JP2012516308A - 放射性ヨウ素化方法 - Google Patents

放射性ヨウ素化方法 Download PDF

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Publication number
JP2012516308A
JP2012516308A JP2011546852A JP2011546852A JP2012516308A JP 2012516308 A JP2012516308 A JP 2012516308A JP 2011546852 A JP2011546852 A JP 2011546852A JP 2011546852 A JP2011546852 A JP 2011546852A JP 2012516308 A JP2012516308 A JP 2012516308A
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JP
Japan
Prior art keywords
compound
formula
group
radioiodinated
acid
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Pending
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JP2011546852A
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English (en)
Japanese (ja)
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JP2012516308A5 (enExample
Inventor
エイヴォリー，ミッシェル
ブラウン，ジェーン
イヴソン，ピーター・ブライアン
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GE Healthcare Ltd
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GE Healthcare Ltd
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Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of JP2012516308A publication Critical patent/JP2012516308A/ja
Publication of JP2012516308A5 publication Critical patent/JP2012516308A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C241/00—Preparation of compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C241/04—Preparation of hydrazides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C07D213/77—Hydrazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
JP2011546852A 2009-01-29 2010-01-29 放射性ヨウ素化方法 Pending JP2012516308A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB0901483.8A GB0901483D0 (en) 2009-01-29 2009-01-29 Radioiodination method
GB0901483.8 2009-01-29
US14841009P 2009-01-30 2009-01-30
US61/148,410 2009-01-30
PCT/EP2010/051053 WO2010086398A1 (en) 2009-01-29 2010-01-29 Radioiodination method

Publications (2)

Publication Number Publication Date
JP2012516308A true JP2012516308A (ja) 2012-07-19
JP2012516308A5 JP2012516308A5 (enExample) 2013-02-07

Family

ID=40469276

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011546852A Pending JP2012516308A (ja) 2009-01-29 2010-01-29 放射性ヨウ素化方法

Country Status (7)

Country Link
US (1) US20110280803A1 (enExample)
EP (1) EP2382185A1 (enExample)
JP (1) JP2012516308A (enExample)
CN (1) CN102300842A (enExample)
BR (1) BRPI1007020A2 (enExample)
GB (1) GB0901483D0 (enExample)
WO (1) WO2010086398A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11589960B2 (en) 2015-07-13 2023-02-28 Iucf-Hyu (Industry-University Cooperation Foundation Hanyang University) Customized alveolar bone tissue and method of forming the same

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4151278A4 (en) 2020-04-14 2024-05-22 The University of Tokyo BIOTIN MODIFIED DIMER AND ITS USES

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4279887A (en) * 1978-11-29 1981-07-21 Medi-Physics, Inc. Amides useful as brain imaging agents
JP2008507562A (ja) * 2004-07-23 2008-03-13 オンコロジック， インコーポレイテッド がんへのホットスポット放射線の多段階送達のための組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206370A (en) * 1989-02-24 1993-04-27 Johnson Matthey, Inc. Certain pyridyl hydrazines and hydrazides useful for protein labeling
US6800728B2 (en) * 2000-03-22 2004-10-05 Solulink Biosciences, Inc. Hydrazine-based and carbonyl-based bifunctional crosslinking reagents
GB0305704D0 (en) * 2003-03-13 2003-04-16 Amersham Plc Radiofluorination methods
GB0520529D0 (en) * 2005-10-10 2005-11-16 Ge Healthcare Ltd Automated radiolabelling method
TW200806326A (en) * 2006-07-28 2008-02-01 Inst Nuclear Energy Res Aec Method for manufacturing iodine-123-ADAM and automatic manufacturing device thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4279887A (en) * 1978-11-29 1981-07-21 Medi-Physics, Inc. Amides useful as brain imaging agents
JP2008507562A (ja) * 2004-07-23 2008-03-13 オンコロジック， インコーポレイテッド がんへのホットスポット放射線の多段階送達のための組成物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN5012007528; ＲＡＮＤＥＲＡＴＨ: '３-（［３-＜１２５＞Ｉ］ＩＯＤＯ-４-ＨＹＤＲＯＸＹＰＨＥＮＹＬ）ＰＲＯＰＩＯＮＹＬ　ＣＡＲＢＯＨＹＤＲＡＺＩＤＥ，　以下備考' ＡＮＡＬＹＴＩＣＡＬ　ＢＩＯＣＨＥＭＩＳＴＲＹ Ｖ１１５　Ｎ２, 198108, Ｐ３９１-３９７, ＡＣＡＤＥＭＩＣ　ＰＲＥＳＳ　ＩＮＣ． *
JPN5012007530; ＳＯＭＡＷＡＲＤＨＡＮＡ　Ｃ　Ｗ: 'ＳＹＮＴＨＥＳＩＳ　ＯＦ　２-［＜１２３＞Ｉ　ＡＮＤ　＜１２４＞Ｉ］-ＩＯＤＯＩＳＯＮＩＣＯＴＩＮＩＣ　ＡＣＩＤ　ＨＹＤＲＡＺＩＤＥ　-　ＰＯＴＥＮＴＩＡＬ　以下備考' ＡＰＰＬＩＥＤ　ＲＡＤＩＡＴＩＯＮ　ＡＮＤ　ＩＳＯＴＯＰＥＳ Ｖ４２　Ｎ３, 1991, Ｐ２１５-２２０ *
JPN5012007531; ＢＡＬＤＷＩＮ　Ｒ　Ｍ: 'ＳＴＲＵＣＴＵＲＥ-ＡＣＴＩＶＩＴＹ　ＲＥＬＡＴＩＯＮＳＨＩＰＳ　ＯＦ　ＩＯＤＩＮＥ-１２３-ＬＡＢＥＬＥＤ　Ｏ-ＩＯＤＯＢＥＮＺＡＭＩＤＥ　ＤＥＲＩＶＡＴＩＶＥＳ' ＪＯＵＲＮＡＬ　ＯＦ　ＲＡＤＩＯＡＮＡＬＹＴＩＣＡＬ　ＣＨＥＭＩＳＴＲＹ Ｖ６５　Ｎ１-２, 1981, Ｐ２６９-２７７ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11589960B2 (en) 2015-07-13 2023-02-28 Iucf-Hyu (Industry-University Cooperation Foundation Hanyang University) Customized alveolar bone tissue and method of forming the same

Also Published As

Publication number Publication date
US20110280803A1 (en) 2011-11-17
BRPI1007020A2 (pt) 2016-03-29
WO2010086398A1 (en) 2010-08-05
CN102300842A (zh) 2011-12-28
GB0901483D0 (en) 2009-03-11
EP2382185A1 (en) 2011-11-02

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