JP2012504018A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012504018A5 JP2012504018A5 JP2011529111A JP2011529111A JP2012504018A5 JP 2012504018 A5 JP2012504018 A5 JP 2012504018A5 JP 2011529111 A JP2011529111 A JP 2011529111A JP 2011529111 A JP2011529111 A JP 2011529111A JP 2012504018 A5 JP2012504018 A5 JP 2012504018A5
- Authority
- JP
- Japan
- Prior art keywords
- dexamethasone
- analog
- derivative
- group
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical class C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 17
- 229940079593 drug Drugs 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 15
- FPVRUILUEYSIMD-RPRRAYFGSA-N [(8s,9r,10s,11s,13s,14s,16r,17r)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(OC(C)=O)[C@@]1(C)C[C@@H]2O FPVRUILUEYSIMD-RPRRAYFGSA-N 0.000 claims 7
- 229960003657 dexamethasone acetate Drugs 0.000 claims 7
- 229920001600 hydrophobic polymer Polymers 0.000 claims 6
- 239000011248 coating agent Substances 0.000 claims 5
- 238000000576 coating method Methods 0.000 claims 5
- 230000001186 cumulative effect Effects 0.000 claims 5
- CGTADGCBEXYWNE-JUKNQOCSSA-N zotarolimus Chemical compound N1([C@H]2CC[C@@H](C[C@@H](C)[C@H]3OC(=O)[C@@H]4CCCCN4C(=O)C(=O)[C@@]4(O)[C@H](C)CC[C@H](O4)C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C3)OC)C[C@H]2OC)C=NN=N1 CGTADGCBEXYWNE-JUKNQOCSSA-N 0.000 claims 5
- 229950009819 zotarolimus Drugs 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000011247 coating layer Substances 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- ZHYGVVKSAGDVDY-QQQXYHJWSA-N 7-o-demethyl cypher Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](O)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 ZHYGVVKSAGDVDY-QQQXYHJWSA-N 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 2
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- IFDVQVHZEKPUSC-UHFFFAOYSA-N cyclohex-3-ene-1,2-dicarboxylic acid Chemical compound OC(=O)C1CCC=CC1C(O)=O IFDVQVHZEKPUSC-UHFFFAOYSA-N 0.000 claims 2
- 229960003957 dexamethasone Drugs 0.000 claims 2
- 229960005167 everolimus Drugs 0.000 claims 2
- 229920002313 fluoropolymer Polymers 0.000 claims 2
- 239000004811 fluoropolymer Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- YCOZIPAWZNQLMR-UHFFFAOYSA-N pentadecane Chemical compound CCCCCCCCCCCCCCC YCOZIPAWZNQLMR-UHFFFAOYSA-N 0.000 claims 2
- 229920005569 poly(vinylidene fluoride-co-hexafluoropropylene) Polymers 0.000 claims 2
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 2
- 229960002930 sirolimus Drugs 0.000 claims 2
- 229960000235 temsirolimus Drugs 0.000 claims 2
- QFJCIRLUMZQUOT-UHFFFAOYSA-N temsirolimus Natural products C1CC(O)C(OC)CC1CC(C)C1OC(=O)C2CCCCN2C(=O)C(=O)C(O)(O2)C(C)CCC2CC(OC)C(C)=CC=CC=CC(C)CC(C)C(=O)C(OC)C(O)C(C)=CC(C)C(=O)C1 QFJCIRLUMZQUOT-UHFFFAOYSA-N 0.000 claims 2
- YYSFXUWWPNHNAZ-PKJQJFMNSA-N umirolimus Chemical compound C1[C@@H](OC)[C@H](OCCOCC)CC[C@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 YYSFXUWWPNHNAZ-PKJQJFMNSA-N 0.000 claims 2
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 1
- BQCIDUSAKPWEOX-UHFFFAOYSA-N 1,1-Difluoroethene Chemical compound FC(F)=C BQCIDUSAKPWEOX-UHFFFAOYSA-N 0.000 claims 1
- 206010002329 Aneurysm Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- PQVDYPCHUGFHAR-PKWREOPISA-N Dexamethasone Tebutate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)COC(=O)CC(C)(C)C)(O)[C@@]1(C)C[C@@H]2O PQVDYPCHUGFHAR-PKWREOPISA-N 0.000 claims 1
- 208000002251 Dissecting Aneurysm Diseases 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 208000032843 Hemorrhage Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 230000003872 anastomosis Effects 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 210000000013 bile duct Anatomy 0.000 claims 1
- 208000034158 bleeding Diseases 0.000 claims 1
- 230000000740 bleeding effect Effects 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 229960000524 dexamethasone isonicotinate Drugs 0.000 claims 1
- 229950000812 dexamethasone palmitate Drugs 0.000 claims 1
- CRVGKGJPQYZRPT-UHFFFAOYSA-N diethylamino acetate Chemical compound CCN(CC)OC(C)=O CRVGKGJPQYZRPT-UHFFFAOYSA-N 0.000 claims 1
- -1 diethylaminomethylene Chemical group 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Chemical group 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 208000030175 lameness Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 claims 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- FYOWZTWVYZOZSI-UHFFFAOYSA-N thiourea dioxide Chemical compound NC(=N)S(O)=O FYOWZTWVYZOZSI-UHFFFAOYSA-N 0.000 claims 1
- 210000003462 vein Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/240,917 | 2008-09-29 | ||
| US12/240,917 US8092822B2 (en) | 2008-09-29 | 2008-09-29 | Coatings including dexamethasone derivatives and analogs and olimus drugs |
| PCT/US2009/057033 WO2010036537A2 (en) | 2008-09-29 | 2009-09-15 | Coatings including dexamethasone derivatives and analogs and olimus drugs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012504018A JP2012504018A (ja) | 2012-02-16 |
| JP2012504018A5 true JP2012504018A5 (enExample) | 2012-08-09 |
| JP5550055B2 JP5550055B2 (ja) | 2014-07-16 |
Family
ID=41360198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011529111A Expired - Fee Related JP5550055B2 (ja) | 2008-09-29 | 2009-09-15 | デキサメタゾン誘導体及び類似体並びにオリムス薬を含むコーティング |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8092822B2 (enExample) |
| EP (1) | EP2349370B1 (enExample) |
| JP (1) | JP5550055B2 (enExample) |
| ES (1) | ES2479193T3 (enExample) |
| WO (1) | WO2010036537A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10441747B2 (en) | 2002-01-22 | 2019-10-15 | Mercator Medsystems, Inc. | Methods and systems for inhibiting vascular inflammation |
| US8709469B2 (en) * | 2004-06-30 | 2014-04-29 | Abbott Cardiovascular Systems Inc. | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device |
| WO2007075585A2 (en) | 2005-12-16 | 2007-07-05 | Interface Associates, Inc. | Multi-layer balloons for medical applications and methods for manufacturing the same |
| US8114429B2 (en) | 2008-09-15 | 2012-02-14 | Cv Ingenuity Corp. | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
| WO2013073538A1 (ja) | 2011-11-17 | 2013-05-23 | 株式会社ニコン | エンコーダ装置、移動量計測方法、光学装置、並びに露光方法及び装置 |
| JP6106688B2 (ja) * | 2011-12-02 | 2017-04-05 | フェイト セラピューティクス，インコーポレイテッド | 虚血を処置する改善された方法 |
| WO2013091722A1 (en) * | 2011-12-23 | 2013-06-27 | Innora Gmbh | Drug-coated medical devices |
| US9220759B2 (en) | 2012-02-23 | 2015-12-29 | Abbott Cardiovascular Systems Inc. | Treatment of diabetic patients with a drug eluting stent and adjunctive therapy |
| US9220584B2 (en) | 2012-03-30 | 2015-12-29 | Abbott Cardiovascular Systems Inc. | Treatment of diabetic patients with a stent and locally administered adjunctive therapy |
| US20130303496A1 (en) * | 2012-05-08 | 2013-11-14 | Abbott Cardiovascular Systems Inc. | Method Of Treating Vascular Lesions |
| US9956385B2 (en) * | 2012-06-28 | 2018-05-01 | The Spectranetics Corporation | Post-processing of a medical device to control morphology and mechanical properties |
| CA2968508C (en) * | 2014-10-27 | 2023-08-08 | Interface Associates, Inc. | Methods of manufacturing nested balloons utilizing pressurized constrained annealing |
| WO2018057788A1 (en) | 2016-09-22 | 2018-03-29 | Mercator Medsystems, Inc. | Treatment of restenosis using temsirolimus |
| AU2018272061A1 (en) * | 2017-05-26 | 2020-01-02 | Mercator Medsystems, Inc. | Combination therapy for treatment of restenosis |
| US11654267B2 (en) | 2018-03-14 | 2023-05-23 | Mercator Medsystems, Inc. | Medical instrument and medical method for localized drug delivery |
| WO2020168106A1 (en) | 2019-02-13 | 2020-08-20 | Notable Labs, Inc. | Combinations of agonists of protein kinase c with steroids or retinoic acids for the treatment of cancer |
| CN112023125B (zh) * | 2019-06-03 | 2023-03-21 | 上海微创医疗器械（集团）有限公司 | 结晶型涂层及其制备方法、载药植入医疗器械及其制备方法 |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4177268A (en) | 1973-05-30 | 1979-12-04 | Jouveinal S.A. | Method of alleviating inflammation by administration of dexamethasone derivatives |
| US5516781A (en) | 1992-01-09 | 1996-05-14 | American Home Products Corporation | Method of treating restenosis with rapamycin |
| GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| US5609629A (en) | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
| US5658940A (en) | 1995-10-06 | 1997-08-19 | Celgene Corporation | Succinimide and maleimide cytokine inhibitors |
| JPH09157060A (ja) | 1995-12-06 | 1997-06-17 | Sumitomo Chem Co Ltd | 無機焼結多孔体およびフィルタ |
| US5990176A (en) | 1997-01-27 | 1999-11-23 | Abbott Laboratories | Fluoroether compositions and methods for inhibiting their degradation in the presence of a Lewis acid |
| US6273913B1 (en) | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
| US7445792B2 (en) | 2003-03-10 | 2008-11-04 | Abbott Laboratories | Medical device having a hydration inhibitor |
| US20060198867A1 (en) | 1997-09-25 | 2006-09-07 | Abbott Laboratories, Inc. | Compositions and methods of administering rapamycin analogs using medical devices for long-term efficacy |
| US6015815A (en) | 1997-09-26 | 2000-01-18 | Abbott Laboratories | Tetrazole-containing rapamycin analogs with shortened half-lives |
| US7399480B2 (en) | 1997-09-26 | 2008-07-15 | Abbott Laboratories | Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances using medical devices |
| US20030129215A1 (en) | 1998-09-24 | 2003-07-10 | T-Ram, Inc. | Medical devices containing rapamycin analogs |
| US6890546B2 (en) | 1998-09-24 | 2005-05-10 | Abbott Laboratories | Medical devices containing rapamycin analogs |
| US7357942B2 (en) | 1997-09-26 | 2008-04-15 | Abbott Laboratories | Compositions, systems, and kits for administering zotarolimus and paclitaxel to blood vessel lumens |
| US7378105B2 (en) | 1997-09-26 | 2008-05-27 | Abbott Laboratories | Drug delivery systems, kits, and methods for administering zotarolimus and paclitaxel to blood vessel lumens |
| US8394398B2 (en) * | 1997-09-26 | 2013-03-12 | Abbott Laboratories | Methods of administering rapamycin analogs with anti-inflammatories using medical devices |
| US6162443A (en) | 1998-01-09 | 2000-12-19 | Abbott Laboratories | Container for an inhalation anesthetic |
| US6083514A (en) | 1998-01-09 | 2000-07-04 | Abbott Laboratories | Polymethylpentene container for an inhalation anesthetic |
| US6074668A (en) | 1998-01-09 | 2000-06-13 | Abbott Laboratories | Container for an inhalation anesthetic |
| US7960405B2 (en) | 1998-09-24 | 2011-06-14 | Abbott Laboratories | Compounds and methods for treatment and prevention of diseases |
| US8257724B2 (en) | 1998-09-24 | 2012-09-04 | Abbott Laboratories | Delivery of highly lipophilic agents via medical devices |
| US6304786B1 (en) * | 1999-03-29 | 2001-10-16 | Cardiac Pacemakers, Inc. | Implantable lead with dissolvable coating for improved fixation and extraction |
| US6503556B2 (en) | 2000-12-28 | 2003-01-07 | Advanced Cardiovascular Systems, Inc. | Methods of forming a coating for a prosthesis |
| US6908624B2 (en) | 1999-12-23 | 2005-06-21 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
| US20050238686A1 (en) | 1999-12-23 | 2005-10-27 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
| AU9486901A (en) | 2000-09-29 | 2002-04-08 | Cordis Corp | Coated medical devices |
| US6743462B1 (en) | 2001-05-31 | 2004-06-01 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for coating implantable devices |
| US7247313B2 (en) | 2001-06-27 | 2007-07-24 | Advanced Cardiovascular Systems, Inc. | Polyacrylates coatings for implantable medical devices |
| US20080145402A1 (en) | 2001-09-10 | 2008-06-19 | Abbott Cardiovascular Systems Inc. | Medical Devices Containing Rapamycin Analogs |
| US7285304B1 (en) | 2003-06-25 | 2007-10-23 | Advanced Cardiovascular Systems, Inc. | Fluid treatment of a polymeric coating on an implantable medical device |
| US7294329B1 (en) | 2002-07-18 | 2007-11-13 | Advanced Cardiovascular Systems, Inc. | Poly(vinyl acetal) coatings for implantable medical devices |
| US7491233B1 (en) | 2002-07-19 | 2009-02-17 | Advanced Cardiovascular Systems Inc. | Purified polymers for coatings of implantable medical devices |
| US7438722B1 (en) | 2002-09-20 | 2008-10-21 | Advanced Cardiovascular Systems, Inc. | Method for treatment of restenosis |
| US7232573B1 (en) | 2002-09-26 | 2007-06-19 | Advanced Cardiovascular Systems, Inc. | Stent coatings containing self-assembled monolayers |
| EP2359689B1 (en) | 2002-09-27 | 2015-08-26 | The General Hospital Corporation | Microfluidic device for cell separation and use thereof |
| US7087263B2 (en) | 2002-10-09 | 2006-08-08 | Advanced Cardiovascular Systems, Inc. | Rare limiting barriers for implantable medical devices |
| EP1572029B1 (en) | 2002-11-07 | 2010-03-24 | Abbott Laboratories | Method of loading beneficial agent to a prosthesis by fluid-jet application |
| US6896965B1 (en) | 2002-11-12 | 2005-05-24 | Advanced Cardiovascular Systems, Inc. | Rate limiting barriers for implantable devices |
| US7758881B2 (en) | 2004-06-30 | 2010-07-20 | Advanced Cardiovascular Systems, Inc. | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device |
| US6926919B1 (en) | 2003-02-26 | 2005-08-09 | Advanced Cardiovascular Systems, Inc. | Method for fabricating a coating for a medical device |
| US7279174B2 (en) | 2003-05-08 | 2007-10-09 | Advanced Cardiovascular Systems, Inc. | Stent coatings comprising hydrophilic additives |
| US7169404B2 (en) | 2003-07-30 | 2007-01-30 | Advanced Cardiovasular Systems, Inc. | Biologically absorbable coatings for implantable devices and methods for fabricating the same |
| US7431959B1 (en) | 2003-07-31 | 2008-10-07 | Advanced Cardiovascular Systems Inc. | Method and system for irradiation of a drug eluting implantable medical device |
| US7261946B2 (en) | 2003-11-14 | 2007-08-28 | Advanced Cardiovascular Systems, Inc. | Block copolymers of acrylates and methacrylates with fluoroalkenes |
| WO2005081655A2 (en) | 2004-02-17 | 2005-09-09 | The Children's Hospital Of Philadelphia | Gene and cell delivery self expanding polymer stents |
| US20050208093A1 (en) | 2004-03-22 | 2005-09-22 | Thierry Glauser | Phosphoryl choline coating compositions |
| US7820732B2 (en) | 2004-04-30 | 2010-10-26 | Advanced Cardiovascular Systems, Inc. | Methods for modulating thermal and mechanical properties of coatings on implantable devices |
| US20050265960A1 (en) | 2004-05-26 | 2005-12-01 | Pacetti Stephen D | Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same |
| US20060246109A1 (en) * | 2005-04-29 | 2006-11-02 | Hossainy Syed F | Concentration gradient profiles for control of agent release rates from polymer matrices |
| US9561309B2 (en) | 2004-05-27 | 2017-02-07 | Advanced Cardiovascular Systems, Inc. | Antifouling heparin coatings |
| US20050271700A1 (en) | 2004-06-03 | 2005-12-08 | Desnoyer Jessica R | Poly(ester amide) coating composition for implantable devices |
| US7563780B1 (en) | 2004-06-18 | 2009-07-21 | Advanced Cardiovascular Systems, Inc. | Heparin prodrugs and drug delivery stents formed therefrom |
| US7494665B1 (en) | 2004-07-30 | 2009-02-24 | Advanced Cardiovascular Systems, Inc. | Polymers containing siloxane monomers |
| US7244443B2 (en) | 2004-08-31 | 2007-07-17 | Advanced Cardiovascular Systems, Inc. | Polymers of fluorinated monomers and hydrophilic monomers |
| US7166680B2 (en) | 2004-10-06 | 2007-01-23 | Advanced Cardiovascular Systems, Inc. | Blends of poly(ester amide) polymers |
| US7390497B2 (en) | 2004-10-29 | 2008-06-24 | Advanced Cardiovascular Systems, Inc. | Poly(ester amide) filler blends for modulation of coating properties |
| US7214759B2 (en) | 2004-11-24 | 2007-05-08 | Advanced Cardiovascular Systems, Inc. | Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same |
| US8609123B2 (en) | 2004-11-29 | 2013-12-17 | Advanced Cardiovascular Systems, Inc. | Derivatized poly(ester amide) as a biobeneficial coating |
| US7632307B2 (en) | 2004-12-16 | 2009-12-15 | Advanced Cardiovascular Systems, Inc. | Abluminal, multilayer coating constructs for drug-delivery stents |
| US7604818B2 (en) | 2004-12-22 | 2009-10-20 | Advanced Cardiovascular Systems, Inc. | Polymers of fluorinated monomers and hydrocarbon monomers |
| US8007775B2 (en) | 2004-12-30 | 2011-08-30 | Advanced Cardiovascular Systems, Inc. | Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same |
| US20060198868A1 (en) * | 2005-01-05 | 2006-09-07 | Dewitt David M | Biodegradable coating compositions comprising blends |
| US7202325B2 (en) | 2005-01-14 | 2007-04-10 | Advanced Cardiovascular Systems, Inc. | Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles |
| US7700659B2 (en) | 2005-03-24 | 2010-04-20 | Advanced Cardiovascular Systems, Inc. | Implantable devices formed of non-fouling methacrylate or acrylate polymers |
| US8778375B2 (en) | 2005-04-29 | 2014-07-15 | Advanced Cardiovascular Systems, Inc. | Amorphous poly(D,L-lactide) coating |
| US8021676B2 (en) | 2005-07-08 | 2011-09-20 | Advanced Cardiovascular Systems, Inc. | Functionalized chemically inert polymers for coatings |
| US7788635B2 (en) | 2005-07-15 | 2010-08-31 | Sony Computer Entertainment Inc. | Technique for processing a computer program |
| US20070020312A1 (en) | 2005-07-20 | 2007-01-25 | Desnoyer Jessica R | Method of fabricating a bioactive agent-releasing implantable medical device |
| JP5285426B2 (ja) * | 2005-10-14 | 2013-09-11 | アボット ラボラトリーズ | 医療デバイスを用いて、パクリタキセルとともにラパマイシン類似体を投与することについての組成物、システム、キット及び方法 |
| US20070128246A1 (en) | 2005-12-06 | 2007-06-07 | Hossainy Syed F A | Solventless method for forming a coating |
| US20070128289A1 (en) | 2005-12-07 | 2007-06-07 | Zhao Jonathon Z | Nano-and/or micro-particulate formulations for local injection-based treatment of vascular diseases |
| US8021678B2 (en) | 2006-02-10 | 2011-09-20 | Advanced Cardiovascular Systems, Inc. | Implantable medical device with polymer coating in a surface area to volume ratio providing surface erosion characteristics |
| US7601383B2 (en) | 2006-02-28 | 2009-10-13 | Advanced Cardiovascular Systems, Inc. | Coating construct containing poly (vinyl alcohol) |
| US7910152B2 (en) | 2006-02-28 | 2011-03-22 | Advanced Cardiovascular Systems, Inc. | Poly(ester amide)-based drug delivery systems with controlled release rate and morphology |
| US20080004694A1 (en) | 2006-05-23 | 2008-01-03 | Abbott Laboratories | Compositions and methods for administering dexamethasone which promote human coronary artery endothelial cell migration |
| US20080003254A1 (en) | 2006-05-23 | 2008-01-03 | Abbott Laboratories | Systems and methods for delivering a rapamycin analog that do not inhibit human coronary artery endothelial cell migration |
| US8703167B2 (en) | 2006-06-05 | 2014-04-22 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug |
| US20080014245A1 (en) | 2006-07-14 | 2008-01-17 | Stephen Pacetti | Drug-eluting implantable medical device with free radical scavenger for protecting drugs during sterilization and related method |
| WO2008048947A2 (en) | 2006-10-16 | 2008-04-24 | Abbott Laboratories | Apparatus for and related method of inhibiting lewis acid degradation in a vaporizer |
| US20090004243A1 (en) | 2007-06-29 | 2009-01-01 | Pacetti Stephen D | Biodegradable triblock copolymers for implantable devices |
| US20090104241A1 (en) | 2007-10-23 | 2009-04-23 | Pacetti Stephen D | Random amorphous terpolymer containing lactide and glycolide |
| US8679519B2 (en) | 2007-10-23 | 2014-03-25 | Abbott Cardiovascular Systems Inc. | Coating designs for the tailored release of dual drugs from polymeric coatings |
-
2008
- 2008-09-29 US US12/240,917 patent/US8092822B2/en not_active Expired - Fee Related
-
2009
- 2009-09-15 JP JP2011529111A patent/JP5550055B2/ja not_active Expired - Fee Related
- 2009-09-15 WO PCT/US2009/057033 patent/WO2010036537A2/en not_active Ceased
- 2009-09-15 EP EP09737224.7A patent/EP2349370B1/en not_active Not-in-force
- 2009-09-15 ES ES09737224.7T patent/ES2479193T3/es active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012504018A5 (enExample) | ||
| CN102309368B (zh) | 一种人体管腔载药支架及其制备方法 | |
| JP5550055B2 (ja) | デキサメタゾン誘導体及び類似体並びにオリムス薬を含むコーティング | |
| Ma et al. | Paclitaxel/sirolimus combination coated drug-eluting stent: in vitro and in vivo drug release studies | |
| US7442721B2 (en) | Durable biocompatible controlled drug release polymeric coatings for medical devices | |
| JP2012500660A5 (enExample) | ||
| JP2005512959A5 (enExample) | ||
| JP5500397B2 (ja) | 機械的安定性が改善した埋め込み型医療デバイスコーティング | |
| WO2009158333A2 (en) | Medical devices for delivery of therapeutic agent in conjunction with galvanic corrosion | |
| JP2009523133A (ja) | 再狭窄病変治療に有用なナノ粒子含有の薬化合物類 | |
| CN102048602A (zh) | 一种网状可降解血管支架及其制备方法 | |
| US12453624B2 (en) | Polymer-free drug eluting vascular stents | |
| CN102091355A (zh) | 一种复合涂层冠脉药物洗脱支架及其制备方法 | |
| Adhami et al. | Drug loaded implantable devices to treat cardiovascular disease | |
| JP6761547B2 (ja) | アンレキサノクスの新たな使用 | |
| CN101007187B (zh) | 一种复合药物洗脱支架及其药物涂层的制备方法 | |
| KR101595267B1 (ko) | 재협착과 염증 조절을 위한 순차적 약물 방출 스텐트의 제조방법 | |
| JP2008534074A5 (enExample) | ||
| JP2015520147A (ja) | 血管病変を治療する改善された方法 | |
| CN112368030A (zh) | 可降解器材上的聚合物层的改进 | |
| CN102078229A (zh) | 一种可降解冠状动脉支架及其制备方法 | |
| US8591571B2 (en) | Drug-eluting stent | |
| CN101641059A (zh) | 一种不对称药物控释涂层冠脉内支架 | |
| CN101496813A (zh) | 抗组织增生(血管再狭窄)组合物及应用方法 | |
| CN117298358A (zh) | 药物涂层、含有其的药物洗脱支架及其制备方法 |