CN102300842A - 放射性碘标记方法 - Google Patents

放射性碘标记方法 Download PDF

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Publication number
CN102300842A
CN102300842A CN2010800062953A CN201080006295A CN102300842A CN 102300842 A CN102300842 A CN 102300842A CN 2010800062953 A CN2010800062953 A CN 2010800062953A CN 201080006295 A CN201080006295 A CN 201080006295A CN 102300842 A CN102300842 A CN 102300842A
Authority
CN
China
Prior art keywords
compound
formula
group
radioiodination
radioiodine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800062953A
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English (en)
Chinese (zh)
Inventor
M·阿沃里
J·布朗
P·B·艾夫森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of CN102300842A publication Critical patent/CN102300842A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C241/00—Preparation of compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C241/04—Preparation of hydrazides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C07D213/77—Hydrazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
CN2010800062953A 2009-01-29 2010-01-29 放射性碘标记方法 Pending CN102300842A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB0901483.8A GB0901483D0 (en) 2009-01-29 2009-01-29 Radioiodination method
GB0901483.8 2009-01-29
US14841009P 2009-01-30 2009-01-30
US61/148410 2009-01-30
PCT/EP2010/051053 WO2010086398A1 (en) 2009-01-29 2010-01-29 Radioiodination method

Publications (1)

Publication Number Publication Date
CN102300842A true CN102300842A (zh) 2011-12-28

Family

ID=40469276

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800062953A Pending CN102300842A (zh) 2009-01-29 2010-01-29 放射性碘标记方法

Country Status (7)

Country Link
US (1) US20110280803A1 (enExample)
EP (1) EP2382185A1 (enExample)
JP (1) JP2012516308A (enExample)
CN (1) CN102300842A (enExample)
BR (1) BRPI1007020A2 (enExample)
GB (1) GB0901483D0 (enExample)
WO (1) WO2010086398A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017010811A1 (ko) 2015-07-13 2017-01-19 한양대학교 산학협력단 맞춤형 치조골 조직 및 그 제조 방법
EP4151278A4 (en) 2020-04-14 2024-05-22 The University of Tokyo BIOTIN MODIFIED DIMER AND ITS USES

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4279887A (en) * 1978-11-29 1981-07-21 Medi-Physics, Inc. Amides useful as brain imaging agents
US5206370A (en) * 1989-02-24 1993-04-27 Johnson Matthey, Inc. Certain pyridyl hydrazines and hydrazides useful for protein labeling
US6800728B2 (en) * 2000-03-22 2004-10-05 Solulink Biosciences, Inc. Hydrazine-based and carbonyl-based bifunctional crosslinking reagents
GB0305704D0 (en) * 2003-03-13 2003-04-16 Amersham Plc Radiofluorination methods
US7615221B2 (en) * 2004-07-23 2009-11-10 Oncologic, Inc. Compositions and methods for treating cancer
GB0520529D0 (en) * 2005-10-10 2005-11-16 Ge Healthcare Ltd Automated radiolabelling method
TW200806326A (en) * 2006-07-28 2008-02-01 Inst Nuclear Energy Res Aec Method for manufacturing iodine-123-ADAM and automatic manufacturing device thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KURT RANDERATH: "3-([3-125I]Iodo-4-hydroxyphenyl)propionyl Carbohydrazide, a New Radioiodination Reagent for Ultrasensitive Detection and Determination of Periodate-Oxidized Nucleoside Derivatives and Other Carbonyl Compound", 《ANALYTICAL BIOCHEMISTR》 *
KURT RANDERATH: "3-([3-125I]Iodo-4-hydroxyphenyl)propionyl Carbohydrazide, a New Radioiodination Reagent for Ultrasensitive Detection and Determination of Periodate-Oxidized Nucleoside Derivatives and Other Carbonyl Compounds", 《ANALYTICAL BIOCHEMISTRY》 *

Also Published As

Publication number Publication date
JP2012516308A (ja) 2012-07-19
US20110280803A1 (en) 2011-11-17
BRPI1007020A2 (pt) 2016-03-29
WO2010086398A1 (en) 2010-08-05
GB0901483D0 (en) 2009-03-11
EP2382185A1 (en) 2011-11-02

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Application publication date: 20111228