JP2012509871A5 - - Google Patents
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- JP2012509871A5 JP2012509871A5 JP2011537432A JP2011537432A JP2012509871A5 JP 2012509871 A5 JP2012509871 A5 JP 2012509871A5 JP 2011537432 A JP2011537432 A JP 2011537432A JP 2011537432 A JP2011537432 A JP 2011537432A JP 2012509871 A5 JP2012509871 A5 JP 2012509871A5
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- cancer
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Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11781108P | 2008-11-25 | 2008-11-25 | |
| US11783908P | 2008-11-25 | 2008-11-25 | |
| US11786108P | 2008-11-25 | 2008-11-25 | |
| US61/117,839 | 2008-11-25 | ||
| US61/117,811 | 2008-11-25 | ||
| US61/117,861 | 2008-11-25 | ||
| US12/366,567 US8062864B2 (en) | 2007-05-21 | 2009-02-05 | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
| US12/366,567 | 2009-02-05 | ||
| US39161509A | 2009-02-24 | 2009-02-24 | |
| US12/391,615 | 2009-02-24 | ||
| US12/391,717 US8178101B2 (en) | 2007-05-21 | 2009-02-24 | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
| US12/391,717 | 2009-02-24 | ||
| US12/399,156 US20090238825A1 (en) | 2007-05-21 | 2009-03-06 | Novel rabbit antibody humanization methods and humanized rabbit antibodies |
| US12/399,156 | 2009-03-06 | ||
| US12/502,581 US8323649B2 (en) | 2008-11-25 | 2009-07-14 | Antibodies to IL-6 and use thereof |
| US12/502,581 | 2009-07-14 | ||
| PCT/US2009/006257 WO2010065072A1 (en) | 2008-11-25 | 2009-11-24 | Antagonists of il-6 to raise albumin and/or lower crp |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014189695A Division JP5815098B2 (ja) | 2008-11-25 | 2014-09-18 | アルブミンを上昇および／またはｃｒｐを低下させるためのｉｌ−６アンタゴニスト |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012509871A JP2012509871A (ja) | 2012-04-26 |
| JP2012509871A5 true JP2012509871A5 (https=) | 2012-12-20 |
| JP5620918B2 JP5620918B2 (ja) | 2014-11-05 |
Family
ID=42233511
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537432A Expired - Fee Related JP5620918B2 (ja) | 2008-11-25 | 2009-11-24 | アルブミンを上昇および／またはｃｒｐを低下させるためのｉｌ−６アンタゴニスト |
| JP2011537436A Expired - Fee Related JP5832292B2 (ja) | 2008-11-25 | 2009-11-24 | 悪液質、虚弱、疲労、および／または発熱を予防または治療するためのｉｌ−６のアンタゴニスト |
| JP2011537433A Expired - Fee Related JP5832291B2 (ja) | 2008-11-25 | 2009-11-24 | 血栓症を予防または治療するためのｉｌ−６のアンタゴニスト |
| JP2011537437A Active JP5898496B2 (ja) | 2008-11-25 | 2009-11-24 | Ｉｌ−６に対する抗体およびその使用 |
| JP2014189695A Expired - Fee Related JP5815098B2 (ja) | 2008-11-25 | 2014-09-18 | アルブミンを上昇および／またはｃｒｐを低下させるためのｉｌ−６アンタゴニスト |
| JP2015104877A Active JP6035373B2 (ja) | 2008-11-25 | 2015-05-22 | Ｉｌ−６に対する抗体およびその使用 |
| JP2015106045A Active JP6050430B2 (ja) | 2008-11-25 | 2015-05-26 | 悪液質、虚弱、疲労、および／または発熱を予防または治療するためのｉｌ−６のアンタゴニスト |
| JP2015106107A Expired - Fee Related JP6050431B2 (ja) | 2008-11-25 | 2015-05-26 | 血栓症を予防または治療するためのｉｌ−６のアンタゴニスト |
| JP2016213750A Expired - Fee Related JP6190028B2 (ja) | 2008-11-25 | 2016-10-31 | Ｉｌ−６に対する抗体およびその使用 |
Family Applications After (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537436A Expired - Fee Related JP5832292B2 (ja) | 2008-11-25 | 2009-11-24 | 悪液質、虚弱、疲労、および／または発熱を予防または治療するためのｉｌ−６のアンタゴニスト |
| JP2011537433A Expired - Fee Related JP5832291B2 (ja) | 2008-11-25 | 2009-11-24 | 血栓症を予防または治療するためのｉｌ−６のアンタゴニスト |
| JP2011537437A Active JP5898496B2 (ja) | 2008-11-25 | 2009-11-24 | Ｉｌ−６に対する抗体およびその使用 |
| JP2014189695A Expired - Fee Related JP5815098B2 (ja) | 2008-11-25 | 2014-09-18 | アルブミンを上昇および／またはｃｒｐを低下させるためのｉｌ−６アンタゴニスト |
| JP2015104877A Active JP6035373B2 (ja) | 2008-11-25 | 2015-05-22 | Ｉｌ−６に対する抗体およびその使用 |
| JP2015106045A Active JP6050430B2 (ja) | 2008-11-25 | 2015-05-26 | 悪液質、虚弱、疲労、および／または発熱を予防または治療するためのｉｌ−６のアンタゴニスト |
| JP2015106107A Expired - Fee Related JP6050431B2 (ja) | 2008-11-25 | 2015-05-26 | 血栓症を予防または治療するためのｉｌ−６のアンタゴニスト |
| JP2016213750A Expired - Fee Related JP6190028B2 (ja) | 2008-11-25 | 2016-10-31 | Ｉｌ−６に対する抗体およびその使用 |
Country Status (19)
| Country | Link |
|---|---|
| EP (5) | EP2361095B1 (https=) |
| JP (9) | JP5620918B2 (https=) |
| KR (4) | KR20110112307A (https=) |
| CN (5) | CN102292107B (https=) |
| AR (1) | AR074227A1 (https=) |
| AU (5) | AU2009323009B2 (https=) |
| BR (1) | BRPI0921569A2 (https=) |
| CA (1) | CA2744400C (https=) |
| DK (1) | DK3338799T3 (https=) |
| EA (1) | EA201100641A1 (https=) |
| HK (1) | HK1256622A1 (https=) |
| IL (2) | IL212728B (https=) |
| MX (7) | MX364874B (https=) |
| NO (1) | NO2367570T3 (https=) |
| NZ (2) | NZ602166A (https=) |
| SG (1) | SG171804A1 (https=) |
| TW (6) | TWI469793B (https=) |
| WO (4) | WO2010065077A2 (https=) |
| ZA (1) | ZA201103803B (https=) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104761637B (zh) | 2006-03-31 | 2021-10-15 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
| US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
| US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
| US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
| US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| DK2164514T3 (en) | 2007-05-21 | 2017-02-27 | Alderbio Holdings Llc | Antibodies to IL-6 and its use |
| US7906117B2 (en) | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
| ES2595638T3 (es) | 2007-09-26 | 2017-01-02 | Chugai Seiyaku Kabushiki Kaisha | Método para modificar el punto isoeléctrico de un anticuerpo mediante la sustitución de aminoácidos en una CDR |
| KR101680906B1 (ko) | 2007-09-26 | 2016-11-30 | 추가이 세이야쿠 가부시키가이샤 | 항체 정상영역 개변체 |
| KR102057826B1 (ko) | 2008-04-11 | 2019-12-20 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| US8323649B2 (en) | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
| KR20110112307A (ko) * | 2008-11-25 | 2011-10-12 | 앨더 바이오파마슈티컬즈, 인코포레이티드 | 알부민을 상승시키고 및／또는 ｃｒｐ를 낮추는 ｉｌ６의 길항제 |
| US9452227B2 (en) | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
| US8337847B2 (en) | 2008-11-25 | 2012-12-25 | Alderbio Holdings Llc | Methods of treating anemia using anti-IL-6 antibodies |
| US8420089B2 (en) | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
| US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| US7947653B1 (en) | 2009-10-09 | 2011-05-24 | Cold Spring Harbor Laboratory | Methods for treating epidermal growth factor receptor tyrosine kinase inhibitor-resistant cancers |
| US8323883B1 (en) | 2009-10-09 | 2012-12-04 | Cold Spring Harbor Laboratory | Methods of assessing therapeutic benefits of patients having cancers resistant to epidermal growth factor receptor kinase inhibitors |
| US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
| CN102740888B (zh) | 2009-11-24 | 2016-10-12 | 奥尔德生物制药公司 | Il-6抗体及其用途 |
| JP2012041271A (ja) * | 2010-08-12 | 2012-03-01 | Univ Of Tokyo | 血栓形成を抑制する作用を有する組成物 |
| KR20190120439A (ko) | 2010-11-08 | 2019-10-23 | 제넨테크, 인크. | 피하 투여용 항―ｉｌ―6 수용체 항체 |
| CA2818813C (en) | 2010-11-23 | 2020-10-06 | Alder Biopharmaceuticals, Inc. | Anti-il-6 antibodies for the treatment of oral mucositis |
| EP2647706B1 (en) | 2010-11-30 | 2023-05-17 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
| CN104066428A (zh) * | 2011-10-12 | 2014-09-24 | 思佰益药业股份有限公司 | 抗癌剂的副作用的预防剂和/或治疗剂 |
| JO3370B1 (ar) | 2011-11-10 | 2019-03-13 | Regeneron Pharma | طريقة لتثبيط نمو الورم عن طريق تثبيط مستقبل انترلوكين 6 |
| PL3326649T3 (pl) * | 2012-05-03 | 2022-04-25 | Boehringer Ingelheim International Gmbh | Przeciwciała anty-il-23p19 |
| HRP20230297T1 (hr) | 2012-07-13 | 2023-05-12 | The Trustees Of The University Of Pennsylvania | UPRAVLJANJE TOKSIČNOŠĆU ZA ANTI-TUMORSKO DJELOVANJE CAR-a |
| WO2014013334A2 (en) * | 2012-07-20 | 2014-01-23 | Agency For Science, Technology And Research | In vitro assay for predicting renal proximal tubular cell toxicity |
| EP2896291B1 (en) * | 2012-09-13 | 2019-03-20 | Chugai Seiyaku Kabushiki Kaisha | Gene knock-in non-human animal |
| RU2656162C2 (ru) | 2012-10-22 | 2018-05-31 | Фоунтейн Биофарма Инк. | Антитела к интерлейкину 6 и их применение |
| RS60026B1 (sr) | 2013-02-18 | 2020-04-30 | Vegenics Pty Ltd | Molekuli koji vezuju ligande i njihove upotrebe |
| KR101332836B1 (ko) * | 2013-05-15 | 2013-11-27 | 재단법인 통합의료진흥원 | 자음강화탕을 포함하는 유방암 치료용 조성물 |
| US10782290B2 (en) | 2013-06-11 | 2020-09-22 | National Center Of Neurology And Psychiatry | Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (RRMS) patient, and method for determining applicability of novel therapy |
| WO2015054293A1 (en) * | 2013-10-07 | 2015-04-16 | Alder Biopharmaceuticals, Inc. | Anti-il-6 antibodies for the treatment of psoriatic arthritis |
| CN103739672B (zh) * | 2013-12-31 | 2015-06-10 | 威特曼生物科技（南京）有限公司 | 一种聚乙二醇修饰的抑制vegfr2酪氨酸激酶多肽及其应用 |
| EP2926815A1 (en) * | 2014-04-03 | 2015-10-07 | Institut Curie | New derivatives of cephalosporin for treating cancer |
| JO3663B1 (ar) * | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
| CN104147120A (zh) * | 2014-09-04 | 2014-11-19 | 成都市飞龙水处理技术研究所 | 一种治疗多发性神经纤维瘤的内服中药液及其制备方法 |
| WO2016070769A1 (zh) * | 2014-11-04 | 2016-05-12 | 北京韩美药品有限公司 | 同时阻断b7/cd28和il6/il6r/gp130信号通路的重组融合蛋白 |
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| US10697883B2 (en) | 2015-05-19 | 2020-06-30 | National Center Of Neurology And Psychiatry | Method for determining application of therapy to multiple sclerosis (MS) patient |
| US11174317B2 (en) | 2015-06-04 | 2021-11-16 | National Center Of Neurology And Psychiatry | Therapeutic agent for mental illness comprising IL-6 inhibitor as active ingredient |
| CA2991637C (en) * | 2015-07-31 | 2022-07-05 | Medimmune Limited | Methods for treating hepcidin-mediated disorders |
| CN105586426B (zh) * | 2016-03-01 | 2019-02-26 | 浙江大学 | 与慢性乙型肝炎病毒感染相关的IL-6基因rs2069852位点标志物及其应用 |
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| KR20200012823A (ko) | 2017-02-01 | 2020-02-05 | 예일 유니버시티 | 이뇨제 내성의 치료 |
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| JP7355319B2 (ja) * | 2017-11-24 | 2023-10-03 | 国立研究開発法人理化学研究所 | ＩＬ‐１β及び／又はＩＬ‐６の発現抑制剤を含む、脳内炎症に起因する疲労を予防、及び／又は、改善するための抗疲労組成物とその利用 |
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| US20210071183A1 (en) * | 2018-02-26 | 2021-03-11 | The Trustees Of Columbia University In The City Of New York | Zinc associated treatment for and diagnosis of cachexia |
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| EP3957324A4 (en) | 2019-04-17 | 2023-02-08 | Hiroshima University | THERAPEUTIC FOR UROLOGICAL ONCOLOGY CHARACTERIZED BY BEING ADMINISTRATED IN COMBINATION WITH IL-6 INHIBITOR AND CCR2 INHIBITOR |
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| KR20220098755A (ko) | 2019-11-05 | 2022-07-12 | 애브비 인코포레이티드 | 나비토클락스를 사용한 골수섬유증 및 mpn 관련 장애 치료에 사용하기 위한 투약 레지멘 |
| CN111053909A (zh) * | 2020-02-27 | 2020-04-24 | 南通大学 | 2019-nCoV3CL水解酶抑制剂与IL-6单抗在制备治疗新冠肺炎药物中的应用 |
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| US20230151107A1 (en) * | 2020-04-04 | 2023-05-18 | Biocon Limited | Anti-cd6 antibody compositions and methods for treating and reducing negative effects of a coronavirus including covid-19 |
| KR20230012539A (ko) | 2020-05-13 | 2023-01-26 | 디스크 메디슨, 인크. | 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체 |
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