RU2011138096A - Агенты для оптической визуализации - Google Patents
Агенты для оптической визуализации Download PDFInfo
- Publication number
- RU2011138096A RU2011138096A RU2011138096/15A RU2011138096A RU2011138096A RU 2011138096 A RU2011138096 A RU 2011138096A RU 2011138096/15 A RU2011138096/15 A RU 2011138096/15A RU 2011138096 A RU2011138096 A RU 2011138096A RU 2011138096 A RU2011138096 A RU 2011138096A
- Authority
- RU
- Russia
- Prior art keywords
- group
- opt
- tissue
- contrast agent
- conjugate
- Prior art date
Links
- 230000003287 optical effect Effects 0.000 title claims abstract 6
- 238000012800 visualization Methods 0.000 title claims 2
- 238000000034 method Methods 0.000 claims abstract 14
- 229920000642 polymer Polymers 0.000 claims abstract 12
- 239000002872 contrast media Substances 0.000 claims abstract 9
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract 7
- 238000012634 optical imaging Methods 0.000 claims abstract 7
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract 7
- 206010028980 Neoplasm Diseases 0.000 claims abstract 6
- 238000001727 in vivo Methods 0.000 claims abstract 3
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims abstract 2
- 125000000304 alkynyl group Chemical group 0.000 claims abstract 2
- 150000001413 amino acids Chemical class 0.000 claims abstract 2
- 238000011503 in vivo imaging Methods 0.000 claims abstract 2
- 125000005647 linker group Chemical group 0.000 claims abstract 2
- 125000006853 reporter group Chemical group 0.000 claims abstract 2
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000005284 excitation Effects 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 1
- 238000000149 argon plasma sintering Methods 0.000 claims 1
- 125000000732 arylene group Chemical group 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 150000002337 glycosamines Chemical class 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- JPBGLQJDCUZXEF-UHFFFAOYSA-N chromenylium Chemical compound [O+]1=CC=CC2=CC=CC=C21 JPBGLQJDCUZXEF-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16153509P | 2009-03-19 | 2009-03-19 | |
| US61/161,535 | 2009-03-19 | ||
| PCT/EP2010/053619 WO2010106169A1 (en) | 2009-03-19 | 2010-03-19 | Optical imaging agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2011138096A true RU2011138096A (ru) | 2013-04-27 |
Family
ID=42331047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011138096/15A RU2011138096A (ru) | 2009-03-19 | 2010-03-19 | Агенты для оптической визуализации |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20120114563A1 (https=) |
| EP (1) | EP2413976A1 (https=) |
| JP (1) | JP2012520856A (https=) |
| KR (1) | KR20110138246A (https=) |
| CN (1) | CN102438659A (https=) |
| AU (1) | AU2010224789A1 (https=) |
| BR (1) | BRPI1009346A2 (https=) |
| CA (1) | CA2755770A1 (https=) |
| MX (1) | MX2011009808A (https=) |
| RU (1) | RU2011138096A (https=) |
| WO (1) | WO2010106169A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201015806D0 (en) | 2010-09-21 | 2010-10-27 | Ge Healthcare As | Vascular imaging agents |
| US10053447B2 (en) | 2010-12-21 | 2018-08-21 | Pierce Biotechnology, Inc | Fluorescent compounds |
| US8889884B1 (en) | 2011-07-14 | 2014-11-18 | Pierce Biotechnology, Inc. | Phosphine derivatives of fluorescent compounds |
| MX350082B (es) | 2011-07-29 | 2017-08-24 | Avelas Biosciences Inc | Moleculas de entrega selectiva y metodos de uso. |
| US9249307B2 (en) | 2011-08-16 | 2016-02-02 | Pierce Biotechnology, Inc. | Benzocyanine compounds |
| GB201116733D0 (en) | 2011-09-28 | 2011-11-09 | Ge Healthcare As | Peptide margin imaging agents |
| US9751868B2 (en) | 2012-02-28 | 2017-09-05 | Pierce Biotechnology, Inc. | Benzocyanine compounds |
| CN104395306B (zh) | 2012-03-02 | 2019-04-23 | 皮尔斯生物科技有限公司 | 作为生物分子的标记染料的吲哚衍生物 |
| WO2014013730A1 (en) * | 2012-07-20 | 2014-01-23 | Canon Kabushiki Kaisha | Compound and photoacoustic imaging contrast medium containing the compound |
| JP6288970B2 (ja) * | 2012-07-20 | 2018-03-07 | キヤノン株式会社 | 化合物、および、前記化合物を有する光音響イメージング用造影剤 |
| CN104540819B (zh) | 2012-08-28 | 2019-04-19 | 皮尔斯生物科技有限公司 | 苯并吡喃鎓化合物 |
| US20150258217A1 (en) * | 2012-10-04 | 2015-09-17 | The General Hospital Corporation | Methods of Synthesizing and Using Peg-Like Fluorochromes |
| WO2014115206A1 (ja) * | 2013-01-28 | 2014-07-31 | 独立行政法人科学技術振興機構 | 組織透明化方法、組織透明化試薬及び組織観察方法 |
| AU2014212308B2 (en) * | 2013-01-30 | 2018-08-09 | Avelas Biosciences, Inc. | Selective delivery molecules and methods of use |
| FR3001463B1 (fr) * | 2013-01-31 | 2015-02-20 | Commissariat Energie Atomique | Particules luminescentes de carbone, procede de preparation et utilisation |
| EP3052136A4 (en) * | 2013-10-02 | 2017-06-21 | University of Massachusetts | Surface functionalized, host-guest polymer nano-assemblies and methods thereof |
| US9416276B2 (en) | 2013-11-07 | 2016-08-16 | Canon Kabushiki Kaisha | Method for producing contrast agent |
| US10245329B2 (en) | 2014-09-08 | 2019-04-02 | Canon Kabushiki Kaisha | Composition having dye and conjugate of polyethyleneglycol and additive and contrast agent for photoacoustic imaging having the same |
| US11027026B2 (en) | 2014-10-16 | 2021-06-08 | Canon Kabushiki Kaisha | Polymer, and contrast agent for photoacoustic imaging, including the polymer |
| WO2016063817A1 (en) | 2014-10-24 | 2016-04-28 | Canon Kabushiki Kaisha | Polymer and contrast agent for photoacoustic imaging including the polymer |
| JP6700750B2 (ja) | 2014-12-09 | 2020-05-27 | キヤノン株式会社 | 化合物、および、前記化合物を有する光学イメージング用造影剤 |
| HUE051161T2 (hu) * | 2014-12-19 | 2021-03-01 | Bracco Imaging Spa | Operáció közbeni képalkotás |
| EP3242690B1 (en) * | 2015-01-06 | 2020-09-16 | De Haas, Anthony H. | Near-infrared fluorescent surgical dye markers |
| JP2017002000A (ja) * | 2015-06-12 | 2017-01-05 | キヤノン株式会社 | 化合物又はその薬学的に受容可能な塩、及び、前記化合物又はその薬学的に受容可能な塩を有する光音響イメージング用造影剤。 |
| JP6789636B2 (ja) | 2015-09-30 | 2020-11-25 | キヤノン株式会社 | 重合体、前記重合体を有する光音響イメージング用造影剤 |
| WO2017057653A1 (en) | 2015-09-30 | 2017-04-06 | Canon Kabushiki Kaisha | Conjugate of polysarcosine and nir contrast agent for photoacoustic imaging |
| CN105688230B (zh) * | 2016-02-02 | 2018-12-11 | 史春梦 | 七甲川吲哚花菁染料-聚乙二醇-叶酸复合物及制备方法和应用 |
| CN109054013A (zh) * | 2018-08-22 | 2018-12-21 | 东北大学 | 一种经修饰的吲哚菁绿及其制备方法 |
| CN109738387A (zh) * | 2018-12-29 | 2019-05-10 | 佛山科学技术学院 | 一种基于吲哚箐绿的光学相干层析成像方法和装置 |
| WO2025197935A1 (ja) * | 2024-03-19 | 2025-09-25 | 国立大学法人 東京大学 | 薬物－ポリマー複合体、医薬組成物、および薬物送達用ポリマー |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5622685A (en) | 1990-05-30 | 1997-04-22 | Deutches Krebsforchunszentrum Stiftung Des Offentlichen Rechts | Polyether-substituted porphyrin anti-tumor agents |
| DE4445065A1 (de) | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
| ATE257014T1 (de) | 1997-04-29 | 2004-01-15 | Amersham Health As | Lichtbilderzeugungskontrastmitteln |
| GB2337523A (en) * | 1998-04-29 | 1999-11-24 | Nycomed Imaging As | Light imaging contrast agents |
| US20100143258A1 (en) * | 2008-12-05 | 2010-06-10 | General Electric Company | Tumor margin imaging agents |
-
2010
- 2010-03-19 RU RU2011138096/15A patent/RU2011138096A/ru not_active Application Discontinuation
- 2010-03-19 KR KR1020117024519A patent/KR20110138246A/ko not_active Withdrawn
- 2010-03-19 BR BRPI1009346A patent/BRPI1009346A2/pt not_active IP Right Cessation
- 2010-03-19 CA CA2755770A patent/CA2755770A1/en not_active Abandoned
- 2010-03-19 EP EP10710834A patent/EP2413976A1/en not_active Withdrawn
- 2010-03-19 AU AU2010224789A patent/AU2010224789A1/en not_active Abandoned
- 2010-03-19 MX MX2011009808A patent/MX2011009808A/es not_active Application Discontinuation
- 2010-03-19 JP JP2012500272A patent/JP2012520856A/ja not_active Withdrawn
- 2010-03-19 CN CN2010800225217A patent/CN102438659A/zh active Pending
- 2010-03-19 US US13/257,318 patent/US20120114563A1/en not_active Abandoned
- 2010-03-19 WO PCT/EP2010/053619 patent/WO2010106169A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US20120114563A1 (en) | 2012-05-10 |
| AU2010224789A1 (en) | 2011-10-06 |
| CA2755770A1 (en) | 2010-09-23 |
| BRPI1009346A2 (pt) | 2017-05-30 |
| MX2011009808A (es) | 2011-09-30 |
| WO2010106169A1 (en) | 2010-09-23 |
| CN102438659A (zh) | 2012-05-02 |
| KR20110138246A (ko) | 2011-12-26 |
| JP2012520856A (ja) | 2012-09-10 |
| EP2413976A1 (en) | 2012-02-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20140718 |