JP2012520679A5 - - Google Patents
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- Publication number
- JP2012520679A5 JP2012520679A5 JP2012500875A JP2012500875A JP2012520679A5 JP 2012520679 A5 JP2012520679 A5 JP 2012520679A5 JP 2012500875 A JP2012500875 A JP 2012500875A JP 2012500875 A JP2012500875 A JP 2012500875A JP 2012520679 A5 JP2012520679 A5 JP 2012520679A5
- Authority
- JP
- Japan
- Prior art keywords
- constant region
- seq
- light chain
- binding protein
- isolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000833 heterodimer Substances 0.000 claims 12
- 102000025171 antigen binding proteins Human genes 0.000 claims 11
- 108091000831 antigen binding proteins Proteins 0.000 claims 11
- 102000039446 nucleic acids Human genes 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 10
- 150000007523 nucleic acids Chemical class 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 9
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 101710139349 Mucosal addressin cell adhesion molecule 1 Proteins 0.000 claims 4
- 102100028793 Mucosal addressin cell adhesion molecule 1 Human genes 0.000 claims 4
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 2
- 208000015943 Coeliac disease Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 230000021164 cell adhesion Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 208000004396 mastitis Diseases 0.000 claims 2
- 230000004481 post-translational protein modification Effects 0.000 claims 2
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims 1
- 206010006458 Bronchitis chronic Diseases 0.000 claims 1
- 206010009137 Chronic sinusitis Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- ODHCTXKNWHHXJC-GSVOUGTGSA-N Pyroglutamic acid Natural products OC(=O)[C@H]1CCC(=O)N1 ODHCTXKNWHHXJC-GSVOUGTGSA-N 0.000 claims 1
- 206010062164 Seronegative arthritis Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 claims 1
- 230000003872 anastomosis Effects 0.000 claims 1
- 102000023732 binding proteins Human genes 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 208000003167 cholangitis Diseases 0.000 claims 1
- 201000001352 cholecystitis Diseases 0.000 claims 1
- 208000023819 chronic asthma Diseases 0.000 claims 1
- 208000007451 chronic bronchitis Diseases 0.000 claims 1
- 208000017760 chronic graft versus host disease Diseases 0.000 claims 1
- 208000027157 chronic rhinosinusitis Diseases 0.000 claims 1
- 208000008609 collagenous colitis Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 201000003146 cystitis Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 201000001564 eosinophilic gastroenteritis Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000008275 microscopic colitis Diseases 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002271 resection Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16215409P | 2009-03-20 | 2009-03-20 | |
| US61/162,154 | 2009-03-20 | ||
| US30682910P | 2010-02-22 | 2010-02-22 | |
| US61/306,829 | 2010-02-22 | ||
| PCT/US2010/027422 WO2010107752A2 (en) | 2009-03-20 | 2010-03-16 | Alpha-4-beta-7 heterodimer specific antagonist antibody |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014043790A Division JP5775615B2 (ja) | 2009-03-20 | 2014-03-06 | アルファ−４−ベータ−７ヘテロ二量体特異的アンタゴニスト抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012520679A JP2012520679A (ja) | 2012-09-10 |
| JP2012520679A5 true JP2012520679A5 (https=) | 2014-03-06 |
| JP5498566B2 JP5498566B2 (ja) | 2014-05-21 |
Family
ID=42224952
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012500875A Active JP5498566B2 (ja) | 2009-03-20 | 2010-03-16 | アルファ−４−ベータ−７ヘテロ二量体特異的アンタゴニスト抗体 |
| JP2014043790A Active JP5775615B2 (ja) | 2009-03-20 | 2014-03-06 | アルファ−４−ベータ−７ヘテロ二量体特異的アンタゴニスト抗体 |
| JP2015134473A Active JP5980384B2 (ja) | 2009-03-20 | 2015-07-03 | アルファ−４−ベータ−７ヘテロ二量体特異的アンタゴニスト抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014043790A Active JP5775615B2 (ja) | 2009-03-20 | 2014-03-06 | アルファ−４−ベータ−７ヘテロ二量体特異的アンタゴニスト抗体 |
| JP2015134473A Active JP5980384B2 (ja) | 2009-03-20 | 2015-07-03 | アルファ−４−ベータ−７ヘテロ二量体特異的アンタゴニスト抗体 |
Country Status (26)
| Country | Link |
|---|---|
| US (6) | US8444981B2 (https=) |
| EP (1) | EP2408816B1 (https=) |
| JP (3) | JP5498566B2 (https=) |
| KR (2) | KR101391472B1 (https=) |
| CN (2) | CN103382222B (https=) |
| AR (1) | AR075882A1 (https=) |
| AU (1) | AU2010226814B2 (https=) |
| CA (2) | CA2851737C (https=) |
| CL (3) | CL2011002306A1 (https=) |
| CO (1) | CO6501170A2 (https=) |
| CR (1) | CR20110544A (https=) |
| EA (1) | EA034783B1 (https=) |
| ES (1) | ES2751946T3 (https=) |
| IL (4) | IL214868A (https=) |
| JO (1) | JO3615B1 (https=) |
| MA (1) | MA33213B1 (https=) |
| MX (4) | MX357211B (https=) |
| MY (2) | MY184957A (https=) |
| NZ (1) | NZ595464A (https=) |
| PE (2) | PE20120497A1 (https=) |
| SG (3) | SG174344A1 (https=) |
| TN (1) | TN2011000433A1 (https=) |
| TW (2) | TWI477511B (https=) |
| UY (1) | UY32501A (https=) |
| WO (1) | WO2010107752A2 (https=) |
| ZA (1) | ZA201107279B (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX367097B (es) | 2011-05-02 | 2019-08-05 | Millennium Pharm Inc | FORMULACION PARA ANTICUERPO ANTI-A4ß7. |
| UA116189C2 (uk) | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| WO2013078375A2 (en) | 2011-11-23 | 2013-05-30 | Amgen Inc. | Administration of alpha4beta7 hetero-dimer-specific antibody |
| ES2702315T3 (es) | 2012-08-24 | 2019-02-28 | Univ California | Anticuerpos y vacunas para su uso en tratar cánceres ROR1 e inhibir metástasis |
| UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| US9708375B2 (en) | 2013-03-15 | 2017-07-18 | Amgen Inc. | Inhibitory polypeptides specific to WNT inhibitors |
| EP3041863A4 (en) | 2013-09-05 | 2017-08-16 | Amgen Inc. | Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles |
| RU2016134913A (ru) * | 2014-02-28 | 2018-03-30 | Астеллас Фарма Инк. | Новое биспецифическое антитело, связывающееся с tlr2 человека и tlr4 человека |
| US10156562B2 (en) | 2014-05-16 | 2018-12-18 | Amgen Inc. | Assay for detecting Th1 and Th2 cell populations |
| EA201790437A1 (ru) | 2014-08-22 | 2017-08-31 | Сорренто Терапьютикс, Инк. | Антигенсвязывающие белки, связывающиеся с cxcr3 |
| WO2016057424A1 (en) | 2014-10-06 | 2016-04-14 | Chemocentryx, Inc. | Combination therapy of inhibitors of c-c chemokine receptor type 9 (ccr9) and anti-alha4beta7 integrin blocking antibodies |
| WO2016086147A1 (en) | 2014-11-26 | 2016-06-02 | Millennium Pharmaceuticals, Inc. | Vedolizumab for the treatment of fistulizing crohn's disease |
| MA41636A (fr) | 2015-03-06 | 2018-01-09 | Millennium Pharm Inc | Méthode de traitement de la cholangite sclérosante primitive |
| EP3328994A4 (en) * | 2015-07-31 | 2019-04-17 | Memorial Sloan-Kettering Cancer Center | CD56-Faced Antigen-Binding Proteins and Uses Thereof |
| SG11201800864XA (en) | 2015-08-11 | 2018-03-28 | Univ Osaka | Antibody |
| CA3017743A1 (en) | 2016-03-14 | 2017-09-21 | Millennium Pharmaceuticals, Inc. | Method of preventing graft versus host disease |
| AU2017234010B2 (en) | 2016-03-14 | 2024-06-13 | Millennium Pharmaceuticals, Inc. | Methods of treating or preventing graft versus host disease |
| AU2017237543B2 (en) * | 2016-03-23 | 2020-02-06 | Institut Pasteur Korea | Antibody that binds to envelope glycoprotein of severe fever with thrombocytopenia syndrome virus, and use for same |
| JP7069032B2 (ja) | 2016-03-24 | 2022-05-17 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | がん免疫治療における胃腸の免疫関連有害事象の治療方法 |
| WO2017165742A1 (en) | 2016-03-24 | 2017-09-28 | Millennium Pharmaceuticals, Inc. | Methods of treating gastrointestinal immune-related adverse events in anti-ctla4 anti-pd-1 combination treatments |
| US12297266B2 (en) | 2016-04-18 | 2025-05-13 | Celldex Therapeutics, Inc. | Agonistic antibodies that bind human CD40 and uses thereof |
| EP3468597A1 (en) | 2016-06-12 | 2019-04-17 | Millennium Pharmaceuticals, Inc. | Method of treating inflammatory bowel disease |
| TWI767915B (zh) | 2016-06-27 | 2022-06-21 | 加州大學董事會 | Ror-1與btk拮抗劑的組合 |
| CA3056011A1 (en) | 2017-03-14 | 2018-09-20 | Amgen Inc. | Control of total afucosylated glycoforms of antibodies produced in cell culture |
| AU2018256840A1 (en) | 2017-04-28 | 2019-11-07 | Millennium Pharmaceuticals, Inc. | Method of treating pediatric disorders with antibodies specific for alpha 4 beta 7 integrin (vedolizumab) |
| US12325737B2 (en) | 2018-03-26 | 2025-06-10 | Amgen Inc. | Total afucosylated glycoforms of antibodies produced in cell culture |
| BR112022005583A2 (pt) | 2019-09-26 | 2022-09-20 | Amgen Inc | Métodos para a produção de composições de anticorpos |
| BR112022017048A2 (pt) | 2020-02-26 | 2022-11-16 | Vir Biotechnology Inc | Anticorpos contra sars-cov-2 e métodos para usar os mesmos |
| US20230273126A1 (en) | 2020-06-04 | 2023-08-31 | Amgen Inc. | Assessment of cleaning procedures of a biotherapeutic manufacturing process |
| KR20230087539A (ko) | 2020-10-15 | 2023-06-16 | 암젠 인크 | 항체 생산 방법에서의 상대적인 비결합 글리칸 |
| KR20240006505A (ko) * | 2021-03-12 | 2024-01-15 | 이칸 스쿨 오브 메디슨 엣 마운트 시나이 | Bk 바이러스에 대한 중화 단클론성 항체 |
| EP4352094A1 (en) | 2021-06-07 | 2024-04-17 | Amgen Inc. | Using fucosidase to control afucosylation level of glycosylated proteins |
| US20250076309A1 (en) | 2021-10-05 | 2025-03-06 | Amgen Inc. | Fc-gamma receptor ii binding and glycan content |
| WO2023215725A1 (en) | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
| AU2024256160A1 (en) | 2023-04-20 | 2025-10-02 | Amgen Inc. | Methods of determining relative unpaired glycan content |
| WO2024249568A1 (en) | 2023-05-30 | 2024-12-05 | Paragon Therapeutics, Inc. | Alpha4beta7 integrin antibody compositions and methods of use |
| WO2024252368A2 (en) | 2023-06-09 | 2024-12-12 | Takeda Pharmaceutical Company Limited | Methods and compositions for treating ulcerative colitis |
| CN121889424A (zh) | 2023-08-14 | 2026-04-17 | 派拉冈医疗公司 | α4β7整联蛋白结合蛋白及使用方法 |
| WO2025038600A1 (en) | 2023-08-14 | 2025-02-20 | Amgen Inc. | Methods for reducing yellow color |
| WO2025101820A1 (en) | 2023-11-08 | 2025-05-15 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
| WO2026058045A1 (en) | 2024-09-12 | 2026-03-19 | Takeda Pharmaceutical Company Limited | Alpha4beta7 inhibitor and il-23 inhibitor combination therapy |
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2010
- 2010-03-16 CN CN201310216898.1A patent/CN103382222B/zh active Active
- 2010-03-16 MX MX2014013424A patent/MX357211B/es active IP Right Grant
- 2010-03-16 MX MX2015002115A patent/MX338969B/es unknown
- 2010-03-16 CA CA2851737A patent/CA2851737C/en active Active
- 2010-03-16 KR KR1020137012483A patent/KR101391472B1/ko active Active
- 2010-03-16 MY MYPI2015002744A patent/MY184957A/en unknown
- 2010-03-16 EA EA201171148A patent/EA034783B1/ru not_active IP Right Cessation
- 2010-03-16 US US12/725,031 patent/US8444981B2/en active Active
- 2010-03-16 AU AU2010226814A patent/AU2010226814B2/en active Active
- 2010-03-16 KR KR1020117024649A patent/KR101346530B1/ko active Active
- 2010-03-16 WO PCT/US2010/027422 patent/WO2010107752A2/en not_active Ceased
- 2010-03-16 TW TW103102822A patent/TWI477511B/zh active
- 2010-03-16 SG SG2011065570A patent/SG174344A1/en unknown
- 2010-03-16 MX MX2011009897A patent/MX2011009897A/es active IP Right Grant
- 2010-03-16 EP EP10708688.6A patent/EP2408816B1/en active Active
- 2010-03-16 MX MX2016001889A patent/MX357213B/es unknown
- 2010-03-16 PE PE2011001661A patent/PE20120497A1/es not_active Application Discontinuation
- 2010-03-16 SG SG10201801337WA patent/SG10201801337WA/en unknown
- 2010-03-16 ES ES10708688T patent/ES2751946T3/es active Active
- 2010-03-16 MY MYPI2011004308A patent/MY162752A/en unknown
- 2010-03-16 NZ NZ595464A patent/NZ595464A/xx unknown
- 2010-03-16 CN CN201080013557.9A patent/CN102388068B/zh active Active
- 2010-03-16 PE PE2016000333A patent/PE20160553A1/es unknown
- 2010-03-16 TW TW99107689A patent/TWI466681B/zh active
- 2010-03-16 JP JP2012500875A patent/JP5498566B2/ja active Active
- 2010-03-16 SG SG10201400798VA patent/SG10201400798VA/en unknown
- 2010-03-16 CA CA2754113A patent/CA2754113C/en active Active
- 2010-03-16 MA MA34274A patent/MA33213B1/fr unknown
- 2010-03-18 JO JOP/2010/0090A patent/JO3615B1/ar active
- 2010-03-18 UY UY0001032501A patent/UY32501A/es not_active Application Discontinuation
- 2010-03-18 AR ARP100100867A patent/AR075882A1/es active IP Right Grant
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2011
- 2011-08-24 TN TN2011000433A patent/TN2011000433A1/fr unknown
- 2011-08-29 IL IL214868A patent/IL214868A/en active IP Right Grant
- 2011-09-16 CL CL2011002306A patent/CL2011002306A1/es unknown
- 2011-09-30 CO CO11128767A patent/CO6501170A2/es not_active Application Discontinuation
- 2011-10-05 ZA ZA2011/07279A patent/ZA201107279B/en unknown
- 2011-10-18 CR CR20110544A patent/CR20110544A/es unknown
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2012
- 2012-03-22 US US13/427,757 patent/US8454962B2/en not_active Expired - Fee Related
- 2012-03-22 US US13/427,745 patent/US8454961B2/en not_active Expired - Fee Related
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2013
- 2013-04-22 US US13/867,498 patent/US8871490B2/en active Active
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2014
- 2014-02-18 CL CL2014000400A patent/CL2014000400A1/es unknown
- 2014-02-18 CL CL2014000401A patent/CL2014000401A1/es unknown
- 2014-03-06 JP JP2014043790A patent/JP5775615B2/ja active Active
- 2014-04-08 IL IL232009A patent/IL232009A/en active IP Right Grant
- 2014-04-08 IL IL232008A patent/IL232008A/en active IP Right Grant
- 2014-09-26 US US14/497,883 patent/US9499620B2/en active Active
-
2015
- 2015-07-03 JP JP2015134473A patent/JP5980384B2/ja active Active
- 2015-07-16 IL IL239965A patent/IL239965A/en active IP Right Grant
-
2016
- 2016-11-09 US US15/347,233 patent/US20170275365A1/en not_active Abandoned
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