HK1256622A1 - Antibodies to il-6 and use thereof - Google Patents

Antibodies to il-6 and use thereof Download PDF

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Publication number
HK1256622A1
HK1256622A1 HK18115754.4A HK18115754A HK1256622A1 HK 1256622 A1 HK1256622 A1 HK 1256622A1 HK 18115754 A HK18115754 A HK 18115754A HK 1256622 A1 HK1256622 A1 HK 1256622A1
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HK
Hong Kong
Prior art keywords
seq
antibody
polypeptide
patient
cancer
Prior art date
Application number
HK18115754.4A
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English (en)
Chinese (zh)
Inventor
Leon Garcia-Martinez
Anne Elisabeth Carvalho-Jensen
Katie Olson
Ben Dutzar
John Latham
Brian Kovacevich
Jeffrey T.L. Smith
Mark Litton
Randall Schatzman
Original Assignee
Alderbio Holdings Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/366,567 external-priority patent/US8062864B2/en
Priority claimed from US12/391,717 external-priority patent/US8178101B2/en
Priority claimed from US12/399,156 external-priority patent/US20090238825A1/en
Priority claimed from US12/502,581 external-priority patent/US8323649B2/en
Application filed by Alderbio Holdings Llc filed Critical Alderbio Holdings Llc
Publication of HK1256622A1 publication Critical patent/HK1256622A1/en

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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • C07K16/248IL-6
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Urology & Nephrology (AREA)
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HK18115754.4A 2008-11-25 2018-12-10 Antibodies to il-6 and use thereof HK1256622A1 (en)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US502581 1983-06-09
US11786108P 2008-11-25 2008-11-25
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US12/366,567 US8062864B2 (en) 2007-05-21 2009-02-05 Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
US366567 2009-02-05
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US12/391,717 US8178101B2 (en) 2007-05-21 2009-02-24 Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
US391717 2009-02-24
US12/399,156 US20090238825A1 (en) 2007-05-21 2009-03-06 Novel rabbit antibody humanization methods and humanized rabbit antibodies
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JP6050430B2 (ja) 2016-12-21
AU2016256810B2 (en) 2019-01-17
IL212728B (en) 2018-02-28
JP2012509874A (ja) 2012-04-26
CN102292449B (zh) 2016-03-30
MX2019005415A (es) 2019-08-12
TWI481413B (zh) 2015-04-21
EP2361095A4 (en) 2013-07-24
AU2009323007A1 (en) 2010-06-10
CN103861106A (zh) 2014-06-18
TWI547502B (zh) 2016-09-01
AU2009323009A1 (en) 2010-06-10
AU2016256810A1 (en) 2016-12-01
CN102438653B (zh) 2019-04-23
MX2011005408A (es) 2011-06-16
MX2011005411A (es) 2011-06-16
TWI533883B (zh) 2016-05-21
WO2010065072A1 (en) 2010-06-10
WO2010065079A2 (en) 2010-06-10
CN103861106B (zh) 2017-03-22
JP2015164951A (ja) 2015-09-17
JP2017048222A (ja) 2017-03-09
KR20110112307A (ko) 2011-10-12
NZ592516A (en) 2013-02-22
EP2361095A1 (en) 2011-08-31
WO2010065072A8 (en) 2010-12-16
AU2009323008A1 (en) 2010-06-10
JP5898496B2 (ja) 2016-04-06
JP6035373B2 (ja) 2016-11-30
CN102438653A (zh) 2012-05-02
CN102292107B (zh) 2014-03-26
MX365985B (es) 2019-06-21
EP2367570B1 (en) 2017-12-20
AU2009323009B2 (en) 2016-01-28
AU2009323007B2 (en) 2016-01-28
JP5832291B2 (ja) 2015-12-16
EP2361096B1 (en) 2019-01-02
CA2744400C (en) 2019-01-15
CN102292106B (zh) 2016-02-03
WO2010065077A3 (en) 2010-09-10
JP5815098B2 (ja) 2015-11-17
TWI617318B (zh) 2018-03-11
CA2744400A1 (en) 2010-06-10
AU2009323002B2 (en) 2016-01-28
MX364874B (es) 2019-05-09
TW201023889A (en) 2010-07-01
JP2012509871A (ja) 2012-04-26
JP5832292B2 (ja) 2015-12-16
CN102292107A (zh) 2011-12-21
DK3338799T3 (da) 2021-06-14

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