JP2012524092A - アモルファスアルファ−（ｎ−スルホンアミド）アセトアミド化合物の生物学的に利用可能なカプセル組成物 - Google Patents

アモルファスアルファ−（ｎ−スルホンアミド）アセトアミド化合物の生物学的に利用可能なカプセル組成物 Download PDF

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Publication number
JP2012524092A
JP2012524092A JP2012506123A JP2012506123A JP2012524092A JP 2012524092 A JP2012524092 A JP 2012524092A JP 2012506123 A JP2012506123 A JP 2012506123A JP 2012506123 A JP2012506123 A JP 2012506123A JP 2012524092 A JP2012524092 A JP 2012524092A
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JP
Japan
Prior art keywords
capsule
peg
pharmaceutical composition
crystallization inhibitor
trifluoropentanamide
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Pending
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JP2012506123A
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English (en)
Japanese (ja)
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JP2012524092A5 (https=
Inventor
サチン・チャンドラン
ラジェシュ・バブラル・ガンジー
ジャクアン・カラニ・レボンズ
ロバート・ケビン・パーローン
クリストファー・ピー・プライス
クリシュナスワミー・スリニバス・ラガーバン
イスマト・ウラー
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of JP2012524092A publication Critical patent/JP2012524092A/ja
Publication of JP2012524092A5 publication Critical patent/JP2012524092A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2012506123A 2009-04-14 2010-04-13 アモルファスアルファ−（ｎ−スルホンアミド）アセトアミド化合物の生物学的に利用可能なカプセル組成物 Pending JP2012524092A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16906109P 2009-04-14 2009-04-14
US61/169,061 2009-04-14
PCT/US2010/030862 WO2010120755A1 (en) 2009-04-14 2010-04-13 Bioavailable capsule compositions of amorphous alpha-(n-sulfonamido)acetamide compound

Publications (2)

Publication Number Publication Date
JP2012524092A true JP2012524092A (ja) 2012-10-11
JP2012524092A5 JP2012524092A5 (https=) 2013-03-28

Family

ID=42235859

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012506123A Pending JP2012524092A (ja) 2009-04-14 2010-04-13 アモルファスアルファ−（ｎ−スルホンアミド）アセトアミド化合物の生物学的に利用可能なカプセル組成物

Country Status (14)

Country Link
US (1) US8252821B2 (https=)
EP (1) EP2419090B1 (https=)
JP (1) JP2012524092A (https=)
KR (1) KR20120022766A (https=)
CN (1) CN102395361A (https=)
AR (1) AR076305A1 (https=)
AU (1) AU2010236602A1 (https=)
BR (1) BRPI1015483A2 (https=)
CA (1) CA2758847A1 (https=)
EA (1) EA201101286A1 (https=)
MX (1) MX2011010514A (https=)
NZ (1) NZ595335A (https=)
TW (1) TW201041609A (https=)
WO (1) WO2010120755A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8934446B2 (en) 2009-10-02 2015-01-13 Lg Electronics Inc. Transmission method and device for a downlink reference signal
JP2022523371A (ja) * 2019-02-22 2022-04-22 ヤンセン ファーマシューティカ エヌ．ベー． 医薬製剤

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CA2471099C (en) 2001-12-20 2011-04-12 Bristol-Myers Squibb Company .alpha.-(n-sulphonamido)acetamide derivatives as .beta.-amyloid inhibitors
US8044077B2 (en) 2009-03-19 2011-10-25 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production
US7977362B2 (en) 2009-03-20 2011-07-12 Bristol-Myers Squibb Company Alpha-(N-benzenesulfonamido)cycloalkyl derivatives
ES2565353T3 (es) 2010-12-16 2016-04-04 Borje S. Andersson Formulaciones farmacéuticas de azol para administración parenteral y métodos para la preparación y el uso de las mismas como tratamiento de enfermedades sensibles a los compuestos de azol
DK2701684T3 (en) 2011-04-28 2017-09-18 Platform Brightworks Two Ltd Improved parenteral formulations of lipophilic pharmaceuticals and methods for their preparation and use
US20130302414A1 (en) * 2012-05-07 2013-11-14 Bristol-Myers Squibb Company Solubilized capsule formulation of 1,1-dimethylethyl [(1s)-1-carbamoyl)pyrrolidin-1-yl]carbonyl}-2,2-dimethylpropyl]carbamate
TWI795381B (zh) 2016-12-21 2023-03-11 比利時商健生藥品公司 作為ｍａｌｔ１抑制劑之吡唑衍生物
EP3953345B1 (en) 2019-04-11 2023-04-05 Janssen Pharmaceutica NV Pyridine rings containing derivatives as malt1 inhibitors
JP2023538099A (ja) * 2020-08-21 2023-09-06 ヤンセン ファーマシューティカ エヌ．ベー． Ｍａｌｔ１阻害剤と、ポリエチレングリコールの脂肪酸との混合物と、を含む、医薬製剤

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JP2001523221A (ja) * 1996-09-01 2001-11-20 ファーモス コーポレイション 親油性物質の促進された生物学的利用能のための固形共沈物
JP2005506990A (ja) * 2001-10-19 2005-03-10 アイソテクニカ インコーポレーテッド 新規のシクロスポリン類似体のマイクロエマルションプレコンセントレート
JP2007535545A (ja) * 2004-04-28 2007-12-06 プロキャリア・インコーポレーテッド 難吸収性薬剤の経口投与のための製剤

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JP2000515153A (ja) 1996-07-22 2000-11-14 モンサント カンパニー チオールスルホンアミド メタロプロテアーゼインヒビター
JPH11343279A (ja) 1998-03-16 1999-12-14 Shionogi & Co Ltd スルホンアミド誘導体およびそれらを含有するＴＮＦ―α産生抑制剤
AU766192B2 (en) 1999-01-27 2003-10-09 Wyeth Holdings Corporation Acetylenic sulfonamide thiol tace inhibitors
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CA2471099C (en) 2001-12-20 2011-04-12 Bristol-Myers Squibb Company .alpha.-(n-sulphonamido)acetamide derivatives as .beta.-amyloid inhibitors
KR20060002908A (ko) 2003-03-31 2006-01-09 와이어쓰 베타 아밀로이드 생산 억제제인 플루오로- 및트리플루오로알킬-함유 헤테로사이클릭 설폰아미드 및 이의유도체
CA2544350A1 (en) 2003-10-29 2005-05-12 Elan Pharmaceuticals, Inc. N-substituted benzene sulfonamides
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US8044077B2 (en) 2009-03-19 2011-10-25 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production
CN102438622A (zh) 2009-03-19 2012-05-02 百时美施贵宝公司 作为β淀粉样肽产生抑制剂的新颖α-(N-磺酰氨基)乙酰胺化合物
US7977362B2 (en) 2009-03-20 2011-07-12 Bristol-Myers Squibb Company Alpha-(N-benzenesulfonamido)cycloalkyl derivatives
US20110071199A1 (en) 2009-03-20 2011-03-24 Bristol-Myers Squibb Company Thiophenyl Sulfonamides for the Treatment of Alzheimer's Disease
TW201043269A (en) 2009-04-14 2010-12-16 Bristol Myers Squibb Co Bioavailable compositions of amorphous alpha-(N-sulfonamido)acetamide compound

Patent Citations (3)

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JP2001523221A (ja) * 1996-09-01 2001-11-20 ファーモス コーポレイション 親油性物質の促進された生物学的利用能のための固形共沈物
JP2005506990A (ja) * 2001-10-19 2005-03-10 アイソテクニカ インコーポレーテッド 新規のシクロスポリン類似体のマイクロエマルションプレコンセントレート
JP2007535545A (ja) * 2004-04-28 2007-12-06 プロキャリア・インコーポレーテッド 難吸収性薬剤の経口投与のための製剤

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JPN6014008835; Ｉｍｂｉｍｂｏ　ＢＰ: 'Ａｌｚｈｅｉｍｅｒ'ｓ　ｄｉｓｅａｓｅ：　gamma-ｓｅｃｒｅｔａｓｅ　ｉｎｈｉｂｉｔｏｒｓ' Ｄｒｕｇ　Ｄｉｓｃｏｖｅｒｙ　Ｔｏｄａｙ：　Ｔｈｅｒａｐｅｕｔｉｃ　Ｓｔｒａｔｅｇｉｅｓ Ｖｏｌ．５　Ｎｏ．３, 2008, ｐｐ．１６９-１７５ *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8934446B2 (en) 2009-10-02 2015-01-13 Lg Electronics Inc. Transmission method and device for a downlink reference signal
US9313003B2 (en) 2009-10-02 2016-04-12 Lg Electronics Inc. Transmission method and device for a downlink reference signal
JP2022523371A (ja) * 2019-02-22 2022-04-22 ヤンセン ファーマシューティカ エヌ．ベー． 医薬製剤

Also Published As

Publication number Publication date
MX2011010514A (es) 2011-11-29
CN102395361A (zh) 2012-03-28
EP2419090A1 (en) 2012-02-22
KR20120022766A (ko) 2012-03-12
TW201041609A (en) 2010-12-01
BRPI1015483A2 (pt) 2016-04-26
AR076305A1 (es) 2011-06-01
EA201101286A1 (ru) 2012-04-30
US8252821B2 (en) 2012-08-28
AU2010236602A1 (en) 2011-10-13
US20100260837A1 (en) 2010-10-14
EP2419090B1 (en) 2013-02-13
CA2758847A1 (en) 2010-10-21
WO2010120755A1 (en) 2010-10-21
NZ595335A (en) 2013-03-28

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