JP2012515054A5 - - Google Patents
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- Publication number
- JP2012515054A5 JP2012515054A5 JP2011546304A JP2011546304A JP2012515054A5 JP 2012515054 A5 JP2012515054 A5 JP 2012515054A5 JP 2011546304 A JP2011546304 A JP 2011546304A JP 2011546304 A JP2011546304 A JP 2011546304A JP 2012515054 A5 JP2012515054 A5 JP 2012515054A5
- Authority
- JP
- Japan
- Prior art keywords
- implant
- cornea
- binder
- methacrylic acid
- hydroxyethyl methacrylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007943 implant Substances 0.000 claims 13
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims 2
- 239000011230 binding agent Substances 0.000 claims 2
- 210000004087 cornea Anatomy 0.000 claims 2
- 239000000017 hydrogel Substances 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims 2
- 239000004926 polymethyl methacrylate Substances 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 claims 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- 230000004888 barrier function Effects 0.000 claims 1
- 239000000560 biocompatible material Substances 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 1
- 229940117841 methacrylic acid copolymer Drugs 0.000 claims 1
- 229920002492 poly(sulfone) Polymers 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 229920002379 silicone rubber Polymers 0.000 claims 1
- 239000004945 silicone rubber Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/355,781 | 2009-01-18 | ||
| US12/355,781 US8109997B2 (en) | 2009-01-18 | 2009-01-18 | Hydrophobic pseudo-endothelial implants for treating corneal edema |
| PCT/US2010/020828 WO2010083173A2 (en) | 2009-01-18 | 2010-01-13 | Hydrophobic pseudo-endothelial implants for treating corneal edema |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012515054A JP2012515054A (ja) | 2012-07-05 |
| JP2012515054A5 true JP2012515054A5 (https=) | 2013-02-28 |
| JP5909094B2 JP5909094B2 (ja) | 2016-04-26 |
Family
ID=42272516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011546304A Active JP5909094B2 (ja) | 2009-01-18 | 2010-01-13 | 角膜浮腫を治療するための疎水性疑似内皮インプラント |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8109997B2 (https=) |
| EP (1) | EP2389137B1 (https=) |
| JP (1) | JP5909094B2 (https=) |
| CN (2) | CN102368975A (https=) |
| ES (1) | ES2442768T3 (https=) |
| WO (1) | WO2010083173A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2437684B1 (en) | 2009-06-03 | 2022-06-15 | ForSight Vision5, Inc. | Anterior segment drug delivery |
| WO2011115974A1 (en) | 2010-03-15 | 2011-09-22 | Indiana University Research And Technology Corporation | Engineered lumenized vascular networks and support matrix |
| BR112013031652A2 (pt) | 2011-06-09 | 2019-09-24 | Univ Miami | métodos de tratamento para doenças retinais |
| US9308083B2 (en) | 2011-10-21 | 2016-04-12 | Endoshield, Llc | Corneal implant and method of delivering a corneal implant |
| CA2927321A1 (en) * | 2013-10-15 | 2015-04-23 | Forsight Vision5, Inc. | Formulations and methods for increasing or reducing mucus |
| US20160184084A1 (en) * | 2014-12-29 | 2016-06-30 | Ofer Daphna | Keratoprosthesis |
| US20160296532A1 (en) | 2015-04-13 | 2016-10-13 | Forsight Vision5, Inc. | Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent |
| US10966863B2 (en) | 2018-01-08 | 2021-04-06 | EyeYon Medical Ltd. | Treatment to improve adhesive properties of corneal implant |
| US20200170786A1 (en) | 2018-12-02 | 2020-06-04 | EyeYon Medical Ltd. | Corneal implant with peripheral skirt |
| CN113101411A (zh) * | 2021-04-14 | 2021-07-13 | 广州宏达医疗设备有限公司 | 一种角膜基质内人工角膜内皮及其制备方法 |
| US11737919B2 (en) * | 2021-06-17 | 2023-08-29 | EyeYon Medical Ltd. | Endothelial ocular implant |
| DE102021130009A1 (de) | 2021-11-17 | 2023-05-17 | Universität Rostock, Körperschaft des öffentlichen Rechts | Stützmembran sowie Verfahren zur Herstellung einer Stützmembran |
| US20240123120A1 (en) * | 2022-07-13 | 2024-04-18 | Eye Institute Of Shandong First Medical University | High-adhesion artificial corneal endothelial sheet, preparation method and use thereof |
| WO2023142471A1 (zh) * | 2022-08-25 | 2023-08-03 | 山东第一医科大学附属眼科研究所(山东省眼科研究所、山东第一医科大学附属青岛眼科医院) | 一种大直径人工角膜内皮片及其应用 |
| US20240108454A1 (en) * | 2022-10-03 | 2024-04-04 | EyeYon Medical Ltd. | Patch to treat corneal perforation |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4983181A (en) * | 1986-10-16 | 1991-01-08 | Cbs Lens, | Collagen hydrogel for promoting epithelial cell growth and artificial lens using the same |
| US4842599A (en) | 1986-10-28 | 1989-06-27 | Ann M. Bronstein | Prosthetic cornea and method of implantation therefor |
| CN1189777A (zh) * | 1995-05-05 | 1998-08-05 | 蛋白质聚合物技术有限公司 | 利用合成交联剂的组织粘合剂 |
| US6106554A (en) * | 1999-02-25 | 2000-08-22 | Bausch & Lomb Surgical, Inc. | Intraocular lens implants for the prevention of secondary cataracts |
| EP1364663A1 (en) * | 2002-05-21 | 2003-11-26 | Commonwealth Scientific And Industrial Research Organisation | Ocular devices with functionalized surface with adhesive properties |
| MXPA05001570A (es) * | 2002-08-09 | 2005-08-19 | Ottawa Health Research Inst | Matriz biosintetica y sus usos. |
| CN1694658A (zh) * | 2002-09-13 | 2005-11-09 | 眼科科学公司 | 用于改善视力的装置和方法 |
| US20060173539A1 (en) * | 2005-01-31 | 2006-08-03 | Yichieh Shiuey | Corneal implants and methods and systems for placement |
| EP1944045B1 (en) * | 2005-07-25 | 2013-09-18 | Foundation for Biomedical Research and Innovation | Sheet-like composition |
| WO2007047425A1 (en) * | 2005-10-12 | 2007-04-26 | Cellular Bioengineering, Inc. | Resorbable cornea button |
| TWI399228B (zh) | 2006-07-21 | 2013-06-21 | Alcon Inc | 低黏性的眼科與耳鼻喉科裝置材料（二） |
| US20080124276A1 (en) | 2006-07-24 | 2008-05-29 | Lifeline Cell Technology | Synthetic cornea from retinal stem cells |
| EP2077900A2 (en) * | 2006-10-30 | 2009-07-15 | SHIUEY, Yichieh | Methods and systems for immobilizing corneal prostheses |
| US20080243156A1 (en) * | 2007-03-30 | 2008-10-02 | Thomas John | Ophthalmic surgical instrument & surgical methods |
| WO2009146151A2 (en) | 2008-04-04 | 2009-12-03 | Forsight Labs, Llc | Corneal onlay devices and methods |
| CN101297977B (zh) * | 2008-06-16 | 2012-02-29 | 中国海洋大学 | 一种生物粘合剂及其应用 |
-
2009
- 2009-01-18 US US12/355,781 patent/US8109997B2/en active Active - Reinstated
-
2010
- 2010-01-13 WO PCT/US2010/020828 patent/WO2010083173A2/en not_active Ceased
- 2010-01-13 CN CN2010800098160A patent/CN102368975A/zh active Pending
- 2010-01-13 ES ES10707705.9T patent/ES2442768T3/es active Active
- 2010-01-13 JP JP2011546304A patent/JP5909094B2/ja active Active
- 2010-01-13 CN CN201610893886.6A patent/CN106913901B/zh active Active
- 2010-01-13 EP EP10707705.9A patent/EP2389137B1/en active Active
-
2012
- 2012-02-07 US US13/367,384 patent/US8500803B2/en active Active
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