CN102438983A - 用于治疗炎症和疼痛的化合物 - Google Patents

用于治疗炎症和疼痛的化合物 Download PDF

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Publication number
CN102438983A
CN102438983A CN2010800216665A CN201080021666A CN102438983A CN 102438983 A CN102438983 A CN 102438983A CN 2010800216665 A CN2010800216665 A CN 2010800216665A CN 201080021666 A CN201080021666 A CN 201080021666A CN 102438983 A CN102438983 A CN 102438983A
Authority
CN
China
Prior art keywords
pain
compound
inflammation
lactate
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800216665A
Other languages
English (en)
Chinese (zh)
Inventor
约瑟夫·P·圣劳伦特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olatec Therapeutics Inc
Original Assignee
Olatec Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olatec Therapeutics Inc filed Critical Olatec Therapeutics Inc
Publication of CN102438983A publication Critical patent/CN102438983A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2010800216665A 2009-03-18 2010-03-16 用于治疗炎症和疼痛的化合物 Pending CN102438983A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16128509P 2009-03-18 2009-03-18
US61/161,285 2009-03-18
PCT/US2010/027501 WO2010107807A2 (en) 2009-03-18 2010-03-16 Compounds for treating inflammation and pain

Publications (1)

Publication Number Publication Date
CN102438983A true CN102438983A (zh) 2012-05-02

Family

ID=42738194

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800216665A Pending CN102438983A (zh) 2009-03-18 2010-03-16 用于治疗炎症和疼痛的化合物

Country Status (11)

Country Link
US (1) US7851650B2 (https=)
EP (1) EP2408740B1 (https=)
JP (1) JP5587969B2 (https=)
KR (1) KR20110128348A (https=)
CN (1) CN102438983A (https=)
AU (1) AU2010226794A1 (https=)
BR (1) BRPI1014528A2 (https=)
CA (1) CA2755678A1 (https=)
MX (1) MX2011009709A (https=)
RU (1) RU2520034C2 (https=)
WO (1) WO2010107807A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104349772A (zh) * 2012-06-11 2015-02-11 欧拉泰克工业有限责任公司 用于治疗炎症和疼痛的化合物

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2787461A1 (en) * 2010-02-04 2011-08-11 Novabay Pharmaceuticals, Inc. Polysaccharide based antimicrobial formulations
MX2013006708A (es) 2010-12-15 2013-09-13 Olatec Ind Llc Composicion de 3-metanosulfonilpropionitrilo para el tratamiento de la inflamacion y el dolor.
KR102002664B1 (ko) 2012-02-27 2019-07-23 오라텍 세라퓨틱스 엘엘씨 3-메틸술포닐프로피오니트릴의 제조 방법
CN104334165B (zh) * 2012-06-05 2017-09-05 欧拉泰克工业有限责任公司 用于治疗炎症和疼痛的药物组合物
US9481644B2 (en) 2012-06-05 2016-11-01 Olatec Therapeutics Llc Pharmaceutical composition comprising omega-(arylsulfonyl)alkylnitrile
CA2875052C (en) 2012-06-05 2020-07-14 Olatec Industries Llc Method for treating skin inflammatory diseases
EP2854785B1 (en) * 2012-06-05 2017-08-09 Olatec Therapeutics LLC Pharmaceutical composition for treating inflammation and pain
JP6189944B2 (ja) * 2012-06-14 2017-08-30 オラテック セラピューティクス リミティド ライアビリティ カンパニー 炎症及び疼痛を治療するための化合物
US9114122B2 (en) 2012-06-14 2015-08-25 Olatec Industries Llc Compounds for treating inflammation and pain
SE536581C2 (sv) 2012-07-24 2014-03-11 Rls Global Ab Ett kit för behandling av sår eller liknande och ett preparat och metoder därav
WO2015081188A1 (en) * 2013-11-27 2015-06-04 Olatec Industries Llc Pharmaceutical composition comprising omega-(arylsulfonyl)alkylnitrile
WO2025097064A1 (en) * 2023-11-03 2025-05-08 Mencanin Steve Novel ampoule for delivery of polymers for wound treatment

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6638701B1 (en) * 2002-12-17 2003-10-28 Eastman Kodak Company Photographic element containing a red dye-forming pyrazolotriazole coupler
US20060247209A1 (en) * 2005-01-25 2006-11-02 Ramin Najafi N-halogenated amino acids, N,N-dihalogenated amino acids and derivatives; compositions and methods of using them
US7423064B2 (en) * 2004-09-24 2008-09-09 Olatec Industries, Llc Composition for treating bacterial, viral, fungal diseases, inflammation and pain

Family Cites Families (7)

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DE3700729A1 (de) * 1987-01-13 1988-07-21 Boehringer Mannheim Gmbh Neue carbonsaeurederivate, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
US5690929A (en) * 1992-11-19 1997-11-25 Anticancer, Inc. Use of methioninase and chemotherapy agents in chemotherapy
PY970104A (es) 1996-08-30 2001-12-03 Monsanto Co Nuevos fluidos solubles en agua para trabajar metales
RU2232752C1 (ru) * 2003-04-04 2004-07-20 Общество с ограниченной ответственностью "Поливит" Способ получения фосфата или сукцината 2-амино-4-метилтио-(s-оксо-s-имино)-масляной кислоты
WO2006118196A1 (ja) * 2005-04-27 2006-11-09 Ajinomoto Co., Inc. Dpp4阻害剤及びその医薬用途
CN101400255B (zh) * 2006-03-20 2012-07-04 欧拉泰克工业有限公司 用于治疗细菌、病毒、真菌疾病、炎症以及疼痛的组合物
WO2008094663A2 (en) * 2007-01-31 2008-08-07 Adam Heller Electrochemical management of pain

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6638701B1 (en) * 2002-12-17 2003-10-28 Eastman Kodak Company Photographic element containing a red dye-forming pyrazolotriazole coupler
US7423064B2 (en) * 2004-09-24 2008-09-09 Olatec Industries, Llc Composition for treating bacterial, viral, fungal diseases, inflammation and pain
US20060247209A1 (en) * 2005-01-25 2006-11-02 Ramin Najafi N-halogenated amino acids, N,N-dihalogenated amino acids and derivatives; compositions and methods of using them

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PETER MIKUŠ等: "Separation of multicomponent mixtures of 2,4-dinitrophenyl labelled amino acids and their enantiomers by capillary zone electrophoresis", 《ELECTROPHORESIS》 *
胡培蓉等: "人类肽-甲硫胺酸亚砜还原酶的cDNA克隆、组织表达谱特征及染色体定位", 《科学通报》 *
陈丹云: "乳酸酯及其衍生物的合成研究进展", 《化工进展》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104349772A (zh) * 2012-06-11 2015-02-11 欧拉泰克工业有限责任公司 用于治疗炎症和疼痛的化合物

Also Published As

Publication number Publication date
JP5587969B2 (ja) 2014-09-10
EP2408740B1 (en) 2013-11-20
US20100240756A1 (en) 2010-09-23
WO2010107807A2 (en) 2010-09-23
CA2755678A1 (en) 2010-09-23
KR20110128348A (ko) 2011-11-29
MX2011009709A (es) 2011-12-06
RU2520034C2 (ru) 2014-06-20
AU2010226794A1 (en) 2011-10-27
WO2010107807A3 (en) 2011-01-13
EP2408740A4 (en) 2012-08-08
EP2408740A2 (en) 2012-01-25
RU2011142008A (ru) 2013-04-27
JP2012520888A (ja) 2012-09-10
BRPI1014528A2 (pt) 2016-04-05
US7851650B2 (en) 2010-12-14

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Application publication date: 20120502