JP2012526822A5 - - Google Patents
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- Publication number
- JP2012526822A5 JP2012526822A5 JP2012510929A JP2012510929A JP2012526822A5 JP 2012526822 A5 JP2012526822 A5 JP 2012526822A5 JP 2012510929 A JP2012510929 A JP 2012510929A JP 2012510929 A JP2012510929 A JP 2012510929A JP 2012526822 A5 JP2012526822 A5 JP 2012526822A5
- Authority
- JP
- Japan
- Prior art keywords
- fluorescent phospholipid
- ether compound
- phospholipid ether
- tissue
- malignant tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 phospholipid ether compound Chemical class 0.000 claims 38
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 29
- 201000011510 cancer Diseases 0.000 claims 23
- 238000000034 method Methods 0.000 claims 17
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 238000009825 accumulation Methods 0.000 claims 5
- 230000001575 pathological effect Effects 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 210000000130 stem cell Anatomy 0.000 claims 4
- 238000001574 biopsy Methods 0.000 claims 2
- 210000003238 esophagus Anatomy 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 238000002271 resection Methods 0.000 claims 2
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 claims 1
- 210000000683 abdominal cavity Anatomy 0.000 claims 1
- 210000000621 bronchi Anatomy 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 210000001953 common bile duct Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000001198 duodenum Anatomy 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 210000000115 thoracic cavity Anatomy 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
- ORGHESHFQPYLAO-UHFFFAOYSA-N vinyl radical Chemical compound C=[CH] ORGHESHFQPYLAO-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/463,998 US20100284931A1 (en) | 2009-05-11 | 2009-05-11 | Fluorescent phospholipid ether compounds, compositions, and methods of use |
| US12/463,990 US20100284930A1 (en) | 2009-05-11 | 2009-05-11 | Fluorescent imaging of skin cancers using phospholipid ether compounds |
| US12/463,998 | 2009-05-11 | ||
| US12/463,983 US20100286510A1 (en) | 2009-05-11 | 2009-05-11 | Use of fluorescent phospholipid ether compounds in biopsies |
| US12/463,978 | 2009-05-11 | ||
| US12/463,970 | 2009-05-11 | ||
| US12/463,978 US20100284929A1 (en) | 2009-05-11 | 2009-05-11 | Fluorescent imaging of tumors using phospholipid ether compounds |
| US12/463,970 US7811548B1 (en) | 2009-05-11 | 2009-05-11 | Fluorescent phospholipid ether compounds and compositions |
| US12/463,983 | 2009-05-11 | ||
| US12/463,990 | 2009-05-11 | ||
| PCT/US2010/034361 WO2010132428A1 (en) | 2009-05-11 | 2010-05-11 | Fluorescent phospholipid ether compounds, compositions, and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014183841A Division JP6006271B2 (ja) | 2009-05-11 | 2014-09-10 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012526822A JP2012526822A (ja) | 2012-11-01 |
| JP2012526822A5 true JP2012526822A5 (OSRAM) | 2013-06-27 |
| JP5702366B2 JP5702366B2 (ja) | 2015-04-15 |
Family
ID=43085298
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012510929A Active JP5702366B2 (ja) | 2009-05-11 | 2010-05-11 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
| JP2014183841A Active JP6006271B2 (ja) | 2009-05-11 | 2014-09-10 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
| JP2015098391A Active JP6073961B2 (ja) | 2009-05-11 | 2015-05-13 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
| JP2016089336A Pending JP2016193907A (ja) | 2009-05-11 | 2016-04-27 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014183841A Active JP6006271B2 (ja) | 2009-05-11 | 2014-09-10 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
| JP2015098391A Active JP6073961B2 (ja) | 2009-05-11 | 2015-05-13 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
| JP2016089336A Pending JP2016193907A (ja) | 2009-05-11 | 2016-04-27 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9616140B2 (OSRAM) |
| EP (1) | EP2429591B1 (OSRAM) |
| JP (4) | JP5702366B2 (OSRAM) |
| ES (1) | ES2549459T3 (OSRAM) |
| WO (1) | WO2010132428A1 (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2549459T3 (es) * | 2009-05-11 | 2015-10-28 | Cellectar, Inc. | Compuestos de éter de fosfolípido fluorescentes, composiciones y procedimientos de uso |
| SI3708192T1 (sl) * | 2009-06-12 | 2023-12-29 | Cellectar, Inc. | Eter fosfolipidne spojine za zdravljenje raka in slikanje in detekcijo rakavih izvornih celic |
| JP2013032297A (ja) * | 2011-08-01 | 2013-02-14 | Univ Of Tsukuba | バイオイメージングのための近赤外発光物質及びその合成方法 |
| JP6260259B2 (ja) * | 2013-12-24 | 2018-01-17 | 日油株式会社 | ボロン酸含有ホスホリルコリン化合物及びその製造方法、並びにヨード基含有化合物修飾剤 |
| SI3750545T1 (sl) * | 2014-11-17 | 2024-06-28 | Cellectar Biosciences, Inc. | Analogi fosfolipidnega etra kot nosilci zdravil, ki ciljajo na raka |
| WO2017079535A1 (en) | 2015-11-06 | 2017-05-11 | Wisconsin Alumni Research Foundation | Long-lived gadolinium based tumor targeted imaging and therapy agents |
| KR20190037226A (ko) * | 2016-06-14 | 2019-04-05 | 셀렉타 바이오사이언시스, 인코퍼레이티드 | 순환 종양 세포의 식별 및 단리를 위한 인지질 에테르 유사체 |
| KR102148067B1 (ko) * | 2016-09-02 | 2020-08-26 | 주식회사 엘지화학 | 화합물 및 이를 포함하는 색변환필름 |
| JP2020066637A (ja) * | 2017-02-27 | 2020-04-30 | 富士フイルム株式会社 | 病理診断用染色剤、細胞核染色方法、病理標本の製造方法、及び色素 |
| JP6495989B1 (ja) | 2017-10-02 | 2019-04-03 | 株式会社アマダホールディングス | プログラム作成装置、溶接システム、及びプログラム作成方法 |
| SI3773544T1 (sl) | 2018-04-10 | 2026-01-30 | Cellectar Biosciences, Inc. | Fosfolipid-flavaglin konjugati ter postopki njihove uporabe za ciljno zdravljenje raka |
| EP3805236B1 (en) | 2018-06-01 | 2026-05-06 | FUJIFILM Corporation | Fluorescent compound and fluorescent labeled biological substance using the same |
| JP7631329B2 (ja) | 2019-10-10 | 2025-02-18 | セレクター・バイオサイエンシズ・インコーポレイテッド | リン脂質－フラバグリン抱合体及び標的化されたがん治療のためのリン脂質－フラバグリン抱合体の使用方法 |
| KR102400464B1 (ko) * | 2020-07-28 | 2022-05-19 | 부산대학교 산학협력단 | 암 줄기세포 검출용 바이오 마커 조성물 |
| WO2022049605A1 (en) * | 2020-09-05 | 2022-03-10 | Council Of Scientific And Industrial Research | A thermoresponsive self-assembled organic material as photonic ink and a process of making thereof |
| CN114957330A (zh) * | 2022-07-06 | 2022-08-30 | 南京师范大学 | 一种新型花菁染料中间体及其制备方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4925649A (en) | 1987-06-12 | 1990-05-15 | The University Of Michigan | Radioiodinated diacylglycerol analogues and methods of use |
| US5347030A (en) | 1987-10-23 | 1994-09-13 | The Board Of Regents Of The University Of Michigan | Radioiodinated phospholipid ether analogues and methods of using same |
| US4965391A (en) | 1987-10-23 | 1990-10-23 | The University Of Michigan | Radioiodinated phospholipid ether analogues |
| US5087721A (en) | 1987-10-23 | 1992-02-11 | The University Of Michigan | Radioiodinated phosphate esters |
| US5369097A (en) | 1991-04-25 | 1994-11-29 | The University Of British Columbia | Phosphonates as anti-cancer agents |
| US5728529A (en) * | 1995-06-23 | 1998-03-17 | Baylor College Of Medicine | Alternative dye-labeled ribonucleotides, deoxyribonucleotides, and dideoxyribonucleotides for automated DNA analysis |
| US5626654A (en) | 1995-12-05 | 1997-05-06 | Xerox Corporation | Ink compositions containing liposomes |
| CA2276284C (en) | 1996-12-04 | 2006-10-10 | The Regents Of The University Of Michigan | Radioiodinated phospholipid ether analogs and methods of using the same |
| US6255519B1 (en) | 1996-12-04 | 2001-07-03 | Regents Of The University Of Michigan | Radioiodinated phospholipid ether analogs and methods of using the same |
| US5830701A (en) * | 1997-03-28 | 1998-11-03 | Tao Medical Electronics Co., Ltd. | Method of detecting hematopoietic progenitor cells |
| US6939985B1 (en) | 1997-04-09 | 2005-09-06 | Commonwealth Scientific And Industrial Research Organisation | Aryl borates |
| US7385038B2 (en) * | 2002-07-18 | 2008-06-10 | Protein Express Co., Ltd. | Non-natural labeled amino acid and method of constructing amino acid/tRNA complex |
| JP4004385B2 (ja) * | 2002-11-07 | 2007-11-07 | 独立行政法人科学技術振興機構 | 二重染色法によるガン検出方法 |
| WO2005063774A1 (en) | 2003-12-22 | 2005-07-14 | Johns Hopkins University | Boronic acid aryl analogs |
| US8540968B2 (en) * | 2004-03-02 | 2013-09-24 | Cellectar, Inc. | Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof |
| DE602005015687D1 (de) | 2004-03-02 | 2009-09-10 | Cellectar Inc | Phospholipid-analoga für die behandlung von krebs |
| JP2008508909A (ja) | 2004-07-08 | 2008-03-27 | セレクター，リミティド ライアビリティ カンパニー | 放射性標識付きリン脂質エーテル類似体を用いる仮想結腸内視術 |
| US7041859B1 (en) | 2004-09-09 | 2006-05-09 | University Of Tennessee Research Foundation | Method for halogenating or radiohalogenating a chemical compound |
| MX2007007497A (es) * | 2004-12-20 | 2008-01-11 | Cellectar Llc | Analogos de fosfolipido eter para la deteccion y tratamiento del cancer. |
| JP2007143624A (ja) * | 2005-11-24 | 2007-06-14 | Hamamatsu Photonics Kk | 蛍光観察装置 |
| US20070297988A1 (en) * | 2006-06-21 | 2007-12-27 | Bin Wu | Optical probes for in vivo imaging |
| BRPI0715783A2 (pt) * | 2006-08-15 | 2013-07-16 | Cellectar Inc | fluorescÊncia pràxima do infravermelho usando corantes anÁlogos de Éter fosfolipÍdico em aplicaÇÕes endoscàpicas |
| WO2008150439A1 (en) | 2007-06-01 | 2008-12-11 | Cellectar, Inc. | Compositions of phospholipid ether boronic acids and esters and methods for their synthesis and use |
| ES2326458B1 (es) * | 2008-04-04 | 2010-07-26 | Consejo Superior De Investigaciones Cientificas (Csic) (85%) | Compuestos fluorescentes para diagnostico de infecciones, procedimiento de obtencion y sus aplicaciones. |
| ES2549459T3 (es) * | 2009-05-11 | 2015-10-28 | Cellectar, Inc. | Compuestos de éter de fosfolípido fluorescentes, composiciones y procedimientos de uso |
| US20100284931A1 (en) | 2009-05-11 | 2010-11-11 | Pinchuk Anatoly | Fluorescent phospholipid ether compounds, compositions, and methods of use |
| US20100284930A1 (en) | 2009-05-11 | 2010-11-11 | Pinchuk Anatoly | Fluorescent imaging of skin cancers using phospholipid ether compounds |
| US8871181B2 (en) | 2009-05-11 | 2014-10-28 | Cellectar, Inc. | Fluorescent phospholipid ether compounds, compositions, and methods of use |
| US20100286510A1 (en) | 2009-05-11 | 2010-11-11 | Pinchuk Anatoly | Use of fluorescent phospholipid ether compounds in biopsies |
| US20100284929A1 (en) | 2009-05-11 | 2010-11-11 | Pinchuk Anatoly | Fluorescent imaging of tumors using phospholipid ether compounds |
| US7811548B1 (en) | 2009-05-11 | 2010-10-12 | Cellectar, Inc. | Fluorescent phospholipid ether compounds and compositions |
| SI3708192T1 (sl) | 2009-06-12 | 2023-12-29 | Cellectar, Inc. | Eter fosfolipidne spojine za zdravljenje raka in slikanje in detekcijo rakavih izvornih celic |
-
2010
- 2010-05-11 ES ES10775385.7T patent/ES2549459T3/es active Active
- 2010-05-11 JP JP2012510929A patent/JP5702366B2/ja active Active
- 2010-05-11 WO PCT/US2010/034361 patent/WO2010132428A1/en not_active Ceased
- 2010-05-11 EP EP10775385.7A patent/EP2429591B1/en active Active
-
2014
- 2014-09-10 JP JP2014183841A patent/JP6006271B2/ja active Active
- 2014-09-23 US US14/493,489 patent/US9616140B2/en active Active
-
2015
- 2015-05-13 JP JP2015098391A patent/JP6073961B2/ja active Active
-
2016
- 2016-04-27 JP JP2016089336A patent/JP2016193907A/ja active Pending
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