JP2012529506A - 粘膜炎治療用組成物の使用 - Google Patents

粘膜炎治療用組成物の使用 Download PDF

Info

Publication number
JP2012529506A
JP2012529506A JP2012514923A JP2012514923A JP2012529506A JP 2012529506 A JP2012529506 A JP 2012529506A JP 2012514923 A JP2012514923 A JP 2012514923A JP 2012514923 A JP2012514923 A JP 2012514923A JP 2012529506 A JP2012529506 A JP 2012529506A
Authority
JP
Japan
Prior art keywords
composition
mucositis
chitosan
range
negatively charged
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012514923A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012529506A5 (enExample
Inventor
アドルフソン,ラーシュ
ラーム,ウッレ
ヴェステルマルク,アンデシュ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EXTHERA AB
Original Assignee
EXTHERA AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EXTHERA AB filed Critical EXTHERA AB
Publication of JP2012529506A publication Critical patent/JP2012529506A/ja
Publication of JP2012529506A5 publication Critical patent/JP2012529506A5/ja
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/722Chitin, chitosan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/721Dextrans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727Heparin; Heparan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2012514923A 2009-06-10 2010-06-10 粘膜炎治療用組成物の使用 Pending JP2012529506A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0950441-6 2009-06-10
SE0950441 2009-06-10
PCT/SE2010/050650 WO2010144044A1 (en) 2009-06-10 2010-06-10 Use of a composition for the treatment of mucositis

Publications (2)

Publication Number Publication Date
JP2012529506A true JP2012529506A (ja) 2012-11-22
JP2012529506A5 JP2012529506A5 (enExample) 2013-07-25

Family

ID=43309105

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012514923A Pending JP2012529506A (ja) 2009-06-10 2010-06-10 粘膜炎治療用組成物の使用

Country Status (9)

Country Link
US (1) US8906883B2 (enExample)
EP (1) EP2440216A4 (enExample)
JP (1) JP2012529506A (enExample)
CN (1) CN102458419A (enExample)
AU (1) AU2010259284A1 (enExample)
BR (1) BRPI1009741A2 (enExample)
CA (1) CA2763092A1 (enExample)
RU (1) RU2011152518A (enExample)
WO (1) WO2010144044A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015022907A1 (ja) * 2013-08-13 2015-02-19 生化学工業株式会社 カチオン化キトサンを含有する医薬
JP2016534057A (ja) * 2013-10-22 2016-11-04 カンテックス ファーマシューティカルズ, インコーポレイテッド 放射線傷害を処置および予防する方法
WO2017029710A1 (ja) * 2015-08-18 2017-02-23 合同会社Pharma Seeds Create NSAIDsまたはヘパリン類含有口腔用組成物

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2555760B1 (en) 2010-04-06 2019-10-16 Synedgen, Inc. Chitosan derivatives for the treatment of mucositis or ulceration
CA2883704C (en) 2012-09-20 2021-09-28 Synedgen, Inc. Methods for treatment or prevention of damage resulting from radiation, trauma or shock
EP3787593A1 (en) * 2018-05-04 2021-03-10 Bonoss Medical Aktiebolag A composition for reduction of scar formation
WO2019236453A1 (en) 2018-06-03 2019-12-12 Glycomira Therapeutics, Inc. Methods for preventing a serious health consequence and/or tissue damage after exposure to ionizing radiation and /or chemotherapy
US20230181624A1 (en) * 2020-04-24 2023-06-15 Intact Therapeutics, Inc. Compositions and methods for treatment of gastrointestinal bleeding
EP3981505B1 (en) * 2020-10-12 2024-11-27 Gambro Lundia AB Membrane with immobilized anticoagulant and process for producing same
EP4401784A4 (en) * 2021-09-17 2025-09-10 Shawn Walker USE OF CHITOSAN COMPLEXES OR COMPOSITIONS TO REDUCE THE INFILTRATION OF ENVIRONMENTAL FACTORS INTO THE BRAIN

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10502663A (ja) * 1994-07-19 1998-03-10 アストラ アクツィエボラーグ 抗癒着剤
JPH10502665A (ja) * 1994-07-19 1998-03-10 メデイカーブ・アクチエボラーグ 創傷治癒剤
JP2000515543A (ja) * 1996-08-06 2000-11-21 メディカーブ・アクチエボラーグ ヘルペスウイルスにより起こる感染を予防または治療するためのキトサンと組み合わされたヘパリンまたはヘパラン硫酸の使用
WO2003090763A1 (en) * 2002-04-24 2003-11-06 Medicarb Ab Composition and kit for the treatment of inflammatory bowel diseases
JP2004525980A (ja) * 2001-04-23 2004-08-26 ニュクリスト ファーマシューティカルズ コーポレーション 粘膜の処置のための金属の使用
JP2008527033A (ja) * 2005-01-19 2008-07-24 ボンオス・メディカル・アー・ベー 増殖因子組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7547433B2 (en) * 2001-02-15 2009-06-16 Access Pharmaceuticals, Inc. Liquid formulations for the prevention and treatment of mucosal diseases and disorders
JP2006508075A (ja) * 2002-10-07 2006-03-09 オラファーマ, インコーポレイテッド 粘膜付着性テトラサイクリン製剤
AU2005285040A1 (en) * 2004-09-14 2006-03-23 Molecular Therapeutics, Inc. D-methionine formulation with improved biopharmaceutical properties
DE102006024831B4 (de) 2006-05-24 2008-03-27 Heraeus Quarzglas Gmbh & Co. Kg Verfahren zur Herstellung eines Halbzeugs aus synthetischem Quarzglas
US20080299050A1 (en) 2006-10-05 2008-12-04 Drugtech Corporation Topical therapies for oral mucositis and other conditions

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10502663A (ja) * 1994-07-19 1998-03-10 アストラ アクツィエボラーグ 抗癒着剤
JPH10502665A (ja) * 1994-07-19 1998-03-10 メデイカーブ・アクチエボラーグ 創傷治癒剤
JP2000515543A (ja) * 1996-08-06 2000-11-21 メディカーブ・アクチエボラーグ ヘルペスウイルスにより起こる感染を予防または治療するためのキトサンと組み合わされたヘパリンまたはヘパラン硫酸の使用
JP2004525980A (ja) * 2001-04-23 2004-08-26 ニュクリスト ファーマシューティカルズ コーポレーション 粘膜の処置のための金属の使用
WO2003090763A1 (en) * 2002-04-24 2003-11-06 Medicarb Ab Composition and kit for the treatment of inflammatory bowel diseases
JP2008527033A (ja) * 2005-01-19 2008-07-24 ボンオス・メディカル・アー・ベー 増殖因子組成物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6014023966; International Journal of Pharmaceutics Vol.93, 1993, pp.233-237 *
JPN6014023969; Biomaterials Vol.30, 20090318, pp.3332-3342 *
JPN6014023972; Biomacromolecules Vol.10, No.6, 20090416, pp.1402-1409 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015022907A1 (ja) * 2013-08-13 2015-02-19 生化学工業株式会社 カチオン化キトサンを含有する医薬
JPWO2015022907A1 (ja) * 2013-08-13 2017-03-02 生化学工業株式会社 カチオン化キトサンを含有する医薬
JP2016534057A (ja) * 2013-10-22 2016-11-04 カンテックス ファーマシューティカルズ, インコーポレイテッド 放射線傷害を処置および予防する方法
WO2017029710A1 (ja) * 2015-08-18 2017-02-23 合同会社Pharma Seeds Create NSAIDsまたはヘパリン類含有口腔用組成物

Also Published As

Publication number Publication date
BRPI1009741A2 (pt) 2016-03-15
CN102458419A (zh) 2012-05-16
WO2010144044A1 (en) 2010-12-16
AU2010259284A1 (en) 2011-12-15
RU2011152518A (ru) 2013-07-20
EP2440216A4 (en) 2013-09-11
CA2763092A1 (en) 2010-12-16
US8906883B2 (en) 2014-12-09
EP2440216A1 (en) 2012-04-18
US20120077773A1 (en) 2012-03-29

Similar Documents

Publication Publication Date Title
JP2012529506A (ja) 粘膜炎治療用組成物の使用
KR100761051B1 (ko) 점막염, 구내염 및 베체트 증후군 치료용 약학적 조성물
US6828308B2 (en) Compositions and methods for the treatment or prevention of inflammation
JP4194653B2 (ja) アフタ口内潰瘍に伴う痛みの即効的解放のための薬剤組成物
ES2361459A1 (es) Gel de quitosano para aplicaciones dermatológicas, proceso de obtención y uso del mismo.
US11337992B2 (en) Liquid composition for use in the treatment of gastroesophageal reflux
CN110740723A (zh) 含壳聚糖调配物及其制备和使用方法
CA2152398A1 (en) Hyaluronic acid-urea pharmaceutical compositions and uses
JP4685242B2 (ja) ヒアルロン酸を用いた放射線膀胱炎の予防、軽減、および治療法
EP3370700B1 (en) Oral gel composition comprising chitosan, pectin, l-carnitine and n-acetylcysteine
CN1660442A (zh) 含海藻糖和透明质酸的烧伤用药传递系统及其制备方法
Koshariya et al. Role of topical Sucralfate in healing of burn wounds
JP6595717B2 (ja) 骨関節炎治療のための親水化されたスルファサラジンおよびヒアルロン酸を含む組成物およびその製造方法
US20150030694A1 (en) Formulations and methods for treating oral inflammation, injury, or pain
EP3773615B1 (en) Liquid composition for use in the treatment of the mucosa of the oro-pharyngo-laryngo-esophageal tract
EP1817044A1 (en) Composition comprising a polysaccharide with bacteria blocking action
EP3087990B1 (en) Gel-forming powder comprising sulfamonomethoxine and chitosan for treating wounds
WO2015023226A1 (en) Use of a composition comprising chitosan and a negatively charge polysaccharide for the treament of salivary dysfuntion
EP3849514A1 (en) A composition for use in the prevention and/or treatment of epistaxis
RU2790528C1 (ru) Способ местного лечения эрозивно-язвенной формы плоского лишая слизистой оболочки рта
Farrer Pharyngitis and tonsillitis
EP2908911A1 (en) Compositions comprising a silver salt of sucrose octasulfate and a potassium salt of sucrose octasulfate for protection of mucosal epithelia
CN111330011A (zh) 一种壳聚糖阴道凝胶
EP3787593A1 (en) A composition for reduction of scar formation
MXPA97006182A (es) Uso de acido hialuronico para el tratamiento de cistitis intersticial

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130606

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130606

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140617

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140917

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140925

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20141017

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20141028

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141117

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20150512