JP2012502969A5 - - Google Patents
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- Publication number
- JP2012502969A5 JP2012502969A5 JP2011527423A JP2011527423A JP2012502969A5 JP 2012502969 A5 JP2012502969 A5 JP 2012502969A5 JP 2011527423 A JP2011527423 A JP 2011527423A JP 2011527423 A JP2011527423 A JP 2011527423A JP 2012502969 A5 JP2012502969 A5 JP 2012502969A5
- Authority
- JP
- Japan
- Prior art keywords
- spy0416
- protein
- spy0167
- mutant
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 76
- 102000036639 antigens Human genes 0.000 claims description 60
- 108091007433 antigens Proteins 0.000 claims description 60
- 102000004169 proteins and genes Human genes 0.000 claims description 51
- 108090000623 proteins and genes Proteins 0.000 claims description 51
- 239000000427 antigen Substances 0.000 claims description 43
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 18
- 208000015181 infectious disease Diseases 0.000 claims description 16
- 150000001413 amino acids Chemical class 0.000 claims description 15
- 241000193996 Streptococcus pyogenes Species 0.000 claims description 10
- 102000039446 nucleic acids Human genes 0.000 claims description 10
- 108020004707 nucleic acids Proteins 0.000 claims description 10
- 150000007523 nucleic acids Chemical class 0.000 claims description 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 9
- 229960005486 vaccine Drugs 0.000 claims description 9
- 102000004890 Interleukin-8 Human genes 0.000 claims description 8
- 108090001007 Interleukin-8 Proteins 0.000 claims description 8
- 229940096397 interleukin-8 Drugs 0.000 claims description 8
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims description 8
- 229920001184 polypeptide Polymers 0.000 claims description 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 7
- 101000617130 Homo sapiens Stromal cell-derived factor 1 Proteins 0.000 claims description 6
- 102100021669 Stromal cell-derived factor 1 Human genes 0.000 claims description 6
- 239000013543 active substance Substances 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- 102100039398 C-X-C motif chemokine 2 Human genes 0.000 claims description 4
- 102100036150 C-X-C motif chemokine 5 Human genes 0.000 claims description 4
- 102100036153 C-X-C motif chemokine 6 Human genes 0.000 claims description 4
- 102100036170 C-X-C motif chemokine 9 Human genes 0.000 claims description 4
- 102000014914 Carrier Proteins Human genes 0.000 claims description 4
- 108010078791 Carrier Proteins Proteins 0.000 claims description 4
- 102000006573 Chemokine CXCL12 Human genes 0.000 claims description 4
- 108010008951 Chemokine CXCL12 Proteins 0.000 claims description 4
- 238000012286 ELISA Assay Methods 0.000 claims description 4
- 101000889128 Homo sapiens C-X-C motif chemokine 2 Proteins 0.000 claims description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 4
- 239000012634 fragment Substances 0.000 claims description 4
- 230000002949 hemolytic effect Effects 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 150000004676 glycans Chemical class 0.000 claims description 3
- 229920001282 polysaccharide Polymers 0.000 claims description 3
- 239000005017 polysaccharide Substances 0.000 claims description 3
- 230000002797 proteolythic effect Effects 0.000 claims description 3
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 claims description 3
- 241000712461 unidentified influenza virus Species 0.000 claims description 3
- 231100000699 Bacterial toxin Toxicity 0.000 claims description 2
- 241000588832 Bordetella pertussis Species 0.000 claims description 2
- 102100025248 C-X-C motif chemokine 10 Human genes 0.000 claims description 2
- 102100025279 C-X-C motif chemokine 11 Human genes 0.000 claims description 2
- 102100025277 C-X-C motif chemokine 13 Human genes 0.000 claims description 2
- 102100025250 C-X-C motif chemokine 14 Human genes 0.000 claims description 2
- 102100039396 C-X-C motif chemokine 16 Human genes 0.000 claims description 2
- 102100036189 C-X-C motif chemokine 3 Human genes 0.000 claims description 2
- 101710085504 C-X-C motif chemokine 6 Proteins 0.000 claims description 2
- 101710085500 C-X-C motif chemokine 9 Proteins 0.000 claims description 2
- 102000016950 Chemokine CXCL1 Human genes 0.000 claims description 2
- 108010014419 Chemokine CXCL1 Proteins 0.000 claims description 2
- 102000019034 Chemokines Human genes 0.000 claims description 2
- 108010012236 Chemokines Proteins 0.000 claims description 2
- 241000193449 Clostridium tetani Species 0.000 claims description 2
- 102000004127 Cytokines Human genes 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims description 2
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims description 2
- 241000194032 Enterococcus faecalis Species 0.000 claims description 2
- 241000991587 Enterovirus C Species 0.000 claims description 2
- 101710115997 Gamma-tubulin complex component 2 Proteins 0.000 claims description 2
- 102100034221 Growth-regulated alpha protein Human genes 0.000 claims description 2
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims description 2
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims description 2
- 101000858088 Homo sapiens C-X-C motif chemokine 10 Proteins 0.000 claims description 2
- 101000858060 Homo sapiens C-X-C motif chemokine 11 Proteins 0.000 claims description 2
- 101000858064 Homo sapiens C-X-C motif chemokine 13 Proteins 0.000 claims description 2
- 101000858068 Homo sapiens C-X-C motif chemokine 14 Proteins 0.000 claims description 2
- 101000889133 Homo sapiens C-X-C motif chemokine 16 Proteins 0.000 claims description 2
- 101000947193 Homo sapiens C-X-C motif chemokine 3 Proteins 0.000 claims description 2
- 101000947186 Homo sapiens C-X-C motif chemokine 5 Proteins 0.000 claims description 2
- 101000947177 Homo sapiens C-X-C motif chemokine 6 Proteins 0.000 claims description 2
- 101000947172 Homo sapiens C-X-C motif chemokine 9 Proteins 0.000 claims description 2
- 101100441523 Homo sapiens CXCL5 gene Proteins 0.000 claims description 2
- 101001069921 Homo sapiens Growth-regulated alpha protein Proteins 0.000 claims description 2
- 101001055222 Homo sapiens Interleukin-8 Proteins 0.000 claims description 2
- 101000947178 Homo sapiens Platelet basic protein Proteins 0.000 claims description 2
- 101000582950 Homo sapiens Platelet factor 4 Proteins 0.000 claims description 2
- 206010061598 Immunodeficiency Diseases 0.000 claims description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 2
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims description 2
- 102000008072 Lymphokines Human genes 0.000 claims description 2
- 108010074338 Lymphokines Proteins 0.000 claims description 2
- 241000712079 Measles morbillivirus Species 0.000 claims description 2
- 241000588655 Moraxella catarrhalis Species 0.000 claims description 2
- 241000711386 Mumps virus Species 0.000 claims description 2
- 241000588650 Neisseria meningitidis Species 0.000 claims description 2
- 101710116435 Outer membrane protein Proteins 0.000 claims description 2
- 201000005702 Pertussis Diseases 0.000 claims description 2
- 102100036154 Platelet basic protein Human genes 0.000 claims description 2
- 102100030304 Platelet factor 4 Human genes 0.000 claims description 2
- 101710188053 Protein D Proteins 0.000 claims description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims description 2
- 101710132893 Resolvase Proteins 0.000 claims description 2
- 241000725643 Respiratory syncytial virus Species 0.000 claims description 2
- 101710084578 Short neurotoxin 1 Proteins 0.000 claims description 2
- 241000191940 Staphylococcus Species 0.000 claims description 2
- 241000191967 Staphylococcus aureus Species 0.000 claims description 2
- 241000193998 Streptococcus pneumoniae Species 0.000 claims description 2
- 101710182223 Toxin B Proteins 0.000 claims description 2
- 101710182532 Toxin a Proteins 0.000 claims description 2
- 239000012190 activator Substances 0.000 claims description 2
- PNNNRSAQSRJVSB-BXKVDMCESA-N aldehydo-L-rhamnose Chemical compound C[C@H](O)[C@H](O)[C@@H](O)[C@@H](O)C=O PNNNRSAQSRJVSB-BXKVDMCESA-N 0.000 claims description 2
- 229940037003 alum Drugs 0.000 claims description 2
- 230000000890 antigenic effect Effects 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 239000000688 bacterial toxin Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229940032049 enterococcus faecalis Drugs 0.000 claims description 2
- 210000002615 epidermis Anatomy 0.000 claims description 2
- 108020001507 fusion proteins Proteins 0.000 claims description 2
- 102000037865 fusion proteins Human genes 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 239000005556 hormone Substances 0.000 claims description 2
- 229940088597 hormone Drugs 0.000 claims description 2
- 229910052742 iron Inorganic materials 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims description 2
- 241000589242 Legionella pneumophila Species 0.000 claims 1
- 241000186779 Listeria monocytogenes Species 0.000 claims 1
- 229940115932 legionella pneumophila Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 2
- 241000589248 Legionella Species 0.000 description 1
- 208000007764 Legionnaires' Disease Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9755108P | 2008-09-17 | 2008-09-17 | |
| US61/097,551 | 2008-09-17 | ||
| PCT/IB2009/006949 WO2010076618A1 (en) | 2008-09-17 | 2009-09-17 | Combination gas vaccines and therapeutics |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014237470A Division JP2015038156A (ja) | 2008-09-17 | 2014-11-25 | 組み合わせｇａｓワクチンおよび治療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012502969A JP2012502969A (ja) | 2012-02-02 |
| JP2012502969A5 true JP2012502969A5 (enExample) | 2012-10-25 |
| JP5680536B2 JP5680536B2 (ja) | 2015-03-04 |
Family
ID=41508998
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011527423A Active JP5680536B2 (ja) | 2008-09-17 | 2009-09-17 | 組み合わせｇａｓワクチンおよび治療法 |
| JP2014237470A Withdrawn JP2015038156A (ja) | 2008-09-17 | 2014-11-25 | 組み合わせｇａｓワクチンおよび治療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014237470A Withdrawn JP2015038156A (ja) | 2008-09-17 | 2014-11-25 | 組み合わせｇａｓワクチンおよび治療法 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20100136041A1 (enExample) |
| EP (1) | EP2344523B1 (enExample) |
| JP (2) | JP5680536B2 (enExample) |
| CN (1) | CN102356090B (enExample) |
| AU (1) | AU2009334428B2 (enExample) |
| BR (1) | BRPI0919236A8 (enExample) |
| CA (1) | CA2737453A1 (enExample) |
| DK (1) | DK2344523T3 (enExample) |
| ES (1) | ES2566740T3 (enExample) |
| HR (1) | HRP20160306T1 (enExample) |
| HU (1) | HUE027618T2 (enExample) |
| MX (1) | MX2011002760A (enExample) |
| NZ (1) | NZ591633A (enExample) |
| PL (1) | PL2344523T3 (enExample) |
| SI (1) | SI2344523T1 (enExample) |
| SM (1) | SMT201600125B (enExample) |
| WO (1) | WO2010076618A1 (enExample) |
| ZA (1) | ZA201102005B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0210128D0 (en) * | 2002-05-02 | 2002-06-12 | Chiron Spa | Nucleic acids and proteins from streptococcus groups A & B |
| SMT201700275T1 (it) | 2009-10-30 | 2017-07-18 | Glaxosmithkline Biologicals Sa | Purificazione di saccaridi capsulari di staphylococcus aureus tipo 5 e tipo 8 |
| CN103239734B (zh) * | 2012-02-10 | 2016-02-24 | 北京艾棣维欣生物技术有限公司 | 用于预防和/或治疗呼吸道合胞病毒感染的疫苗 |
| GB201206366D0 (en) | 2012-04-11 | 2012-05-23 | Absynth Biologics Ltd | Bacterial vaccine |
| RU2662970C2 (ru) * | 2012-09-18 | 2018-07-31 | Новартис Аг | Везикулы наружной мембраны |
| AU2015246654B2 (en) | 2014-04-15 | 2019-08-08 | Griffith University | Group A streptococcus vaccine |
| WO2015169773A2 (en) * | 2014-05-07 | 2015-11-12 | Glaxosmithkline Biologicals S.A. | Mutants of spy0269 |
| US10329601B2 (en) * | 2015-12-28 | 2019-06-25 | Ionian Technologies, Inc. | Nicking and extension amplification reaction (NEAR) of Streptococcus species |
| CN112442472B (zh) * | 2020-11-30 | 2023-05-26 | 四川大学华西医院 | 抗艰难梭菌的重组乳酸乳球菌、活载体疫苗及其制备方法 |
| JP7601913B2 (ja) * | 2021-01-19 | 2024-12-17 | デンカ株式会社 | タンパク質、溶血性連鎖球菌ワクチン、ｄｎａ、ベクター、形質転換体、タンパク質を製造する方法、バキュロウイルス、アグロバクテリウム、ラテックス粒子、キット及び抗ストレプトリジンｏ抗体の測定方法 |
| GB202215414D0 (en) | 2022-10-18 | 2022-11-30 | Glaxosmithkline Biologicals Sa | Vaccine |
| CN116875520B (zh) * | 2023-07-12 | 2024-06-14 | 吉林农业大学 | 表达核糖体失活蛋白的乳酸菌及其在抗轮状病毒中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8827038D0 (en) * | 1988-11-18 | 1988-12-21 | Kehoe M | Streptolysin o antigens & uses |
| US5866135A (en) * | 1994-04-21 | 1999-02-02 | North American Vaccine, Inc. | Group A streptococcal polysaccharide immunogenic compositions and methods |
| EP1648500B1 (en) * | 2003-07-31 | 2014-07-09 | Novartis Vaccines and Diagnostics, Inc. | Immunogenic compositions for streptococcus pyogenes |
| AU2005294275B2 (en) * | 2004-10-08 | 2012-09-13 | Glaxosmithkline Biologicals S.A. | Immunogenic and therapeutic compositions for Streptococcus pyogenes |
| AU2007348285A1 (en) * | 2006-10-30 | 2008-09-12 | Novartis Ag | Immunogenic and therapeutic compositions for streptococcus pyogenes |
| AU2008299376B2 (en) * | 2007-09-12 | 2013-02-28 | Glaxosmithkline Biologicals S.A. | GAS57 mutant antigens and GAS57 antibodies |
| NZ586430A (en) * | 2007-12-21 | 2012-09-28 | Novartis Ag | Mutant forms of streptolysin o (slo) |
-
2009
- 2009-09-17 DK DK09786278.3T patent/DK2344523T3/da active
- 2009-09-17 HU HUE09786278A patent/HUE027618T2/en unknown
- 2009-09-17 JP JP2011527423A patent/JP5680536B2/ja active Active
- 2009-09-17 CA CA2737453A patent/CA2737453A1/en not_active Abandoned
- 2009-09-17 EP EP09786278.3A patent/EP2344523B1/en active Active
- 2009-09-17 HR HRP20160306TT patent/HRP20160306T1/hr unknown
- 2009-09-17 MX MX2011002760A patent/MX2011002760A/es active IP Right Grant
- 2009-09-17 WO PCT/IB2009/006949 patent/WO2010076618A1/en not_active Ceased
- 2009-09-17 US US12/561,619 patent/US20100136041A1/en not_active Abandoned
- 2009-09-17 BR BRPI0919236A patent/BRPI0919236A8/pt not_active Application Discontinuation
- 2009-09-17 CN CN200980142304.9A patent/CN102356090B/zh active Active
- 2009-09-17 ES ES09786278.3T patent/ES2566740T3/es active Active
- 2009-09-17 SI SI200931421A patent/SI2344523T1/sl unknown
- 2009-09-17 AU AU2009334428A patent/AU2009334428B2/en active Active
- 2009-09-17 PL PL09786278.3T patent/PL2344523T3/pl unknown
- 2009-09-17 NZ NZ591633A patent/NZ591633A/xx not_active IP Right Cessation
-
2011
- 2011-03-16 ZA ZA2011/02005A patent/ZA201102005B/en unknown
-
2014
- 2014-11-13 US US14/540,627 patent/US20150132337A1/en not_active Abandoned
- 2014-11-25 JP JP2014237470A patent/JP2015038156A/ja not_active Withdrawn
-
2016
- 2016-04-29 SM SM201600125T patent/SMT201600125B/it unknown
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