CN102239165A - 二酰甘油酰基转移酶抑制剂 - Google Patents
二酰甘油酰基转移酶抑制剂 Download PDFInfo
- Publication number
- CN102239165A CN102239165A CN2009801482136A CN200980148213A CN102239165A CN 102239165 A CN102239165 A CN 102239165A CN 2009801482136 A CN2009801482136 A CN 2009801482136A CN 200980148213 A CN200980148213 A CN 200980148213A CN 102239165 A CN102239165 A CN 102239165A
- Authority
- CN
- China
- Prior art keywords
- carboxylic acid
- amino
- ethyl
- piperazine
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *Cc1c(*(*)C(C(*)O)=C)cccc1 Chemical compound *Cc1c(*(*)C(C(*)O)=C)cccc1 0.000 description 6
- HKWCPDJGPAXURF-UHFFFAOYSA-N CC(C)(CC(N(CC1)CCN1c(cc1)ccc1NC(c([s]c1ccc2)cc1c2Cl)=O)=O)C(O)=O Chemical compound CC(C)(CC(N(CC1)CCN1c(cc1)ccc1NC(c([s]c1ccc2)cc1c2Cl)=O)=O)C(O)=O HKWCPDJGPAXURF-UHFFFAOYSA-N 0.000 description 1
- ZQQJBVXJWRDNLI-INIZCTEOSA-N CCOC(N(CC1)C[C@H]1Nc(nc1)ccc1NC(c([n](C)c1cc(OC)c2)cc1c2OC)=O)=O Chemical compound CCOC(N(CC1)C[C@H]1Nc(nc1)ccc1NC(c([n](C)c1cc(OC)c2)cc1c2OC)=O)=O ZQQJBVXJWRDNLI-INIZCTEOSA-N 0.000 description 1
- XTJANZBPVLVPQT-INIZCTEOSA-N CCOC(N(CC1)C[C@H]1Nc(nc1)ccc1NC(c([n](C)c1ccc2OC)cc1c2OC)=O)=O Chemical compound CCOC(N(CC1)C[C@H]1Nc(nc1)ccc1NC(c([n](C)c1ccc2OC)cc1c2OC)=O)=O XTJANZBPVLVPQT-INIZCTEOSA-N 0.000 description 1
- WOCUWDWANUXQHS-UHFFFAOYSA-N CCOc1c(cc(C(Nc(cc2)ccc2N(CC2)CCN2C(CC(C)(C)C(O)=O)=O)=O)[n]2C)c2ccc1 Chemical compound CCOc1c(cc(C(Nc(cc2)ccc2N(CC2)CCN2C(CC(C)(C)C(O)=O)=O)=O)[n]2C)c2ccc1 WOCUWDWANUXQHS-UHFFFAOYSA-N 0.000 description 1
- KVWKCLPDBWMAPW-UHFFFAOYSA-N CC[n](c(C(Nc(cc1)cnc1N(CC1)CCN1C(OC(C)(C)C)=O)=O)cc1c2Cl)c1ccc2Cl Chemical compound CC[n](c(C(Nc(cc1)cnc1N(CC1)CCN1C(OC(C)(C)C)=O)=O)cc1c2Cl)c1ccc2Cl KVWKCLPDBWMAPW-UHFFFAOYSA-N 0.000 description 1
- AMNGBHKKUGMHDI-UHFFFAOYSA-N CC[n](c(C(Nc1ccc(N(C)CCOC)nc1)=O)cc1c2)c1ccc2OC(F)(F)F Chemical compound CC[n](c(C(Nc1ccc(N(C)CCOC)nc1)=O)cc1c2)c1ccc2OC(F)(F)F AMNGBHKKUGMHDI-UHFFFAOYSA-N 0.000 description 1
- WMEKGDGLGBWKKU-UHFFFAOYSA-N CC[n](c(C(Nc1ccc(N2CCNCC2)nc1)=O)cc1c2)c1ccc2Cl Chemical compound CC[n](c(C(Nc1ccc(N2CCNCC2)nc1)=O)cc1c2)c1ccc2Cl WMEKGDGLGBWKKU-UHFFFAOYSA-N 0.000 description 1
- NWGLTGHIGQJZQS-UHFFFAOYSA-N CC[n]1c2cccc(OCC(C)C)c2cc1C(Nc1ccc(N2CCNCC2)nc1)=O Chemical compound CC[n]1c2cccc(OCC(C)C)c2cc1C(Nc1ccc(N2CCNCC2)nc1)=O NWGLTGHIGQJZQS-UHFFFAOYSA-N 0.000 description 1
- OSCUDRTTZPYAOB-UHFFFAOYSA-N CC[n]1c2ccccc2cc1C(Nc1ccc(N(C)CCOC)nc1)=O Chemical compound CC[n]1c2ccccc2cc1C(Nc1ccc(N(C)CCOC)nc1)=O OSCUDRTTZPYAOB-UHFFFAOYSA-N 0.000 description 1
- REZFAAMAMILUEY-UHFFFAOYSA-N CNC(c1cc(c(Cl)c(cc2)Cl)c2[nH]1)=O Chemical compound CNC(c1cc(c(Cl)c(cc2)Cl)c2[nH]1)=O REZFAAMAMILUEY-UHFFFAOYSA-N 0.000 description 1
- PXUPRPQAYRVDDB-UHFFFAOYSA-N COc(ccc1c2cc(C(Nc3ccc(N4CCNCC4)nc3)=N)[nH]1)c2OC Chemical compound COc(ccc1c2cc(C(Nc3ccc(N4CCNCC4)nc3)=N)[nH]1)c2OC PXUPRPQAYRVDDB-UHFFFAOYSA-N 0.000 description 1
- QNPZEGSQAMEPOU-MEMLXQNLSA-N C[n](c(CNc1ccc(N(CC2)CCN2C([C@H]2CC[C@H](CO)CC2)=O)nc1)c1)c2c1c(OC)ccc2 Chemical compound C[n](c(CNc1ccc(N(CC2)CCN2C([C@H]2CC[C@H](CO)CC2)=O)nc1)c1)c2c1c(OC)ccc2 QNPZEGSQAMEPOU-MEMLXQNLSA-N 0.000 description 1
- UNJPNMHTAJKAFB-UHFFFAOYSA-N O=C(c([s]c1ccc2)cc1c2Cl)Nc1ccc(N2CCNCC2)nc1 Chemical compound O=C(c([s]c1ccc2)cc1c2Cl)Nc1ccc(N2CCNCC2)nc1 UNJPNMHTAJKAFB-UHFFFAOYSA-N 0.000 description 1
- WECAGSYHQYGUAK-UHFFFAOYSA-N O=C(c1cc(c(Cl)c(cc2)Cl)c2[nH]1)Nc(cc1)cnc1N1CCNCC1 Chemical compound O=C(c1cc(c(Cl)c(cc2)Cl)c2[nH]1)Nc(cc1)cnc1N1CCNCC1 WECAGSYHQYGUAK-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11946708P | 2008-12-03 | 2008-12-03 | |
| US61/119,467 | 2008-12-03 | ||
| PCT/US2009/064971 WO2010065310A1 (en) | 2008-12-03 | 2009-11-18 | Inhibitors of diacylglycerol acyltransferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102239165A true CN102239165A (zh) | 2011-11-09 |
Family
ID=42231833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801482136A Pending CN102239165A (zh) | 2008-12-03 | 2009-11-18 | 二酰甘油酰基转移酶抑制剂 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8124766B2 (https=) |
| EP (1) | EP2367817A4 (https=) |
| JP (1) | JP2012510515A (https=) |
| CN (1) | CN102239165A (https=) |
| AU (1) | AU2009322774A1 (https=) |
| CA (1) | CA2744152A1 (https=) |
| IL (1) | IL212916A0 (https=) |
| WO (1) | WO2010065310A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116457346A (zh) * | 2020-10-08 | 2023-07-18 | 默沙东有限责任公司 | 作为新型二酰基甘油酯o-酰基转移酶2抑制剂的吲哚酮衍生物的制备 |
| WO2024199387A1 (zh) * | 2023-03-30 | 2024-10-03 | 微境生物医药科技(上海)有限公司 | 作为DGKζ抑制剂的化合物 |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8115011B2 (en) | 2007-05-22 | 2012-02-14 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8153644B2 (en) | 2007-05-22 | 2012-04-10 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8211884B2 (en) * | 2008-08-06 | 2012-07-03 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| JP4900361B2 (ja) * | 2008-10-21 | 2012-03-21 | ソニー株式会社 | 画像処理装置、画像処理方法およびプログラム |
| US8324385B2 (en) * | 2008-10-30 | 2012-12-04 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| JP2012512252A (ja) * | 2008-12-17 | 2012-05-31 | ブイアイエイ・ファーマシューティカルズ・インコーポレーテッド | ジアシルグリセロールアシルトランスフェラーゼの阻害剤 |
| PA8854101A1 (es) | 2008-12-18 | 2010-07-27 | Ortho Mcneil Janssen Pharm | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
| EA019685B1 (ru) | 2009-02-06 | 2014-05-30 | Янссен Фармасьютикалз, Инк. | Новые замещенные бициклические гетероциклические соединения в качестве модуляторов гамма-секретазы |
| TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
| BRPI1011190A8 (pt) | 2009-05-07 | 2016-11-16 | Janssen Pharmaceuticals Inc | Derivados de indazol e aza-indazol substituídos como moduladores de gama secretase |
| ES2519565T3 (es) | 2009-07-15 | 2014-11-07 | Janssen Pharmaceuticals Inc. | Derivados de triazol e imidazol sustituidos como moduladores de gamma secretasa |
| EP2477498A4 (en) * | 2009-09-14 | 2013-02-27 | Merck Sharp & Dohme | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE |
| EP2523949B1 (en) | 2010-01-15 | 2014-08-20 | Janssen Pharmaceuticals Inc. | Novel substituted triazole derivatives as gamma secretase modulators |
| CA2827969A1 (en) | 2011-03-24 | 2012-09-27 | Janssen Pharmaceuticals, Inc. | Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators |
| TWI567079B (zh) | 2011-07-15 | 2017-01-21 | 健生醫藥公司 | 作為伽瑪分泌酶調節劑之新穎的經取代的吲哚衍生物 |
| NZ702611A (en) | 2012-05-16 | 2016-10-28 | Cellzome Ltd | Substituted 3, 4 - dihydro - 2h - pyrido [1, 2 -a] pyrazine - 1, 6 - dione derivatives useful for the treatment of (inter alia) alzheimer’s disease |
| AU2013366668B2 (en) | 2012-12-20 | 2017-07-20 | Janssen Pharmaceutica Nv | Novel tricyclic 3,4-dihydro-2H-pyrido[1,2-alpha]pyrazine -1,6-dione derivatives as gamma secretase modulators |
| ES2612215T3 (es) | 2013-01-17 | 2017-05-12 | Janssen Pharmaceutica, N.V. | Novedosos derivados de pirido-piperazinona sustituidos como moduladores de gamma secretasa |
| US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
| WO2021262484A1 (en) * | 2020-06-24 | 2021-12-30 | Pmv Pharmaceuticals, Inc. | Combination therapy for treatment of cancer |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3250771A (en) * | 1962-12-17 | 1966-05-10 | Geigy Chem Corp | 5-monocarbocyclic aryl-n-lower alkyl-2-pyrrolidine carboxylic acid, esters, amides and derivatives thereof |
| US3929793A (en) * | 1973-07-24 | 1975-12-30 | Boehringer Mannheim Gmbh | Certain piperazine-containing indole compounds |
| US4066654A (en) * | 1975-04-16 | 1978-01-03 | G. D. Searle & Co. | 1-triarylalkyl-4-phenyl-4-piperidine carboxylic acids and derivatives |
| US20040019067A1 (en) * | 1999-01-22 | 2004-01-29 | Amgen Inc. | Kinase inhibitors |
| US7094896B2 (en) * | 2001-01-22 | 2006-08-22 | Hoffmann-La Roche Inc. | Diaminothiazoles having antiproliferative activity |
| WO2008099221A1 (en) * | 2007-02-15 | 2008-08-21 | Prosidion Limited | Amide and urea derivatives for the treatment of metabolic diseases |
| WO2008141976A1 (en) * | 2007-05-22 | 2008-11-27 | Via Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002333456B2 (en) | 2001-08-31 | 2008-07-17 | Sanofi-Aventis Deutschland Gmbh | Diaryl cycloalkyl derivatives, method for producing the same and the use thereof as PPAR activators |
| AU2003261935A1 (en) | 2002-09-06 | 2004-03-29 | Takeda Pharmaceutical Company Limited | Furan or thiophene derivative and medicinal use thereof |
| RU2342388C2 (ru) * | 2002-11-22 | 2008-12-27 | Джапан Тобакко Инк. | Конденсированные бициклические азотсодержащие гетероциклы, обладающие dgat ингибирующим действием |
| AU2006258917A1 (en) | 2005-06-11 | 2006-12-21 | Astrazeneca Ab | Oxadiazole derivatives as DGAT inhibitors |
| KR20080063865A (ko) | 2005-11-28 | 2008-07-07 | 에프. 호프만-라 로슈 아게 | 다이아실글리세롤 아실전이효소(ｄｇａｔ)의 저해제 |
-
2009
- 2009-11-18 AU AU2009322774A patent/AU2009322774A1/en not_active Abandoned
- 2009-11-18 JP JP2011539569A patent/JP2012510515A/ja not_active Withdrawn
- 2009-11-18 EP EP09830855A patent/EP2367817A4/en not_active Withdrawn
- 2009-11-18 US US12/621,109 patent/US8124766B2/en not_active Expired - Fee Related
- 2009-11-18 CA CA2744152A patent/CA2744152A1/en not_active Abandoned
- 2009-11-18 WO PCT/US2009/064971 patent/WO2010065310A1/en not_active Ceased
- 2009-11-18 CN CN2009801482136A patent/CN102239165A/zh active Pending
-
2011
- 2011-05-16 IL IL212916A patent/IL212916A0/en unknown
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3250771A (en) * | 1962-12-17 | 1966-05-10 | Geigy Chem Corp | 5-monocarbocyclic aryl-n-lower alkyl-2-pyrrolidine carboxylic acid, esters, amides and derivatives thereof |
| US3929793A (en) * | 1973-07-24 | 1975-12-30 | Boehringer Mannheim Gmbh | Certain piperazine-containing indole compounds |
| US4066654A (en) * | 1975-04-16 | 1978-01-03 | G. D. Searle & Co. | 1-triarylalkyl-4-phenyl-4-piperidine carboxylic acids and derivatives |
| US20040019067A1 (en) * | 1999-01-22 | 2004-01-29 | Amgen Inc. | Kinase inhibitors |
| US7094896B2 (en) * | 2001-01-22 | 2006-08-22 | Hoffmann-La Roche Inc. | Diaminothiazoles having antiproliferative activity |
| WO2008099221A1 (en) * | 2007-02-15 | 2008-08-21 | Prosidion Limited | Amide and urea derivatives for the treatment of metabolic diseases |
| WO2008141976A1 (en) * | 2007-05-22 | 2008-11-27 | Via Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116457346A (zh) * | 2020-10-08 | 2023-07-18 | 默沙东有限责任公司 | 作为新型二酰基甘油酯o-酰基转移酶2抑制剂的吲哚酮衍生物的制备 |
| WO2024199387A1 (zh) * | 2023-03-30 | 2024-10-03 | 微境生物医药科技(上海)有限公司 | 作为DGKζ抑制剂的化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2744152A1 (en) | 2010-06-10 |
| EP2367817A4 (en) | 2012-05-09 |
| WO2010065310A1 (en) | 2010-06-10 |
| US8124766B2 (en) | 2012-02-28 |
| US20100145047A1 (en) | 2010-06-10 |
| IL212916A0 (en) | 2011-07-31 |
| EP2367817A1 (en) | 2011-09-28 |
| AU2009322774A1 (en) | 2011-06-30 |
| JP2012510515A (ja) | 2012-05-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102239165A (zh) | 二酰甘油酰基转移酶抑制剂 | |
| CN101835757B (zh) | 二酰甘油酰基转移酶抑制剂 | |
| JP5076091B2 (ja) | ジアシルグリセロールアシルトランスフェラーゼ（ｄｇａｔ）のインヒビター | |
| US8058299B2 (en) | Diacylglycerol acyltransferase inhibitors | |
| US8115011B2 (en) | Diacylglycerol acyltransferase inhibitors | |
| US20090076275A1 (en) | Diacylglycerol acyltransferase inhibitors | |
| US7485752B2 (en) | Diacylglycerol acyltransferase inhibitors | |
| US8153644B2 (en) | Diacylglycerol acyltransferase inhibitors | |
| US8211914B2 (en) | Inhibitors of diacylglycerol acyltransferase | |
| AU2006210056A1 (en) | Inhibitors of diacylglycerol acyltransferase (DGAT) | |
| US20090099201A1 (en) | Diacylglycerol Acyltransferase Inhibitors | |
| US20090163546A1 (en) | Diacylglycerol acyltransferase inhibitors | |
| US8211884B2 (en) | Diacylglycerol acyltransferase inhibitors | |
| CN101316844A (zh) | 二酰甘油酰基转移酶(dgat)抑制剂 | |
| HK1163071A (en) | Inhibitors of diacylglycerol acyltransferase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1163071 Country of ref document: HK |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20111109 |
|
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1163071 Country of ref document: HK |