JP2012525861A - 医療用子宮内システム - Google Patents
医療用子宮内システム Download PDFInfo
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- JP2012525861A JP2012525861A JP2012507785A JP2012507785A JP2012525861A JP 2012525861 A JP2012525861 A JP 2012525861A JP 2012507785 A JP2012507785 A JP 2012507785A JP 2012507785 A JP2012507785 A JP 2012507785A JP 2012525861 A JP2012525861 A JP 2012525861A
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- deposit
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/20—Tampons, e.g. catamenial tampons; Accessories therefor
- A61F13/26—Means for inserting tampons, i.e. applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
- A61F6/142—Wirelike structures, e.g. loops, rings, spirals
- A61F6/144—Wirelike structures, e.g. loops, rings, spirals with T-configuration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Vascular Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
本発明の特徴および利点は、以下の図面を参照すれば十分理解できる。
Claims (15)
- 機能性子宮出血、月経過多、月経困難症、子宮内膜症、子宮筋腫、更年期不定愁訴、骨粗しょう症、および、泌尿生殖器萎縮から成る群から選択される病状の治療において用いる子宮内システムであって、
治療有効量の生物学的に活性な化合物のデポジットと、
前記デポジットを受け入れるための内部空間を画定し、前記デポジットの外面の実質的部分へのアクセスを可能にする開放構造を有するフレームと、
雌哺乳類の子宮内に前記フレームを保持するための1つ以上の保持要素と、
を備える子宮内システム。 - 前記フレームが、ほぼ柔軟であり、デポジットと相互に作用して、フレーム単独の曲げ剛性とデポジット単独の曲げ剛性との和よりも大きい曲げ剛性を有する機械的構造を形成する、請求項1に記載のシステム。
- 前記デポジットが、前記フレームのステム部内に位置するロッド形状のデポジットであり、前記フレームのステム部自体の曲げ剛性よりも大きい曲げ剛性を有する、請求項1に記載のシステム。
- 前記デポジットが、速度制御膜によって取り囲まれるポリマーマトリクスコアを備える、請求項1〜3のいずれか一項に記載のシステム。
- 前記デポジットが、実質的に形状安定性であり、使用中に腐食されない、請求項1〜4のいずれか一項に記載のシステム。
- 前記化合物が、ホルモン、抗ホルモン、または、部分作動薬部分作動薬、部分拮抗薬、もしくは、それらの組み合わせなどの混合プロファイルを有するホルモンである、請求項1〜5のいずれか一項に記載のシステム。
- 前記ホルモン、抗ホルモン、または、混合プロファイルを有するホルモンが、プロゲステロン受容体作動薬、プロゲステロン受容体拮抗薬、または、SPRM(選択的プロゲステロン受容体モジュレータ)などの混合プロファイルプロゲステロン受容体リガンドを含む、請求項6に記載のシステム。
- 前記ホルモン、抗ホルモン、または、混合プロファイルを有するホルモンが、エストロゲン受容体作動薬、エストロゲン受容体拮抗薬、または、SERM(選択的エストロゲン受容体モジュレータ)などの混合プロファイルエストロゲン受容体リガンドを含む、請求項6に記載のシステム。
- 前記化合物が、ER調節活性を有し、17ベータ−エストラジオール、エストリオール、共役ウマエストロゲン、ER−アルファ選択的アゴニスト単独またはプロゲステロンとの組み合わせ、タモキシフェンまたはその活性代謝物、フルベストラント、アロマターゼ阻害薬、アナストロゾール、レトロゾール、および、エキセメスタンなどのエストラジオールの新たな形成を阻止する化合物から成る群から選択される、請求項1〜5のいずれか一項に記載のシステム。
- 前記ホルモン、抗ホルモン、または、混合プロファイルを有するホルモンが、アンドロゲン受容体作動薬、アンドロゲン受容体拮抗薬、または、混合プロファイルアンドロゲン受容体リガンドを含むアンドロゲン受容体調節活性を有する化合物を含む、請求項6に記載のシステム。
- 前記治療有効量の前記生物学的に活性な化合物が非ホルモン化合物を含む、請求項1〜5のいずれか一項に記載のシステム。
- 治療有効量の前記生物学的に活性な化合物が非ステロイドホルモンを含む、請求項1〜10のいずれか一項に記載のシステム。
- 前記フレームは、前記デポジットの外面の少なくとも50%へのアクセスを可能にする開放構造を有する、請求項1〜12のいずれか一項に記載のシステム。
- 子宮内システムの製造方法であって、
内部空間と開放構造とを有するフレームを形成する工程、
機能性子宮出血、月経過多、月経困難症、子宮内膜症、子宮筋腫、更年期不定愁訴、骨粗しょう症、および、泌尿生殖器萎縮から成る群から選択される病状の治療にとって治療有効量の生物学的に活性な化合物のデポジットであり、速度制御構造を備える外面を有するデポジットを提供する工程、および
前記外面の実質的部分が前記開放構造を通じて露出されるように前記デポジットを前記内部空間内に挿入する工程
を含む方法。 - 前記化合物を含有するポリマーマトリクスコアと速度制御膜との共押出しによって前記デポジットを形成する工程を更に含む、請求項14に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09159353.3 | 2009-05-04 | ||
EP09159353 | 2009-05-04 | ||
PCT/EP2010/055948 WO2010128004A1 (en) | 2009-05-04 | 2010-05-03 | Intrauterine system for use in medical treatment |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2012525861A true JP2012525861A (ja) | 2012-10-25 |
JP5555766B2 JP5555766B2 (ja) | 2014-07-23 |
Family
ID=40943385
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012507785A Expired - Fee Related JP5555766B2 (ja) | 2009-05-04 | 2010-05-03 | 医療用子宮内システム |
Country Status (16)
Country | Link |
---|---|
US (2) | US8568374B2 (ja) |
EP (1) | EP2427154A1 (ja) |
JP (1) | JP5555766B2 (ja) |
KR (1) | KR20120020151A (ja) |
CN (1) | CN102438562B (ja) |
AU (1) | AU2010244494B2 (ja) |
BR (1) | BRPI1016147A2 (ja) |
CA (1) | CA2760171A1 (ja) |
CO (1) | CO6450625A2 (ja) |
IL (1) | IL215842A (ja) |
MX (1) | MX2011011748A (ja) |
MY (1) | MY179350A (ja) |
NZ (1) | NZ596005A (ja) |
RU (1) | RU2529477C2 (ja) |
WO (1) | WO2010128004A1 (ja) |
ZA (1) | ZA201107862B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2018509389A (ja) * | 2015-01-30 | 2018-04-05 | リ・ガリ・ベスローテン・フエンノートシャップLi Galli B.V. | 膣用薬物送達デバイス |
Families Citing this family (33)
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EP2303391B1 (en) * | 2008-06-25 | 2014-08-13 | Medimetrics Personalized Drug Delivery B.V. | Electronic pill comprising a plurality of medicine reservoirs |
FI20080524A0 (fi) | 2008-09-17 | 2008-09-17 | Bayer Schering Pharma Oy | Insertteri |
US20110166508A1 (en) | 2008-09-17 | 2011-07-07 | Lyytikaeinen Heikki | inserter |
FI20080523A0 (fi) | 2008-09-17 | 2008-09-17 | Bayer Schering Pharma Oy | Insertteri |
JP5497176B2 (ja) | 2009-08-12 | 2014-05-21 | コーニンクレッカ フィリップス エヌ ヴェ | 圧縮可能な薬品貯槽を備える薬品送出装置 |
EP2482914A1 (en) * | 2009-09-29 | 2012-08-08 | Koninklijke Philips Electronics N.V. | Intrauterine electronic capsule for administering a substance |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
WO2013078422A2 (en) | 2011-11-23 | 2013-05-30 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
BR112015002746A2 (pt) * | 2012-08-09 | 2017-07-04 | Mithra Pharmaceuticals S A | dispositivo intrauterino |
US9339364B2 (en) * | 2012-10-10 | 2016-05-17 | The Procter & Gamble Company | Intravaginal device withdrawal assembly |
US20150320766A1 (en) * | 2012-12-14 | 2015-11-12 | Laboratoire Hra-Pharma | Copper intrauterine device |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20160235583A1 (en) * | 2013-02-21 | 2016-08-18 | The Procter & Gamble Company | Intravaginal device withdrawal assembly |
RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
WO2016171543A1 (en) | 2015-04-22 | 2016-10-27 | Cadens Beheer B.V. | Improved contraceptive methods and compositions and devices for use therein |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
WO2017173071A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
KR101851737B1 (ko) * | 2016-04-26 | 2018-04-24 | 주식회사 엔도비전 | 자궁경부 유착 방지 장치 |
FR3078486B1 (fr) * | 2018-03-01 | 2021-01-22 | Steve Eisenhut | Dispositif hygienique |
ES1217271Y (es) * | 2018-07-24 | 2018-12-05 | Font Caselles Ramon | Aplicador de tampones |
AU2020384227A1 (en) * | 2019-11-12 | 2022-05-26 | Poly-Med, Inc. | Contraceptive medical devices |
TW202131879A (zh) * | 2020-01-24 | 2021-09-01 | 芬蘭商拜耳股份有限公司 | 具備鎖定部件之子宮內系統 |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3656483A (en) * | 1970-01-15 | 1972-04-18 | Biolog Concepts Inc | Intrauterine medicator |
JPH10510168A (ja) * | 1994-07-05 | 1998-10-06 | レイラス オサケユイチア | 活性剤の放出のためのデバイス |
WO2009036999A1 (en) * | 2007-09-21 | 2009-03-26 | N.V. Organon | Drug delivery system |
JP2009513231A (ja) * | 2005-10-28 | 2009-04-02 | インターエージー | 送達システム |
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US4188951A (en) * | 1972-08-17 | 1980-02-19 | Alza Corporation | Intrauterine system embracing selected copolymeric membranes for administering beneficial agent |
US4102998A (en) | 1972-10-02 | 1978-07-25 | Morton Gutnick | Process for the prevention of venereal disease |
NL173707C (nl) | 1974-02-14 | 1984-03-01 | Multilan Sa | Samenstel van intra-uterine anticonceptiemiddel en bijbehorende inbrenghuls. |
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FR2577797A1 (fr) * | 1985-02-22 | 1986-08-29 | Benardin Henri | Dispositif de contraception feminine |
DE4125575C2 (de) | 1991-08-02 | 1997-10-02 | Piening Wolf Dietrich Dr Med | Intrauterinpessar |
TW358031B (en) * | 1997-04-11 | 1999-05-11 | Akze Nobel N V | Drug delivery system for 2 or more active substances |
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BE1014635A3 (ja) * | 2002-02-12 | 2004-02-03 | Wildemeersch Dirk | |
EP1400258A1 (en) * | 2002-09-18 | 2004-03-24 | Schering Oy | Pharmaceutical composition delivery device and its manufacturing process |
GB0307082D0 (en) | 2003-03-27 | 2003-04-30 | Gyne Ideas Ltd | Drug delivery device and method |
DE602004026173D1 (de) * | 2003-04-29 | 2010-05-06 | Gen Hospital Corp | Verfahren und vorrichtungen für die verzögerte freisetzung von mehreren arzneimitteln |
FR2881046A1 (fr) | 2005-01-25 | 2006-07-28 | 7 Med Ind Sa | Procede de fabrication d'un reservoir contenant une substance active diffusant a travers le reservoir et installation pour sa mise en oeuvre |
EP2057972A1 (en) | 2007-11-07 | 2009-05-13 | N.V. Organon | Intrauterine deposit |
-
2010
- 2010-04-29 US US12/770,105 patent/US8568374B2/en active Active
- 2010-05-03 CA CA2760171A patent/CA2760171A1/en not_active Abandoned
- 2010-05-03 WO PCT/EP2010/055948 patent/WO2010128004A1/en active Application Filing
- 2010-05-03 JP JP2012507785A patent/JP5555766B2/ja not_active Expired - Fee Related
- 2010-05-03 MY MYPI2011005242A patent/MY179350A/en unknown
- 2010-05-03 RU RU2011149223/14A patent/RU2529477C2/ru not_active IP Right Cessation
- 2010-05-03 EP EP10715875A patent/EP2427154A1/en not_active Withdrawn
- 2010-05-03 BR BRPI1016147A patent/BRPI1016147A2/pt not_active IP Right Cessation
- 2010-05-03 MX MX2011011748A patent/MX2011011748A/es active IP Right Grant
- 2010-05-03 KR KR1020117028872A patent/KR20120020151A/ko active IP Right Grant
- 2010-05-03 NZ NZ596005A patent/NZ596005A/xx not_active IP Right Cessation
- 2010-05-03 CN CN201080019981.4A patent/CN102438562B/zh not_active Expired - Fee Related
- 2010-05-03 AU AU2010244494A patent/AU2010244494B2/en not_active Ceased
-
2011
- 2011-10-23 IL IL215842A patent/IL215842A/en not_active IP Right Cessation
- 2011-10-27 ZA ZA2011/07862A patent/ZA201107862B/en unknown
- 2011-11-04 CO CO11150252A patent/CO6450625A2/es not_active Application Discontinuation
-
2013
- 2013-11-06 US US14/036,252 patent/US20140296833A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3656483A (en) * | 1970-01-15 | 1972-04-18 | Biolog Concepts Inc | Intrauterine medicator |
JPH10510168A (ja) * | 1994-07-05 | 1998-10-06 | レイラス オサケユイチア | 活性剤の放出のためのデバイス |
JP2009513231A (ja) * | 2005-10-28 | 2009-04-02 | インターエージー | 送達システム |
WO2009036999A1 (en) * | 2007-09-21 | 2009-03-26 | N.V. Organon | Drug delivery system |
JP2010539205A (ja) * | 2007-09-21 | 2010-12-16 | ナームローゼ・フエンノートチヤツプ・オルガノン | ドラッグデリバリーシステム |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2018509389A (ja) * | 2015-01-30 | 2018-04-05 | リ・ガリ・ベスローテン・フエンノートシャップLi Galli B.V. | 膣用薬物送達デバイス |
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BRPI1016147A2 (pt) | 2016-04-19 |
AU2010244494B2 (en) | 2014-03-06 |
IL215842A0 (en) | 2012-01-31 |
NZ596005A (en) | 2013-02-22 |
CO6450625A2 (es) | 2012-05-31 |
WO2010128004A1 (en) | 2010-11-11 |
KR20120020151A (ko) | 2012-03-07 |
CN102438562B (zh) | 2014-11-26 |
CA2760171A1 (en) | 2010-11-11 |
EP2427154A1 (en) | 2012-03-14 |
US8568374B2 (en) | 2013-10-29 |
JP5555766B2 (ja) | 2014-07-23 |
RU2529477C2 (ru) | 2014-09-27 |
US20140296833A1 (en) | 2014-10-02 |
ZA201107862B (en) | 2012-09-26 |
CN102438562A (zh) | 2012-05-02 |
US20100280464A1 (en) | 2010-11-04 |
AU2010244494A1 (en) | 2011-11-17 |
RU2011149223A (ru) | 2013-06-10 |
MY179350A (en) | 2020-11-04 |
IL215842A (en) | 2013-02-28 |
MX2011011748A (es) | 2011-12-08 |
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