CN102458419A - 组合物用于治疗粘膜炎的用途 - Google Patents

组合物用于治疗粘膜炎的用途 Download PDF

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Publication number
CN102458419A
CN102458419A CN2010800254173A CN201080025417A CN102458419A CN 102458419 A CN102458419 A CN 102458419A CN 2010800254173 A CN2010800254173 A CN 2010800254173A CN 201080025417 A CN201080025417 A CN 201080025417A CN 102458419 A CN102458419 A CN 102458419A
Authority
CN
China
Prior art keywords
compositions
chitosan
scope
mucositis
electronegative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800254173A
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English (en)
Chinese (zh)
Inventor
拉斯·阿道夫森
奥利·拉姆
安德斯·韦斯特马克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EXTHERA AB
Original Assignee
EXTHERA AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EXTHERA AB filed Critical EXTHERA AB
Publication of CN102458419A publication Critical patent/CN102458419A/zh
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/722Chitin, chitosan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/721Dextrans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727Heparin; Heparan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physiology (AREA)
  • Dispersion Chemistry (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN2010800254173A 2009-06-10 2010-06-10 组合物用于治疗粘膜炎的用途 Pending CN102458419A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0950441-6 2009-06-10
SE0950441 2009-06-10
PCT/SE2010/050650 WO2010144044A1 (en) 2009-06-10 2010-06-10 Use of a composition for the treatment of mucositis

Publications (1)

Publication Number Publication Date
CN102458419A true CN102458419A (zh) 2012-05-16

Family

ID=43309105

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800254173A Pending CN102458419A (zh) 2009-06-10 2010-06-10 组合物用于治疗粘膜炎的用途

Country Status (9)

Country Link
US (1) US8906883B2 (enExample)
EP (1) EP2440216A4 (enExample)
JP (1) JP2012529506A (enExample)
CN (1) CN102458419A (enExample)
AU (1) AU2010259284A1 (enExample)
BR (1) BRPI1009741A2 (enExample)
CA (1) CA2763092A1 (enExample)
RU (1) RU2011152518A (enExample)
WO (1) WO2010144044A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113164430A (zh) * 2018-06-03 2021-07-23 格莱科米拉治疗公司 用于在暴露于电离辐射和/或化学疗法之后预防严重健康后果和/或组织损伤的方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2773017T3 (es) 2010-04-06 2020-07-09 Synedgen Inc Derivados de quitosano para el tratamiento de mucositis o ulceración
US10022393B2 (en) 2012-09-20 2018-07-17 Synedgen, Inc. Methods for treatment or prevention of damage resulting from radiation, trauma or shock
CN105451745B (zh) * 2013-08-13 2018-03-27 生化学工业株式会社 含有阳离子化壳聚糖的药物
JP2016534057A (ja) * 2013-10-22 2016-11-04 カンテックス ファーマシューティカルズ, インコーポレイテッド 放射線傷害を処置および予防する方法
JP6315741B2 (ja) * 2015-08-18 2018-04-25 合同会社Pharma Seeds Create NSAIDsまたはヘパリン類含有口腔用組成物
WO2019211483A1 (en) * 2018-05-04 2019-11-07 Bonoss Medical Aktiebolag A composition for reduction of scar formation
WO2021216494A1 (en) * 2020-04-24 2021-10-28 Intact Therapeutics, Inc. Compositions and methods for treatment of gastrointestinal bleeding
EP3981505B1 (en) * 2020-10-12 2024-11-27 Gambro Lundia AB Membrane with immobilized anticoagulant and process for producing same
EP4401784A4 (en) * 2021-09-17 2025-09-10 Shawn Walker USE OF CHITOSAN COMPLEXES OR COMPOSITIONS TO REDUCE THE INFILTRATION OF ENVIRONMENTAL FACTORS INTO THE BRAIN

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1227493A (zh) * 1996-08-06 1999-09-01 梅迪卡布公司 肝素或硫酸乙酰肝素与脱乙酰壳多糖结合用于预防或治疗由疱疹病毒引起的感染
CN1627948A (zh) * 2002-04-24 2005-06-15 麦迪卡博公司 治疗炎症性肠病的组合物和试剂盒

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9402531L (sv) * 1994-07-19 1996-01-20 Medicarb Ab Sårläkningsmedel
SE9402529D0 (sv) * 1994-07-19 1994-07-19 Astra Ab Anti-adherensmedel
EP1363600B1 (en) * 2001-02-15 2008-10-01 Access Pharmaceuticals, Inc. Liquid formulations for the prevention and treatment of mucosal diseases and disorders
EP1383521A2 (en) * 2001-04-23 2004-01-28 Nucryst Pharmaceuticals Corp. Medicament containing a metal such as silver, gold, platinum or palladium as an antimicrobial agent and their use to induce apoptosis in cancerous tissue
US20040167099A1 (en) * 2002-10-07 2004-08-26 Orapharma, Inc. Mucoadhesive tetracycline formulations
JP2008513455A (ja) * 2004-09-14 2008-05-01 モレキュラー セラピューティクス インコーポレーティッド 改良された生物薬剤学的性質をもつd−メチオニン製剤
JP2008527033A (ja) * 2005-01-19 2008-07-24 ボンオス・メディカル・アー・ベー 増殖因子組成物
DE102006024831B4 (de) * 2006-05-24 2008-03-27 Heraeus Quarzglas Gmbh & Co. Kg Verfahren zur Herstellung eines Halbzeugs aus synthetischem Quarzglas
US20080299050A1 (en) 2006-10-05 2008-12-04 Drugtech Corporation Topical therapies for oral mucositis and other conditions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1227493A (zh) * 1996-08-06 1999-09-01 梅迪卡布公司 肝素或硫酸乙酰肝素与脱乙酰壳多糖结合用于预防或治疗由疱疹病毒引起的感染
CN1627948A (zh) * 2002-04-24 2005-06-15 麦迪卡博公司 治疗炎症性肠病的组合物和试剂盒

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
托马斯: "《临床实验诊断学-实验结果的应用和评估》", 31 May 2004, 上海科学技术出版社, article "单纯疱疹病毒(HSV)1型", pages: 1236 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113164430A (zh) * 2018-06-03 2021-07-23 格莱科米拉治疗公司 用于在暴露于电离辐射和/或化学疗法之后预防严重健康后果和/或组织损伤的方法

Also Published As

Publication number Publication date
CA2763092A1 (en) 2010-12-16
BRPI1009741A2 (pt) 2016-03-15
JP2012529506A (ja) 2012-11-22
AU2010259284A1 (en) 2011-12-15
WO2010144044A1 (en) 2010-12-16
RU2011152518A (ru) 2013-07-20
EP2440216A4 (en) 2013-09-11
US20120077773A1 (en) 2012-03-29
US8906883B2 (en) 2014-12-09
EP2440216A1 (en) 2012-04-18

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Application publication date: 20120516