JP2012504467A - 睡眠時無呼吸を治療する経静脈法 - Google Patents
睡眠時無呼吸を治療する経静脈法 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3601—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of respiratory organs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/686—Permanently implanted devices, e.g. pacemakers, other stimulators, biochips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/70—Means for positioning the patient in relation to the detecting, measuring or recording means
- A61B5/704—Tables
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4806—Sleep evaluation
- A61B5/4818—Sleep apnoea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/848—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37205—Microstimulators, e.g. implantable through a cannula
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Abstract
Description
Claims (15)
- 移植可能パルス発生器と、
前記パルス発生器に接続され、血管系の中を通して摺動可能に前進させるように構成された移植可能リード線と、を備え、
前記リード線は、刺激部を含んでおり、前記リード線は舌下神経に最も近い位置に前記刺激部を配置するように構成された長さを有する、閉塞性睡眠時無呼吸の治療システム。 - 前記移植可能パルス発生器に接続され、第1の外部呼吸センサまたは第2の内部呼吸センサのうちの少なくとも1つを形成する呼吸センサを含む、請求項1に記載のシステム。
- 前記呼吸センサが第1の検出要素と、前記リード線の長さに沿って前記第1の検出要素から離間した第2の検出要素と、を含み、前記それぞれの第1および第2の検出要素は経胸腔生体インピーダンスを検出するように構成されている、請求項2に記載のシステム。
- 前記リード線が、
ベース部と、
前記ベース部から延設され、第1の刺激電極構造を含む第1の部分と、
前記ベース部から延設され、前記第1の部分から分離して、第2の刺激電極構造を含む第2の部分と、を含み、
前記それぞれの第1および第2の部分は身体の両側に配置できるように構成された長さを有する、請求項2に記載のシステム。 - 前記刺激部が、
前記刺激部の長さに沿って互いに離間した、独立してプログラム可能な複数の電極要素の配列を含み、
前記配列は前記各電極要素の異なる組み合わせを経由して刺激信号を印加するように構成されている、請求項1に記載のシステム。 - 前記電極要素のうちの少なくともいくつかが、前記刺激部の外表面上で円周方向に互いに離間している、請求項4に記載のシステム。
- 前記刺激部が、
前記血管系の中を通って前進させるためのほぼまっすぐな状態と、前記舌下神経の位置で、前記血管系の中の前記刺激部を解放可能に固定するための拡張したコイル状態と、の間で変動可能なコイル構造の少なくとも一部を含む第1の固定装置、または
前記血管系の中を通って前進中においてほぼ折り畳んだ虚脱状態と、前記舌下神経を刺激するための位置で半径方向に拡張した状態と、の間で変動可能なステント構造を含む第2の固定装置、のうちの少なくとも1つを含む、請求項1に記載のシステム。 - 前記刺激部が、前記リード線の外表面のまわりに放射状に配置されたつめ状突起の配列を含む第3の固定装置を含み、ほぼ折り畳んだ虚脱状態では、前記つめ状突起が前記リード線の前記外表面に対してほぼ平坦に置かれており、拡張した状態では、前記つめ状突起が前記リード線の前記外表面から離れてほぼ外方に突き出ている、請求項1に記載のシステム。
- 舌下神経に最も近い位置に経静脈法的に挿入されるように構成された超小型刺激器具と、患者支持器と、を備える閉塞性睡眠時無呼吸の治療システムであって、
前記超小型刺激器具が、
前記舌下神経に最も近い位置に血管系の中に前記超小型刺激器具を固定するように構成された固定装置機構と、
神経刺激信号を生成するように構成された回路と、を含み、
前記患者支持器が、
電力供給装置と、コントローラと、前記超小型刺激器具に最も近い位置に前記患者支持器を位置決めするときに無線で前記超小型刺激器具に電力を送るように構成された電力伝送機構と、を内蔵する患者支持器と、を含む、閉塞性睡眠時無呼吸の治療システム。 - 前記固定装置機構が、
ベース部と、前記ベース部から延設した複数のつめ状突起とを含むつめ状突起構造を備えており、
前記超小型刺激器具が前記ベース部に固定されており、
前記つめ状突起構造は、
前記各つめ状突起が前記超小型刺激器具の長手方向軸に対してほぼ平行に延びている非作動状態と、
前記つめ状突起が前記血管系の側壁に係合するように前記超小型刺激器具からほぼ外方に突き出ている作動状態と、の間で変動可能である、請求項9に記載のシステム。 - 前記固定装置機構が、ステントを備えており、
前記ステントは、前記超小型刺激器具が前記舌下神経に最も近い位置に配置された前記血管系の直径よりも小さい寸法の圧縮された第1の直径を有する非作動状態と、
前記刺激部が前記舌下神経に最も近い位置に位置決めされた前記血管系の前記直径よりも大きい寸法の拡張された第2の直径を有する作動状態と、の間で変動可能である、請求項9に記載のシステム。 - 前記ステントが、ほぼ管状の構造を示す支柱の配列を備え、前記超小型刺激器具が、前記ほぼ管状の構造の外表面に固定されている、請求項11に記載のシステム。
- 前記ステントが、ほぼ管状の構造を示すとともに、前記超小型刺激器具を1つ以上の各支柱に固定して前記超小型刺激器具を前記ほぼ管状の構造の内側の位置につるすように配置されたテザーを含む支柱の配列を備えた、請求項11に記載のシステム。
- 前記患者支持器が、前記電力供給装置と、前記コントローラと、前記電力伝送機構と、を内蔵し、前記患者支持器は少なくとも前記電力伝送機構を内蔵するヘッドレスト構造を含む、請求項9に記載のシステム。
- 外部呼吸センサを備えた、請求項9に記載のシステム。
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US10195208P | 2008-10-01 | 2008-10-01 | |
US61/101,952 | 2008-10-01 | ||
PCT/US2009/059060 WO2010039853A1 (en) | 2008-10-01 | 2009-09-30 | Transvenous method of treating sleep apnea |
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JP2012504467A true JP2012504467A (ja) | 2012-02-23 |
JP5547200B2 JP5547200B2 (ja) | 2014-07-09 |
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US (3) | US9889299B2 (ja) |
EP (2) | EP3714771A1 (ja) |
JP (1) | JP5547200B2 (ja) |
WO (1) | WO2010039853A1 (ja) |
Cited By (5)
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JP2015512285A (ja) * | 2012-03-19 | 2015-04-27 | カーディアック ペースメイカーズ, インコーポレイテッド | 神経損傷をモニタするためのシステム及び方法 |
JP2019503722A (ja) * | 2015-11-17 | 2019-02-14 | インスパイア・メディカル・システムズ・インコーポレイテッドInspire Medical Systems, Inc. | 睡眠呼吸障害(sdb)微小刺激治療装置 |
JP2022524115A (ja) * | 2019-03-08 | 2022-04-27 | バンダービルト・ユニバーシティ | 睡眠呼吸障害を治療するためのシステム及び方法 |
US11839767B2 (en) | 2020-01-10 | 2023-12-12 | Nuxcel2, L.L.C. | Systems and methods for stimulation of cranial nerves |
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EP3381366A1 (en) | 2010-03-12 | 2018-10-03 | Inspire Medical Systems, Inc. | System for identifying a location for nerve stimulation |
US8983572B2 (en) | 2010-10-29 | 2015-03-17 | Inspire Medical Systems, Inc. | System and method for patient selection in treating sleep disordered breathing |
EP2658601A1 (en) | 2010-12-29 | 2013-11-06 | Cardiac Pacemakers, Inc. | Neuro cardiac therapy using sensed pressure |
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JP7432736B2 (ja) | 2020-01-10 | 2024-02-16 | ニューエクセル2 エル.エル.シー. | 脳神経を刺激するためのシステム及び方法 |
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EP2331201B1 (en) | 2020-04-29 |
US20180296829A1 (en) | 2018-10-18 |
US20110202119A1 (en) | 2011-08-18 |
EP2331201A1 (en) | 2011-06-15 |
US9889299B2 (en) | 2018-02-13 |
WO2010039853A1 (en) | 2010-04-08 |
EP3714771A1 (en) | 2020-09-30 |
US11083899B2 (en) | 2021-08-10 |
US11806537B2 (en) | 2023-11-07 |
JP5547200B2 (ja) | 2014-07-09 |
US20220023647A1 (en) | 2022-01-27 |
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