JP2012520085A - 生物活性ｒｎａの送達のための組成物及び方法 - Google Patents
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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| JP2017505638A (ja) * | 2014-02-14 | 2017-02-23 | シンヴィヴォ コーポレイション | ハイブリッドタンパクおよびその使用 |
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| WO2011130749A2 (en) | 2010-04-16 | 2011-10-20 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Identification of mutations in herpes simplex virus envelope glycoproteins that enable or enhance vector retargeting to novel non-hsv receptors |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2625189B1 (en) | 2010-10-01 | 2018-06-27 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| WO2012159164A1 (en) * | 2011-05-23 | 2012-11-29 | Phylogica Limited | Method of determining, identifying or isolating cell-penetrating peptides |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DE19216461T1 (de) | 2011-10-03 | 2021-10-07 | Modernatx, Inc. | Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon |
| CA3018046A1 (en) | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| AU2012358181A1 (en) * | 2011-12-23 | 2014-07-10 | Egen, Inc. | Compositions and methods for the delivery of biologically active RNAs |
| WO2013101690A1 (en) * | 2011-12-29 | 2013-07-04 | modeRNA Therapeutics | Modified mrnas encoding cell-penetrating polypeptides |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| WO2013151665A2 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins associated with human disease |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| PL2922554T3 (pl) | 2012-11-26 | 2022-06-20 | Modernatx, Inc. | Na zmodyfikowany na końcach |
| US9909123B2 (en) * | 2013-03-15 | 2018-03-06 | Techulon Inc. | Antisense molecules for treatment of Staphylococcus aureus infection |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| WO2015002956A1 (en) * | 2013-07-01 | 2015-01-08 | Ohio State Innovation Foundation | Exosome delivery system |
| EP3024936B1 (en) | 2013-07-25 | 2019-09-04 | Exicure, Inc. | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| US10568898B2 (en) | 2013-08-13 | 2020-02-25 | Northwestern University | Lipophilic nanoparticles for drug delivery |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| BR112016009465A8 (pt) | 2013-10-28 | 2018-01-30 | Univ Pittsburgh Commonwealth Sys Higher Education | vetor de hsv oncolítico. |
| TR201908550T4 (tr) | 2014-06-04 | 2019-07-22 | Exicure Inc | Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi. |
| WO2016028940A1 (en) | 2014-08-19 | 2016-02-25 | Northwestern University | Protein/oligonucleotide core-shell nanoparticle therapeutics |
| CR20170181A (es) | 2014-10-06 | 2017-05-31 | Exicure Inc | Compuestos anti-tnf |
| US9816080B2 (en) * | 2014-10-31 | 2017-11-14 | President And Fellows Of Harvard College | Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs) |
| US10078092B2 (en) | 2015-03-18 | 2018-09-18 | Northwestern University | Assays for measuring binding kinetics and binding capacity of acceptors for lipophilic or amphiphilic molecules |
| KR20180136435A (ko) | 2016-01-27 | 2018-12-24 | 온코루스, 인크. | 종양 살상형 바이러스 벡터 및 그의 용도 |
| US11639371B2 (en) * | 2016-02-17 | 2023-05-02 | The Chinese University Of Hong Kong | Peptidylic inhibitors of nucleolin (NCL) targeting CAG-repeat RNA toxicity and methods for reducing polyQ-mediated toxicity in polyQ diseases |
| CN109414414A (zh) | 2016-03-16 | 2019-03-01 | 戴维·格拉德斯通研究所 | 用于治疗肥胖症和/或糖尿病以及用于鉴定候选治疗剂的方法和组合物 |
| AU2017290828A1 (en) | 2016-06-30 | 2019-01-24 | Virogin Biotech Canada Ltd | Pseudotyped oncolytic viral delivery of therapeutic polypeptides |
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| EP3731850A4 (en) | 2017-12-29 | 2021-12-01 | Oncorus, Inc. | ONCOLYTIC VIRUS DELIVERY OF THERAPEUTIC POLYPEPTIDES |
| EP3818167A4 (en) * | 2018-07-05 | 2022-04-13 | The Regents of The University of California | COMPOSITIONS AND METHODS FOR DELIVERING RNA TO A CELL |
| WO2021062196A1 (en) | 2019-09-26 | 2021-04-01 | President And Fellows Of Harvard College | Minimal arrestin domain containing protein 1 (arrdc1) constructs |
| US20250263690A1 (en) * | 2022-06-15 | 2025-08-21 | Duke University | Protein library display systems and methods thereof |
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| CN100549179C (zh) * | 2006-08-07 | 2009-10-14 | 汪运山 | 胃癌靶向AFP基因的siRNAs表达载体及其用途 |
| SI2539451T1 (sl) * | 2010-02-24 | 2016-04-29 | Arrowhead Research Corporation | Sestavki za ciljano dostavo sirna |
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2010
- 2010-03-15 JP JP2011554275A patent/JP2012520085A/ja active Pending
- 2010-03-15 KR KR1020117024110A patent/KR20110128345A/ko not_active Ceased
- 2010-03-15 AU AU2010223888A patent/AU2010223888A1/en not_active Abandoned
- 2010-03-15 CA CA2755245A patent/CA2755245A1/en not_active Abandoned
- 2010-03-15 CN CN2010800210226A patent/CN102625842A/zh active Pending
- 2010-03-15 US US12/724,408 patent/US8569065B2/en active Active
- 2010-03-15 EP EP10751551A patent/EP2406379A4/en not_active Withdrawn
- 2010-03-15 WO PCT/US2010/027365 patent/WO2010105277A1/en not_active Ceased
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2013
- 2013-03-11 US US13/793,961 patent/US20140005254A1/en not_active Abandoned
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017505638A (ja) * | 2014-02-14 | 2017-02-23 | シンヴィヴォ コーポレイション | ハイブリッドタンパクおよびその使用 |
Also Published As
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|---|---|
| US20140005254A1 (en) | 2014-01-02 |
| AU2010223888A1 (en) | 2011-10-06 |
| EP2406379A4 (en) | 2012-09-26 |
| EP2406379A1 (en) | 2012-01-18 |
| CA2755245A1 (en) | 2010-09-16 |
| CN102625842A (zh) | 2012-08-01 |
| KR20110128345A (ko) | 2011-11-29 |
| US8569065B2 (en) | 2013-10-29 |
| WO2010105277A1 (en) | 2010-09-16 |
| US20100233141A1 (en) | 2010-09-16 |
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