JP2012524064A5 - - Google Patents
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- Publication number
- JP2012524064A5 JP2012524064A5 JP2012505884A JP2012505884A JP2012524064A5 JP 2012524064 A5 JP2012524064 A5 JP 2012524064A5 JP 2012505884 A JP2012505884 A JP 2012505884A JP 2012505884 A JP2012505884 A JP 2012505884A JP 2012524064 A5 JP2012524064 A5 JP 2012524064A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- ascorbic acid
- per milliliter
- item
- range
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 96
- 229960005070 ascorbic acid Drugs 0.000 claims description 48
- 235000010323 ascorbic acid Nutrition 0.000 claims description 48
- 239000011668 ascorbic acid Substances 0.000 claims description 48
- 150000001875 compounds Chemical class 0.000 claims description 29
- 229940121896 radiopharmaceutical Drugs 0.000 claims description 27
- 239000012217 radiopharmaceutical Substances 0.000 claims description 27
- 230000002799 radiopharmaceutical effect Effects 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 24
- RMXZKEPDYBTFOS-LRFGSCOBSA-N 2-tert-butyl-4-chloro-5-[[4-(2-fluoranylethoxymethyl)phenyl]methoxy]pyridazin-3-one Chemical compound O=C1N(C(C)(C)C)N=CC(OCC=2C=CC(COCC[18F])=CC=2)=C1Cl RMXZKEPDYBTFOS-LRFGSCOBSA-N 0.000 claims description 8
- 239000005663 Pyridaben Substances 0.000 claims description 7
- DWFZBUWUXWZWKD-UHFFFAOYSA-N pyridaben Chemical compound C1=CC(C(C)(C)C)=CC=C1CSC1=C(Cl)C(=O)N(C(C)(C)C)N=C1 DWFZBUWUXWZWKD-UHFFFAOYSA-N 0.000 claims description 7
- -1 2-substituted chromone Chemical class 0.000 claims description 5
- 239000005657 Fenpyroximate Substances 0.000 claims description 4
- 229930182661 Piericidin Natural products 0.000 claims description 4
- 239000005658 Tebufenpyrad Substances 0.000 claims description 4
- YYJNOYZRYGDPNH-MFKUBSTISA-N fenpyroximate Chemical compound C=1C=C(C(=O)OC(C)(C)C)C=CC=1CO/N=C/C=1C(C)=NN(C)C=1OC1=CC=CC=C1 YYJNOYZRYGDPNH-MFKUBSTISA-N 0.000 claims description 4
- BBLGCDSLCDDALX-LKGBESRRSA-N piericidin A Chemical compound COC=1NC(C\C=C(/C)C\C=C\C(\C)=C\[C@@H](C)[C@@H](O)C(\C)=C\C)=C(C)C(=O)C=1OC BBLGCDSLCDDALX-LKGBESRRSA-N 0.000 claims description 4
- 229940080817 rotenone Drugs 0.000 claims description 4
- JUVIOZPCNVVQFO-UHFFFAOYSA-N rotenone Natural products O1C2=C3CC(C(C)=C)OC3=CC=C2C(=O)C2C1COC1=C2C=C(OC)C(OC)=C1 JUVIOZPCNVVQFO-UHFFFAOYSA-N 0.000 claims description 4
- 239000003381 stabilizer Substances 0.000 claims description 4
- ZZYSLNWGKKDOML-UHFFFAOYSA-N tebufenpyrad Chemical compound CCC1=NN(C)C(C(=O)NCC=2C=CC(=CC=2)C(C)(C)C)=C1Cl ZZYSLNWGKKDOML-UHFFFAOYSA-N 0.000 claims description 4
- PRUJRDQIPHYFDT-HUYCHCPVSA-N 2-[[4-(2-(18F)fluoranylethoxymethyl)phenyl]methoxy]pyridazin-3-one Chemical compound [18F]CCOCC1=CC=C(CON2N=CC=CC2=O)C=C1 PRUJRDQIPHYFDT-HUYCHCPVSA-N 0.000 claims 3
- 239000005656 Fenazaquin Substances 0.000 claims 2
- DMYHGDXADUDKCQ-UHFFFAOYSA-N fenazaquin Chemical compound C1=CC(C(C)(C)C)=CC=C1CCOC1=NC=NC2=CC=CC=C12 DMYHGDXADUDKCQ-UHFFFAOYSA-N 0.000 claims 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16935309P | 2009-04-15 | 2009-04-15 | |
| US61/169,353 | 2009-04-15 | ||
| PCT/US2010/001120 WO2010120368A2 (en) | 2009-04-15 | 2010-04-15 | Stabilization of radiopharmaceutical compositions using ascorbic acid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012524064A JP2012524064A (ja) | 2012-10-11 |
| JP2012524064A5 true JP2012524064A5 (https=) | 2013-05-30 |
| JP5662416B2 JP5662416B2 (ja) | 2015-01-28 |
Family
ID=42983052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012505884A Active JP5662416B2 (ja) | 2009-04-15 | 2010-04-15 | アスコルビン酸による放射性医薬組成物の安定化 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US9687571B2 (https=) |
| EP (1) | EP2419096B1 (https=) |
| JP (1) | JP5662416B2 (https=) |
| KR (2) | KR20160030589A (https=) |
| CN (2) | CN107261159B (https=) |
| AU (1) | AU2016201367B2 (https=) |
| CA (1) | CA2758883C (https=) |
| DK (1) | DK2419096T3 (https=) |
| ES (1) | ES2770364T3 (https=) |
| IL (1) | IL215823A (https=) |
| LT (1) | LT2419096T (https=) |
| PT (1) | PT2419096T (https=) |
| WO (1) | WO2010120368A2 (https=) |
| ZA (1) | ZA201108351B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7344702B2 (en) | 2004-02-13 | 2008-03-18 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardial perfusion imaging |
| ES2405655T3 (es) | 2006-12-26 | 2013-05-31 | Lantheus Medical Imaging, Inc. | N-[3-bromo-4-(3-[18F]fluoropropoxi)-bencil]-guanidina para la formación de imágenes de la inervación cardíaca |
| WO2009108376A2 (en) | 2008-02-29 | 2009-09-03 | Lantheus Medical Imaging, Inc. | Contrast agents for applications including perfusion imaging |
| KR20160030589A (ko) | 2009-04-15 | 2016-03-18 | 랜티우스 메디컬 이메징, 인크. | 아스코르브산을 사용한 방사성 약제 조성물의 안정화 |
| DK3323810T3 (da) | 2010-02-08 | 2022-03-28 | Lantheus Medical Imaging Inc | Automatiseret reaktionssystem, kassette og indretning til syntese af billeddannelsesmidler |
| ES2763815T3 (es) | 2010-05-11 | 2020-06-01 | Lantheus Medical Imaging Inc | Composiciones, métodos y sistemas para la síntesis y uso de agentes de formación de imágenes |
| CN108484449A (zh) | 2011-09-09 | 2018-09-04 | 蓝瑟斯医学影像公司 | 用于合成和使用显像剂的组合物、方法和系统 |
| CA2852395C (en) * | 2011-10-21 | 2020-04-28 | Lantheus Medical Imaging, Inc. | Compositions comprising ascorbic acid and pyridaben and pyridaben analogs attached to an imaging moiety and related methods |
| WO2013070471A1 (en) | 2011-11-11 | 2013-05-16 | Lantheus Medical Imaging, Inc. | Evaluation of presence of and vulnerability to atrial fibrillation and other indications using matrix metalloproteinase-based imaging |
| PT2836241T (pt) * | 2012-04-10 | 2019-05-30 | Lantheus Medical Imaging Inc | Métodos de síntese de radiofármacos |
| AU2013203000B9 (en) | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
| WO2016111797A1 (en) * | 2015-01-09 | 2016-07-14 | Immunomedics, Inc. | Radiosensitivity of fluorophores and use of radioprotective agents for dual-modality imaging |
| WO2017014599A1 (ko) * | 2015-07-22 | 2017-01-26 | 주식회사 씨코헬스케어 | [18f]플루오로-도파의 방사화학적 순도를 안정화시키는 조성물 및 이의 제조방법 |
| JP2019531706A (ja) * | 2016-08-12 | 2019-11-07 | インブイティ・インコーポレイテッドＩｎｖｕｉｔｙ， Ｉｎｃ． | 術前および術中の組織の局在化および視覚化のための組織特異的マーカー |
| GB201805253D0 (en) * | 2018-03-29 | 2018-05-16 | Ge Healthcare Ltd Ip | Solid phase extraction |
| WO2020202831A1 (ja) * | 2019-03-29 | 2020-10-08 | 国立研究開発法人量子科学技術研究開発機構 | 放射性医薬の製造方法及び放射性医薬 |
| GB201915206D0 (en) | 2019-10-21 | 2019-12-04 | Ge Healthcare Ltd | Use of cyclodextrins as a radiostabilizer |
| KR102207372B1 (ko) * | 2020-03-31 | 2021-01-27 | 재단법인 아산사회복지재단 | 방사성 의약품의 안정화제 및 이를 포함하는 방사성 의약 조성물 |
| WO2022156907A1 (en) | 2021-01-25 | 2022-07-28 | Vrije Universiteit Brussel | Method and kit for labeling a biomolecule with one or more detectable labels, including a radiolabel |
| GB202108608D0 (en) * | 2021-06-16 | 2021-07-28 | Ge Healthcare Ltd | Preparation of a ph-adjusted ascorbic acid solution |
| CN114835690B (zh) * | 2022-07-04 | 2022-09-27 | 北京先通国际医药科技股份有限公司 | 含化合物i的液体组合物的制备方法、及在心肌灌注pet显像中的用途 |
| CN114832118B (zh) * | 2022-07-04 | 2022-09-27 | 北京先通国际医药科技股份有限公司 | 化合物i液体组合物、制备方法及其用途 |
| WO2024259346A1 (en) | 2023-06-16 | 2024-12-19 | Progenics Pharmaceuticals, Inc | Improved synthesis of the prostate specific membrane antigen (psma) radiolabeled inhibitor [18f]dcfpyl |
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| WO2009108376A2 (en) | 2008-02-29 | 2009-09-03 | Lantheus Medical Imaging, Inc. | Contrast agents for applications including perfusion imaging |
| KR20160030589A (ko) | 2009-04-15 | 2016-03-18 | 랜티우스 메디컬 이메징, 인크. | 아스코르브산을 사용한 방사성 약제 조성물의 안정화 |
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| DK3323810T3 (da) | 2010-02-08 | 2022-03-28 | Lantheus Medical Imaging Inc | Automatiseret reaktionssystem, kassette og indretning til syntese af billeddannelsesmidler |
| ES2763815T3 (es) | 2010-05-11 | 2020-06-01 | Lantheus Medical Imaging Inc | Composiciones, métodos y sistemas para la síntesis y uso de agentes de formación de imágenes |
| CN108484449A (zh) | 2011-09-09 | 2018-09-04 | 蓝瑟斯医学影像公司 | 用于合成和使用显像剂的组合物、方法和系统 |
| CA2852395C (en) | 2011-10-21 | 2020-04-28 | Lantheus Medical Imaging, Inc. | Compositions comprising ascorbic acid and pyridaben and pyridaben analogs attached to an imaging moiety and related methods |
-
2010
- 2010-04-15 KR KR1020167005875A patent/KR20160030589A/ko not_active Withdrawn
- 2010-04-15 JP JP2012505884A patent/JP5662416B2/ja active Active
- 2010-04-15 LT LTEP10764772.9T patent/LT2419096T/lt unknown
- 2010-04-15 EP EP10764772.9A patent/EP2419096B1/en active Active
- 2010-04-15 ES ES10764772T patent/ES2770364T3/es active Active
- 2010-04-15 KR KR1020117027231A patent/KR101602992B1/ko active Active
- 2010-04-15 DK DK10764772.9T patent/DK2419096T3/da active
- 2010-04-15 CN CN201710231042.XA patent/CN107261159B/zh active Active
- 2010-04-15 US US13/264,276 patent/US9687571B2/en active Active
- 2010-04-15 CA CA2758883A patent/CA2758883C/en active Active
- 2010-04-15 CN CN201080026254.0A patent/CN102458396B/zh active Active
- 2010-04-15 PT PT107647729T patent/PT2419096T/pt unknown
- 2010-04-15 WO PCT/US2010/001120 patent/WO2010120368A2/en not_active Ceased
-
2011
- 2011-10-23 IL IL215823A patent/IL215823A/en active IP Right Grant
- 2011-11-14 ZA ZA2011/08351A patent/ZA201108351B/en unknown
-
2016
- 2016-03-02 AU AU2016201367A patent/AU2016201367B2/en active Active
-
2017
- 2017-05-23 US US15/602,141 patent/US20180071411A1/en not_active Abandoned
-
2019
- 2019-08-26 US US16/551,588 patent/US20200222562A1/en not_active Abandoned
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