JP2012520856A - 光学イメージング剤 - Google Patents

光学イメージング剤 Download PDF

Info

Publication number
JP2012520856A
JP2012520856A JP2012500272A JP2012500272A JP2012520856A JP 2012520856 A JP2012520856 A JP 2012520856A JP 2012500272 A JP2012500272 A JP 2012500272A JP 2012500272 A JP2012500272 A JP 2012500272A JP 2012520856 A JP2012520856 A JP 2012520856A
Authority
JP
Japan
Prior art keywords
group
opt
tissue
polymer
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2012500272A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012520856A5 (https=
Inventor
カーター，ランドール・リー
キャッスル，ジェイソン・ウィリアム
フィッシュ，ケネス・マイケル
スード，アヌプ
ステイプル，ナタリー・アン
リー，ビライン・ダー−ラン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Electric Co
Original Assignee
General Electric Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Electric Co filed Critical General Electric Co
Publication of JP2012520856A publication Critical patent/JP2012520856A/ja
Publication of JP2012520856A5 publication Critical patent/JP2012520856A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
JP2012500272A 2009-03-19 2010-03-19 光学イメージング剤 Withdrawn JP2012520856A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16153509P 2009-03-19 2009-03-19
US61/161,535 2009-03-19
PCT/EP2010/053619 WO2010106169A1 (en) 2009-03-19 2010-03-19 Optical imaging agents

Publications (2)

Publication Number Publication Date
JP2012520856A true JP2012520856A (ja) 2012-09-10
JP2012520856A5 JP2012520856A5 (https=) 2013-05-02

Family

ID=42331047

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012500272A Withdrawn JP2012520856A (ja) 2009-03-19 2010-03-19 光学イメージング剤

Country Status (11)

Country Link
US (1) US20120114563A1 (https=)
EP (1) EP2413976A1 (https=)
JP (1) JP2012520856A (https=)
KR (1) KR20110138246A (https=)
CN (1) CN102438659A (https=)
AU (1) AU2010224789A1 (https=)
BR (1) BRPI1009346A2 (https=)
CA (1) CA2755770A1 (https=)
MX (1) MX2011009808A (https=)
RU (1) RU2011138096A (https=)
WO (1) WO2010106169A1 (https=)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2992904A1 (en) 2014-09-08 2016-03-09 Canon Kabushiki Kaisha Composition having dye and conjugate of polyethyleneglycol and additive and contrast agent for photoacoustic imaging having the same
WO2016060277A1 (en) 2014-10-16 2016-04-21 Canon Kabushiki Kaisha Polymer, and contrast agent for photoacoustic imaging, including the polymer
WO2016092799A1 (en) 2014-12-09 2016-06-16 Canon Kabushiki Kaisha Cyanine derivatives and their use for optical imaging
US9416276B2 (en) 2013-11-07 2016-08-16 Canon Kabushiki Kaisha Method for producing contrast agent
EP3103795A1 (en) 2015-06-12 2016-12-14 Canon Kabushiki Kaisha Compound or salt thereof and photoacoustic imaging contrast agent containing compound or salt thereof
WO2017057653A1 (en) 2015-09-30 2017-04-06 Canon Kabushiki Kaisha Conjugate of polysarcosine and nir contrast agent for photoacoustic imaging
JP2018500338A (ja) * 2014-12-19 2018-01-11 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． 術中イメージング
US10398788B2 (en) 2014-10-24 2019-09-03 Canon Kabushiki Kaisha Polymer and contrast agent for photoacoustic imaging including the polymer
US10828380B2 (en) 2015-09-30 2020-11-10 Canon Kabushiki Kaisha Conjugate of polysarcosine and NIR contrast agent for photoacoustic imaging
WO2025197935A1 (ja) * 2024-03-19 2025-09-25 国立大学法人 東京大学 薬物－ポリマー複合体、医薬組成物、および薬物送達用ポリマー

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201015806D0 (en) 2010-09-21 2010-10-27 Ge Healthcare As Vascular imaging agents
EP3029027B1 (en) 2010-12-21 2018-06-27 Pierce Biotechnology, Inc. Fluorescent compounds
US8889884B1 (en) 2011-07-14 2014-11-18 Pierce Biotechnology, Inc. Phosphine derivatives of fluorescent compounds
CA2841249C (en) 2011-07-29 2023-09-26 Avelas Biosciences, Inc. Selective delivery molecules and methods of use
US9249307B2 (en) 2011-08-16 2016-02-02 Pierce Biotechnology, Inc. Benzocyanine compounds
GB201116733D0 (en) 2011-09-28 2011-11-09 Ge Healthcare As Peptide margin imaging agents
US9751868B2 (en) 2012-02-28 2017-09-05 Pierce Biotechnology, Inc. Benzocyanine compounds
WO2013130761A1 (en) 2012-03-02 2013-09-06 Pierce Biotechnology, Inc. Indole derivatives as labeling dye for biomolecule
CN104470546B (zh) * 2012-07-20 2018-02-27 佳能株式会社 化合物和含有所述化合物的光声成像造影剂
JP6288970B2 (ja) * 2012-07-20 2018-03-07 キヤノン株式会社 化合物、および、前記化合物を有する光音響イメージング用造影剤
US9676787B2 (en) 2012-08-28 2017-06-13 Pierce Biotechnology, Inc. Benzopyrylium compounds
WO2014055253A1 (en) * 2012-10-04 2014-04-10 The General Hospital Corporation Methods of synthesizing and using peg-like fluorochromes
WO2014115206A1 (ja) * 2013-01-28 2014-07-31 独立行政法人科学技術振興機構 組織透明化方法、組織透明化試薬及び組織観察方法
EA031930B1 (ru) 2013-01-30 2019-03-29 Авелас Байосайенсиз, Инк. Молекула селективной доставки для визуализации злокачественной ткани
FR3001463B1 (fr) * 2013-01-31 2015-02-20 Commissariat Energie Atomique Particules luminescentes de carbone, procede de preparation et utilisation
EP3052136A4 (en) * 2013-10-02 2017-06-21 University of Massachusetts Surface functionalized, host-guest polymer nano-assemblies and methods thereof
US10383957B2 (en) 2015-01-06 2019-08-20 Anthony H. de Haas Near-infrared fluorescent surgical dye markers
CN105688230B (zh) * 2016-02-02 2018-12-11 史春梦 七甲川吲哚花菁染料-聚乙二醇-叶酸复合物及制备方法和应用
CN109054013A (zh) * 2018-08-22 2018-12-21 东北大学 一种经修饰的吲哚菁绿及其制备方法
CN109738387A (zh) * 2018-12-29 2019-05-10 佛山科学技术学院 一种基于吲哚箐绿的光学相干层析成像方法和装置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622685A (en) 1990-05-30 1997-04-22 Deutches Krebsforchunszentrum Stiftung Des Offentlichen Rechts Polyether-substituted porphyrin anti-tumor agents
DE4445065A1 (de) 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
WO1998048838A1 (en) 1997-04-29 1998-11-05 Nycomed Imaging As Compounds
GB2337523A (en) * 1998-04-29 1999-11-24 Nycomed Imaging As Light imaging contrast agents
US20100143258A1 (en) * 2008-12-05 2010-06-10 General Electric Company Tumor margin imaging agents

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9416276B2 (en) 2013-11-07 2016-08-16 Canon Kabushiki Kaisha Method for producing contrast agent
US10245329B2 (en) 2014-09-08 2019-04-02 Canon Kabushiki Kaisha Composition having dye and conjugate of polyethyleneglycol and additive and contrast agent for photoacoustic imaging having the same
US20160067359A1 (en) 2014-09-08 2016-03-10 Canon Kabushiki Kaisha Composition having dye and conjugate of polyethyleneglycol and additive and contrast agent for photoacoustic imaging having the same
EP2992904A1 (en) 2014-09-08 2016-03-09 Canon Kabushiki Kaisha Composition having dye and conjugate of polyethyleneglycol and additive and contrast agent for photoacoustic imaging having the same
WO2016060277A1 (en) 2014-10-16 2016-04-21 Canon Kabushiki Kaisha Polymer, and contrast agent for photoacoustic imaging, including the polymer
US11027026B2 (en) 2014-10-16 2021-06-08 Canon Kabushiki Kaisha Polymer, and contrast agent for photoacoustic imaging, including the polymer
US10398788B2 (en) 2014-10-24 2019-09-03 Canon Kabushiki Kaisha Polymer and contrast agent for photoacoustic imaging including the polymer
WO2016092799A1 (en) 2014-12-09 2016-06-16 Canon Kabushiki Kaisha Cyanine derivatives and their use for optical imaging
US10655059B2 (en) 2014-12-09 2020-05-19 Canon Kabushiki Kaisha Compound and contrast agent for optical imaging having the compound
JP2018500338A (ja) * 2014-12-19 2018-01-11 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． 術中イメージング
EP3103795A1 (en) 2015-06-12 2016-12-14 Canon Kabushiki Kaisha Compound or salt thereof and photoacoustic imaging contrast agent containing compound or salt thereof
WO2017057653A1 (en) 2015-09-30 2017-04-06 Canon Kabushiki Kaisha Conjugate of polysarcosine and nir contrast agent for photoacoustic imaging
US10828380B2 (en) 2015-09-30 2020-11-10 Canon Kabushiki Kaisha Conjugate of polysarcosine and NIR contrast agent for photoacoustic imaging
WO2025197935A1 (ja) * 2024-03-19 2025-09-25 国立大学法人 東京大学 薬物－ポリマー複合体、医薬組成物、および薬物送達用ポリマー

Also Published As

Publication number Publication date
BRPI1009346A2 (pt) 2017-05-30
RU2011138096A (ru) 2013-04-27
EP2413976A1 (en) 2012-02-08
WO2010106169A1 (en) 2010-09-23
CA2755770A1 (en) 2010-09-23
MX2011009808A (es) 2011-09-30
AU2010224789A1 (en) 2011-10-06
KR20110138246A (ko) 2011-12-26
US20120114563A1 (en) 2012-05-10
CN102438659A (zh) 2012-05-02

Similar Documents

Publication Publication Date Title
JP2012520856A (ja) 光学イメージング剤
RU2475266C2 (ru) Оптические агенты визуализации
CN105492905B (zh) 炎性疾病的荧光成像
JP2010534711A (ja) ペプチドイメージング剤
ES2923148T3 (es) Formulación y método de preparación
AU2008249820A1 (en) Optical imaging agents
JP7007412B2 (ja) 蛍光イメージングのためのｉｒ色素
US7947256B2 (en) Biocompatible fluorescent imaging agents
JP2011513211A (ja) 療法選択方法
JP2012513382A (ja) 蛍光プローブ
US20110268660A1 (en) Method for detecting dysplasia
US20130331690A1 (en) Vascular imaging agents
US20070258904A1 (en) Optical Imaging Contrast Agents
WO2013045662A1 (en) Peptide margin imaging agents
RU2802481C2 (ru) Состав для оптической визуализации, способ его получения и применение
WO2013045650A2 (en) Infusion imaging method

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130314

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130314

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130329

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20131107

A072 Dismissal of procedure [no reply to invitation to correct request for examination]

Free format text: JAPANESE INTERMEDIATE CODE: A073

Effective date: 20140325