JP2012501646A5 - - Google Patents

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Publication number
JP2012501646A5
JP2012501646A5 JP2011526037A JP2011526037A JP2012501646A5 JP 2012501646 A5 JP2012501646 A5 JP 2012501646A5 JP 2011526037 A JP2011526037 A JP 2011526037A JP 2011526037 A JP2011526037 A JP 2011526037A JP 2012501646 A5 JP2012501646 A5 JP 2012501646A5
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JP
Japan
Prior art keywords
synaptic vesicle
platform
well
electrode pairs
vesicle cycling
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JP2011526037A
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English (en)
Japanese (ja)
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JP2012501646A (ja
JP5789513B2 (ja
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Priority claimed from PCT/US2009/004932 external-priority patent/WO2010027446A2/en
Publication of JP2012501646A publication Critical patent/JP2012501646A/ja
Publication of JP2012501646A5 publication Critical patent/JP2012501646A5/ja
Application granted granted Critical
Publication of JP5789513B2 publication Critical patent/JP5789513B2/ja
Expired - Fee Related legal-status Critical Current
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JP2011526037A 2008-09-04 2009-08-31 シナプス小胞サイクリングアッセイおよびシステム Expired - Fee Related JP5789513B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9436108P 2008-09-04 2008-09-04
US61/094,361 2008-09-04
PCT/US2009/004932 WO2010027446A2 (en) 2008-09-04 2009-08-31 Synaptic vesicle cycling assays and systems

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015151623A Division JP6106225B2 (ja) 2008-09-04 2015-07-31 シナプス小胞サイクリングアッセイおよびシステム

Publications (3)

Publication Number Publication Date
JP2012501646A JP2012501646A (ja) 2012-01-26
JP2012501646A5 true JP2012501646A5 (enExample) 2012-10-18
JP5789513B2 JP5789513B2 (ja) 2015-10-07

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Family Applications (2)

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JP2011526037A Expired - Fee Related JP5789513B2 (ja) 2008-09-04 2009-08-31 シナプス小胞サイクリングアッセイおよびシステム
JP2015151623A Expired - Fee Related JP6106225B2 (ja) 2008-09-04 2015-07-31 シナプス小胞サイクリングアッセイおよびシステム

Family Applications After (1)

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JP2015151623A Expired - Fee Related JP6106225B2 (ja) 2008-09-04 2015-07-31 シナプス小胞サイクリングアッセイおよびシステム

Country Status (8)

Country Link
US (2) US20120053084A1 (enExample)
EP (1) EP2329275A2 (enExample)
JP (2) JP5789513B2 (enExample)
KR (1) KR20110073494A (enExample)
CN (1) CN102203622A (enExample)
AU (2) AU2009288657A1 (enExample)
CA (1) CA2744804C (enExample)
WO (1) WO2010027446A2 (enExample)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011511665A (ja) * 2008-02-04 2011-04-14 バイエル・ヘルスケア・エルエルシー 半導体を素材とする分析対象物センサー及び方法
US9217155B2 (en) 2008-05-28 2015-12-22 University Of Massachusetts Isolation of novel AAV'S and uses thereof
US8734809B2 (en) 2009-05-28 2014-05-27 University Of Massachusetts AAV's and uses thereof
US9057734B2 (en) 2010-08-23 2015-06-16 President And Fellows Of Harvard College Optogenetic probes for measuring membrane potential
US9207237B2 (en) 2010-08-23 2015-12-08 President And Fellows Of Harvard College Systems, methods, and workflows for optogenetics analysis
US9488637B2 (en) * 2011-01-26 2016-11-08 The Curators Of The University Of Missouri Combination of single-cell electroporation and electrical recording using the same electrode
WO2012145624A2 (en) 2011-04-21 2012-10-26 University Of Massachusetts Raav-based compositions and methods for treating alpha-1 anti-trypsin deficiencies
US20150004637A1 (en) * 2011-11-23 2015-01-01 President And Fellows Of Harvard College Systems and methods for imaging at high spatial and/or temporal precision
US9696275B2 (en) 2012-10-12 2017-07-04 The Curators Of The University Of Missouri Addressable electrode arrays in multiple fluidic compartments and uses thereof
WO2014065330A1 (ja) 2012-10-25 2014-05-01 浜松ホトニクス株式会社 細胞観察装置、電気刺激装置、及び細胞観察方法
WO2014065329A1 (ja) * 2012-10-25 2014-05-01 浜松ホトニクス株式会社 細胞観察装置及び細胞観察方法
JP6370544B2 (ja) * 2013-11-11 2018-08-08 浜松ホトニクス株式会社 細胞観察装置及び細胞観察方法
EP3095853B1 (en) 2014-01-16 2019-01-30 Hamamatsu Photonics K.K. Cell observation device, electrostimulation device, and cell observation method
WO2015127128A2 (en) 2014-02-19 2015-08-27 University Of Massachusetts Recombinant aavs having useful transcytosis properties
DK3119797T3 (da) 2014-03-18 2021-03-15 Univ Massachusetts Raav-baserede sammensætninger og fremgangsmåder til behandling af amyotrofisk lateralsklerose
JP2017521044A (ja) * 2014-04-22 2017-08-03 キュー−ステート バイオサイエンシーズ， インコーポレイテッドＱ−Ｓｔａｔｅ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ． 疼痛及び感覚障害のための化合物の分析
US10975391B2 (en) 2014-04-25 2021-04-13 University Of Massachusetts Recombinant AAV vectors useful for reducing immunity against transgene products
WO2015195769A2 (en) 2014-06-18 2015-12-23 President And Fellows Of Harvard College Optogenetic probes for measuring membrane potential
WO2016033501A1 (en) 2014-08-28 2016-03-03 Robert John Petcavich Method of fabricating cell arrays and uses thereof
US10711270B2 (en) 2014-10-03 2020-07-14 University Of Massachusetts High efficiency library-identified AAV vectors
US10370432B2 (en) 2014-10-03 2019-08-06 University Of Massachusetts Heterologous targeting peptide grafted AAVS
RU2020140209A (ru) 2014-10-21 2021-01-25 Юниверсити Оф Массачусетс Варианты рекомбинантных aav и их применения
US10077463B2 (en) 2015-01-15 2018-09-18 President And Fellows Of Harvard College Optical selection of cells
EP3256170B1 (en) 2015-02-13 2020-09-23 University of Massachusetts Compositions and methods for transient delivery of nucleases
US10048275B2 (en) 2015-03-13 2018-08-14 Q-State Biosciences, Inc. Cardiotoxicity screening methods
US11020443B2 (en) 2015-04-23 2021-06-01 University Of Massachusetts Modulation of AAV vector transgene expression
WO2016172008A1 (en) 2015-04-24 2016-10-27 University Of Massachusetts Modified aav constructions and uses thereof
US11248212B2 (en) 2015-06-30 2022-02-15 StemoniX Inc. Surface energy directed cell self assembly
US10760053B2 (en) 2015-10-15 2020-09-01 StemoniX Inc. Method of manufacturing or differentiating mammalian pluripotent stem cells or progenitor cells using a hollow fiber bioreactor
US11426469B2 (en) 2015-10-22 2022-08-30 University Of Massachusetts Prostate-targeting adeno-associated virus serotype vectors
CA3002982A1 (en) 2015-10-22 2017-04-27 University Of Massachusetts Methods and compositions for treating metabolic imbalance in neurodegenerative disease
US11826433B2 (en) 2016-02-02 2023-11-28 University Of Massachusetts Method to enhance the efficiency of systemic AAV gene delivery to the central nervous system
CA3012344A1 (en) 2016-02-12 2017-08-17 University Of Massachusetts Anti-angiogenic mirna therapeutics for inhibiting corneal neovascularization
EP3225279B1 (en) * 2016-03-31 2023-12-20 Université de Rennes Brain tissue stimulation apparatus and computer program
WO2017176929A1 (en) 2016-04-05 2017-10-12 University Of Massachusetts Compositions and methods for selective inhibition of grainyhead-like protein expression
US11413356B2 (en) 2016-04-15 2022-08-16 University Of Massachusetts Methods and compositions for treating metabolic imbalance
US11882815B2 (en) 2016-06-15 2024-01-30 University Of Massachusetts Recombinant adeno-associated viruses for delivering gene editing molecules to embryonic cells
US10457940B2 (en) 2016-09-22 2019-10-29 University Of Massachusetts AAV treatment of Huntington's disease
AU2017341849B2 (en) 2016-10-13 2024-03-21 University Of Massachusetts AAV capsid designs
JP7327803B2 (ja) 2017-05-09 2023-08-16 ユニバーシティ オブ マサチューセッツ 筋萎縮性側索硬化症（ａｌｓ）を処置する方法
CN111448321A (zh) 2017-09-22 2020-07-24 马萨诸塞大学 Sod1双表达载体及其用途
CA3096102A1 (en) 2018-04-13 2019-10-17 University Of Massachusetts Bicistronic aav vectors encoding hexosaminidase alpha and beta-subunits and uses thereof
JP7065433B2 (ja) * 2018-08-14 2022-05-12 日本電信電話株式会社 電極及びその製造方法、並びに積層体
KR20210087462A (ko) 2018-10-05 2021-07-12 유니버시티 오브 매사추세츠 Gm1 및 gm2 강글리오시드증의 치료를 위한 raav 벡터
SG11202111169YA (en) * 2019-07-16 2021-11-29 Meso Scale Technologies Llc Assay apparatuses, methods and reagents
EP4271789A4 (en) * 2020-12-31 2024-11-27 Q-State Biosciences, Inc. PLATE IMAGE PRODUCER
JP2024501848A (ja) 2020-12-31 2024-01-16 キュー－ステート バイオサイエンシーズ， インコーポレイテッド 光遺伝学のためのイメージャの較正および正規化
EP4271982A4 (en) * 2020-12-31 2024-11-27 Q-State Biosciences, Inc. Optical plate controller and reader
EP4271978A4 (en) 2020-12-31 2024-12-18 Q-State Biosciences, Inc. MICROSCOPE WITH SPATIAL IMAGING AND BEAM HOMOGENIZER
JP2024516303A (ja) * 2021-05-04 2024-04-12 キュー－ステート バイオサイエンシーズ， インコーポレイテッド 薬物フィンガプリンティング
JP2024525493A (ja) 2021-06-30 2024-07-12 キュー－ステート バイオサイエンシーズ， インコーポレイテッド 多重光学刺激および読出
US20250277028A1 (en) * 2022-04-25 2025-09-04 Jiksak Bioengineering, Inc. Targeting agent
WO2025084395A1 (ja) * 2023-10-19 2025-04-24 株式会社Jiksak Bioengineering 抗シナプトタグミン２抗体
WO2025089346A1 (ja) * 2023-10-25 2025-05-01 株式会社Jiksak Bioengineering 抗シナプトフィジン抗体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2210911T3 (es) 1998-07-17 2004-07-01 Vertex Pharmaceuticals (San Diego) Llc Detector y dispositivo de seleccion para canales ionicos.
US6686193B2 (en) * 2000-07-10 2004-02-03 Vertex Pharmaceuticals, Inc. High throughput method and system for screening candidate compounds for activity against target ion channels
US7615356B2 (en) * 2000-07-10 2009-11-10 Vertex Pharmaceuticals (San Diego) Llc Ion channel assay methods
WO2003006103A2 (en) 2001-07-12 2003-01-23 Merck & Co., Inc. Electrical field stimulation of eukaryotic cells
US7221981B2 (en) * 2002-03-28 2007-05-22 Northstar Neuroscience, Inc. Electrode geometries for efficient neural stimulation
US20070274923A1 (en) 2005-01-11 2007-11-29 Philippe Brulet Non-invasive real-time in vivo bioluminescence imaging of local Ca2+ dynamics in living organisms

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