JP2012502949A - 抗生物質使用を減らすためのアザペロンの使用 - Google Patents
抗生物質使用を減らすためのアザペロンの使用 Download PDFInfo
- Publication number
- JP2012502949A JP2012502949A JP2011527317A JP2011527317A JP2012502949A JP 2012502949 A JP2012502949 A JP 2012502949A JP 2011527317 A JP2011527317 A JP 2011527317A JP 2011527317 A JP2011527317 A JP 2011527317A JP 2012502949 A JP2012502949 A JP 2012502949A
- Authority
- JP
- Japan
- Prior art keywords
- azaperone
- administered
- drinking water
- animal
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- XTKDAFGWCDAMPY-UHFFFAOYSA-N azaperone Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCN(C=2N=CC=CC=2)CC1 XTKDAFGWCDAMPY-UHFFFAOYSA-N 0.000 title claims abstract description 62
- 229950003616 azaperone Drugs 0.000 title claims abstract description 53
- 230000003115 biocidal effect Effects 0.000 title claims abstract description 13
- 241001465754 Metazoa Species 0.000 claims abstract description 31
- 238000000034 method Methods 0.000 claims abstract description 19
- 235000020188 drinking water Nutrition 0.000 claims description 35
- 239000003651 drinking water Substances 0.000 claims description 35
- 239000003814 drug Substances 0.000 claims description 23
- 241000282887 Suidae Species 0.000 claims description 22
- 239000003242 anti bacterial agent Substances 0.000 claims description 20
- 229940088710 antibiotic agent Drugs 0.000 claims description 15
- 229940079593 drug Drugs 0.000 claims description 14
- 235000013305 food Nutrition 0.000 claims description 10
- 241000282849 Ruminantia Species 0.000 claims description 3
- 244000144977 poultry Species 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 238000002347 injection Methods 0.000 description 8
- 239000007924 injection Substances 0.000 description 8
- 206010012735 Diarrhoea Diseases 0.000 description 7
- 244000144972 livestock Species 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000008188 pellet Substances 0.000 description 4
- 239000000902 placebo Substances 0.000 description 4
- 229940068196 placebo Drugs 0.000 description 4
- 206010039897 Sedation Diseases 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000036280 sedation Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- SPFYMRJSYKOXGV-UHFFFAOYSA-N Baytril Chemical compound C1CN(CC)CCN1C(C(=C1)F)=CC2=C1C(=O)C(C(O)=O)=CN2C1CC1 SPFYMRJSYKOXGV-UHFFFAOYSA-N 0.000 description 2
- 239000004100 Oxytetracycline Substances 0.000 description 2
- 229960000723 ampicillin Drugs 0.000 description 2
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 229960000740 enrofloxacin Drugs 0.000 description 2
- 229960000625 oxytetracycline Drugs 0.000 description 2
- 235000019366 oxytetracycline Nutrition 0.000 description 2
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 2
- 230000000384 rearing effect Effects 0.000 description 2
- 239000008399 tap water Substances 0.000 description 2
- 235000020679 tap water Nutrition 0.000 description 2
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 208000031872 Body Remains Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 241000271571 Dromaius novaehollandiae Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000286209 Phasianidae Species 0.000 description 1
- 241000272534 Struthio camelus Species 0.000 description 1
- 230000016571 aggressive behavior Effects 0.000 description 1
- NNAIYOXJNVGUOM-UHFFFAOYSA-N amperozide Chemical compound C1CN(C(=O)NCC)CCN1CCCC(C=1C=CC(F)=CC=1)C1=CC=C(F)C=C1 NNAIYOXJNVGUOM-UHFFFAOYSA-N 0.000 description 1
- 229950000388 amperozide Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- FFSAXUULYPJSKH-UHFFFAOYSA-N butyrophenone Chemical compound CCCC(=O)C1=CC=CC=C1 FFSAXUULYPJSKH-UHFFFAOYSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- UHZZMRAGKVHANO-UHFFFAOYSA-M chlormequat chloride Chemical compound [Cl-].C[N+](C)(C)CCCl UHZZMRAGKVHANO-UHFFFAOYSA-M 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000002036 metaphylactic effect Effects 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000003176 neuroleptic agent Substances 0.000 description 1
- 210000002445 nipple Anatomy 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 229940001470 psychoactive drug Drugs 0.000 description 1
- 239000004089 psychotropic agent Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 229940125725 tranquilizer Drugs 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
- Medicinal Preparation (AREA)
- Pyridine Compounds (AREA)
Abstract
Description
薬量でアザペロンを投与する場合、これはリットル当たり2.2〜13.1mgの範囲の飲料水中のアザペロンの濃度に変換される。
処方1:(100mg/ml):
アザペロン 100mg
クエン酸 80mg
パラヒドロキシ安息香酸メチル 2mg
パラヒドロキシ安息香酸プロピル 0.2mg
精製水 1mlとするのに十分な量
である。
離乳後の下痢及びそれに伴う抗生物質の使用、行動、飼料転換(feed conversion)、成長及び成長の均一性への、飲料水を介して継続的に経口投与されるアザペロンの効果を調べるために、離乳したブタにおいて研究を行った。
離乳後の下痢の開始及びそれに伴う抗生物質の治療的使用への経口的アザペロン投与の効果を評価するために、グループ1〜4において下痢の発生を追跡し、Principal Investigatorにより毎日記録した。個々の囲いのすべてをPrincipal Investigatorにより検査し、下痢の得点を以下の通りに記した:
N=下痢なし
P=軟便
V=液便
Claims (15)
- 動物に抗生物質を与える必要性の減少における使用のための薬剤としてのアザペロンであって、ここで該薬剤を0.5mg/kg/日〜3.0mg/kg/日の範囲の投薬量で該動物に継続的に経口投与するアザペロン。
- 該薬剤を食物又は飲料水と一緒に投与する請求項1に記載の薬剤としてのアザペロン。
- 該薬剤を飲料水と一緒に投与する請求項2に記載の薬剤としてのアザペロン。
- 該薬剤を飲料水供給系を介して投与する請求項3に記載の薬剤としてのアザペロン。
- 動物に抗生物質を与える必要性の減少における使用のための薬剤としてのアザペロンであって、ここで該薬剤を飲料水のリットル当たり2mg〜13.0mgの範囲の濃度で該動物に継続的に経口投与するアザペロン。
- アザペロンを飲料水のリットル当たり6mgの濃度で投与する請求項5に記載の薬剤としてのアザペロン。
- アザペロンを1〜6日間投与する請求項1〜6のいずれかに記載の薬剤としてのアザペロン。
- アザペロンを3日間投与する請求項7に記載の薬剤としてのアザペロン。
- 動物が家禽、反芻動物及びブタから選ばれる請求項1〜8のいずれかに記載の薬剤としてのアザペロン。
- アザペロンを0.5mg/kg/日〜3.0mg/kg/日の範囲の投薬量で動物に継続的に経口投与することを含んでなる、動物に抗生物質を与える必要性を減らす方法。
- アザペロンを食物又は飲料水と一緒に投与する請求項10に記載の方法。
- アザペロンを飲料水のリットル当たり2mg〜13.0mgの範囲の濃度で動物に継続的に経口投与することを含んでなる、動物に抗生物質を与える必要性を減らす方法。
- アザペロンを飲料水のリットル当たり6mgの濃度で投与する請求項12に記載の方法。
- アザペロンを1〜6日間、特に3日間投与する請求項10〜13のいずれかに従う方法。
- 動物が家禽、反芻動物及びブタから選ばれる請求項10〜14のいずれかに従う方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08164594 | 2008-09-18 | ||
EP08164594.7 | 2008-09-18 | ||
PCT/EP2009/062045 WO2010031809A1 (en) | 2008-09-18 | 2009-09-17 | Use of azaperone for reducing antibiotic usage |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014227322A Division JP2015061850A (ja) | 2008-09-18 | 2014-11-07 | 抗生物質使用を減らすためのアザペロンの使用 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2012502949A true JP2012502949A (ja) | 2012-02-02 |
JP5893406B2 JP5893406B2 (ja) | 2016-03-23 |
Family
ID=39862992
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011527317A Expired - Fee Related JP5893406B2 (ja) | 2008-09-18 | 2009-09-17 | 抗生物質使用を減らすためのアザペロンの使用 |
JP2014227322A Pending JP2015061850A (ja) | 2008-09-18 | 2014-11-07 | 抗生物質使用を減らすためのアザペロンの使用 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014227322A Pending JP2015061850A (ja) | 2008-09-18 | 2014-11-07 | 抗生物質使用を減らすためのアザペロンの使用 |
Country Status (9)
Country | Link |
---|---|
US (1) | US9049874B2 (ja) |
EP (1) | EP2346350A1 (ja) |
JP (2) | JP5893406B2 (ja) |
KR (1) | KR20110070861A (ja) |
AU (1) | AU2009294602B2 (ja) |
CA (1) | CA2733420A1 (ja) |
EA (1) | EA018623B1 (ja) |
MX (1) | MX2011002895A (ja) |
WO (1) | WO2010031809A1 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2537518A1 (en) * | 2011-06-24 | 2012-12-26 | Elanco Animal Health Ireland Limited | Fast dissolving azaperone granulate formulation |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002501019A (ja) * | 1998-01-21 | 2002-01-15 | フィドゥラン | ストレス、不安及び攻撃性を低減するブタ鎮静フェロモン |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0948963B1 (en) | 1998-01-21 | 2003-05-07 | Fideline | Pig appeasing pheromones to decrease stress, anxiety and aggressiveness |
-
2009
- 2009-09-17 US US13/119,736 patent/US9049874B2/en not_active Expired - Fee Related
- 2009-09-17 AU AU2009294602A patent/AU2009294602B2/en not_active Ceased
- 2009-09-17 MX MX2011002895A patent/MX2011002895A/es active IP Right Grant
- 2009-09-17 WO PCT/EP2009/062045 patent/WO2010031809A1/en active Application Filing
- 2009-09-17 EP EP09783112A patent/EP2346350A1/en not_active Withdrawn
- 2009-09-17 KR KR20117008279A patent/KR20110070861A/ko not_active Application Discontinuation
- 2009-09-17 EA EA201170455A patent/EA018623B1/ru not_active IP Right Cessation
- 2009-09-17 JP JP2011527317A patent/JP5893406B2/ja not_active Expired - Fee Related
- 2009-09-17 CA CA2733420A patent/CA2733420A1/en not_active Abandoned
-
2014
- 2014-11-07 JP JP2014227322A patent/JP2015061850A/ja active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002501019A (ja) * | 1998-01-21 | 2002-01-15 | フィドゥラン | ストレス、不安及び攻撃性を低減するブタ鎮静フェロモン |
Non-Patent Citations (2)
Title |
---|
JPN6013058958; Applied Animal Behaviour Science 23, 1989, p.39-47 * |
JPN6013058961; Journal of Chromatography 283, 1984, p.211-221 * |
Also Published As
Publication number | Publication date |
---|---|
MX2011002895A (es) | 2011-04-11 |
US20110172243A1 (en) | 2011-07-14 |
EA201170455A1 (ru) | 2011-08-30 |
AU2009294602B2 (en) | 2014-03-27 |
JP2015061850A (ja) | 2015-04-02 |
AU2009294602A1 (en) | 2010-03-25 |
EA018623B1 (ru) | 2013-09-30 |
JP5893406B2 (ja) | 2016-03-23 |
US9049874B2 (en) | 2015-06-09 |
KR20110070861A (ko) | 2011-06-24 |
WO2010031809A1 (en) | 2010-03-25 |
CA2733420A1 (en) | 2010-03-25 |
EP2346350A1 (en) | 2011-07-27 |
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