JP2012510512A5 - - Google Patents
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- Publication number
- JP2012510512A5 JP2012510512A5 JP2011539506A JP2011539506A JP2012510512A5 JP 2012510512 A5 JP2012510512 A5 JP 2012510512A5 JP 2011539506 A JP2011539506 A JP 2011539506A JP 2011539506 A JP2011539506 A JP 2011539506A JP 2012510512 A5 JP2012510512 A5 JP 2012510512A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- hdac2
- formula
- composition
- alkylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11969808P | 2008-12-03 | 2008-12-03 | |
| US61/119,698 | 2008-12-03 | ||
| PCT/US2009/006355 WO2010065117A1 (en) | 2008-12-03 | 2009-12-02 | Inhibition of hdac2 to promote memory |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012510512A JP2012510512A (ja) | 2012-05-10 |
| JP2012510512A5 true JP2012510512A5 (https=) | 2013-01-24 |
Family
ID=42233521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011539506A Pending JP2012510512A (ja) | 2008-12-03 | 2009-12-02 | 記憶を推進するためのｈｄａｃ２の阻害 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20120101147A1 (https=) |
| EP (1) | EP2367599A4 (https=) |
| JP (1) | JP2012510512A (https=) |
| CN (1) | CN102271763A (https=) |
| AU (1) | AU2009322958B2 (https=) |
| CA (1) | CA2745073A1 (https=) |
| NZ (1) | NZ593447A (https=) |
| WO (1) | WO2010065117A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009154697A2 (en) | 2008-05-28 | 2009-12-23 | Massachusetts Institute Of Technology | Disc-1 pathway activators in the control of neurogenesis |
| WO2011053876A1 (en) | 2009-10-30 | 2011-05-05 | Massachusetts Institute Of Technology | The use of ci-994 and dinaline for the treatment of memory/cognition and anxiety disorders |
| WO2012016081A2 (en) * | 2010-07-30 | 2012-02-02 | The Regents Of The University Of California | Method and therapeutic for the treatment and regulation of memory formation |
| CN102477001B (zh) * | 2010-11-29 | 2015-07-15 | 江苏先声药物研究有限公司 | 一种苯甲酰胺类组蛋白去乙酰化酶抑制剂 |
| EP2701699B1 (en) | 2011-04-28 | 2019-10-16 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| WO2013016193A2 (en) | 2011-07-22 | 2013-01-31 | Massachusetts Istitute Of Technology | Activators of class i histone deacetlyases (hdacs) and uses thereof |
| US20130028956A1 (en) * | 2011-07-29 | 2013-01-31 | Andre Fischer | Method for preventing or treating memory impairment and pharmaceutical compositions useful therefore |
| WO2013096744A1 (en) * | 2011-12-21 | 2013-06-27 | Novira Therapeutics, Inc. | Hepatitis b antiviral agents |
| WO2014018913A2 (en) * | 2012-07-27 | 2014-01-30 | University Of Connecticut | Santacruzamate a compositions and analogs and methods of use |
| JP6337255B2 (ja) | 2012-07-27 | 2018-06-06 | ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. | ヒストンデアセチラーゼの阻害剤 |
| WO2014046871A1 (en) * | 2012-09-04 | 2014-03-27 | Massachusetts Institute Of Technology | The use of gene expression profiling as a biomarker for assessing the efficacy of hdac inhibitor treatment in neurodegenerative conditions |
| US9914717B2 (en) | 2012-12-20 | 2018-03-13 | The Broad Institute, Inc. | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors |
| HK1214587A1 (en) | 2012-12-28 | 2016-07-29 | Nippon Zoki Pharmaceutical Co., Ltd. | Cinnamamide derivative |
| KR101486248B1 (ko) * | 2013-04-29 | 2015-01-27 | 숙명여자대학교산학협력단 | Ｄｎａ 메틸화 저해제를 포함하는 상염색체 우성 다낭신 개선 또는 치료용 약학 조성물 |
| EP2801569A1 (en) | 2013-05-09 | 2014-11-12 | Ikerchem, S.L. | Histone deacetylase inhibitors based on derivatives of tricyclic polyhydroacridine and analogs possessing fused saturated five- and seven-membered rings |
| MX2016006633A (es) * | 2013-11-24 | 2016-12-02 | Univ Taipei Medical | Uso de hidroxamatos de indolilo e indolinilo para tratar trastornos neurodegenerativos o deficiencias cognitivas. |
| US20170173083A1 (en) * | 2014-03-26 | 2017-06-22 | The Brigham And Women's Hospital, Inc. | Compositions and methods for ex vivo expansion of human hematopoietic stem/progenitor cells |
| WO2016134271A1 (en) * | 2015-02-19 | 2016-08-25 | Massachusetts Institute Of Technology | Systems and methods for selective memory enhancement and/or disruption |
| ES2807878T3 (es) * | 2015-06-08 | 2021-02-24 | Univ California | Uso de la modulación de H3K9me3 para potenciar la función cognitiva |
| WO2017039726A1 (en) | 2015-08-28 | 2017-03-09 | Uwm Research Foundation, Inc. | Novel hdac inhibitors and methods of treatment using the same |
| KR20200028982A (ko) * | 2017-07-13 | 2020-03-17 | 메사추세츠 인스티튜트 오브 테크놀로지 | 시냅스 기능을 증진시키기 위한 hdac2-sp3 복합체 표적화 |
| WO2019014656A1 (en) | 2017-07-14 | 2019-01-17 | Han Si Ping | METALLIC OLIGONUCLEOTIDE JONCTIONS FOR THE ADMINISTRATION OF THERAPEUTIC AGENTS |
| EP3665281A4 (en) * | 2017-08-10 | 2021-05-05 | City of Hope | CONDITIONAL SIRNA AND ITS USE IN THE TREATMENT OF CARDIAC HYERTROPHY |
| AU2018331278A1 (en) | 2017-09-18 | 2020-03-26 | Massachusetts Institute Of Technology | Cyclin-dependent kinase 5 (CDK5) inhibitory peptides |
| CA3125731A1 (en) | 2018-01-12 | 2019-07-18 | KDAc Therapeutics, Inc. | Combination of a selective histone deacetylase 3 (hdac3) inhibitor and an immunotherapy agent for the treatment of cancer |
| WO2019235501A1 (ja) * | 2018-06-06 | 2019-12-12 | 塩野義製薬株式会社 | ヒストン脱アセチル化酵素阻害剤 |
| CN113166750B (zh) | 2018-08-10 | 2025-02-18 | 希望之城 | 可编程的条件性sirna及其用途 |
| JP7522726B2 (ja) * | 2019-03-28 | 2024-07-25 | 株式会社カネカ | ピロールイミダゾール（ポリ）アミドの製造方法 |
| EP3982968A4 (en) * | 2019-06-13 | 2023-07-05 | Dana-Farber Cancer Institute, Inc. | DEVELOPMENT OF HDAC3 CATALYTIC INHIBITOR AND USES THEREOF |
| WO2021117759A1 (ja) | 2019-12-10 | 2021-06-17 | 塩野義製薬株式会社 | 含窒素芳香族複素環式基を有するヒストン脱アセチル化酵素阻害剤 |
| CN110951738B (zh) * | 2019-12-23 | 2021-10-15 | 华南农业大学 | 猪hdac2基因的表达抑制剂及其应用 |
| CN112062826A (zh) * | 2020-06-01 | 2020-12-11 | 暨南大学 | 一种与中枢神经衰老相关的乙酰化修饰h2b蛋白标记分子及其应用 |
| IL313081A (en) | 2021-12-03 | 2024-07-01 | Tango Therapeutics Inc | New HDAC inhibitors and their medical use |
| CN116270932B (zh) * | 2021-12-13 | 2024-08-23 | 南京大学 | 一种具有治疗脑损伤疾病的安宫牛黄丸小rna组合及其应用 |
| CN115192714B (zh) * | 2022-07-08 | 2024-09-17 | 沈阳药科大学 | Hdac6抑制剂在制备治疗dnmt3a基因缺失癌症的药物中的用途 |
| WO2024245060A1 (zh) * | 2023-06-02 | 2024-12-05 | 苏州浦合医药科技有限公司 | HDAC1-CoREST高选择性抑制剂 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040077591A1 (en) * | 2002-03-28 | 2004-04-22 | The Brigham And Women's Hospital, Inc. | Histone deacetylase inhibitors for the treatment of multiple sclerosis, amyotrophic lateral sclerosis and Alzheimer's Disease |
| US20050054647A1 (en) * | 2002-12-27 | 2005-03-10 | Detlev Schuppan | New pharmaceutical combination |
| TW200424174A (en) * | 2003-02-06 | 2004-11-16 | Hoffmann La Roche | New TP diamide |
| EP1697538A1 (en) * | 2003-12-18 | 2006-09-06 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Method for identifying histone deacetylase inhibitors |
| US20060018921A1 (en) * | 2004-07-16 | 2006-01-26 | Baylor College Of Medicine | Histone deacetylase inhibitors and cognitive applications |
| CA2587013A1 (en) * | 2004-11-08 | 2006-05-18 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| US7642253B2 (en) * | 2005-05-11 | 2010-01-05 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| JP2009507081A (ja) * | 2005-09-07 | 2009-02-19 | ブレインセルス，インコーポレイティド | ＨＤａｃ阻害による神経発生の調整 |
| WO2008086452A2 (en) * | 2007-01-10 | 2008-07-17 | Columbia University | Treatment and prevention of alzheimer's disease |
-
2009
- 2009-12-02 CA CA2745073A patent/CA2745073A1/en not_active Abandoned
- 2009-12-02 EP EP09830725A patent/EP2367599A4/en not_active Withdrawn
- 2009-12-02 US US13/132,179 patent/US20120101147A1/en not_active Abandoned
- 2009-12-02 NZ NZ593447A patent/NZ593447A/xx not_active IP Right Cessation
- 2009-12-02 CN CN2009801532239A patent/CN102271763A/zh active Pending
- 2009-12-02 AU AU2009322958A patent/AU2009322958B2/en not_active Ceased
- 2009-12-02 WO PCT/US2009/006355 patent/WO2010065117A1/en not_active Ceased
- 2009-12-02 JP JP2011539506A patent/JP2012510512A/ja active Pending
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