JP2012514592A - 発明の名称 - Google Patents
発明の名称 Download PDFInfo
- Publication number
- JP2012514592A JP2012514592A JP2011544101A JP2011544101A JP2012514592A JP 2012514592 A JP2012514592 A JP 2012514592A JP 2011544101 A JP2011544101 A JP 2011544101A JP 2011544101 A JP2011544101 A JP 2011544101A JP 2012514592 A JP2012514592 A JP 2012514592A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- sunscreen
- absorbers
- vitamin
- benzophenone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims abstract description 107
- 239000000516 sunscreening agent Substances 0.000 claims abstract description 86
- 230000000475 sunscreen effect Effects 0.000 claims abstract description 83
- 230000005855 radiation Effects 0.000 claims abstract description 25
- 239000006096 absorbing agent Substances 0.000 claims abstract description 24
- 238000004519 manufacturing process Methods 0.000 claims abstract description 17
- 230000004224 protection Effects 0.000 claims abstract description 15
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims abstract description 13
- 201000010099 disease Diseases 0.000 claims abstract description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 9
- 239000012707 chemical precursor Substances 0.000 claims abstract description 7
- -1 Ubinal A Plus Chemical compound 0.000 claims description 40
- XNEFYCZVKIDDMS-UHFFFAOYSA-N avobenzone Chemical compound C1=CC(OC)=CC=C1C(=O)CC(=O)C1=CC=C(C(C)(C)C)C=C1 XNEFYCZVKIDDMS-UHFFFAOYSA-N 0.000 claims description 34
- 229960005193 avobenzone Drugs 0.000 claims description 30
- 238000009472 formulation Methods 0.000 claims description 30
- FMRHJJZUHUTGKE-UHFFFAOYSA-N Ethylhexyl salicylate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1O FMRHJJZUHUTGKE-UHFFFAOYSA-N 0.000 claims description 28
- 239000004904 UV filter Substances 0.000 claims description 26
- 229960003921 octisalate Drugs 0.000 claims description 26
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 claims description 25
- 239000004480 active ingredient Substances 0.000 claims description 23
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 claims description 23
- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 claims description 22
- 229960004881 homosalate Drugs 0.000 claims description 20
- 229960001173 oxybenzone Drugs 0.000 claims description 19
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 claims description 14
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 13
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 12
- 229960001679 octinoxate Drugs 0.000 claims description 12
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical group C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 claims description 12
- 229960000601 octocrylene Drugs 0.000 claims description 12
- 230000015572 biosynthetic process Effects 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 11
- NZZIMKJIVMHWJC-UHFFFAOYSA-N dibenzoylmethane Chemical compound C=1C=CC=CC=1C(=O)CC(=O)C1=CC=CC=C1 NZZIMKJIVMHWJC-UHFFFAOYSA-N 0.000 claims description 10
- CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 claims description 10
- JGUMTYWKIBJSTN-UHFFFAOYSA-N 2-ethylhexyl 4-[[4,6-bis[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 JGUMTYWKIBJSTN-UHFFFAOYSA-N 0.000 claims description 9
- 206010042496 Sunburn Diseases 0.000 claims description 9
- 230000036541 health Effects 0.000 claims description 9
- 239000006210 lotion Substances 0.000 claims description 9
- MJVGBKJNTFCUJM-UHFFFAOYSA-N mexenone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=C(C)C=C1 MJVGBKJNTFCUJM-UHFFFAOYSA-N 0.000 claims description 9
- QUAMTGJKVDWJEQ-UHFFFAOYSA-N octabenzone Chemical compound OC1=CC(OCCCCCCCC)=CC=C1C(=O)C1=CC=CC=C1 QUAMTGJKVDWJEQ-UHFFFAOYSA-N 0.000 claims description 9
- LALVCWMSKLEQMK-UHFFFAOYSA-N 1-phenyl-3-(4-propan-2-ylphenyl)propane-1,3-dione Chemical compound C1=CC(C(C)C)=CC=C1C(=O)CC(=O)C1=CC=CC=C1 LALVCWMSKLEQMK-UHFFFAOYSA-N 0.000 claims description 8
- 241000282412 Homo Species 0.000 claims description 8
- WYWZRNAHINYAEF-AWEZNQCLSA-N [(2s)-2-ethylhexyl] 4-(dimethylamino)benzoate Chemical compound CCCC[C@H](CC)COC(=O)C1=CC=C(N(C)C)C=C1 WYWZRNAHINYAEF-AWEZNQCLSA-N 0.000 claims description 8
- FQUNFJULCYSSOP-UHFFFAOYSA-N bisoctrizole Chemical compound N1=C2C=CC=CC2=NN1C1=CC(C(C)(C)CC(C)(C)C)=CC(CC=2C(=C(C=C(C=2)C(C)(C)CC(C)(C)C)N2N=C3C=CC=CC3=N2)O)=C1O FQUNFJULCYSSOP-UHFFFAOYSA-N 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 239000002207 metabolite Substances 0.000 claims description 8
- 229960002638 padimate o Drugs 0.000 claims description 8
- HEOCBCNFKCOKBX-RELGSGGGSA-N (1s,2e,4r)-4,7,7-trimethyl-2-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-3-one Chemical compound C1=CC(C)=CC=C1\C=C/1C(=O)[C@]2(C)CC[C@H]\1C2(C)C HEOCBCNFKCOKBX-RELGSGGGSA-N 0.000 claims description 7
- MEZZCSHVIGVWFI-UHFFFAOYSA-N 2,2'-Dihydroxy-4-methoxybenzophenone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1O MEZZCSHVIGVWFI-UHFFFAOYSA-N 0.000 claims description 7
- ORWUQAQITKSSRZ-UHFFFAOYSA-N 2-hydroxyethyl 4-[bis[2-(2-hydroxyethoxy)ethyl]amino]benzoate Chemical compound OCCOCCN(CCOCCO)C1=CC=C(C(=O)OCCO)C=C1 ORWUQAQITKSSRZ-UHFFFAOYSA-N 0.000 claims description 7
- SODJJEXAWOSSON-UHFFFAOYSA-N bis(2-hydroxy-4-methoxyphenyl)methanone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=C(OC)C=C1O SODJJEXAWOSSON-UHFFFAOYSA-N 0.000 claims description 7
- QDCHWIWENYCPIL-UHFFFAOYSA-L disodium;4-hydroxy-5-(2-hydroxy-4-methoxy-5-sulfonatobenzoyl)-2-methoxybenzenesulfonate Chemical compound [Na+].[Na+].C1=C(S([O-])(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC(S([O-])(=O)=O)=C(OC)C=C1O QDCHWIWENYCPIL-UHFFFAOYSA-L 0.000 claims description 7
- LXTZRIBXKVRLOA-UHFFFAOYSA-N padimate a Chemical compound CCCCCOC(=O)C1=CC=C(N(C)C)C=C1 LXTZRIBXKVRLOA-UHFFFAOYSA-N 0.000 claims description 7
- ZXDDPOHVAMWLBH-UHFFFAOYSA-N 2,4-Dihydroxybenzophenone Chemical compound OC1=CC(O)=CC=C1C(=O)C1=CC=CC=C1 ZXDDPOHVAMWLBH-UHFFFAOYSA-N 0.000 claims description 6
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 claims description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
- 229960004050 aminobenzoic acid Drugs 0.000 claims description 6
- 239000012965 benzophenone Substances 0.000 claims description 6
- 229940079894 benzophenone-9 Drugs 0.000 claims description 6
- WXNRYSGJLQFHBR-UHFFFAOYSA-N bis(2,4-dihydroxyphenyl)methanone Chemical compound OC1=CC(O)=CC=C1C(=O)C1=CC=C(O)C=C1O WXNRYSGJLQFHBR-UHFFFAOYSA-N 0.000 claims description 6
- MCPKSFINULVDNX-UHFFFAOYSA-N drometrizole Chemical compound CC1=CC=C(O)C(N2N=C3C=CC=CC3=N2)=C1 MCPKSFINULVDNX-UHFFFAOYSA-N 0.000 claims description 6
- 229950000999 mexenone Drugs 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 239000011787 zinc oxide Substances 0.000 claims description 6
- VHWSRELATOUTAG-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-aminobenzoate Chemical compound NC1=CC=CC=C1C(=O)OCC(O)CO VHWSRELATOUTAG-UHFFFAOYSA-N 0.000 claims description 5
- HMKKFLSUPRUBOO-IUPFWZBJSA-N 3,4-dihydroxy-5-[3,4,5-tris[[(z)-octadec-9-enoyl]oxy]benzoyl]oxybenzoic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC1=C(OC(=O)CCCCCCC\C=C/CCCCCCCC)C(OC(=O)CCCCCCC\C=C/CCCCCCCC)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(O)=O)O)=C1 HMKKFLSUPRUBOO-IUPFWZBJSA-N 0.000 claims description 5
- UBNYRXMKIIGMKK-RMKNXTFCSA-N amiloxate Chemical compound COC1=CC=C(\C=C\C(=O)OCCC(C)C)C=C1 UBNYRXMKIIGMKK-RMKNXTFCSA-N 0.000 claims description 5
- XVAMCHGMPYWHNL-UHFFFAOYSA-N bemotrizinol Chemical compound OC1=CC(OCC(CC)CCCC)=CC=C1C1=NC(C=2C=CC(OC)=CC=2)=NC(C=2C(=CC(OCC(CC)CCCC)=CC=2)O)=N1 XVAMCHGMPYWHNL-UHFFFAOYSA-N 0.000 claims description 5
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 claims description 5
- YEAYGXLRPMKZBP-KQGICBIGSA-N bis(2-hydroxyethyl)azanium;(e)-3-(4-methoxyphenyl)prop-2-enoate Chemical compound OCCNCCO.COC1=CC=C(\C=C\C(O)=O)C=C1 YEAYGXLRPMKZBP-KQGICBIGSA-N 0.000 claims description 5
- 229960004697 enzacamene Drugs 0.000 claims description 5
- 229960002824 padimate a Drugs 0.000 claims description 5
- 230000019612 pigmentation Effects 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 238000001228 spectrum Methods 0.000 claims description 5
- 229960000368 sulisobenzone Drugs 0.000 claims description 5
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 239000004408 titanium dioxide Substances 0.000 claims description 4
- ZQTYRTSKQFQYPQ-UHFFFAOYSA-N trisiloxane Chemical compound [SiH3]O[SiH2]O[SiH3] ZQTYRTSKQFQYPQ-UHFFFAOYSA-N 0.000 claims description 4
- UEVAMYPIMMOEFW-UHFFFAOYSA-N trolamine salicylate Chemical compound OCCN(CCO)CCO.OC(=O)C1=CC=CC=C1O UEVAMYPIMMOEFW-UHFFFAOYSA-N 0.000 claims description 4
- JWUBBDSIWDLEOM-NQZHSCJISA-N 25-hydroxy-3 epi cholecalciferol Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@H](O)CCC1=C JWUBBDSIWDLEOM-NQZHSCJISA-N 0.000 claims description 3
- HEAHZSUCFKFERC-LRVMPXQBSA-N [(2e)-2-[[4-[(z)-[7,7-dimethyl-3-oxo-4-(sulfomethyl)-2-bicyclo[2.2.1]heptanylidene]methyl]phenyl]methylidene]-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonic acid Chemical compound CC1(C)C2CCC1(CS(O)(=O)=O)C(=O)\C2=C/C(C=C1)=CC=C1\C=C/1C(=O)C2(CS(O)(=O)=O)CCC\1C2(C)C HEAHZSUCFKFERC-LRVMPXQBSA-N 0.000 claims description 3
- 229960004101 bemotrizinol Drugs 0.000 claims description 3
- 239000002537 cosmetic Substances 0.000 claims description 3
- FDATWRLUYRHCJE-UHFFFAOYSA-N diethylamino hydroxybenzoyl hexyl benzoate Chemical compound CCCCCCOC(=O)C1=CC=CC=C1C(=O)C1=CC=C(N(CC)CC)C=C1O FDATWRLUYRHCJE-UHFFFAOYSA-N 0.000 claims description 3
- 239000003974 emollient agent Substances 0.000 claims description 3
- 239000000499 gel Substances 0.000 claims description 3
- 230000003711 photoprotective effect Effects 0.000 claims description 3
- 239000002243 precursor Substances 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 229960001860 salicylate Drugs 0.000 claims description 3
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 claims description 3
- 241000894006 Bacteria Species 0.000 claims description 2
- 241000283690 Bos taurus Species 0.000 claims description 2
- 241000282472 Canis lupus familiaris Species 0.000 claims description 2
- 241000283707 Capra Species 0.000 claims description 2
- 241000283086 Equidae Species 0.000 claims description 2
- 241000282326 Felis catus Species 0.000 claims description 2
- 206010020772 Hypertension Diseases 0.000 claims description 2
- 239000004909 Moisturizer Substances 0.000 claims description 2
- 208000008589 Obesity Diseases 0.000 claims description 2
- 241000282887 Suidae Species 0.000 claims description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 229960003747 ecamsule Drugs 0.000 claims description 2
- 239000003995 emulsifying agent Substances 0.000 claims description 2
- 239000000077 insect repellent Substances 0.000 claims description 2
- 239000007934 lip balm Substances 0.000 claims description 2
- 206010025135 lupus erythematosus Diseases 0.000 claims description 2
- 230000001333 moisturizer Effects 0.000 claims description 2
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- 210000002966 serum Anatomy 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 229960004418 trolamine Drugs 0.000 claims description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 2
- ITZXULOAYIAYNU-UHFFFAOYSA-N cerium(4+) Chemical compound [Ce+4] ITZXULOAYIAYNU-UHFFFAOYSA-N 0.000 claims 4
- 229960003055 bisoctrizole Drugs 0.000 claims 3
- 229940030300 trolamine salicylate Drugs 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 2
- YIYBRXKMQFDHSM-UHFFFAOYSA-N 2,2'-Dihydroxybenzophenone Chemical compound OC1=CC=CC=C1C(=O)C1=CC=CC=C1O YIYBRXKMQFDHSM-UHFFFAOYSA-N 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
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- SOXAGEOHPCXXIO-DVOMOZLQSA-N menthyl anthranilate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)C1=CC=CC=C1N SOXAGEOHPCXXIO-DVOMOZLQSA-N 0.000 claims 1
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- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 claims 1
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- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims 1
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Abstract
【選択図】 なし
Description
以下に異名を示すと、プレビタミンD3はコレカルシフェロールであり、25−ヒドロキシビタミンは25(OH)D3又はカルシジオールであり、1,25−ジヒドロキシビタミンD3は1,25(OH)2D3又はカルシトリオールである。本特許において、ビタミンDはビタミンD3を表し、ときには広義の意味で用いられる。
1つの有機分子の吸光範囲中でさえ、吸収は均一でなく、その範囲の端近くでは吸収は通常低くなることを理解することが重要である。日焼け止め剤の製造業者は、一般的にUVスペクトルの異なる部分を遮断するために複数の活性成分を使用しており、それによって放射光の広いスペクトルからの保護を提供している。
DNAの吸光スペクトルは、250〜265nmにおいて高い吸光度を、265〜290nmにおいて中程度の吸光度を、290〜308nmにおいて低い吸光度からゼロの吸光度を示す。本発明の日焼け止め製剤の観点から、皮膚への透過が許される波長は、一般的に290〜315nmであり、DNA及びRNAによる吸光が行われにくい範囲である。
としても知られている、CAS #:56265−46−4)、パラ−メトキシ桂皮酸イソアミル(4−メトキシ桂皮酸イソペンテニル、IMC、ネオへリオパンE1000またはアミロキサート、CAS #:71617−10−2)、ジベンゾイルメタン(ジベンゾイルメタンとしても知られている、CAS #: 120−46−7)、ビスオクトリゾール(チノソーブM、メチレン ビス−ベンゾトリアゾリルテトラメチルブチルフェノールまたはMBBTとしても知られている、CAS # 103597−45−1)、酸化亜鉛(ZnOとしても知られている)、二酸化チタン(酸化チタン(IV)、TiO2またはチタニア)、酸化セリウム(IV)(セリア、酸化セリウムまたはCeO2としても知られている)、エンスリゾール(フェニルベンズイミダゾールスルホン酸、フェニルベンズイミダゾール、2−フェニルベンズイミダゾール−5−スルホン酸、PBSA、パーソルHS、CAS #:27503−81−7)、アミノ安息香酸(4−アミノ安息香酸、パラ−アミノ安息香酸またはPABAとしても知られている、CAS #:150−13−0)、パジメートO(他にはパジメートO、エチルヘキシルジメチルPABA、2−エチルヘキシル4−ジメチルアミノ安息香酸塩、エスカロール507、オクチルジメチルPABAまたはOD−PABAとしても知られている、CAS #:21245−02−3)、パディメート−A(アミル パラ−ジメチルアミノ安息香酸塩、アミル パラジメチルアミノ安息香酸塩またはアミルジメチルPABAとしても知られている、CAS # 21245−01−2)、グリセリルアミノ安息香酸塩(グリセリルパラ−アミノ安息香酸塩、グリセリルPABA、グリセリル1−(4−アミノ安息香酸塩)、モノグリセリルエステルまたはリサジメート、CAS #:136−44−7)、エチルヘキシルトリアゾン(オクチルトリアゾン、エチルヘキシルトリアゾン、ユビナールT150またはETとしても知られている、CAS #:88122−99−0)、トロラミンサリチル酸(トリエタノールアミンサリチル酸またはTEAサリチル酸、CAS #:002174−16−5)、ドロメトリゾールトリシロキサン(DTS、メキソリルXLとしても知られている、CAS #:155633−54−8)、ベモトリジノール(チノソーブS、ビス−エチルヘキシルオキシフェノールメトキシフェニルトリアジン、ビス(エチルヘキシルオキシフェノール)トリアジン、BEMTまたはアニソトリアジンとしても知られている、CAS #:187393−00−6)、イスコトリジノール(Iscotrizinol)(ユバソーブHEB、ジエチルヘキシルブタミドトリアゾン、ジオクチルブタミドトリアゾンまたはDBT、CAS #:154702−15−5)、及び、ジガロイルトリオレエート(他には5−(3,3−ジメチルノルボルニリデン)−3ペンテン−2−オン、CAS #17048−39−4)。ビタミンDが生成する範囲においてそれらの吸収のため、米国公報番号2004/0091433 A1に記載されたような化学式の化合物は、本発明の成分としては不適当である。
当該特質により損なうことを除いて、本発明により考察される。例えば、オキシベンゾン、TDSA及びビスジスリゾールジナトリウムにおける吸収曲線の変動は、試料を中和するのに使用された基剤(TEAまたはNaOH)の結果として報告された。
特定の領域に塗布される。例えば、日焼け止め使用者は、彼または彼女の腕及び脚のみに適当な成分を有し、顔には不適当な成分を有する日焼け止めを同時に使用したくなることがある。
Claims (34)
- 紫外線に対する防御を提供するのに適切な組成物であって、この組成物は、1つ又は複数の活性ある紫外線吸収剤を含有するものであり、それにより、健康に良く疾病に対抗する量のビタミンD3及びその化学的前駆体を身体に生産させるのに十分な量の紫外線Bが、皮膚に入ることを許すものである、組成物。
- 請求項1記載の組成物において、この組成物は、1つ又は複数の紫外線吸収剤をさらに有する日焼け止め剤であって、ここで、この1つ又は複数の紫外線吸収剤は、皮膚の平方センチメートル毎に、0.01〜50mgのローションの量で塗布されるとき、295〜315nmの範囲における紫外線の約0%〜75%を吸収するものである。
- 請求項1記載の組成物において、この組成物は、1つ又は複数の紫外線吸収剤をさらに有する日焼け止め剤であって、ここで、前記1つ又は複数の紫外線吸収剤は、メラジメート(Meradimate)、スリソベンゾン(Sulisobenzone)、ユビナールA Plus(Uvinul A Plus)、ベンゾフェノン−9、オキシベンゾン(Oxybenzone)、メキセノン(Mexenon)、エカムスル(Ecamsule)、オクトクリレン(Octocrylene)、アボベンゾン(Avobenzone)、エウソレックス8020(Eusolex 8020)、ポリシリコン−15、ビスジスリゾールナトリウム(Bisdisulizole disodium)、PEG−25 PABA、ホモサレート(Homosalate)、オクチサレート(Octisalate)、及びこれらの混合物からなる群から選択されるものである。
- 請求項3記載の組成物において、この組成物は、薬学的に許容可能な塩、及びその代謝物を有するものである。
- 請求項1記載の組成物において、この組成物は、アボベンゾン、オクチサレート、及びオキシベンゾンを有するものである。
- 請求項5記載の組成物において、この組成物は、全組成物重量に基づいて、約1%〜約5%のアボベンゼン、約1.1%〜約4.2%のオクチサレート、及び約0.9%〜約3.6%のオキシベンゾンを有するものである。
- 請求項1記載の組成物において、この組成物は、アボベンゾン又はエカムスルから選択されるUVAフィルターを主とする1つ又は2つの活性成分と、オクトクリレン、オキシベンゾン、オクチサレート、スリソベンゾン、ホモサレート、又はメラジメート、並びにこれらの混合物から選択されるUVBフィルターを主とする1つ又は2つの活性成分とを有するものである。
- 請求項7記載の組成物において、この組成物は、全組成物重量に基づいて、約1%〜約5%のアボベンゼン、1%〜約10%のエカムスル、0.5%〜約7%のオクトクリレン、0.5%〜約6%のオキシベンゾン、0.5%〜約6%のオクチサレート、0.5%〜約6%のスリソベンゾン、0.5%〜約7%のホモサレート、又は0.5%〜約5%のメラジメート、並びにこれらの混合物を有するものである。
- 請求項1記載の組成物において、前記健康に良く疾病に対抗する量のビタミンD3及びその化学的前駆体は、最小紅斑量の皮膚の紫外線への各暴露につき1〜100ng/mLの血清中25−ヒドロキシビタミンD3を上昇させることを有するものである。
- 請求項1記載の組成物において、前記健康に良く疾病に対抗する量のビタミンD3及びその化学的前駆体は、ビタミンD3濃度を、骨減少症、骨粗鬆症、骨軟化症、くる病、細菌性感染症、ウイルス感染、多発性硬化症、関節リウマチ、乳癌、卵巣癌、結腸直腸癌、前立腺癌、非ホジキンリンパ腫、ホジキンリンパ腫、インフルエンザ、1型糖尿病、2型糖尿病、肥満、狼瘡、高血圧、脳卒中、心筋梗塞、歯周炎、及び痴呆を予防するか又は治療するのに充分なだけ上昇させることを有するものである。
- 請求項1記載の組成物において、この組成物は、日焼け止め剤であって、ローション、クリーム、スプレー、保湿剤、ジェル、リップクリーム、防虫剤、化粧品、防水剤、浸透促進剤、カプセル化剤、乳化剤、液体溶媒、皮膚軟化剤、有機化学的安定剤、及びこれらの混合物などの、局所に塗布するための美容学的及び薬学的な担体と併用して、皮膚に塗布されるものである。
- 請求項1記載の組成物において、この組成物は、日焼け止め剤であって、太陽又は日焼け用ベッドからの光への暴露の前、又は最中において、安全でかつ効果的な量を、1回又は複数回、皮膚に塗布されるものである。
- 請求項1記載の組成物において、この組成物は、日焼け止め剤であって、ヒト、イヌ及びネコなどの伴侶動物、並びにウマ、ウシ、ブタ、及びヤギなどの家畜の皮膚に塗布されるものである。
- 請求項1記載の組成物において、この組成物は、全組成物の重量に基づいて約0.01%〜約60%の、光保護的に効果的な量の紫外線フィルターを有する。
- 請求項1記載の組成物において、この組成物は、単独で、ビタミンD3を補足して、ビタミンD2を補足して、又はこれらを混合して、使用されるものである。
- 請求項1記載の組成物において、この組成物は、身体の一部に、又は基本的には身体の全部に使用されるものである。
- 請求項1記載の組成物において、この組成物は、全スペクトルの日焼け止め剤が身体の他の部分に塗布されるとともに、身体の一部に塗布されるものである。
- 請求項1記載の組成物において、この組成物は、最初に塗布され、次いで約5分〜12時間の期間の後に、全スペクトルの日焼け止め剤が塗布されるものである。
- 日焼け止め製剤であって、活性ある紫外線吸収剤を全て排除するものであって、この紫外線吸収剤は、それ単独によって、又はその他の紫外線吸収剤との組み合わせによって、紫外線Bを充分すぎる割合で遮断するために、健康に良く疾病に対抗する量のビタミンD3及びその化学的前駆体を身体が生産出来なくなるものである、日焼け止め製剤。
- 請求項19記載の組成物において、この組成物は、1つ又は複数の紫外線吸収剤を排除するものであり、この1つ又は複数の紫外線吸収剤は、ベンゾフェノン、2,4−ジヒドロキシベンゾフェノン、2,2’,4,4’−テトラヒドロキシベンゾフェノン、2,2’−ジヒドロキシ−4,4’−ジメトキシベンゾフェノン、2,2’−ジヒドロキシ−4−メトキシベンゾフェノン、2−ヒドロキシ−4−(オクチルオキシ)ベンゾフェノン、4−メチルベンジリデンカンフル、シノキサート、オクチノキサート、ジエタノールアミンp−メトキシシンナメート、イソアミルp−メトキシシンナメート、ジベンゾイルメタン、ビスオクトリゾール(Bisoctrizole)、亜鉛オキシド、チタンジオキシド、セリウム(IV)、エンスリゾール(Ensulizole)、アミノ安息香酸、パジメート−O(Padimate−O)、パジメート−A、グリセリルアミノベンゾエート、エチルヘキシルトリアゾン(Ethylhexyl Triazone)、トロールアミンサリシレート(Trolamine Salicylate)、ドロメトリゾールトリシロキサン(Drometrizole Trisiloxane)、ベモトリジノール(Bemotrizinol)、イスコトリジノール(Iscotrizinol)、ジガロイルトリオレエート(Digalloyl trioleate)、及びこれらの混合物からなる群から選択されるものである。
- 請求項20記載の組成物において、この組成物は、薬学的に許容可能な塩、及びその代謝物を有するものである。
- 日焼け止め剤であって、295nmより小さい紫外線、及び315nmより大きい紫外線を主に吸収するために選択された物質を主に有する、日焼け止め剤。
- 請求項22記載の日焼け止め剤において、この日焼け止め剤は295〜315nmの紫外線を吸収する物質を実質的に排除するものである。
- 日焼け止め剤を塗布する方法であって、
請求項22及び23のいずれかの製剤を有する第1の日焼け止め剤を塗布する工程と、
一定時間を経過させる工程であって、この一定時間は少なくとも10分である、前記経過させる工程と、
前記第1の日焼け止め剤とは異なる第2の日焼け止め剤を塗布する工程であって、この第2の日焼け止め剤は295〜315nmの放射光を効率的に吸収するものである、前記塗布する工程と
を有する方法。 - 日焼け止め製剤であって、活性ある紫外線吸収剤を全て除外するものであって、この紫外線吸収剤は、それ単独によって、又はその他の紫外線吸収剤との組み合わせによって、紫外線Bを充分すぎる割合で遮断するために、健康に良く疾病に対抗する量のビタミンD3及びその化学的前駆体を身体が生産出来なくなるものである、日焼け止め製剤。
- 請求項25記載の組成物において、この組成物は、1つ又は複数の紫外線吸収剤を除外するものであり、この1つ又は複数の紫外線吸収剤は、ベンゾフェノン、2,4−ジヒドロキシベンゾフェノン、2,2’,4,4’−テトラヒドロキシベンゾフェノン、2,2’−ジヒドロキシ−4,4’−ジメトキシベンゾフェノン、2,2’−ジヒドロキシ−4−メトキシベンゾフェノン、2−ヒドロキシ−4−(オクチルオキシ)ベンゾフェノン、4−メチルベンジリデンカンフル、シノキサート、オクチノキサート、ジエタノールアミンp−メトキシシンナメート、イソアミルp−メトキシシンナメート、ジベンゾイルメタン、ビスオクトリゾール(Bisoctrizole)、亜鉛オキシド、チタンジオキシド、セリウム(IV)、エンスリゾール(Ensulizole)、アミノ安息香酸、パジメート−O(Padimate−O)、パジメート−A、グリセリルアミノベンゾエート、エチルヘキシルトリアゾン(Ethylhexyl Triazone)、トロールアミンサリシレート(Trolamine Salicylate)、ドロメトリゾールトリシロキサン(Drometrizole Trisiloxane)、ベモトリジノール(Bemotrizinol)、イスコトリジノール(Iscotrizinol)、ジガロイルトリオレエート(Digalloyl trioleate)、及びこれらの混合物からなる群から選択されるものである。
- D3及びその前駆体の形成を促進する方法であって、ローションを皮膚に塗布する工程であって、前記ローションは、メラジメート、スリソベンゾン、ユビナールA Plus、ベンゾフェノン−9、オキシベンゾン、メキセノン、エカムスル、オクトクリレン、アボベンゾン、エウソレックス8020、ポリシリコン−15、ビスジスリゾールナトリウム、PEG−25 PABA、ホモサレート、オクチサレート、及びこれらの混合物からなる群から選択される、1つ又は複数の紫外線吸収剤を含み、ベンゾフェノン、2,4−ジヒドロキシベンゾフェノン、また前記2,2’,4,4’−テトラヒドロキシベンゾフェノン、2,2’−ジヒドロキシ−4,4’−ジメトキシベンゾフェノン、2,2’−ジヒドロキシ−4−メトキシベンゾフェノン、2−ヒドロキシ−4−(オクチルオキシ)ベンゾフェノン、4−メチルベンジリデンカンフル、シノキサート、オクチノキサート、ジエタノールアミンp−メトキシシンナメート、イソアミルp−メトキシシンナメート、ジベンゾイルメタン、ビスオクトリゾール、亜鉛オキシド、チタンジオキシド、セリウム(IV)、エンスリゾール、アミノ安息香酸、パジメート−O、パジメート−A、グリセリルアミノベンゾエート、エチルヘキシルトリアゾン、トロールアミンサリシレート、ドロメトリゾールトリシロキサン、ベモトリジノール、イスコトリジノール、ジガロイルトリオレエート、及びこれらの混合物からなる群から選択される、紫外線吸収剤を実質的に含まないものである、前記塗布する工程を有する方法。
- 紫外線に対する防御を提供するのに適切な組成物であって、1つ又は複数の活性ある紫外線吸収剤を含有するものであり、それにより、顕著な任意的色素沈着(日焼け)を身体に発生させるのに十分な量の紫外線Bが、皮膚に入ることを許すものである、組成物。
- 請求項28記載の組成物において、この組成物は、1つ又は複数の紫外線吸収剤をさらに有する日焼け止め剤であって、ここで、この1つ又は複数の紫外線吸収剤は、皮膚の平方センチメートル毎に、0.01〜50mgのローションの量で塗布されるとき、295〜315nmの範囲における紫外線の約0%〜75%を吸収するものである。
- 請求項28記載の組成物において、この組成物は、1つ又は複数の紫外線吸収剤をさらに有する日焼け止め剤であり、前記1つ又は複数の紫外線吸収剤は、メラジメート、スリソベンゾン、ユビナールA Plus、ベンゾフェノン−9、オキシベンゾン、メキセノン、エカムスル、オクトクリレン、アボベンゾン、エウソレックス8020、ポリシリコン−15、ビスジスリゾールナトリウム、PEG−25 PABA、ホモサレート、オクチサレート、及びこれらの混合物からなる群から選択されるものである。
- 請求項30記載の組成物において、この組成物は、薬学的に許容可能な塩、及びその代謝物を有するものである。
- 請求項28記載の組成物において、この組成物は、アボベンゾン、オクチサレート、及びオキシベンゾンを有するものである。
- 請求項32記載の組成物において、この組成物は、全組成物重量に基づいて、約1%〜約5%のアボベンゼン、約1.1%〜約4.2%のオクチサレート、及び約0.9%〜約3.6%のオキシベンゾンを有するものである。
- 顕著な任意的色素沈着(日焼け)を促進する方法であって、ローションを皮膚に塗布する工程であって、前記ローションは、メラジメート、スリソベンゾン、ユビナールA Plus、ベンゾフェノン−9、オキシベンゾン、メキセノン、エカムスル、オクトクリレン、アボベンゾン、エウソレックス8020、ポリシリコン−15、ビスジスリゾールナトリウム、PEG−25 PABA、ホモサレート、オクチサレート、及びこれらの混合物からなる群から選択される、1つ又は複数の紫外線吸収剤を含み、ベンゾフェノン、2,4−ジヒドロキシベンゾフェノン、また前記2,2’,4,4’−テトラヒドロキシベンゾフェノン、2,2’−ジヒドロキシ−4,4’−ジメトキシベンゾフェノン、2,2’−ジヒドロキシ−4−メトキシベンゾフェノン、2−ヒドロキシ−4−(オクチルオキシ)ベンゾフェノン、4−メチルベンジリデンカンフル、シノキサート、オクチノキサート、ジエタノールアミンp−メトキシシンナメート、イソアミルp−メトキシシンナメート、ジベンゾイルメタン、ビスオクトリゾール、亜鉛オキシド、チタンジオキシド、セリウム(IV)、エンスリゾール、アミノ安息香酸、パジメート−O、パジメート−A、グリセリルアミノベンゾエート、エチルヘキシルトリアゾン、トロールアミンサリシレート、ドロメトリゾールトリシロキサン、ベモトリジノール、イスコトリジノール、ジガロイルトリオレエート、及びこれらの混合物からなる群から選択される、紫外線吸収剤を実質的に含まないものである、前記塗布する工程を有する方法。
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BRPI0924172A2 (pt) | 2016-02-10 |
AU2009334372A1 (en) | 2011-08-25 |
US9724544B2 (en) | 2017-08-08 |
US20110268678A1 (en) | 2011-11-03 |
WO2010076731A2 (en) | 2010-07-08 |
WO2010076731A3 (en) | 2010-11-25 |
EP2384193A4 (en) | 2013-05-22 |
CA2748441C (en) | 2017-10-03 |
AU2009334372B2 (en) | 2016-05-12 |
JP5917151B2 (ja) | 2016-05-11 |
BRPI0924172B1 (pt) | 2024-02-20 |
EP2384193A2 (en) | 2011-11-09 |
NZ593932A (en) | 2013-11-29 |
CA2748441A1 (en) | 2010-07-08 |
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