JP2012520888A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012520888A5 JP2012520888A5 JP2012500894A JP2012500894A JP2012520888A5 JP 2012520888 A5 JP2012520888 A5 JP 2012520888A5 JP 2012500894 A JP2012500894 A JP 2012500894A JP 2012500894 A JP2012500894 A JP 2012500894A JP 2012520888 A5 JP2012520888 A5 JP 2012520888A5
- Authority
- JP
- Japan
- Prior art keywords
- pain
- compound
- pharmaceutical composition
- acid ester
- inflammation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical group CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- 208000002193 Pain Diseases 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 206010061218 Inflammation Diseases 0.000 claims 5
- 230000004054 inflammatory process Effects 0.000 claims 5
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims 4
- 229930195729 fatty acid Natural products 0.000 claims 4
- 239000000194 fatty acid Substances 0.000 claims 4
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical group Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 claims 4
- 229960004452 methionine Drugs 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- JBTWLSYIZRCDFO-UHFFFAOYSA-N ethyl methyl carbonate Chemical compound CCOC(=O)OC JBTWLSYIZRCDFO-UHFFFAOYSA-N 0.000 claims 3
- 150000004665 fatty acids Chemical class 0.000 claims 3
- 150000003903 lactic acid esters Chemical class 0.000 claims 3
- 229930182817 methionine Natural products 0.000 claims 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 3
- 239000003960 organic solvent Substances 0.000 claims 3
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 2
- 239000008346 aqueous phase Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- QQQMUBLXDAFBRH-UHFFFAOYSA-N dodecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)O QQQMUBLXDAFBRH-UHFFFAOYSA-N 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000002140 halogenating effect Effects 0.000 claims 2
- XFOQWQKDSMIPHT-UHFFFAOYSA-N 2,3-dichloro-6-(trifluoromethyl)pyridine Chemical compound FC(F)(F)C1=CC=C(Cl)C(Cl)=N1 XFOQWQKDSMIPHT-UHFFFAOYSA-N 0.000 claims 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical group O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 1
- 208000006820 Arthralgia Diseases 0.000 claims 1
- 229930182818 D-methionine Natural products 0.000 claims 1
- 125000000296 D-methionine group Chemical group [H]N([H])[C@@]([H])(C(=O)[*])C([H])([H])C([H])([H])SC([H])([H])[H] 0.000 claims 1
- 206010015150 Erythema Diseases 0.000 claims 1
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 claims 1
- 229930195722 L-methionine Natural products 0.000 claims 1
- 208000000112 Myalgia Diseases 0.000 claims 1
- 206010041290 Soft tissue inflammation Diseases 0.000 claims 1
- 206010042674 Swelling Diseases 0.000 claims 1
- 206010066371 Tendon pain Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- -1 fatty acid ester Chemical class 0.000 claims 1
- 208000018937 joint inflammation Diseases 0.000 claims 1
- 239000002480 mineral oil Substances 0.000 claims 1
- 235000010446 mineral oil Nutrition 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000013465 muscle pain Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 230000008961 swelling Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- BORJONZPSTVSFP-UHFFFAOYSA-N tetradecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)C(C)O BORJONZPSTVSFP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16128509P | 2009-03-18 | 2009-03-18 | |
| US61/161,285 | 2009-03-18 | ||
| PCT/US2010/027501 WO2010107807A2 (en) | 2009-03-18 | 2010-03-16 | Compounds for treating inflammation and pain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012520888A JP2012520888A (ja) | 2012-09-10 |
| JP2012520888A5 true JP2012520888A5 (https=) | 2013-05-02 |
| JP5587969B2 JP5587969B2 (ja) | 2014-09-10 |
Family
ID=42738194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012500894A Expired - Fee Related JP5587969B2 (ja) | 2009-03-18 | 2010-03-16 | 炎症及び疼痛の処置用の化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7851650B2 (https=) |
| EP (1) | EP2408740B1 (https=) |
| JP (1) | JP5587969B2 (https=) |
| KR (1) | KR20110128348A (https=) |
| CN (1) | CN102438983A (https=) |
| AU (1) | AU2010226794A1 (https=) |
| BR (1) | BRPI1014528A2 (https=) |
| CA (1) | CA2755678A1 (https=) |
| MX (1) | MX2011009709A (https=) |
| RU (1) | RU2520034C2 (https=) |
| WO (1) | WO2010107807A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2787461A1 (en) * | 2010-02-04 | 2011-08-11 | Novabay Pharmaceuticals, Inc. | Polysaccharide based antimicrobial formulations |
| MX2013006708A (es) | 2010-12-15 | 2013-09-13 | Olatec Ind Llc | Composicion de 3-metanosulfonilpropionitrilo para el tratamiento de la inflamacion y el dolor. |
| KR102002664B1 (ko) | 2012-02-27 | 2019-07-23 | 오라텍 세라퓨틱스 엘엘씨 | 3-메틸술포닐프로피오니트릴의 제조 방법 |
| CN104334165B (zh) * | 2012-06-05 | 2017-09-05 | 欧拉泰克工业有限责任公司 | 用于治疗炎症和疼痛的药物组合物 |
| US9481644B2 (en) | 2012-06-05 | 2016-11-01 | Olatec Therapeutics Llc | Pharmaceutical composition comprising omega-(arylsulfonyl)alkylnitrile |
| CA2875052C (en) | 2012-06-05 | 2020-07-14 | Olatec Industries Llc | Method for treating skin inflammatory diseases |
| EP2854785B1 (en) * | 2012-06-05 | 2017-08-09 | Olatec Therapeutics LLC | Pharmaceutical composition for treating inflammation and pain |
| WO2013188214A1 (en) | 2012-06-11 | 2013-12-19 | Olatec Industries Llc | Compounds for treating inflammation and pain |
| JP6189944B2 (ja) * | 2012-06-14 | 2017-08-30 | オラテック セラピューティクス リミティド ライアビリティ カンパニー | 炎症及び疼痛を治療するための化合物 |
| US9114122B2 (en) | 2012-06-14 | 2015-08-25 | Olatec Industries Llc | Compounds for treating inflammation and pain |
| SE536581C2 (sv) | 2012-07-24 | 2014-03-11 | Rls Global Ab | Ett kit för behandling av sår eller liknande och ett preparat och metoder därav |
| WO2015081188A1 (en) * | 2013-11-27 | 2015-06-04 | Olatec Industries Llc | Pharmaceutical composition comprising omega-(arylsulfonyl)alkylnitrile |
| WO2025097064A1 (en) * | 2023-11-03 | 2025-05-08 | Mencanin Steve | Novel ampoule for delivery of polymers for wound treatment |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3700729A1 (de) * | 1987-01-13 | 1988-07-21 | Boehringer Mannheim Gmbh | Neue carbonsaeurederivate, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| US5690929A (en) * | 1992-11-19 | 1997-11-25 | Anticancer, Inc. | Use of methioninase and chemotherapy agents in chemotherapy |
| PY970104A (es) | 1996-08-30 | 2001-12-03 | Monsanto Co | Nuevos fluidos solubles en agua para trabajar metales |
| US6638701B1 (en) * | 2002-12-17 | 2003-10-28 | Eastman Kodak Company | Photographic element containing a red dye-forming pyrazolotriazole coupler |
| RU2232752C1 (ru) * | 2003-04-04 | 2004-07-20 | Общество с ограниченной ответственностью "Поливит" | Способ получения фосфата или сукцината 2-амино-4-метилтио-(s-оксо-s-имино)-масляной кислоты |
| US7423064B2 (en) | 2004-09-24 | 2008-09-09 | Olatec Industries, Llc | Composition for treating bacterial, viral, fungal diseases, inflammation and pain |
| TWI386201B (zh) * | 2005-01-25 | 2013-02-21 | Novabay Pharmaceuticals Inc | Ｎ-鹵化胺基酸、ｎ，ｎ-二鹵化胺基酸與其衍生物；以及使用其之組合物與方法 |
| WO2006118196A1 (ja) * | 2005-04-27 | 2006-11-09 | Ajinomoto Co., Inc. | Dpp4阻害剤及びその医薬用途 |
| CN101400255B (zh) * | 2006-03-20 | 2012-07-04 | 欧拉泰克工业有限公司 | 用于治疗细菌、病毒、真菌疾病、炎症以及疼痛的组合物 |
| WO2008094663A2 (en) * | 2007-01-31 | 2008-08-07 | Adam Heller | Electrochemical management of pain |
-
2010
- 2010-03-16 EP EP10753988.4A patent/EP2408740B1/en not_active Not-in-force
- 2010-03-16 AU AU2010226794A patent/AU2010226794A1/en not_active Abandoned
- 2010-03-16 KR KR1020117024374A patent/KR20110128348A/ko not_active Withdrawn
- 2010-03-16 MX MX2011009709A patent/MX2011009709A/es active IP Right Grant
- 2010-03-16 JP JP2012500894A patent/JP5587969B2/ja not_active Expired - Fee Related
- 2010-03-16 BR BRPI1014528A patent/BRPI1014528A2/pt not_active IP Right Cessation
- 2010-03-16 US US12/725,212 patent/US7851650B2/en not_active Expired - Fee Related
- 2010-03-16 RU RU2011142008/04A patent/RU2520034C2/ru not_active IP Right Cessation
- 2010-03-16 CA CA2755678A patent/CA2755678A1/en not_active Abandoned
- 2010-03-16 CN CN2010800216665A patent/CN102438983A/zh active Pending
- 2010-03-16 WO PCT/US2010/027501 patent/WO2010107807A2/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012520888A5 (https=) | ||
| RU2011142008A (ru) | Соединения для лечения воспаления и боли | |
| JP2020519661A5 (https=) | ||
| WO2016105118A3 (ko) | Gpr120 효능제로서의 바이아릴 유도체 | |
| JP2014517008A5 (https=) | ||
| JP2013515006A5 (https=) | ||
| JP2008509191A5 (https=) | ||
| JP2015504056A (ja) | ヒストンデアセチラーゼ８の阻害剤としての珪皮酸ヒドロキシアミド | |
| JP2013518050A5 (https=) | ||
| EP2682387A3 (en) | C7-fluoro substituted tetracycline compounds | |
| JP2017524735A5 (https=) | ||
| RU2018120242A (ru) | Хинолиновые соединения, способы их получения и их применения в качестве лекарственного средства, ингибирующего транспортер уратов | |
| PE20050965A1 (es) | Procedimiento para la preparacion de compuestos de aminocrotonilo | |
| JP2011506588A5 (https=) | ||
| MX378007B (es) | Derivados de biarilo como agonistas de gpr120. | |
| BR112018011777A2 (pt) | composições de fenfluramina e métodos para o preparo das mesmas | |
| Zhao et al. | Transition-metal-free trifluoromethylthiolation and difluoromethylthiolation of thiols with trifluoromethanesulfonyl chloride and difluoromethanesulfonyl chloride | |
| JP2015508092A5 (https=) | ||
| JP2013523623A5 (https=) | ||
| RU2007133802A (ru) | Кристаллические формы производной имидазола | |
| JP2019151627A5 (https=) | ||
| MX2013006877A (es) | Composiciones farmaceuticas para inhibidores selectivos del factor xa para administracion oral. | |
| EA201270653A1 (ru) | Антагонист dpи его применение | |
| JP2018503691A5 (https=) | ||
| WO2010045582A3 (en) | Compositions and methods for treating or preventing hypoxic or ischemic injury |