JP2012508255A5 - - Google Patents
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- Publication number
- JP2012508255A5 JP2012508255A5 JP2011535727A JP2011535727A JP2012508255A5 JP 2012508255 A5 JP2012508255 A5 JP 2012508255A5 JP 2011535727 A JP2011535727 A JP 2011535727A JP 2011535727 A JP2011535727 A JP 2011535727A JP 2012508255 A5 JP2012508255 A5 JP 2012508255A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- peptide
- composition
- amphiphile
- hydrophilic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 109
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims description 48
- OGQYPPBGSLZBEG-UHFFFAOYSA-N dimethyl(dioctadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC OGQYPPBGSLZBEG-UHFFFAOYSA-N 0.000 claims description 45
- 239000002121 nanofiber Substances 0.000 claims description 40
- 239000000203 mixture Substances 0.000 claims description 39
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 30
- 230000021164 cell adhesion Effects 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 23
- 230000015556 catabolic process Effects 0.000 claims description 22
- 238000006731 degradation reaction Methods 0.000 claims description 22
- 210000002889 endothelial cell Anatomy 0.000 claims description 18
- 230000002209 hydrophobic effect Effects 0.000 claims description 18
- 229920000728 polyester Polymers 0.000 claims description 16
- 210000003038 endothelium Anatomy 0.000 claims description 14
- 229920001610 polycaprolactone Polymers 0.000 claims description 12
- 239000004632 polycaprolactone Substances 0.000 claims description 12
- 230000002792 vascular Effects 0.000 claims description 11
- 210000003709 heart valve Anatomy 0.000 claims description 6
- 210000000329 smooth muscle myocyte Anatomy 0.000 claims description 6
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 4
- 150000001735 carboxylic acids Chemical class 0.000 claims description 4
- 238000003776 cleavage reaction Methods 0.000 claims description 4
- 239000011159 matrix material Substances 0.000 claims description 4
- 230000007017 scission Effects 0.000 claims description 4
- 102000005741 Metalloproteases Human genes 0.000 claims description 3
- 108010006035 Metalloproteases Proteins 0.000 claims description 3
- 239000000853 adhesive Substances 0.000 claims description 3
- 230000001070 adhesive effect Effects 0.000 claims description 3
- 230000004956 cell adhesive effect Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 101710197241 Accessory gland-specific peptide 70A Proteins 0.000 claims description 2
- 201000001320 Atherosclerosis Diseases 0.000 claims description 2
- 230000002152 alkylating effect Effects 0.000 claims description 2
- 230000029936 alkylation Effects 0.000 claims description 2
- 238000005804 alkylation reaction Methods 0.000 claims description 2
- 230000009435 amidation Effects 0.000 claims description 2
- 238000007112 amidation reaction Methods 0.000 claims description 2
- 210000001367 artery Anatomy 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims description 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- 238000001523 electrospinning Methods 0.000 claims description 2
- 229930195729 fatty acid Natural products 0.000 claims description 2
- 239000000194 fatty acid Substances 0.000 claims description 2
- 150000004665 fatty acids Chemical class 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 230000001404 mediated effect Effects 0.000 claims description 2
- 230000017854 proteolysis Effects 0.000 claims description 2
- 238000001338 self-assembly Methods 0.000 claims description 2
- 210000003462 vein Anatomy 0.000 claims description 2
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 102000000424 Matrix Metalloproteinase 2 Human genes 0.000 description 2
- 108010016165 Matrix Metalloproteinase 2 Proteins 0.000 description 2
- MUMXDRRTIYLYMY-YJKCNMNRSA-N (Z)-[dodecyl-[6-(dodecylazaniumyl)hexyl]amino]-oxido-oxidoiminoazanium Chemical compound CCCCCCCCCCCC[NH2+]CCCCCCN(CCCCCCCCCCCC)[N+](\[O-])=N\[O-] MUMXDRRTIYLYMY-YJKCNMNRSA-N 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 108091005601 modified peptides Proteins 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11257808P | 2008-11-07 | 2008-11-07 | |
| US61/112,578 | 2008-11-07 | ||
| US12/497,305 | 2009-07-02 | ||
| US12/497,305 US8735354B2 (en) | 2008-11-07 | 2009-07-02 | Endothelium mimicking nanomatrix |
| PCT/US2009/063732 WO2010054316A2 (en) | 2008-11-07 | 2009-11-09 | Endothelium mimicking nanomatrix |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012508255A JP2012508255A (ja) | 2012-04-05 |
| JP2012508255A5 true JP2012508255A5 (https=) | 2012-11-08 |
| JP5693458B2 JP5693458B2 (ja) | 2015-04-01 |
Family
ID=42153619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011535727A Active JP5693458B2 (ja) | 2008-11-07 | 2009-11-09 | 内皮を模倣するナノマトリックス |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8735354B2 (https=) |
| EP (1) | EP2365820B1 (https=) |
| JP (1) | JP5693458B2 (https=) |
| KR (3) | KR20170117246A (https=) |
| CN (1) | CN102355904A (https=) |
| AU (1) | AU2009313243B2 (https=) |
| CA (1) | CA2742782C (https=) |
| ES (1) | ES2699459T3 (https=) |
| WO (1) | WO2010054316A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8735354B2 (en) | 2008-11-07 | 2014-05-27 | Uab Research Foundation | Endothelium mimicking nanomatrix |
| JP5792442B2 (ja) * | 2010-09-01 | 2015-10-14 | 帝人株式会社 | 細胞特異的ペプチドを含有する繊維構造体 |
| WO2013065814A1 (ja) * | 2011-11-04 | 2013-05-10 | ニプロ株式会社 | 注射針 |
| US20150037293A1 (en) * | 2012-03-06 | 2015-02-05 | The Uab Research Foundation | Technologies for pancreatic islet transplantation |
| CA2899477C (en) | 2013-02-07 | 2019-09-17 | The Regents Of The University Of Michigan | Thromboresistant/bactericidal s-nitroso-n-acetylpenicillamine (snap)-doped nitric oxide release polymers with enhanced stability |
| US9517275B2 (en) * | 2013-09-30 | 2016-12-13 | Northwestern University | Targeted therapy for the prevention of restenosis in the cardiovascular system |
| US20150335685A1 (en) * | 2014-05-20 | 2015-11-26 | Emory University | Engineered stem cell therapy for cardiac repair |
| EP3362079B1 (en) | 2015-10-14 | 2022-04-06 | Northwestern University | Nanofiber paste for growth factor delivery and bone regeneration |
| US12344863B2 (en) | 2016-11-07 | 2025-07-01 | Emory University | Method of producing stem cell-derived endothelial cells and uses thereof |
| CN107034586A (zh) * | 2017-04-21 | 2017-08-11 | 天津工业大学 | 一种聚羟基丁酸酯/聚吡咯复合导电纳米纤维膜及其制备方法 |
| CN112891625A (zh) * | 2021-02-01 | 2021-06-04 | 南方医科大学南方医院 | 一种聚多巴胺二次聚合胶原海绵支架及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002513400A (ja) * | 1997-02-06 | 2002-05-08 | デューク ユニバーシティ メディカル センター | Ｎｏ修飾ヘモグロビンおよびそのための使用 |
| US7713923B2 (en) | 2003-06-25 | 2010-05-11 | Massachusetts Institute Of Technology | Self-assembling peptides incorporating modifications and methods of use thereof |
| US20070293927A1 (en) | 2004-02-17 | 2007-12-20 | The Children's Hospital Of Philadelphia | Gene and Cell Delivery Self Expanding Polymer Stents |
| US8114431B2 (en) | 2006-09-19 | 2012-02-14 | Georgia Tech Research Corporation | Biomolecular coating for implants |
| US8114834B2 (en) | 2006-11-09 | 2012-02-14 | Northwestern University | Self-assembling peptide amphiphiles |
| AU2008210149B2 (en) * | 2007-01-30 | 2011-07-14 | Hemoteq Ag | Biodegradable vascular support |
| US9237945B2 (en) * | 2007-01-30 | 2016-01-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Bioerodible wraps and uses therefor |
| JP2008253297A (ja) * | 2007-03-30 | 2008-10-23 | Univ Kansai Medical | 医療用チューブ |
| US8735354B2 (en) | 2008-11-07 | 2014-05-27 | Uab Research Foundation | Endothelium mimicking nanomatrix |
-
2009
- 2009-07-02 US US12/497,305 patent/US8735354B2/en active Active
- 2009-11-09 ES ES09825552T patent/ES2699459T3/es active Active
- 2009-11-09 KR KR1020177029163A patent/KR20170117246A/ko not_active Ceased
- 2009-11-09 EP EP09825552.4A patent/EP2365820B1/en active Active
- 2009-11-09 WO PCT/US2009/063732 patent/WO2010054316A2/en not_active Ceased
- 2009-11-09 CN CN2009801540150A patent/CN102355904A/zh active Pending
- 2009-11-09 KR KR1020187033168A patent/KR20180125627A/ko not_active Ceased
- 2009-11-09 JP JP2011535727A patent/JP5693458B2/ja active Active
- 2009-11-09 KR KR1020117013015A patent/KR101822200B1/ko active Active
- 2009-11-09 CA CA2742782A patent/CA2742782C/en active Active
- 2009-11-09 AU AU2009313243A patent/AU2009313243B2/en active Active
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