JP2012510515A5 - - Google Patents

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Publication number
JP2012510515A5
JP2012510515A5 JP2011539569A JP2011539569A JP2012510515A5 JP 2012510515 A5 JP2012510515 A5 JP 2012510515A5 JP 2011539569 A JP2011539569 A JP 2011539569A JP 2011539569 A JP2011539569 A JP 2011539569A JP 2012510515 A5 JP2012510515 A5 JP 2012510515A5
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JP
Japan
Prior art keywords
acid
carbonyl
oxo
carboxylic acid
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2011539569A
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English (en)
Japanese (ja)
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JP2012510515A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/064971 external-priority patent/WO2010065310A1/en
Publication of JP2012510515A publication Critical patent/JP2012510515A/ja
Publication of JP2012510515A5 publication Critical patent/JP2012510515A5/ja
Withdrawn legal-status Critical Current

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JP2011539569A 2008-12-03 2009-11-18 ジアシルグリセロールアシルトランスフェラーゼの阻害剤 Withdrawn JP2012510515A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11946708P 2008-12-03 2008-12-03
US61/119,467 2008-12-03
PCT/US2009/064971 WO2010065310A1 (en) 2008-12-03 2009-11-18 Inhibitors of diacylglycerol acyltransferase

Publications (2)

Publication Number Publication Date
JP2012510515A JP2012510515A (ja) 2012-05-10
JP2012510515A5 true JP2012510515A5 (https=) 2013-01-10

Family

ID=42231833

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011539569A Withdrawn JP2012510515A (ja) 2008-12-03 2009-11-18 ジアシルグリセロールアシルトランスフェラーゼの阻害剤

Country Status (8)

Country Link
US (1) US8124766B2 (https=)
EP (1) EP2367817A4 (https=)
JP (1) JP2012510515A (https=)
CN (1) CN102239165A (https=)
AU (1) AU2009322774A1 (https=)
CA (1) CA2744152A1 (https=)
IL (1) IL212916A0 (https=)
WO (1) WO2010065310A1 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8115011B2 (en) 2007-05-22 2012-02-14 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
US8153644B2 (en) 2007-05-22 2012-04-10 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
US8211884B2 (en) * 2008-08-06 2012-07-03 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
JP4900361B2 (ja) * 2008-10-21 2012-03-21 ソニー株式会社 画像処理装置、画像処理方法およびプログラム
US8324385B2 (en) * 2008-10-30 2012-12-04 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
JP2012512252A (ja) * 2008-12-17 2012-05-31 ブイアイエイ・ファーマシューティカルズ・インコーポレーテッド ジアシルグリセロールアシルトランスフェラーゼの阻害剤
PA8854101A1 (es) 2008-12-18 2010-07-27 Ortho Mcneil Janssen Pharm Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa
EA019685B1 (ru) 2009-02-06 2014-05-30 Янссен Фармасьютикалз, Инк. Новые замещенные бициклические гетероциклические соединения в качестве модуляторов гамма-секретазы
TWI461425B (zh) 2009-02-19 2014-11-21 Janssen Pharmaceuticals Inc 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類
BRPI1011190A8 (pt) 2009-05-07 2016-11-16 Janssen Pharmaceuticals Inc Derivados de indazol e aza-indazol substituídos como moduladores de gama secretase
ES2519565T3 (es) 2009-07-15 2014-11-07 Janssen Pharmaceuticals Inc. Derivados de triazol e imidazol sustituidos como moduladores de gamma secretasa
EP2477498A4 (en) * 2009-09-14 2013-02-27 Merck Sharp & Dohme INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE
EP2523949B1 (en) 2010-01-15 2014-08-20 Janssen Pharmaceuticals Inc. Novel substituted triazole derivatives as gamma secretase modulators
CA2827969A1 (en) 2011-03-24 2012-09-27 Janssen Pharmaceuticals, Inc. Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators
TWI567079B (zh) 2011-07-15 2017-01-21 健生醫藥公司 作為伽瑪分泌酶調節劑之新穎的經取代的吲哚衍生物
NZ702611A (en) 2012-05-16 2016-10-28 Cellzome Ltd Substituted 3, 4 - dihydro - 2h - pyrido [1, 2 -a] pyrazine - 1, 6 - dione derivatives useful for the treatment of (inter alia) alzheimer’s disease
AU2013366668B2 (en) 2012-12-20 2017-07-20 Janssen Pharmaceutica Nv Novel tricyclic 3,4-dihydro-2H-pyrido[1,2-alpha]pyrazine -1,6-dione derivatives as gamma secretase modulators
ES2612215T3 (es) 2013-01-17 2017-05-12 Janssen Pharmaceutica, N.V. Novedosos derivados de pirido-piperazinona sustituidos como moduladores de gamma secretasa
US10562897B2 (en) 2014-01-16 2020-02-18 Janssen Pharmaceutica Nv Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
WO2021262484A1 (en) * 2020-06-24 2021-12-30 Pmv Pharmaceuticals, Inc. Combination therapy for treatment of cancer
AR123701A1 (es) * 2020-10-08 2023-01-04 Merck Sharp & Dohme Preparación de derivados de oxindol como nuevos inhibidores de la diacilglicerol o-aciltransferasa 2
CN120826398A (zh) * 2023-03-30 2025-10-21 微境生物医药科技(上海)有限公司 作为DGKζ抑制剂的化合物

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
US3250771A (en) * 1962-12-17 1966-05-10 Geigy Chem Corp 5-monocarbocyclic aryl-n-lower alkyl-2-pyrrolidine carboxylic acid, esters, amides and derivatives thereof
DE2337461A1 (de) * 1973-07-24 1975-02-06 Boehringer Mannheim Gmbh Neue indolderivate und verfahren zu deren herstellung
US4066654A (en) * 1975-04-16 1978-01-03 G. D. Searle & Co. 1-triarylalkyl-4-phenyl-4-piperidine carboxylic acids and derivatives
US6495558B1 (en) * 1999-01-22 2002-12-17 Amgen Inc. Kinase inhibitors
US6756374B2 (en) * 2001-01-22 2004-06-29 Hoffmann-La Roche Inc. Diaminothiazoles having antiproliferative activity
AU2002333456B2 (en) 2001-08-31 2008-07-17 Sanofi-Aventis Deutschland Gmbh Diaryl cycloalkyl derivatives, method for producing the same and the use thereof as PPAR activators
AU2003261935A1 (en) 2002-09-06 2004-03-29 Takeda Pharmaceutical Company Limited Furan or thiophene derivative and medicinal use thereof
RU2342388C2 (ru) * 2002-11-22 2008-12-27 Джапан Тобакко Инк. Конденсированные бициклические азотсодержащие гетероциклы, обладающие dgat ингибирующим действием
AU2006258917A1 (en) 2005-06-11 2006-12-21 Astrazeneca Ab Oxadiazole derivatives as DGAT inhibitors
KR20080063865A (ko) 2005-11-28 2008-07-07 에프. 호프만-라 로슈 아게 다이아실글리세롤 아실전이효소(ｄｇａｔ)의 저해제
WO2008099221A1 (en) * 2007-02-15 2008-08-21 Prosidion Limited Amide and urea derivatives for the treatment of metabolic diseases
BRPI0811947A2 (pt) 2007-05-22 2014-11-11 Via Pharmaceuticals Inc Composto, processo para a preparação de um composto, composição farmacêutica, uso de um composto e método de tratamento de obesidade, diabetes do tipo ii, dislipidemia ou síndrome metabólica

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