EA022631B1 - Лекарственная форма, содержащая масляную кислоту или глутамин, и способ лечения состояния с повышенным уровнем глюкозы у субъекта - Google Patents
Лекарственная форма, содержащая масляную кислоту или глутамин, и способ лечения состояния с повышенным уровнем глюкозы у субъекта Download PDFInfo
- Publication number
- EA022631B1 EA022631B1 EA201190068A EA201190068A EA022631B1 EA 022631 B1 EA022631 B1 EA 022631B1 EA 201190068 A EA201190068 A EA 201190068A EA 201190068 A EA201190068 A EA 201190068A EA 022631 B1 EA022631 B1 EA 022631B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- composition
- diabetes
- subject
- glutamine
- matrix
- Prior art date
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Classifications
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
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| PCT/US2010/020629 WO2010081079A2 (en) | 2009-01-12 | 2010-01-11 | Composition and method for treatment of diabetes |
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| SM (1) | SMT201700278T1 (enExample) |
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Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2364161B1 (en) * | 2008-11-26 | 2020-03-11 | Satiogen Pharmaceuticals, Inc. | Compositions containing satiogens and methods of use |
| US20150224081A1 (en) * | 2009-01-12 | 2015-08-13 | Biokier, Inc. | Composition and method for treatment of diabetes |
| WO2012151252A2 (en) * | 2011-05-02 | 2012-11-08 | Biokier, Inc. | Composition and method for treatment of diabetes |
| US20220071895A1 (en) * | 2009-01-12 | 2022-03-10 | Biokier, Inc. | Composition and method for treatment of diabetes |
| US9144586B2 (en) | 2010-04-07 | 2015-09-29 | Incube Labs, Llc | Method for treating glucose related disorders using stem cell-derived gastro-intestinal cells |
| WO2011143511A2 (en) | 2010-05-12 | 2011-11-17 | Columbia University | Methods for producing enteroendocrine cells that make and secrete insulin |
| KR20130055220A (ko) | 2011-11-18 | 2013-05-28 | 삼성전자주식회사 | 동박적층판 및 이를 사용한 금속코어기판의 제조방법 |
| JP6089042B2 (ja) * | 2011-11-21 | 2017-03-01 | エマウス メディカル インコーポレイテッド | 糖尿病及び関連症状の治療のための方法及び組成物 |
| US20150073057A1 (en) * | 2013-09-06 | 2015-03-12 | Biokier, Inc. | Composition and method for treatment of diabetes |
| EP3160503B1 (en) | 2014-06-26 | 2021-02-17 | The Trustees of Columbia University in the City of New York | Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells |
| CN114366802A (zh) * | 2015-04-22 | 2022-04-19 | 西达-赛奈医疗中心 | 用于治疗2型糖尿病的肠内递送的苦味寡肽 |
| WO2016210384A2 (en) | 2015-06-25 | 2016-12-29 | Synlogic, Inc. | Bacteria engineered to treat metabolic diseases |
| US9668991B1 (en) | 2015-12-09 | 2017-06-06 | International Business Machines Corporation | SCFA colonic composition |
| CN107684550B (zh) * | 2016-08-03 | 2020-04-10 | 徐天宏 | 糖尿病治疗产品及其制备与应用 |
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| US20210084956A1 (en) | 2018-02-23 | 2021-03-25 | Ambra Bioscience Llc | Compositions and methods for hunger control and weight management |
| CN112839643A (zh) | 2018-06-20 | 2021-05-25 | 胺细拉健康公司 | 用于治疗肌肉中脂肪浸润的组合物及方法 |
| CN114340615A (zh) | 2019-08-12 | 2022-04-12 | 麻省理工学院 | 用于施用治疗剂的制品和方法 |
| US20230190686A1 (en) * | 2021-12-17 | 2023-06-22 | Biokier, Inc. | Composition and method for treatment of diabetes |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20030203004A1 (en) * | 2002-04-24 | 2003-10-30 | Kelm Gary Robert | Compositions comprising short and long chain fatty acids and methods of their use for the management of body weight |
| EP1790333A1 (en) * | 2005-10-21 | 2007-05-30 | Promefarm s.r.l. | Gastroresistant tablet comprising a butyric acid compound |
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| ZA885473B (en) * | 1987-08-07 | 1989-03-29 | Century Lab Inc | Free fatty acids for treatment of diabetes mellitus |
| IT1245890B (it) * | 1991-04-12 | 1994-10-25 | Alfa Wassermann Spa | Formulazioni farmaceutiche per uso orale gastroresistenti contenenti acidi biliari. |
| WO1999007342A1 (en) | 1997-08-11 | 1999-02-18 | Alza Corporation | Prolonged release active agent dosage form adapted for gastric retention |
| US6652882B1 (en) | 1997-10-06 | 2003-11-25 | Intellipharmaceutics Corp | Controlled release formulation containing bupropion |
| GB9722426D0 (en) | 1997-10-23 | 1997-12-24 | Univ London Pharmacy | Controlled release formulations |
| IL142650A (en) | 1998-04-08 | 2007-06-03 | Galmed Int Ltd | Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes |
| HK1046244B (zh) | 1999-06-14 | 2005-06-03 | 科斯默技术有限公司 | 控制释放与掩蔽味道的口服药物组合物 |
| DE60230591D1 (de) | 2001-02-26 | 2009-02-12 | Kissei Pharmaceutical | Glykopyranosyloxypyrazolderivate und deren medizinische verwendung |
| US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| EP1506963B1 (en) | 2003-10-28 | 2005-04-13 | Adorkem Technology SpA | Method for the preparation of citalopram |
| ITMI20040187A1 (it) | 2004-02-06 | 2004-05-06 | Cosmo Spa | Composizioni farmaceutiche o dietetiche a base di acidi grassi a catena corta e zuccheri complessi per le disfunzioni intestinali |
| ITMI20041295A1 (it) | 2004-06-25 | 2004-09-25 | Cosmo Spa | Composizioni farmaceutiche antimicrobiche orali |
| JP2006056881A (ja) | 2004-07-21 | 2006-03-02 | Takeda Chem Ind Ltd | 縮合環化合物 |
| JP2006063064A (ja) | 2004-07-27 | 2006-03-09 | Takeda Chem Ind Ltd | 受容体作動剤 |
| AU2006250354A1 (en) | 2005-05-23 | 2006-11-30 | Japan Tobacco Inc. | Pyrazole compound and therapeutic agent for diabetes comprising the same |
| DE102005046237A1 (de) * | 2005-09-28 | 2007-04-05 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Buttersäureester von Kohlenhydraten und Kohlenhydratpolyolen |
| KR20080089494A (ko) | 2006-01-20 | 2008-10-06 | 스미스클라인 비참 코포레이션 | 화합물 |
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| CA2673054C (en) * | 2006-12-15 | 2016-05-10 | Tima Foundation | Novel compositions and uses thereof |
| EP2364161B1 (en) * | 2008-11-26 | 2020-03-11 | Satiogen Pharmaceuticals, Inc. | Compositions containing satiogens and methods of use |
| WO2010062861A2 (en) | 2008-11-26 | 2010-06-03 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of obesity and diabetes |
| SG173612A1 (en) | 2009-02-10 | 2011-09-29 | Amarin Pharma Inc | Use of eicosapentaenoic acid ethyl ester for treating hypertriglyceridemia |
| KR102012111B1 (ko) | 2009-06-15 | 2019-08-19 | 아마린 파마, 인크. | 병용 스타틴 요법을 받는 대상체에서 ｌｄｌ－ｃ 수준을 상승시키지 않으면서 트리글리세리드를 저하시키기 위한 조성물 및 방법 |
| BR122019016628B8 (pt) | 2009-09-23 | 2021-07-27 | Amarin Corp Plc | uso de uma composição compreendendo um derivado de hidróxi de atorvastatina ou sal farmaceuticamente aceitável do mesmo e um óleo compreendendo etil eicosapentaenoato ou etil docosahexaenoato para a fabricação de um medicamento para o tratamento de uma doença cardiovascular |
-
2010
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- 2010-01-11 CN CN201080004432XA patent/CN102355896A/zh active Pending
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2011
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2012
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2017
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030203004A1 (en) * | 2002-04-24 | 2003-10-30 | Kelm Gary Robert | Compositions comprising short and long chain fatty acids and methods of their use for the management of body weight |
| EP1790333A1 (en) * | 2005-10-21 | 2007-05-30 | Promefarm s.r.l. | Gastroresistant tablet comprising a butyric acid compound |
Non-Patent Citations (3)
| Title |
|---|
| F. REIMANN, et al., "Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells", Diabetologia, 2004, Vol. 47, p. 1592-1601, ISSN 0012-186X, See p. 1592-1593, 1599, fig. 1-3, 6-7, abstract * |
| JERRY R. GREENFILD, et al., "Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects", American Journal of Clinical Nutrition, Epub 03 December 2008, Vol. 89, No. 1, p. 106-113, ISSN 1938-3297 (electronic), See p. 106-106, 111-123; fig. 2; abstract * |
| LI, et al., "Combination of GLP-1 and sodium butyrate promote differentiation of pancreatic progenitor cells into insulin-producing cells", Tissue and Cell, 2008, Vol. 40, p. 437-445, ISSN 0040-8166, See the whole document * |
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