JP2012519671A - 初期段階の皮膚腫瘍の予防的又は治療的処置のためのペプチド - Google Patents
初期段階の皮膚腫瘍の予防的又は治療的処置のためのペプチド Download PDFInfo
- Publication number
- JP2012519671A JP2012519671A JP2011552477A JP2011552477A JP2012519671A JP 2012519671 A JP2012519671 A JP 2012519671A JP 2011552477 A JP2011552477 A JP 2011552477A JP 2011552477 A JP2011552477 A JP 2011552477A JP 2012519671 A JP2012519671 A JP 2012519671A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- peptide
- early stage
- therapeutic treatment
- dicitide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 58
- 238000011282 treatment Methods 0.000 title claims abstract description 35
- 208000000453 Skin Neoplasms Diseases 0.000 title claims abstract description 30
- 206010029098 Neoplasm skin Diseases 0.000 title claims abstract description 21
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 18
- 230000000069 prophylactic effect Effects 0.000 title claims abstract description 14
- 102000004196 processed proteins & peptides Human genes 0.000 title description 22
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 claims abstract description 18
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 claims abstract description 18
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 9
- 206010028980 Neoplasm Diseases 0.000 claims description 41
- 201000011510 cancer Diseases 0.000 claims description 17
- 238000011161 development Methods 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 10
- 208000009621 actinic keratosis Diseases 0.000 claims description 8
- 241000124008 Mammalia Species 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 6
- 239000003085 diluting agent Substances 0.000 claims description 4
- 239000003112 inhibitor Substances 0.000 claims description 4
- 230000003449 preventive effect Effects 0.000 claims description 4
- 201000010153 skin papilloma Diseases 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract description 9
- 241000699670 Mus sp. Species 0.000 description 27
- 208000003154 papilloma Diseases 0.000 description 20
- 210000003491 skin Anatomy 0.000 description 15
- 150000001413 amino acids Chemical class 0.000 description 14
- 230000000977 initiatory effect Effects 0.000 description 13
- ARSRBNBHOADGJU-UHFFFAOYSA-N 7,12-dimethyltetraphene Chemical compound C1=CC2=CC=CC=C2C2=C1C(C)=C(C=CC=C1)C1=C2C ARSRBNBHOADGJU-UHFFFAOYSA-N 0.000 description 12
- VFZRZRDOXPRTSC-UHFFFAOYSA-N DMBA Natural products COC1=CC(OC)=CC(C=O)=C1 VFZRZRDOXPRTSC-UHFFFAOYSA-N 0.000 description 12
- 235000001014 amino acid Nutrition 0.000 description 12
- 229940024606 amino acid Drugs 0.000 description 12
- 241001465754 Metazoa Species 0.000 description 10
- 201000000849 skin cancer Diseases 0.000 description 10
- 230000018109 developmental process Effects 0.000 description 9
- 150000003839 salts Chemical class 0.000 description 9
- 230000000699 topical effect Effects 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 239000006071 cream Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 206010041823 squamous cell carcinoma Diseases 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000006467 substitution reaction Methods 0.000 description 6
- 208000005623 Carcinogenesis Diseases 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 230000036952 cancer formation Effects 0.000 description 5
- 231100000504 carcinogenesis Toxicity 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000003211 malignant effect Effects 0.000 description 5
- 239000012049 topical pharmaceutical composition Substances 0.000 description 5
- 239000003981 vehicle Substances 0.000 description 5
- 206010004146 Basal cell carcinoma Diseases 0.000 description 4
- 230000004071 biological effect Effects 0.000 description 4
- 230000000711 cancerogenic effect Effects 0.000 description 4
- 230000004734 cutaneous carcinogenesis Effects 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 231100000315 carcinogenic Toxicity 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 201000001441 melanoma Diseases 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical compound C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 125000001165 hydrophobic group Chemical group 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 230000009545 invasion Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000036210 malignancy Effects 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 229940100611 topical cream Drugs 0.000 description 2
- 230000005740 tumor formation Effects 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 241000157302 Bison bison athabascae Species 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 206010064912 Malignant transformation Diseases 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 206010061309 Neoplasm progression Diseases 0.000 description 1
- 208000006994 Precancerous Conditions Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 206010064390 Tumour invasion Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 210000002469 basement membrane Anatomy 0.000 description 1
- 206010004398 benign neoplasm of skin Diseases 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000009400 cancer invasion Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000033077 cellular process Effects 0.000 description 1
- 229960002798 cetrimide Drugs 0.000 description 1
- 230000006328 chemical modification of amino acids Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 229940008099 dimethicone Drugs 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 244000144993 groups of animals Species 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 102000029316 human TGF-beta1 type III receptor (730-743) Human genes 0.000 description 1
- 108091022242 human TGF-beta1 type III receptor (730-743) Proteins 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 230000036212 malign transformation Effects 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 231100000590 oncogenic Toxicity 0.000 description 1
- 230000002246 oncogenic effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- -1 pomade Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 230000000722 protumoral effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 201000008261 skin carcinoma Diseases 0.000 description 1
- 239000002884 skin cream Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 235000000891 standard diet Nutrition 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000007838 tissue remodeling Effects 0.000 description 1
- 229940099456 transforming growth factor beta 1 Drugs 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 230000005748 tumor development Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 239000000717 tumor promoter Substances 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ESP200900694 | 2009-03-06 | ||
| ES200900694A ES2347627B1 (es) | 2009-03-06 | 2009-03-06 | Peptido para el tratamiento profilactico o terapeutico de tumores de la piel en estadios iniciales. |
| PCT/ES2010/070121 WO2010100310A1 (es) | 2009-03-06 | 2010-03-04 | Péptido para el tratamiento profiláctico o terapéutico de tumores de la piel en estadios iniciales |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012519671A true JP2012519671A (ja) | 2012-08-30 |
| JP2012519671A5 JP2012519671A5 (enExample) | 2013-04-18 |
Family
ID=42709234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011552477A Pending JP2012519671A (ja) | 2009-03-06 | 2010-03-04 | 初期段階の皮膚腫瘍の予防的又は治療的処置のためのペプチド |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8658599B2 (enExample) |
| EP (1) | EP2404611A4 (enExample) |
| JP (1) | JP2012519671A (enExample) |
| CN (1) | CN102341115A (enExample) |
| AR (1) | AR075783A1 (enExample) |
| AU (1) | AU2010219857A1 (enExample) |
| BR (1) | BRPI1013363A8 (enExample) |
| CA (1) | CA2753461A1 (enExample) |
| ES (1) | ES2347627B1 (enExample) |
| MX (1) | MX2011009225A (enExample) |
| RU (1) | RU2011140477A (enExample) |
| TW (1) | TW201036625A (enExample) |
| WO (1) | WO2010100310A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014183018A2 (en) * | 2013-05-10 | 2014-11-13 | Southern Research Institute | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASES THROUGH INHIBITING TGF-β ACTIVITY |
| CN110483648A (zh) * | 2019-08-27 | 2019-11-22 | 南京安吉生物科技有限公司 | 一种融合多肽及其应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007048857A1 (es) * | 2005-10-24 | 2007-05-03 | Proyecto De Biomedicina Cima, S.L. | USO DE PÉPTIDOS INHIBIDORES DE TGF- βl EN LA PREPARACIÓN DE UN AGENTE MODULADOR DE LA RESPUESTA INMUNE |
| JP2007523943A (ja) * | 2004-02-27 | 2007-08-23 | アンティセンス ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 医薬組成物 |
| JP2011523857A (ja) * | 2008-06-13 | 2011-08-25 | プロイェクト、デ、ビオメディシナ、シーマ、ソシエダッド、リミターダ | 生物学的活性を有する化合物の投与のための複合体 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2146552B1 (es) | 1998-11-24 | 2001-04-16 | Inst Cientifico Tecnol Navarra | Peptidos inhibidores de tgf/31 |
-
2009
- 2009-03-06 ES ES200900694A patent/ES2347627B1/es not_active Expired - Fee Related
-
2010
- 2010-03-03 AR ARP100100633A patent/AR075783A1/es not_active Application Discontinuation
- 2010-03-04 BR BRPI1013363A patent/BRPI1013363A8/pt not_active IP Right Cessation
- 2010-03-04 AU AU2010219857A patent/AU2010219857A1/en not_active Abandoned
- 2010-03-04 CA CA2753461A patent/CA2753461A1/en not_active Abandoned
- 2010-03-04 US US13/255,059 patent/US8658599B2/en not_active Expired - Fee Related
- 2010-03-04 JP JP2011552477A patent/JP2012519671A/ja active Pending
- 2010-03-04 WO PCT/ES2010/070121 patent/WO2010100310A1/es not_active Ceased
- 2010-03-04 RU RU2011140477/10A patent/RU2011140477A/ru not_active Application Discontinuation
- 2010-03-04 CN CN2010800105516A patent/CN102341115A/zh active Pending
- 2010-03-04 EP EP10748370A patent/EP2404611A4/en not_active Withdrawn
- 2010-03-04 MX MX2011009225A patent/MX2011009225A/es not_active Application Discontinuation
- 2010-03-05 TW TW099106502A patent/TW201036625A/zh unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007523943A (ja) * | 2004-02-27 | 2007-08-23 | アンティセンス ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 医薬組成物 |
| WO2007048857A1 (es) * | 2005-10-24 | 2007-05-03 | Proyecto De Biomedicina Cima, S.L. | USO DE PÉPTIDOS INHIBIDORES DE TGF- βl EN LA PREPARACIÓN DE UN AGENTE MODULADOR DE LA RESPUESTA INMUNE |
| JP2011523857A (ja) * | 2008-06-13 | 2011-08-25 | プロイェクト、デ、ビオメディシナ、シーマ、ソシエダッド、リミターダ | 生物学的活性を有する化合物の投与のための複合体 |
Non-Patent Citations (2)
| Title |
|---|
| JPN6014029913; Ｈａｎ ｅｔ ａｌ．: Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｉｎｖｅｓｔｉｇａｔｉｏｎ Ｖｏｌ．１１５， Ｎｏ．７, ｐ．１７１４-１７２３（２００５） * |
| JPN6014029915; Ａｋｈｕｒｓｔ: Ｃｕｒｒｅｎｔ Ｏｐｉｎｉｏｎ ｉｎ ｉｎｖｅｓｔｉｇａｔｉｏｎａｌ Ｄｒｕｇｓ Ｖｏｌ．７， Ｎｏ．６, ｐ．５１３-５２１（２００６） * |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2011009225A (es) | 2011-10-10 |
| CN102341115A (zh) | 2012-02-01 |
| WO2010100310A1 (es) | 2010-09-10 |
| BRPI1013363A8 (pt) | 2016-07-19 |
| TW201036625A (en) | 2010-10-16 |
| AR075783A1 (es) | 2011-04-27 |
| AU2010219857A1 (en) | 2011-10-06 |
| EP2404611A4 (en) | 2012-11-21 |
| ES2347627A1 (es) | 2010-11-02 |
| EP2404611A1 (en) | 2012-01-11 |
| BRPI1013363A2 (pt) | 2016-03-29 |
| CA2753461A1 (en) | 2010-09-10 |
| ES2347627B1 (es) | 2011-10-10 |
| RU2011140477A (ru) | 2013-04-27 |
| US20120065144A1 (en) | 2012-03-15 |
| US8658599B2 (en) | 2014-02-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Thi Hai Yen et al. | An overview on keratinocyte growth factor: from the molecular properties to clinical applications | |
| CN101820765A (zh) | 包含雄激素受体降解(ard)增强剂的组合物和预防性或治疗性治疗皮肤病与脱发的方法 | |
| JP2012508750A (ja) | 創傷形成後の毛包再生を促進する繊維芽細胞増殖因子‐９ | |
| US8652540B2 (en) | Method of using rhein for treating fibrotic conditions and tumors | |
| JP2012519671A (ja) | 初期段階の皮膚腫瘍の予防的又は治療的処置のためのペプチド | |
| US10857199B2 (en) | Compounds and methods for increasing hair growth | |
| JP6684350B2 (ja) | 短い合成ペプチド及びその使用 | |
| KR102003153B1 (ko) | 레졸빈 d2를 유효성분으로 함유하는 피부 염증 치료용 조성물 | |
| EP3435990B1 (en) | Stable pharmaceutical compositions for topical administration and uses thereof | |
| US20230285336A1 (en) | Composition for prevention and treatment of skin diseases caused by genetic mutation comprising ferulic acid and analogs thereof | |
| KR20230022002A (ko) | miR-16-5p 및 소마토스타틴 유사체를 포함하는 종양 예방 또는 치료용 약학적 조성물 | |
| CN106983738B (zh) | 甲状腺激素及其药学上可接受的盐或前药在制备治疗和/或预防皮肤疾病的药物中的应用 | |
| US20190365705A1 (en) | Topical tocotrienol compositions and methods of increasing skin stem cells | |
| US20240226233A1 (en) | Composition comprising zag-derived peptide for improving scars and keloids | |
| JP2018021044A (ja) | 脱毛症及び／又は毛髪色素脱失を治療するためのｐｅｄｆ由来のポリペプチドの使用 | |
| US9586989B1 (en) | Non-toxic skin cancer therapy with copper peptides | |
| AU2022336409A1 (en) | Protein compositions for the treatment of inflammatory diseases | |
| JP4477504B2 (ja) | 鎮痒剤 | |
| KR20190125102A (ko) | 이소트레티노인-펩타이드 결합체를 유효성분으로 포함하는 비만의 예방 또는 치료용 조성물 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20120813 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20120813 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130304 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20130304 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140715 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20141224 |