JP2012515163A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012515163A5 JP2012515163A5 JP2011545487A JP2011545487A JP2012515163A5 JP 2012515163 A5 JP2012515163 A5 JP 2012515163A5 JP 2011545487 A JP2011545487 A JP 2011545487A JP 2011545487 A JP2011545487 A JP 2011545487A JP 2012515163 A5 JP2012515163 A5 JP 2012515163A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- matrix
- phase
- delivery system
- amphiphilic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 24
- 239000011159 matrix material Substances 0.000 claims description 15
- 150000001875 compounds Chemical class 0.000 claims description 6
- 238000012377 drug delivery Methods 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 210000001072 colon Anatomy 0.000 claims description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 4
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
- 239000003613 bile acid Substances 0.000 claims 1
- 230000000112 colonic effect Effects 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 239000003629 gastrointestinal hormone Substances 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 150000004668 long chain fatty acids Chemical class 0.000 claims 1
- 210000002438 upper gastrointestinal tract Anatomy 0.000 claims 1
- 229920000642 polymer Polymers 0.000 description 3
- 239000002253 acid Substances 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- OPJKGTJXHVPYIM-UHFFFAOYSA-N 2-methylprop-2-enamide;phenol Chemical compound CC(=C)C(N)=O.OC1=CC=CC=C1 OPJKGTJXHVPYIM-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- 229920000856 Amylose Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 229920002567 Chondroitin Polymers 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 229930182556 Polyacetal Natural products 0.000 description 1
- 108010039918 Polylysine Proteins 0.000 description 1
- 229920001710 Polyorthoester Polymers 0.000 description 1
- 239000000227 bioadhesive Substances 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- -1 cyclodexthn Polymers 0.000 description 1
- 229960002086 dextran Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 229920006324 polyoxymethylene Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14395109P | 2009-01-12 | 2009-01-12 | |
| US61/143,951 | 2009-01-12 | ||
| US29377310P | 2010-01-11 | 2010-01-11 | |
| US61/293,773 | 2010-01-11 | ||
| PCT/US2010/020629 WO2010081079A2 (en) | 2009-01-12 | 2010-01-11 | Composition and method for treatment of diabetes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012515163A JP2012515163A (ja) | 2012-07-05 |
| JP2012515163A5 true JP2012515163A5 (enExample) | 2013-02-14 |
| JP5702306B2 JP5702306B2 (ja) | 2015-04-15 |
Family
ID=42317190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011545487A Active JP5702306B2 (ja) | 2009-01-12 | 2010-01-11 | 糖尿病治療のための組成物及び方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8470885B2 (enExample) |
| EP (1) | EP2376077B1 (enExample) |
| JP (1) | JP5702306B2 (enExample) |
| KR (4) | KR20170138573A (enExample) |
| CN (1) | CN102355896A (enExample) |
| AU (1) | AU2010203413B2 (enExample) |
| BR (1) | BRPI1006145B8 (enExample) |
| CA (1) | CA2748827C (enExample) |
| CL (1) | CL2011001692A1 (enExample) |
| CY (1) | CY1119010T1 (enExample) |
| DK (1) | DK2376077T3 (enExample) |
| EA (1) | EA022631B1 (enExample) |
| ES (1) | ES2628233T3 (enExample) |
| HR (1) | HRP20170886T1 (enExample) |
| HU (1) | HUE034551T2 (enExample) |
| LT (1) | LT2376077T (enExample) |
| MX (1) | MX2011007393A (enExample) |
| PL (1) | PL2376077T3 (enExample) |
| PT (1) | PT2376077T (enExample) |
| RS (1) | RS56054B1 (enExample) |
| SI (1) | SI2376077T1 (enExample) |
| SM (1) | SMT201700278T1 (enExample) |
| WO (1) | WO2010081079A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2364161B1 (en) * | 2008-11-26 | 2020-03-11 | Satiogen Pharmaceuticals, Inc. | Compositions containing satiogens and methods of use |
| US20150224081A1 (en) * | 2009-01-12 | 2015-08-13 | Biokier, Inc. | Composition and method for treatment of diabetes |
| WO2012151252A2 (en) * | 2011-05-02 | 2012-11-08 | Biokier, Inc. | Composition and method for treatment of diabetes |
| US20220071895A1 (en) * | 2009-01-12 | 2022-03-10 | Biokier, Inc. | Composition and method for treatment of diabetes |
| US9144586B2 (en) | 2010-04-07 | 2015-09-29 | Incube Labs, Llc | Method for treating glucose related disorders using stem cell-derived gastro-intestinal cells |
| WO2011143511A2 (en) | 2010-05-12 | 2011-11-17 | Columbia University | Methods for producing enteroendocrine cells that make and secrete insulin |
| KR20130055220A (ko) | 2011-11-18 | 2013-05-28 | 삼성전자주식회사 | 동박적층판 및 이를 사용한 금속코어기판의 제조방법 |
| JP6089042B2 (ja) * | 2011-11-21 | 2017-03-01 | エマウス メディカル インコーポレイテッド | 糖尿病及び関連症状の治療のための方法及び組成物 |
| US20150073057A1 (en) * | 2013-09-06 | 2015-03-12 | Biokier, Inc. | Composition and method for treatment of diabetes |
| EP3160503B1 (en) | 2014-06-26 | 2021-02-17 | The Trustees of Columbia University in the City of New York | Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells |
| CN114366802A (zh) * | 2015-04-22 | 2022-04-19 | 西达-赛奈医疗中心 | 用于治疗2型糖尿病的肠内递送的苦味寡肽 |
| WO2016210384A2 (en) | 2015-06-25 | 2016-12-29 | Synlogic, Inc. | Bacteria engineered to treat metabolic diseases |
| US9668991B1 (en) | 2015-12-09 | 2017-06-06 | International Business Machines Corporation | SCFA colonic composition |
| CN107684550B (zh) * | 2016-08-03 | 2020-04-10 | 徐天宏 | 糖尿病治疗产品及其制备与应用 |
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| US20210084956A1 (en) | 2018-02-23 | 2021-03-25 | Ambra Bioscience Llc | Compositions and methods for hunger control and weight management |
| CN112839643A (zh) | 2018-06-20 | 2021-05-25 | 胺细拉健康公司 | 用于治疗肌肉中脂肪浸润的组合物及方法 |
| CN114340615A (zh) | 2019-08-12 | 2022-04-12 | 麻省理工学院 | 用于施用治疗剂的制品和方法 |
| US20230190686A1 (en) * | 2021-12-17 | 2023-06-22 | Biokier, Inc. | Composition and method for treatment of diabetes |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA885473B (en) * | 1987-08-07 | 1989-03-29 | Century Lab Inc | Free fatty acids for treatment of diabetes mellitus |
| IT1245890B (it) * | 1991-04-12 | 1994-10-25 | Alfa Wassermann Spa | Formulazioni farmaceutiche per uso orale gastroresistenti contenenti acidi biliari. |
| WO1999007342A1 (en) | 1997-08-11 | 1999-02-18 | Alza Corporation | Prolonged release active agent dosage form adapted for gastric retention |
| US6652882B1 (en) | 1997-10-06 | 2003-11-25 | Intellipharmaceutics Corp | Controlled release formulation containing bupropion |
| GB9722426D0 (en) | 1997-10-23 | 1997-12-24 | Univ London Pharmacy | Controlled release formulations |
| IL142650A (en) | 1998-04-08 | 2007-06-03 | Galmed Int Ltd | Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes |
| HK1046244B (zh) | 1999-06-14 | 2005-06-03 | 科斯默技术有限公司 | 控制释放与掩蔽味道的口服药物组合物 |
| DE60230591D1 (de) | 2001-02-26 | 2009-02-12 | Kissei Pharmaceutical | Glykopyranosyloxypyrazolderivate und deren medizinische verwendung |
| US20030203004A1 (en) * | 2002-04-24 | 2003-10-30 | Kelm Gary Robert | Compositions comprising short and long chain fatty acids and methods of their use for the management of body weight |
| US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| EP1506963B1 (en) | 2003-10-28 | 2005-04-13 | Adorkem Technology SpA | Method for the preparation of citalopram |
| ITMI20040187A1 (it) | 2004-02-06 | 2004-05-06 | Cosmo Spa | Composizioni farmaceutiche o dietetiche a base di acidi grassi a catena corta e zuccheri complessi per le disfunzioni intestinali |
| ITMI20041295A1 (it) | 2004-06-25 | 2004-09-25 | Cosmo Spa | Composizioni farmaceutiche antimicrobiche orali |
| JP2006056881A (ja) | 2004-07-21 | 2006-03-02 | Takeda Chem Ind Ltd | 縮合環化合物 |
| JP2006063064A (ja) | 2004-07-27 | 2006-03-09 | Takeda Chem Ind Ltd | 受容体作動剤 |
| AU2006250354A1 (en) | 2005-05-23 | 2006-11-30 | Japan Tobacco Inc. | Pyrazole compound and therapeutic agent for diabetes comprising the same |
| DE102005046237A1 (de) * | 2005-09-28 | 2007-04-05 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Buttersäureester von Kohlenhydraten und Kohlenhydratpolyolen |
| ITMI20052000A1 (it) | 2005-10-21 | 2007-04-22 | Promefarm S R L | Compressa gastroresitente a base di butirrato di sodio |
| KR20080089494A (ko) | 2006-01-20 | 2008-10-06 | 스미스클라인 비참 코포레이션 | 화합물 |
| WO2008067219A2 (en) | 2006-11-29 | 2008-06-05 | Kalypsys, Inc. | Quinazolinone modulators of tgr5 |
| CA2673054C (en) * | 2006-12-15 | 2016-05-10 | Tima Foundation | Novel compositions and uses thereof |
| EP2364161B1 (en) * | 2008-11-26 | 2020-03-11 | Satiogen Pharmaceuticals, Inc. | Compositions containing satiogens and methods of use |
| WO2010062861A2 (en) | 2008-11-26 | 2010-06-03 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of obesity and diabetes |
| SG173612A1 (en) | 2009-02-10 | 2011-09-29 | Amarin Pharma Inc | Use of eicosapentaenoic acid ethyl ester for treating hypertriglyceridemia |
| KR102012111B1 (ko) | 2009-06-15 | 2019-08-19 | 아마린 파마, 인크. | 병용 스타틴 요법을 받는 대상체에서 ｌｄｌ－ｃ 수준을 상승시키지 않으면서 트리글리세리드를 저하시키기 위한 조성물 및 방법 |
| BR122019016628B8 (pt) | 2009-09-23 | 2021-07-27 | Amarin Corp Plc | uso de uma composição compreendendo um derivado de hidróxi de atorvastatina ou sal farmaceuticamente aceitável do mesmo e um óleo compreendendo etil eicosapentaenoato ou etil docosahexaenoato para a fabricação de um medicamento para o tratamento de uma doença cardiovascular |
-
2010
- 2010-01-11 EP EP10729620.4A patent/EP2376077B1/en active Active
- 2010-01-11 US US13/143,766 patent/US8470885B2/en active Active
- 2010-01-11 MX MX2011007393A patent/MX2011007393A/es active IP Right Grant
- 2010-01-11 JP JP2011545487A patent/JP5702306B2/ja active Active
- 2010-01-11 HU HUE10729620A patent/HUE034551T2/en unknown
- 2010-01-11 BR BRPI1006145A patent/BRPI1006145B8/pt not_active IP Right Cessation
- 2010-01-11 CN CN201080004432XA patent/CN102355896A/zh active Pending
- 2010-01-11 DK DK10729620.4T patent/DK2376077T3/en active
- 2010-01-11 KR KR1020177034790A patent/KR20170138573A/ko not_active Ceased
- 2010-01-11 RS RS20170584A patent/RS56054B1/sr unknown
- 2010-01-11 ES ES10729620.4T patent/ES2628233T3/es active Active
- 2010-01-11 KR KR1020117015982A patent/KR20110120866A/ko not_active Ceased
- 2010-01-11 SM SM20170278T patent/SMT201700278T1/it unknown
- 2010-01-11 KR KR1020197015093A patent/KR20190062609A/ko not_active Ceased
- 2010-01-11 CA CA2748827A patent/CA2748827C/en active Active
- 2010-01-11 WO PCT/US2010/020629 patent/WO2010081079A2/en not_active Ceased
- 2010-01-11 LT LTEP10729620.4T patent/LT2376077T/lt unknown
- 2010-01-11 AU AU2010203413A patent/AU2010203413B2/en not_active Ceased
- 2010-01-11 KR KR1020177007518A patent/KR20170034928A/ko not_active Ceased
- 2010-01-11 HR HRP20170886TT patent/HRP20170886T1/hr unknown
- 2010-01-11 EA EA201190068A patent/EA022631B1/ru unknown
- 2010-01-11 PL PL10729620T patent/PL2376077T3/pl unknown
- 2010-01-11 PT PT107296204T patent/PT2376077T/pt unknown
- 2010-01-11 SI SI201031473T patent/SI2376077T1/sl unknown
-
2011
- 2011-07-11 CL CL2011001692A patent/CL2011001692A1/es unknown
-
2012
- 2012-10-08 US US13/646,778 patent/US8680085B2/en active Active
-
2017
- 2017-06-12 CY CY20171100614T patent/CY1119010T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012515163A5 (enExample) | ||
| Javanbakht et al. | Carboxymethyl cellulose-based oral delivery systems | |
| Aycan et al. | Development of pH-responsive chitosan-based hydrogel modified with bone ash for controlled release of amoxicillin | |
| Mi et al. | Chitin/PLGA blend microspheres as a biodegradable drug-delivery system: phase-separation, degradation and release behavior | |
| Levis et al. | Use of coated microtubular halloysite for the sustained release of diltiazem hydrochloride and propranolol hydrochloride | |
| Rao et al. | Novel thermo/pH sensitive nanogels composed from poly (N-vinylcaprolactam) for controlled release of an anticancer drug | |
| Fan et al. | Formation mechanism of monodisperse, low molecular weight chitosan nanoparticles by ionic gelation technique | |
| Carreira et al. | Temperature and pH responsive polymers based on chitosan: applications and new graft copolymerization strategies based on living radical polymerization | |
| Rao et al. | pH sensitive halloysite-sodium hyaluronate/poly (hydroxyethyl methacrylate) nanocomposites for colon cancer drug delivery | |
| Das et al. | Modified biopolymer-dextrin based crosslinked hydrogels: application in controlled drug delivery | |
| Tang et al. | Physical hydrogels with self-assembled nanostructures as drug delivery systems | |
| Yu et al. | Hybrid nanospheres and vesicles based on pectin as drug carriers | |
| JP2013508033A5 (enExample) | ||
| JP2013514977A5 (enExample) | ||
| RU2019129082A (ru) | Фармацевтическая композиция, содержащая электрогидродинамически полученные волокна, композиция, имеющая улучшенное время удержания в месте применения | |
| JP2017524743A5 (enExample) | ||
| JP2017520567A (ja) | 可溶性生物製剤、治療薬およびイメージング剤をカプセル化するためのプロセス | |
| Liu et al. | Preparation and characterization of glutaraldehyde cross-linked O-carboxymethylchitosan microspheres for controlled delivery of pazufloxacin mesilate | |
| Thakker et al. | Inter-polymer complex microspheres of chitosan and cellulose acetate phthalate for oral delivery of 5-fluorouracil | |
| JP2015120756A5 (enExample) | ||
| Işıklan et al. | Development and characterization of dual sensitive poly (N, N-diethyl acrylamide) grafted alginate microparticles | |
| Chang et al. | Thermo-responsive shell cross-linked PMMA-bP (NIPAAm-co-NAS) micelles for drug delivery | |
| Mura et al. | In vitro study of N-succinyl chitosan for targeted delivery of 5-aminosalicylic acid to colon | |
| Panday et al. | Calcium silicate‐reinforced pH‐sensitive alginate‐gellan gum composite hydrogels for prolonged drug delivery | |
| Ajaz et al. | Assessing the pH responsive and mucoadhesive behavior of dexamethasone sodium phosphate loaded itaconic acid-grafted-poly (acrylamide)/carbopol semi-interpenetrating networks |