JP2012509678A - 組換えウイルス発現のためのプロモーター - Google Patents

組換えウイルス発現のためのプロモーター Download PDF

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JP2012509678A
JP2012509678A JP2011537890A JP2011537890A JP2012509678A JP 2012509678 A JP2012509678 A JP 2012509678A JP 2011537890 A JP2011537890 A JP 2011537890A JP 2011537890 A JP2011537890 A JP 2011537890A JP 2012509678 A JP2012509678 A JP 2012509678A
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promoter
nucleic acid
polynucleotide
vector
nucleotides
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JP2012509678A5 (https=
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スタイガーヴァルド,ロビン
ヘンシェル,クリスティーン マインシンガー
フェルダー,エヴァ
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バヴァリアン・ノルディック・アクティーゼルスカブ
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/24011Poxviridae
    • C12N2710/24111Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/023Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a poxvirus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2830/00Vector systems having a special element relevant for transcription
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    • C12N2840/00Vectors comprising a special translation-regulating system
    • C12N2840/60Vectors comprising a special translation-regulating system from viruses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
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  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2011537890A 2008-11-27 2009-11-27 組換えウイルス発現のためのプロモーター Pending JP2012509678A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08020617 2008-11-27
EP08020617.0 2008-11-27
PCT/EP2009/008459 WO2010060632A1 (en) 2008-11-27 2009-11-27 Promoters for recombinant viral expression

Related Child Applications (1)

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JP2015230172A Division JP6291467B2 (ja) 2008-11-27 2015-11-26 組換えウイルス発現のためのプロモーター

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JP2012509678A true JP2012509678A (ja) 2012-04-26
JP2012509678A5 JP2012509678A5 (https=) 2012-11-29

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JP2011537890A Pending JP2012509678A (ja) 2008-11-27 2009-11-27 組換えウイルス発現のためのプロモーター
JP2015230172A Active JP6291467B2 (ja) 2008-11-27 2015-11-26 組換えウイルス発現のためのプロモーター

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US (2) US8772023B2 (https=)
EP (1) EP2367944B1 (https=)
JP (2) JP2012509678A (https=)
AU (1) AU2009319336B2 (https=)
CA (1) CA2741724C (https=)
DK (1) DK2367944T3 (https=)
NZ (1) NZ592082A (https=)
WO (1) WO2010060632A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
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JP2018516599A (ja) * 2015-05-29 2018-06-28 コーロン ライフ サイエンス インコーポレイテッドKolon Life Science, Inc. ポックスウイルス由来のプロモーターおよびそれを含むベクター

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CN102325888B (zh) 2008-11-21 2016-09-07 巴法里安诺迪克有限公司 包含多个同源核苷酸序列的载体
DK2788021T3 (en) 2011-12-09 2017-04-10 Bavarian Nordic As POXVIRUS VECTOR FOR EXPRESSION OF BACTERIAL ANTIGENES CONNECTED TO TETANANOX INFRAGMENT C
EP2864487B1 (en) 2012-06-22 2018-12-05 Bavarian Nordic A/S Poxviral vectors for low antibody response after a first priming immunization
US9828414B2 (en) 2012-10-28 2017-11-28 Bavarian Nordic A/S Pr13.5 promoter for robust T-cell and antibody responses
CN107709554A (zh) * 2015-06-15 2018-02-16 巴法里安诺迪克有限公司 重组经修饰痘苗病毒安卡拉(mva)口蹄疫病毒(fmdv)疫苗
FR3042121A1 (fr) 2015-10-08 2017-04-14 Jean-Marc Limacher Composition anti-tumorale
US10881725B2 (en) 2016-01-29 2021-01-05 Bavarian Nordic A/S Recombinant modified vaccinia virus Ankara (MVA) equine encephalitis virus vaccine
CA3036799C (en) 2016-09-28 2025-05-13 Bavarian Nordic A/S COMPOSITIONS AND METHODS FOR IMPROVING THE STABILITY OF TRANSGENES IN POXVIRUSES
WO2018091680A1 (en) 2016-11-18 2018-05-24 Transgene Sa Cowpox-based oncolytic vectors
KR20190097240A (ko) 2016-12-28 2019-08-20 트랜스진 에스.에이. 종양용해성 바이러스 및 치료 분자
CN110958887B (zh) 2017-06-15 2023-10-31 扬森疫苗与预防公司 编码hiv抗原的痘病毒载体及其使用方法
WO2019020543A1 (en) 2017-07-28 2019-01-31 Transgene Sa ONCOLYTIC VIRUSES EXPRESSING AGENTS TARGETING METABOLIC IMMUNE MODULATORS
KR102754876B1 (ko) 2017-08-24 2025-01-13 버베리안 노딕 에이/에스 재조합 mva 및 항체의 정맥내 투여에 의한 암 치료를 위한 병용 요법
CN111741766A (zh) 2017-12-19 2020-10-02 杨森科学爱尔兰无限公司 用于诱导针对乙型肝炎病毒(hbv)的免疫应答的方法和组合物
WO2020011754A1 (en) 2018-07-09 2020-01-16 Transgene Chimeric vaccinia viruses
JP7555334B2 (ja) 2018-10-05 2024-09-24 バヴァリアン・ノルディック・アクティーゼルスカブ 組み換えmva、及び免疫チェックポイントアンタゴニストまたは免疫チェックポイントアゴニストの静脈内投与によって、がんを治療する併用療法
MX2021005560A (es) 2018-11-20 2021-06-23 Bavarian Nordic As Terapia para el tratamiento del cancer con administracion intratumoral y/o intravenosa de un virus vaccinia ankara (mva) recombinante que codifica ligando 4-1bbl (cd137l) y/o ligando del cumulo o grupo de diferenciacion 40 (cd40l).
CN114867491B (zh) 2019-11-20 2025-08-15 巴法里安诺迪克有限公司 用于肿瘤内和/或静脉内施用以治疗癌症的重组mva病毒
US20220118081A1 (en) 2020-10-20 2022-04-21 Janssen Vaccines & Prevention B.V. HIV vaccine regimens
US20250049903A1 (en) 2021-12-23 2025-02-13 Bavarian Nordic A/S Therapy for Modulating Immune Response with Recombinant MVA Encoding IL-12
EP4452305A1 (en) 2021-12-23 2024-10-30 Bavarian Nordic A/S Recombinant mva viruses for intraperitoneal administration for treating cancer
JP2025525380A (ja) 2022-06-29 2025-08-05 バヴァリアン・ノルディック・アクティーゼルスカブ 組み換え改変saRNA(VRP)及びワクシニアウイルスアンカラ(MVA)プライム-ブーストレジメン
CA3261778A1 (en) 2022-08-18 2024-02-22 Transgene CHIMERIC POXVIRUSES
EP4648781A1 (en) 2023-01-12 2025-11-19 Bavarian Nordic A/S Recombinant modified sarna (vrp) for cancer vaccine
FR3160186A1 (fr) 2024-03-13 2025-09-19 Odimma Therapeutics Vecteur non-viral pour transcription augmentee
WO2026041811A1 (en) 2024-08-23 2026-02-26 Transgene Recombinant poxvirus and method for regulating the expression of toxic conditional gene products of said recombinant poxvirus in a producing cell

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JP2007512009A (ja) * 2003-11-24 2007-05-17 バヴァリアン・ノルディック・アクティーゼルスカブ 改変ワクシニアウイルスアンカラにおける発現用プロモーター
WO2013189611A1 (en) * 2012-06-22 2013-12-27 Bavarian Nordic A/S Poxviral vectors for low antibody response after a first priming immunization

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WO2013189611A1 (en) * 2012-06-22 2013-12-27 Bavarian Nordic A/S Poxviral vectors for low antibody response after a first priming immunization

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JPN5012004026; LI Y: 'HIGH-LEVEL EXPRESSION OF AMSACTA MOOREI ENTOMOPOXVIRUS SPHEROIDIN DEPENDS 以下備考' JOURNAL OF GENERAL VIROLOGY V79 N3, 19980301, P613-622, SOCIETY FOR GENERAL MICROBIOLOGY *
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018516599A (ja) * 2015-05-29 2018-06-28 コーロン ライフ サイエンス インコーポレイテッドKolon Life Science, Inc. ポックスウイルス由来のプロモーターおよびそれを含むベクター
US11001860B2 (en) 2015-05-29 2021-05-11 Kolon Life Science, Inc. Poxvirus-derived promoter, and vector comprising same

Also Published As

Publication number Publication date
EP2367944A1 (en) 2011-09-28
EP2367944B1 (en) 2019-01-09
WO2010060632A1 (en) 2010-06-03
US8772023B2 (en) 2014-07-08
JP2016073297A (ja) 2016-05-12
CA2741724C (en) 2016-10-04
JP6291467B2 (ja) 2018-03-14
US20140342403A1 (en) 2014-11-20
CA2741724A1 (en) 2010-06-03
AU2009319336B2 (en) 2015-03-26
US20120121617A1 (en) 2012-05-17
NZ592082A (en) 2013-03-28
DK2367944T3 (en) 2019-04-15
AU2009319336A1 (en) 2010-06-03

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