CN102639133B - 亚氨基糖和治疗布尼亚病毒性疾病以及披膜病毒性疾病的方法 - Google Patents

亚氨基糖和治疗布尼亚病毒性疾病以及披膜病毒性疾病的方法 Download PDF

Info

Publication number
CN102639133B
CN102639133B CN201080033499.6A CN201080033499A CN102639133B CN 102639133 B CN102639133 B CN 102639133B CN 201080033499 A CN201080033499 A CN 201080033499A CN 102639133 B CN102639133 B CN 102639133B
Authority
CN
China
Prior art keywords
virus
purposes according
disease
alkyl
fever
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201080033499.6A
Other languages
English (en)
Chinese (zh)
Other versions
CN102639133A (zh
Inventor
厄本·拉姆斯泰特
布伦南·克洛斯
妮科尔·齐兹曼
雷蒙德·A·德韦克
特里·D·巴特斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Oxford
United Therapeutics Corp
Original Assignee
University of Oxford
United Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Oxford, United Therapeutics Corp filed Critical University of Oxford
Publication of CN102639133A publication Critical patent/CN102639133A/zh
Application granted granted Critical
Publication of CN102639133B publication Critical patent/CN102639133B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
CN201080033499.6A 2009-06-12 2010-06-11 亚氨基糖和治疗布尼亚病毒性疾病以及披膜病毒性疾病的方法 Expired - Fee Related CN102639133B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18661409P 2009-06-12 2009-06-12
US61/186,614 2009-06-12
PCT/US2010/038247 WO2010144759A1 (en) 2009-06-12 2010-06-11 Iminosugars and methods of treating bunyaviral and togaviral diseases

Publications (2)

Publication Number Publication Date
CN102639133A CN102639133A (zh) 2012-08-15
CN102639133B true CN102639133B (zh) 2015-03-11

Family

ID=43306958

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080033499.6A Expired - Fee Related CN102639133B (zh) 2009-06-12 2010-06-11 亚氨基糖和治疗布尼亚病毒性疾病以及披膜病毒性疾病的方法

Country Status (8)

Country Link
US (2) US8426445B2 (enExample)
EP (1) EP2440205B1 (enExample)
JP (1) JP5634510B2 (enExample)
KR (1) KR101463661B1 (enExample)
CN (1) CN102639133B (enExample)
CA (1) CA2765086C (enExample)
ES (1) ES2524361T3 (enExample)
WO (1) WO2010144759A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2579628T3 (es) 2009-02-23 2016-08-12 Emergent Virology Llc Iminoazúcares y métodos de tratamiento de enfermedades virales
US8426445B2 (en) * 2009-06-12 2013-04-23 United Therapeutics Corporation Iminosugars and methods of treating bunyaviral and togaviral diseases
IN2014MN02539A (enExample) 2012-06-06 2015-07-24 Unither Virology Llc
CN102875450B (zh) * 2012-10-25 2015-04-08 上海丝绸集团股份有限公司 一种从桑叶中提取制备1-脱氧野尻霉素的工艺方法
EP2968300A4 (en) * 2013-03-15 2016-09-28 Unither Virology Llc ANTIBACTERIAL COMPOUNDS
CA2924026C (en) 2013-09-16 2021-12-28 Emergent Virology Llc Deoxynojirimycin derivatives and methods of their using
CN104357583B (zh) * 2014-10-31 2016-11-09 中国检验检疫科学研究院 巴马哈森林病毒的实时荧光rt-pcr检测试剂盒和方法
BR112017008898B1 (pt) * 2014-11-05 2022-11-29 Emergent Virology Llc Compostos de iminoaçúcares, suas composições farmacêuticas e usos dos mesmos para tratar doenças virais
CN114681472B (zh) * 2019-03-13 2023-06-30 中国人民解放军军事科学院军事医学研究院 氨基葡萄糖及其衍生物作为抗病毒药物的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006077427A2 (en) * 2005-01-21 2006-07-27 Mnl Pharma Limited Antiviral drug combinations

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1555654A (en) * 1977-06-25 1979-11-14 Exxon Research Engineering Co Agricultural burner apparatus
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
DE2834122A1 (de) * 1978-08-03 1980-02-14 Bayer Ag Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose
DE2839309A1 (de) * 1978-09-09 1980-03-27 Bayer Ag 3,4,5-trihydroxypiperidin-derivate
DE2853573A1 (de) * 1978-12-12 1980-07-03 Bayer Ag Herstellung von n-substituierten derivaten des l-desoxynojirimycins
DE3038901A1 (de) * 1980-10-15 1982-05-06 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins
DE3611841A1 (de) 1986-04-09 1987-10-15 Bayer Ag Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten
US5043273A (en) 1989-08-17 1991-08-27 Monsanto Company Phosphorylated glycosidase inhibitor prodrugs
US5103008A (en) * 1989-08-17 1992-04-07 Monsanto Company Compound, N-butyl-deoxynojirimycin-6-phosphate
US4994572A (en) * 1989-10-12 1991-02-19 Monsanto Company Synthesis of nojirimycin derivatives
US5030638A (en) * 1990-02-26 1991-07-09 G. D. Searle & Co. Method of antiviral enhancement
US5200523A (en) 1990-10-10 1993-04-06 Monsanto Company Synthesis of nojirimycin derivatives
US5206251A (en) * 1992-04-01 1993-04-27 G. D. Searle & Co. 2- and 3- amino and azido derivatives of 1,5-iminosugars
US5399567A (en) * 1993-05-13 1995-03-21 Monsanto Company Method of treating cholera
WO1995022975A1 (en) 1994-02-25 1995-08-31 G.D. Searle & Co. Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus
BR9813508A (pt) * 1997-12-11 2000-10-03 Univ Oxford Inibição de replicação viral associada com membrana
US6809083B1 (en) 1998-02-12 2004-10-26 Richard A. Mueller Use of N-substituted-1, 5-dideoxy-1, 5-imino-D-glucitol compounds for treating hepatitis virus infections
EP1714676A3 (en) 1998-02-12 2006-11-15 G.D. Searle LLC. Use of N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
US6689759B1 (en) * 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
US6610703B1 (en) 1998-12-10 2003-08-26 G.D. Searle & Co. Method for treatment of glycolipid storage diseases
GB9828474D0 (en) * 1998-12-24 1999-02-17 British Aerospace Surface topology inspection
CA2362914C (en) * 1999-02-12 2009-04-14 G.D. Searle & Co. Use of substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
GB0100889D0 (en) * 2001-01-12 2001-02-21 Oxford Glycosciences Uk Ltd Compounds
EP1196190B1 (en) 1999-07-26 2003-03-19 G.D. SEARLE & CO. Use of long-chain n-alkyl derivatives of deoxynojirimycin and a glucocerebrosidase enzyme for the manufacture of a medicament for the treatment of glycolipid storage diseases
US7256005B2 (en) * 1999-08-10 2007-08-14 The Chancellor, Masters And Scholars Of The University Of Oxford Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity
WO2004069190A2 (en) * 2003-01-31 2004-08-19 Mount Sinai School Of Medicine Of New York University Combination therapy for treating protein deficiency disorders
US7446098B2 (en) * 2003-02-18 2008-11-04 Mount Sinai School Of Medicine Of New York University Combination therapy for treating protein deficiencies
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
US20060211752A1 (en) 2004-03-16 2006-09-21 Kohn Leonard D Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
US20050256168A1 (en) * 2004-04-28 2005-11-17 Block Timothy M Compositions for oral administration for the treatment of interferon-responsive disorders
US7524829B2 (en) * 2004-11-01 2009-04-28 Avi Biopharma, Inc. Antisense antiviral compounds and methods for treating a filovirus infection
KR20080056688A (ko) * 2005-03-16 2008-06-23 유니버시티 오브 옥스퍼드 Ｈｉｖ－ｉ용 만노스 면역원
EP3441090A1 (en) * 2005-05-17 2019-02-13 Amicus Therapeutics, Inc. A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives
AU2006272497B2 (en) 2005-07-27 2012-07-19 University Of Florida Research Foundation, Inc. Small compounds that correct protein misfolding and uses thereof
AU2006272586A1 (en) * 2005-07-27 2007-02-01 University Of Florida Research Foundation, Inc. Use of heat shock to treat ocular disease
US20070244184A1 (en) * 2006-01-09 2007-10-18 Simon Fraser University Glycosidase inhibitors and methods of synthesizing same
ATE479696T1 (de) * 2006-04-24 2010-09-15 Amc Amsterdam Verbessertes verfahren zur behandlung von cystischer fibrose
WO2007140184A2 (en) * 2006-05-24 2007-12-06 United Therapeutics Corporation Deoxynojirimycin and d-arabinitol analogs and methods of using
WO2008088581A2 (en) 2006-08-02 2008-07-24 United Therapeutics Corporation Liposome treatment of viral infections
EP2054076A2 (en) * 2006-08-21 2009-05-06 United Therapeutics Corporation Combination therapy for treatment of viral infections
WO2008068548A1 (en) 2006-12-08 2008-06-12 Institut Necker Use of inhibitors of the glycosylation process for the prevention and treatment of genetic diseases
US20090252785A1 (en) * 2008-03-26 2009-10-08 University Of Oxford Endoplasmic reticulum targeting liposomes
US9040488B2 (en) * 2008-09-02 2015-05-26 Baruch S. Blumberg Institute Imino sugar derivatives demonstrate potent antiviral activity and reduced toxicity
US8703744B2 (en) * 2009-03-27 2014-04-22 The Chancellor, Masters And Scholars Of The University Of Oxford Cholesterol level lowering liposomes
US8426445B2 (en) * 2009-06-12 2013-04-23 United Therapeutics Corporation Iminosugars and methods of treating bunyaviral and togaviral diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006077427A2 (en) * 2005-01-21 2006-07-27 Mnl Pharma Limited Antiviral drug combinations

Also Published As

Publication number Publication date
JP2012530061A (ja) 2012-11-29
ES2524361T3 (es) 2014-12-05
KR101463661B1 (ko) 2014-11-19
CA2765086C (en) 2015-12-15
KR20120038960A (ko) 2012-04-24
CA2765086A1 (en) 2010-12-16
WO2010144759A1 (en) 2010-12-16
CN102639133A (zh) 2012-08-15
JP5634510B2 (ja) 2014-12-03
EP2440205A1 (en) 2012-04-18
US20100317696A1 (en) 2010-12-16
EP2440205B1 (en) 2014-08-27
US20130150405A1 (en) 2013-06-13
EP2440205A4 (en) 2013-04-24
US8748460B2 (en) 2014-06-10
US8426445B2 (en) 2013-04-23

Similar Documents

Publication Publication Date Title
CN102639133B (zh) 亚氨基糖和治疗布尼亚病毒性疾病以及披膜病毒性疾病的方法
US9943532B2 (en) Iminosugars and methods of treating viral diseases
EP2473046B1 (en) Iminosugars for their use in the treatment of filoviral diseases
US20110065752A1 (en) Methods of treating orthomyxoviral infections
JP5951996B2 (ja) イミノ糖及びアレナウイルス感染症を治療する方法
HK1172270A (en) Iminosugars and methods of treating bunyaviral and togaviral diseases
HK1165675B (en) Iminosugars and methods of treating arenaviral infections

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1172270

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20150311

Termination date: 20180611

CF01 Termination of patent right due to non-payment of annual fee