JP2012508239A5 - - Google Patents
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- Publication number
- JP2012508239A5 JP2012508239A5 JP2011535632A JP2011535632A JP2012508239A5 JP 2012508239 A5 JP2012508239 A5 JP 2012508239A5 JP 2011535632 A JP2011535632 A JP 2011535632A JP 2011535632 A JP2011535632 A JP 2011535632A JP 2012508239 A5 JP2012508239 A5 JP 2012508239A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pyrazolo
- imidazol
- piperidin
- pyrimidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 4-Fluoro-3-trifluoromethyl-phenyl Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 229940124302 mTOR inhibitor Drugs 0.000 claims 5
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 4
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 4
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 4
- 206010041067 Small cell lung cancer Diseases 0.000 claims 4
- 208000005017 glioblastoma Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 4
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 2
- 208000017604 Hodgkin disease Diseases 0.000 claims 2
- 208000017662 Hodgkin disease lymphocyte depletion type stage unspecified Diseases 0.000 claims 2
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 2
- 206010049459 Lymphangioleiomyomatosis Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 2
- 229960004316 cisplatin Drugs 0.000 claims 2
- 201000010897 colon adenocarcinoma Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 229960005167 everolimus Drugs 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- FYXRSVDHGLUMHB-UHFFFAOYSA-N 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl]piperidin-1-yl]-1h-pyrazolo[3,4-d]pyrimidine Chemical compound N1=C(C2CCN(CC2)C=2C=3C=NNC=3N=CN=2)N(C)C=C1C1=CC=C(F)C(C(F)(F)F)=C1 FYXRSVDHGLUMHB-UHFFFAOYSA-N 0.000 claims 1
- UEGFNRZYLNKXAD-UHFFFAOYSA-N 4-methylbenzenesulfonic acid;pyrimidine Chemical compound C1=CN=CN=C1.CC1=CC=C(S(O)(=O)=O)C=C1 UEGFNRZYLNKXAD-UHFFFAOYSA-N 0.000 claims 1
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229960000235 temsirolimus Drugs 0.000 claims 1
- QFJCIRLUMZQUOT-UHFFFAOYSA-N temsirolimus Natural products C1CC(O)C(OC)CC1CC(C)C1OC(=O)C2CCCCN2C(=O)C(=O)C(O)(O2)C(C)CCC2CC(OC)C(C)=CC=CC=CC(C)CC(C)C(=O)C(OC)C(O)C(C)=CC(C)C(=O)C1 QFJCIRLUMZQUOT-UHFFFAOYSA-N 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11327908P | 2008-11-11 | 2008-11-11 | |
| US61/113,279 | 2008-11-11 | ||
| PCT/US2009/063188 WO2010056574A1 (en) | 2008-11-11 | 2009-11-04 | P70 s6 kinase inhibitor and mtor inhibitor combination therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012508239A JP2012508239A (ja) | 2012-04-05 |
| JP2012508239A5 true JP2012508239A5 (OSRAM) | 2012-12-20 |
Family
ID=41650365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011535632A Withdrawn JP2012508239A (ja) | 2008-11-11 | 2009-11-04 | Ｐ７０ｓ６キナーゼ阻害剤およびｍｔｏｒ阻害剤の併用療法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20110212977A1 (OSRAM) |
| EP (1) | EP2355820A1 (OSRAM) |
| JP (1) | JP2012508239A (OSRAM) |
| KR (1) | KR20110075014A (OSRAM) |
| CN (1) | CN102209539B (OSRAM) |
| AU (1) | AU2009314335B2 (OSRAM) |
| BR (1) | BRPI0921840A2 (OSRAM) |
| CA (1) | CA2743242A1 (OSRAM) |
| EA (1) | EA018824B1 (OSRAM) |
| MX (1) | MX2011005003A (OSRAM) |
| WO (1) | WO2010056574A1 (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140378500A1 (en) * | 2012-02-01 | 2014-12-25 | 20/20 Gene Systems, Inc. | Methods for predicting tumor reponse to targeted therapies |
| AU2014228385B2 (en) | 2013-03-11 | 2018-08-09 | Merck Patent Gmbh | 6-[4-(1-H-imidazol-2-yl]piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity |
| CN105916503B (zh) | 2014-01-14 | 2020-04-14 | 米伦纽姆医药公司 | 杂芳基化合物和其用途 |
| JP2017502092A (ja) | 2014-01-14 | 2017-01-19 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヘテロアリール及びその使用 |
| GB201918815D0 (en) * | 2019-12-19 | 2020-02-05 | Imperial College Innovations Ltd | Treatment of cancer |
| CN115190803A (zh) * | 2020-01-10 | 2022-10-14 | 共免疫公司 | 治疗肿瘤的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA83484C2 (uk) * | 2003-03-05 | 2008-07-25 | Уайт | Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція |
| US8076338B2 (en) * | 2004-04-23 | 2011-12-13 | Exelixis, Inc. | Kinase modulators and methods of use |
| JP5274842B2 (ja) * | 2004-12-28 | 2013-08-28 | エグゼリクシス， インコーポレイテッド | 免疫疾患、炎症疾患および増殖疾患の処置のためのセリン−スレオニンキナーゼモジュレーター（ｐ７０Ｓ６Ｋ、Ａｋｔ−１およびＡｋｔ−２）としての［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジンまたは［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジン化合物 |
| EP1946120A2 (en) * | 2005-10-18 | 2008-07-23 | George Mason Intellectual Properties, Inc. | Mtor pathway theranostic |
| AR064416A1 (es) * | 2006-12-21 | 2009-04-01 | Cancer Rec Tech Ltd | Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas. |
| UA99284C2 (ru) * | 2007-05-11 | 2012-08-10 | Елі Ліллі Енд Компані | ИНГИБИТОРЫ р70 S6-КИНАЗЫ |
-
2009
- 2009-11-04 CA CA2743242A patent/CA2743242A1/en not_active Abandoned
- 2009-11-04 BR BRPI0921840A patent/BRPI0921840A2/pt not_active IP Right Cessation
- 2009-11-04 KR KR1020117010616A patent/KR20110075014A/ko not_active Abandoned
- 2009-11-04 JP JP2011535632A patent/JP2012508239A/ja not_active Withdrawn
- 2009-11-04 EP EP09752048A patent/EP2355820A1/en not_active Withdrawn
- 2009-11-04 AU AU2009314335A patent/AU2009314335B2/en not_active Expired - Fee Related
- 2009-11-04 US US13/126,489 patent/US20110212977A1/en not_active Abandoned
- 2009-11-04 EA EA201170681A patent/EA018824B1/ru not_active IP Right Cessation
- 2009-11-04 MX MX2011005003A patent/MX2011005003A/es not_active Application Discontinuation
- 2009-11-04 CN CN2009801449528A patent/CN102209539B/zh not_active Expired - Fee Related
- 2009-11-04 WO PCT/US2009/063188 patent/WO2010056574A1/en not_active Ceased
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