02-07 US US13/761,583 patent/US8748460B2/en not_active Expired - Fee Related
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