JP2012510515A5 - - Google Patents

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Publication number
JP2012510515A5
JP2012510515A5 JP2011539569A JP2011539569A JP2012510515A5 JP 2012510515 A5 JP2012510515 A5 JP 2012510515A5 JP 2011539569 A JP2011539569 A JP 2011539569A JP 2011539569 A JP2011539569 A JP 2011539569A JP 2012510515 A5 JP2012510515 A5 JP 2012510515A5
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JP
Japan
Prior art keywords
acid
carbonyl
oxo
carboxylic acid
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2011539569A
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English (en)
Japanese (ja)
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JP2012510515A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/064971 external-priority patent/WO2010065310A1/en
Publication of JP2012510515A publication Critical patent/JP2012510515A/ja
Publication of JP2012510515A5 publication Critical patent/JP2012510515A5/ja
Withdrawn legal-status Critical Current

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JP2011539569A 2008-12-03 2009-11-18 ジアシルグリセロールアシルトランスフェラーゼの阻害剤 Withdrawn JP2012510515A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11946708P 2008-12-03 2008-12-03
US61/119,467 2008-12-03
PCT/US2009/064971 WO2010065310A1 (en) 2008-12-03 2009-11-18 Inhibitors of diacylglycerol acyltransferase

Publications (2)

Publication Number Publication Date
JP2012510515A JP2012510515A (ja) 2012-05-10
JP2012510515A5 true JP2012510515A5 (https=) 2013-01-10

Family

ID=42231833

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011539569A Withdrawn JP2012510515A (ja) 2008-12-03 2009-11-18 ジアシルグリセロールアシルトランスフェラーゼの阻害剤

Country Status (8)

Country Link
US (1) US8124766B2 (https=)
EP (1) EP2367817A4 (https=)
JP (1) JP2012510515A (https=)
CN (1) CN102239165A (https=)
AU (1) AU2009322774A1 (https=)
CA (1) CA2744152A1 (https=)
IL (1) IL212916A0 (https=)
WO (1) WO2010065310A1 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8153644B2 (en) * 2007-05-22 2012-04-10 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
US8115011B2 (en) * 2007-05-22 2012-02-14 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
US8211884B2 (en) * 2008-08-06 2012-07-03 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
JP4900361B2 (ja) * 2008-10-21 2012-03-21 ソニー株式会社 画像処理装置、画像処理方法およびプログラム
US8324385B2 (en) * 2008-10-30 2012-12-04 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
AU2009333333A1 (en) * 2008-12-17 2011-06-30 Via Pharmaceuticals, Inc Inhibitors of diacylglycerol aclytransferase
PA8854101A1 (es) 2008-12-18 2010-07-27 Ortho Mcneil Janssen Pharm Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa
WO2010089292A1 (en) 2009-02-06 2010-08-12 Ortho-Mcneil-Janssen Pharmaceuticals, Inc Novel substituted bicyclic heterocyclic compounds as gamma secretase modulators
TWI461425B (zh) 2009-02-19 2014-11-21 Janssen Pharmaceuticals Inc 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類
AU2010262036B2 (en) 2009-05-07 2014-10-30 Cellzome Limited Novel substituted indazole and aza-indazole derivatives as gamma secretase modulators
JP2012532912A (ja) 2009-07-15 2012-12-20 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド ガンマセクレターゼモジュレーターとしての置換されたトリアゾールおよびイミダゾール誘導体
US20120172369A1 (en) * 2009-09-14 2012-07-05 Ting Pauline C Inhibitors of diacylglycerol acyltransferase
BR112012017310A2 (pt) 2010-01-15 2016-04-19 Janssen Pharmaceuticals Inc derivados de triazol substituídos como moduladores de gama secretase
AU2012230348A1 (en) 2011-03-24 2013-08-29 Cellzome Limited Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators
KR101913135B1 (ko) 2011-07-15 2018-10-30 얀센 파마슈티칼즈, 인코포레이티드 감마 세크레타제 조절 인자로서의 신규의 치환 인돌 유도체
US9181245B2 (en) 2012-05-16 2015-11-10 Janssen Pharmaceuticals, Inc. Substituted pyrido[1,2-a]pyrazines and substituted pyrido[1,2-a][1,4]diazepines for the treatment of (inter alia) Alzheimer's disease
CA2889249C (en) 2012-12-20 2021-02-16 Francois Paul Bischoff Tricyclic 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives as gamma secretase modulators
CA2891755C (en) 2013-01-17 2021-10-26 Janssen Pharmaceutica Nv Substituted pyrido-piperazinone derivatives as gamma secretase modulators
US10562897B2 (en) 2014-01-16 2020-02-18 Janssen Pharmaceutica Nv Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
US11938124B2 (en) 2020-06-24 2024-03-26 Pmv Pharmaceuticals, Inc. Combination therapy for treatment of cancer
EP4225735A1 (en) * 2020-10-08 2023-08-16 Merck Sharp & Dohme LLC Preparation of oxindole derivatives as novel diacylglyceride o-acyltransferase 2 inhibitors
CN120826398A (zh) * 2023-03-30 2025-10-21 微境生物医药科技(上海)有限公司 作为DGKζ抑制剂的化合物

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US3250771A (en) 1962-12-17 1966-05-10 Geigy Chem Corp 5-monocarbocyclic aryl-n-lower alkyl-2-pyrrolidine carboxylic acid, esters, amides and derivatives thereof
DE2337461A1 (de) 1973-07-24 1975-02-06 Boehringer Mannheim Gmbh Neue indolderivate und verfahren zu deren herstellung
US4066654A (en) * 1975-04-16 1978-01-03 G. D. Searle & Co. 1-triarylalkyl-4-phenyl-4-piperidine carboxylic acids and derivatives
US6495558B1 (en) * 1999-01-22 2002-12-17 Amgen Inc. Kinase inhibitors
US6756374B2 (en) * 2001-01-22 2004-06-29 Hoffmann-La Roche Inc. Diaminothiazoles having antiproliferative activity
HRP20040199A2 (en) 2001-08-31 2005-04-30 Aventis Pharma Deutschland Gmbh Diaryl cycloalkyl derivatives, method for producing the same and the use thereof as ppar activators
AU2003261935A1 (en) 2002-09-06 2004-03-29 Takeda Pharmaceutical Company Limited Furan or thiophene derivative and medicinal use thereof
KR100772297B1 (ko) 2002-11-22 2007-11-02 니뽄 다바코 산교 가부시키가이샤 융합 비시클릭 질소-함유 헤테로사이클
KR20080015113A (ko) 2005-06-11 2008-02-18 아스트라제네카 아베 Ｄｇａｔ 억제제로서의 옥사디아졸 유도체
CA2630269C (en) 2005-11-28 2011-07-05 F. Hoffmann-La Roche Ag Inhibitors of diacyglycerol acyltransferase (dgat)
WO2008099221A1 (en) * 2007-02-15 2008-08-21 Prosidion Limited Amide and urea derivatives for the treatment of metabolic diseases
AU2008253118B2 (en) * 2007-05-22 2013-11-21 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors

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