CN102438659A - 光学成像剂 - Google Patents

光学成像剂 Download PDF

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Publication number
CN102438659A
CN102438659A CN2010800225217A CN201080022521A CN102438659A CN 102438659 A CN102438659 A CN 102438659A CN 2010800225217 A CN2010800225217 A CN 2010800225217A CN 201080022521 A CN201080022521 A CN 201080022521A CN 102438659 A CN102438659 A CN 102438659A
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CN
China
Prior art keywords
tissue
tumor
polymer
opt
conjugate
Prior art date
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Pending
Application number
CN2010800225217A
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English (en)
Chinese (zh)
Inventor
R·L·卡特
J·W·卡斯尔
K·M·费希
A·苏德
N·A·斯塔普尔斯
B·D·李
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General Electric Co
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General Electric Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Electric Co filed Critical General Electric Co
Publication of CN102438659A publication Critical patent/CN102438659A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
CN2010800225217A 2009-03-19 2010-03-19 光学成像剂 Pending CN102438659A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16153509P 2009-03-19 2009-03-19
US61/161535 2009-03-19
PCT/EP2010/053619 WO2010106169A1 (en) 2009-03-19 2010-03-19 Optical imaging agents

Publications (1)

Publication Number Publication Date
CN102438659A true CN102438659A (zh) 2012-05-02

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ID=42331047

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800225217A Pending CN102438659A (zh) 2009-03-19 2010-03-19 光学成像剂

Country Status (11)

Country Link
US (1) US20120114563A1 (https=)
EP (1) EP2413976A1 (https=)
JP (1) JP2012520856A (https=)
KR (1) KR20110138246A (https=)
CN (1) CN102438659A (https=)
AU (1) AU2010224789A1 (https=)
BR (1) BRPI1009346A2 (https=)
CA (1) CA2755770A1 (https=)
MX (1) MX2011009808A (https=)
RU (1) RU2011138096A (https=)
WO (1) WO2010106169A1 (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104470546A (zh) * 2012-07-20 2015-03-25 佳能株式会社 化合物和含有所述化合物的光声成像造影剂
CN105102484A (zh) * 2013-01-30 2015-11-25 艾维拉斯生物科学公司 选择性递送分子及使用方法
CN105688230A (zh) * 2016-02-02 2016-06-22 史春梦 七甲川吲哚花菁染料-聚乙二醇-叶酸复合物及制备方法和应用
CN106243013A (zh) * 2015-06-12 2016-12-21 佳能株式会社 化合物或其盐以及含有该化合物或其盐的光声成像造影剂
US20180057536A1 (en) 2011-07-29 2018-03-01 Avelas Biosciences, Inc. Selective delivery molecules and methods of use
CN109054013A (zh) * 2018-08-22 2018-12-21 东北大学 一种经修饰的吲哚菁绿及其制备方法
CN109738387A (zh) * 2018-12-29 2019-05-10 佛山科学技术学院 一种基于吲哚箐绿的光学相干层析成像方法和装置

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* Cited by examiner, † Cited by third party
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GB201015806D0 (en) 2010-09-21 2010-10-27 Ge Healthcare As Vascular imaging agents
US10053447B2 (en) 2010-12-21 2018-08-21 Pierce Biotechnology, Inc Fluorescent compounds
US8889884B1 (en) 2011-07-14 2014-11-18 Pierce Biotechnology, Inc. Phosphine derivatives of fluorescent compounds
US9249307B2 (en) 2011-08-16 2016-02-02 Pierce Biotechnology, Inc. Benzocyanine compounds
GB201116733D0 (en) 2011-09-28 2011-11-09 Ge Healthcare As Peptide margin imaging agents
US9751868B2 (en) 2012-02-28 2017-09-05 Pierce Biotechnology, Inc. Benzocyanine compounds
CN104395306B (zh) 2012-03-02 2019-04-23 皮尔斯生物科技有限公司 作为生物分子的标记染料的吲哚衍生物
JP6288970B2 (ja) * 2012-07-20 2018-03-07 キヤノン株式会社 化合物、および、前記化合物を有する光音響イメージング用造影剤
CN104540819B (zh) 2012-08-28 2019-04-19 皮尔斯生物科技有限公司 苯并吡喃鎓化合物
US20150258217A1 (en) * 2012-10-04 2015-09-17 The General Hospital Corporation Methods of Synthesizing and Using Peg-Like Fluorochromes
WO2014115206A1 (ja) * 2013-01-28 2014-07-31 独立行政法人科学技術振興機構 組織透明化方法、組織透明化試薬及び組織観察方法
FR3001463B1 (fr) * 2013-01-31 2015-02-20 Commissariat Energie Atomique Particules luminescentes de carbone, procede de preparation et utilisation
EP3052136A4 (en) * 2013-10-02 2017-06-21 University of Massachusetts Surface functionalized, host-guest polymer nano-assemblies and methods thereof
US9416276B2 (en) 2013-11-07 2016-08-16 Canon Kabushiki Kaisha Method for producing contrast agent
US10245329B2 (en) 2014-09-08 2019-04-02 Canon Kabushiki Kaisha Composition having dye and conjugate of polyethyleneglycol and additive and contrast agent for photoacoustic imaging having the same
US11027026B2 (en) 2014-10-16 2021-06-08 Canon Kabushiki Kaisha Polymer, and contrast agent for photoacoustic imaging, including the polymer
WO2016063817A1 (en) 2014-10-24 2016-04-28 Canon Kabushiki Kaisha Polymer and contrast agent for photoacoustic imaging including the polymer
JP6700750B2 (ja) 2014-12-09 2020-05-27 キヤノン株式会社 化合物、および、前記化合物を有する光学イメージング用造影剤
HUE051161T2 (hu) * 2014-12-19 2021-03-01 Bracco Imaging Spa Operáció közbeni képalkotás
EP3242690B1 (en) * 2015-01-06 2020-09-16 De Haas, Anthony H. Near-infrared fluorescent surgical dye markers
JP6789636B2 (ja) 2015-09-30 2020-11-25 キヤノン株式会社 重合体、前記重合体を有する光音響イメージング用造影剤
WO2017057653A1 (en) 2015-09-30 2017-04-06 Canon Kabushiki Kaisha Conjugate of polysarcosine and nir contrast agent for photoacoustic imaging
WO2025197935A1 (ja) * 2024-03-19 2025-09-25 国立大学法人 東京大学 薬物－ポリマー複合体、医薬組成物、および薬物送達用ポリマー

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GB2337523A (en) * 1998-04-29 1999-11-24 Nycomed Imaging As Light imaging contrast agents

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US5622685A (en) 1990-05-30 1997-04-22 Deutches Krebsforchunszentrum Stiftung Des Offentlichen Rechts Polyether-substituted porphyrin anti-tumor agents
DE4445065A1 (de) 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
ATE257014T1 (de) 1997-04-29 2004-01-15 Amersham Health As Lichtbilderzeugungskontrastmitteln
US20100143258A1 (en) * 2008-12-05 2010-06-10 General Electric Company Tumor margin imaging agents

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GB2337523A (en) * 1998-04-29 1999-11-24 Nycomed Imaging As Light imaging contrast agents

Non-Patent Citations (2)

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Title
BJÖRN RIEFKE, ET AL.: "Tumor Detection with Cyanine Dye-Poly(ethylene Glycol) Conjugates as Contrast Agents for Near-Infrared Imaging", 《SPIE》 *
KAI LICHA, ET AL.: "Synthesis and Characterization of Cyanine Dye-Poly(ethylene Glycol) Conjugates as Contrast Agents for In Vivo Fluorescence Imaging", 《SPIE》 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10239919B2 (en) 2011-07-29 2019-03-26 Avelas Biosciences, Inc. Selective delivery molecules and methods of use
US20180057536A1 (en) 2011-07-29 2018-03-01 Avelas Biosciences, Inc. Selective delivery molecules and methods of use
US10570178B2 (en) 2011-07-29 2020-02-25 Avelas Biosciences, Inc. Selective delivery molecules and methods of use
CN104470546A (zh) * 2012-07-20 2015-03-25 佳能株式会社 化合物和含有所述化合物的光声成像造影剂
US9592307B2 (en) 2012-07-20 2017-03-14 Canon Kabushiki Kaisha Compound and photoacoustic imaging contrast medium containing the compound
CN105102484A (zh) * 2013-01-30 2015-11-25 艾维拉斯生物科学公司 选择性递送分子及使用方法
US11052160B2 (en) 2013-01-30 2021-07-06 Avelas Biosciences, Inc. Selective delivery molecules and methods of use
CN105102484B (zh) * 2013-01-30 2020-03-10 艾维拉斯生物科学公司 选择性递送分子及使用方法
US10226539B2 (en) 2013-01-30 2019-03-12 Avelas Biosciences, Inc. Selective delivery molecules and methods of use
CN106243013A (zh) * 2015-06-12 2016-12-21 佳能株式会社 化合物或其盐以及含有该化合物或其盐的光声成像造影剂
CN105688230B (zh) * 2016-02-02 2018-12-11 史春梦 七甲川吲哚花菁染料-聚乙二醇-叶酸复合物及制备方法和应用
CN105688230A (zh) * 2016-02-02 2016-06-22 史春梦 七甲川吲哚花菁染料-聚乙二醇-叶酸复合物及制备方法和应用
CN109054013A (zh) * 2018-08-22 2018-12-21 东北大学 一种经修饰的吲哚菁绿及其制备方法
CN109738387A (zh) * 2018-12-29 2019-05-10 佛山科学技术学院 一种基于吲哚箐绿的光学相干层析成像方法和装置

Also Published As

Publication number Publication date
US20120114563A1 (en) 2012-05-10
AU2010224789A1 (en) 2011-10-06
CA2755770A1 (en) 2010-09-23
RU2011138096A (ru) 2013-04-27
BRPI1009346A2 (pt) 2017-05-30
MX2011009808A (es) 2011-09-30
WO2010106169A1 (en) 2010-09-23
KR20110138246A (ko) 2011-12-26
JP2012520856A (ja) 2012-09-10
EP2413976A1 (en) 2012-02-08

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Application publication date: 20120502