JP2012503013A5 - - Google Patents
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- Publication number
- JP2012503013A5 JP2012503013A5 JP2011528020A JP2011528020A JP2012503013A5 JP 2012503013 A5 JP2012503013 A5 JP 2012503013A5 JP 2011528020 A JP2011528020 A JP 2011528020A JP 2011528020 A JP2011528020 A JP 2011528020A JP 2012503013 A5 JP2012503013 A5 JP 2012503013A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- cell
- composition
- binding protein
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9819308P | 2008-09-18 | 2008-09-18 | |
| US61/098,193 | 2008-09-18 | ||
| PCT/US2009/057592 WO2010033879A2 (en) | 2008-09-18 | 2009-09-18 | Inhibiting interaction between hif-1a and p300/cbp with hydrogen bond surrogate-based helices |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014186970A Division JP2015061833A (ja) | 2008-09-18 | 2014-09-12 | ＨＩＦ−１αと水素結合代替ヘリックスを有するｐ３００／ＣＢＰの間の相互作用の阻害 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012503013A JP2012503013A (ja) | 2012-02-02 |
| JP2012503013A5 true JP2012503013A5 (https=) | 2012-05-24 |
Family
ID=42040175
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011528020A Withdrawn JP2012503013A (ja) | 2008-09-18 | 2009-09-18 | ＨＩＦ−１αと水素結合代替ヘリックスを有するｐ３００／ＣＢＰの間の相互作用の阻害 |
| JP2014186970A Pending JP2015061833A (ja) | 2008-09-18 | 2014-09-12 | ＨＩＦ−１αと水素結合代替ヘリックスを有するｐ３００／ＣＢＰの間の相互作用の阻害 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014186970A Pending JP2015061833A (ja) | 2008-09-18 | 2014-09-12 | ＨＩＦ−１αと水素結合代替ヘリックスを有するｐ３００／ＣＢＰの間の相互作用の阻害 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9399666B2 (https=) |
| EP (1) | EP2344520B1 (https=) |
| JP (2) | JP2012503013A (https=) |
| CN (1) | CN102216322A (https=) |
| AU (1) | AU2009293020A1 (https=) |
| BR (1) | BRPI0919414A2 (https=) |
| CA (1) | CA2737614A1 (https=) |
| ES (1) | ES2446249T3 (https=) |
| WO (1) | WO2010033879A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008061192A2 (en) * | 2006-11-15 | 2008-05-22 | Dana-Farber Cancer Institute, Inc. | Stabilized maml peptides and uses thereof |
| CN105061577A (zh) | 2006-12-14 | 2015-11-18 | 爱勒让治疗公司 | 双巯基大环化系统 |
| ES2398310T3 (es) | 2007-02-23 | 2013-03-15 | Aileron Therapeutics, Inc. | Péptidos macrocíclicos unidos a triazol |
| AU2008232709C1 (en) | 2007-03-28 | 2015-01-15 | President And Fellows Of Harvard College | Stitched polypeptides |
| US9399666B2 (en) | 2008-09-18 | 2016-07-26 | New York University | Inhibiting interaction between the HIF-1ALPHA and p300/CBP with hydrogen bond surrogate-based helices |
| ES2666458T3 (es) | 2008-09-22 | 2018-05-04 | Aileron Therapeutics, Inc. | Macrociclos peptidomiméticos |
| EP2352507A4 (en) | 2008-11-24 | 2012-04-25 | Aileron Therapeutics Inc | PEPTIDOMIMETIC MACROCYCLES WITH IMPROVED PROPERTIES |
| WO2010083347A2 (en) | 2009-01-14 | 2010-07-22 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| US20130072439A1 (en) | 2009-09-22 | 2013-03-21 | Huw M. Nash | Peptidomimetic macrocycles |
| KR20170058446A (ko) | 2010-08-13 | 2017-05-26 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| US8511577B2 (en) | 2011-02-24 | 2013-08-20 | Nest Labs, Inc. | Thermostat with power stealing delay interval at transitions between power stealing states |
| JP6239979B2 (ja) * | 2011-03-04 | 2017-11-29 | ニューヨーク・ユニバーシティ | Ｒａｓの調節因子としての水素結合代替大環状分子 |
| AR088392A1 (es) | 2011-10-18 | 2014-05-28 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos |
| CN104066435A (zh) * | 2011-12-21 | 2014-09-24 | 纽约大学 | 蛋白水解抗性的氢键替代螺旋 |
| HK1205454A1 (en) | 2012-02-15 | 2015-12-18 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| CA2862038C (en) | 2012-02-15 | 2021-05-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| BR112015009470A2 (pt) | 2012-11-01 | 2019-12-17 | Aileron Therapeutics Inc | aminoácidos dissubstituídos e seus métodos de preparação e uso |
| EP2945631A4 (en) * | 2013-01-19 | 2016-06-29 | Univ New York | OLIGOOXOPIPERAZINE FOR THE REACTIVATION OF P53 |
| WO2014113792A1 (en) * | 2013-01-19 | 2014-07-24 | New York University | Hydrogen-bond surrogate peptides and peptidomimetics for p53 reactivation |
| US20150065436A1 (en) * | 2013-09-03 | 2015-03-05 | University Of Southern California | INHIBITING INTERACTION BETWEEN HIF-1ALPHA AND p300/CBP WITH HYDROGEN BOND SURROGATE-BASED HELICES |
| SG11201702175YA (en) | 2014-09-24 | 2017-04-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and formulations thereof |
| WO2016049359A1 (en) | 2014-09-24 | 2016-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| US10253067B2 (en) | 2015-03-20 | 2019-04-09 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| US10059741B2 (en) | 2015-07-01 | 2018-08-28 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| JP2018528217A (ja) | 2015-09-10 | 2018-09-27 | エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | Ｍｃｌ−１のモジュレーターとしてのペプチド模倣大環状分子 |
| WO2018008984A1 (ko) * | 2016-07-05 | 2018-01-11 | 이화여자대학교 산학협력단 | 에피디티오디옥소피페라진 화합물 또는 이의 유도체, 또는 이들의 약학적으로 허용가능한 염을 포함하는 폐동맥고혈압 예방 또는 치료용 약학적 조성물 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6986881B1 (en) | 1999-06-04 | 2006-01-17 | Dana-Farber Cancer Institute, Inc. | Identification of compounds that modify transcriptional responses to hypoxia |
| GB0211920D0 (en) | 2002-05-23 | 2002-07-03 | Isis Innovations Ltd | Assay |
| WO2005118620A2 (en) * | 2004-05-27 | 2005-12-15 | New York University | Methods for preparing internally constraied peptides and peptidomimetics |
| ITMI20042477A1 (it) | 2004-12-23 | 2005-03-23 | Cell Therapeutics Europe Srl | Uso di antibiotici a strutura dichetoditiopiperazinica per la preparazione di composizioni farmaceutiche antiangiogeniche |
| KR100860060B1 (ko) * | 2006-10-12 | 2008-09-24 | 한국과학기술연구원 | ＨＩＦ-１α Ｃ-말단 펩타이드와 ＣＢＰ 또는 ｐ３００단백질과의 결합을 정량분석하는 방법 및 상기 방법을이용한 단백질 복합체 형성을 저해하는 억제제의 스크리닝방법 |
| US9399666B2 (en) | 2008-09-18 | 2016-07-26 | New York University | Inhibiting interaction between the HIF-1ALPHA and p300/CBP with hydrogen bond surrogate-based helices |
| AU2009294871A1 (en) * | 2008-09-22 | 2010-03-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
-
2009
- 2009-09-18 US US13/119,108 patent/US9399666B2/en active Active
- 2009-09-18 WO PCT/US2009/057592 patent/WO2010033879A2/en not_active Ceased
- 2009-09-18 AU AU2009293020A patent/AU2009293020A1/en not_active Abandoned
- 2009-09-18 JP JP2011528020A patent/JP2012503013A/ja not_active Withdrawn
- 2009-09-18 EP EP09815315.8A patent/EP2344520B1/en not_active Not-in-force
- 2009-09-18 BR BRPI0919414A patent/BRPI0919414A2/pt not_active IP Right Cessation
- 2009-09-18 CN CN2009801461214A patent/CN102216322A/zh active Pending
- 2009-09-18 CA CA2737614A patent/CA2737614A1/en not_active Abandoned
- 2009-09-18 ES ES09815315.8T patent/ES2446249T3/es active Active
-
2014
- 2014-09-12 JP JP2014186970A patent/JP2015061833A/ja active Pending
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