JP2012500636A5 - - Google Patents
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- Publication number
- JP2012500636A5 JP2012500636A5 JP2011524251A JP2011524251A JP2012500636A5 JP 2012500636 A5 JP2012500636 A5 JP 2012500636A5 JP 2011524251 A JP2011524251 A JP 2011524251A JP 2011524251 A JP2011524251 A JP 2011524251A JP 2012500636 A5 JP2012500636 A5 JP 2012500636A5
- Authority
- JP
- Japan
- Prior art keywords
- solid
- extract
- pressure treatment
- filter cake
- containing biological
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007787 solid Substances 0.000 claims 29
- 239000012065 filter cake Substances 0.000 claims 16
- 108090000790 Enzymes Proteins 0.000 claims 12
- 102000004190 Enzymes Human genes 0.000 claims 12
- 229940088598 enzyme Drugs 0.000 claims 12
- 239000000706 filtrate Substances 0.000 claims 11
- 230000004071 biological effect Effects 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 239000004480 active ingredient Substances 0.000 claims 7
- 230000000694 effects Effects 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 238000001914 filtration Methods 0.000 claims 5
- 208000035404 Autolysis Diseases 0.000 claims 4
- 206010057248 Cell death Diseases 0.000 claims 4
- 108010019160 Pancreatin Proteins 0.000 claims 4
- 230000001747 exhibiting effect Effects 0.000 claims 4
- 229940055695 pancreatin Drugs 0.000 claims 4
- 230000035485 pulse pressure Effects 0.000 claims 4
- 230000028043 self proteolysis Effects 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 3
- 239000007791 liquid phase Substances 0.000 claims 3
- 244000052769 pathogen Species 0.000 claims 3
- 230000001717 pathogenic effect Effects 0.000 claims 3
- 230000003612 virological effect Effects 0.000 claims 3
- 210000004907 gland Anatomy 0.000 claims 2
- 239000013067 intermediate product Substances 0.000 claims 2
- 230000000813 microbial effect Effects 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- 230000001376 precipitating effect Effects 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 239000010419 fine particle Substances 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 231100000614 poison Toxicity 0.000 claims 1
- 238000002203 pretreatment Methods 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000003440 toxic substance Substances 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008039860 | 2008-08-27 | ||
| DE102008039860.8 | 2008-08-27 | ||
| EP09007797.5 | 2009-06-12 | ||
| EP09007797A EP2165717A1 (de) | 2008-08-27 | 2009-06-12 | Verfahren zur Verringerung der viralen und mikrobiellen Belastung feststoffhaltiger biologischer Extrakte |
| PCT/EP2009/004318 WO2010022808A1 (de) | 2008-08-27 | 2009-06-16 | Verfahren zur verringerung der viralen und mikrobiellen belastung feststoffhaltiger biologischer extrakte |
| EPPCT/EP2009/004318 | 2009-06-16 | ||
| PCT/EP2009/006216 WO2010022946A1 (de) | 2008-08-27 | 2009-08-27 | Verfahren zur verringerung der viralen und mikrobiellen belastung feststoffhaltiger biologischer extrakte |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015124437A Division JP6109881B2 (ja) | 2008-08-27 | 2015-06-22 | 固体含有生物抽出物のウイルスおよび微生物含有量を低減する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012500636A JP2012500636A (ja) | 2012-01-12 |
| JP2012500636A5 true JP2012500636A5 (https=) | 2012-08-16 |
Family
ID=41110856
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011524251A Pending JP2012500636A (ja) | 2008-08-27 | 2009-08-27 | 固体含有生物抽出物のウイルスおよび微生物含有量を低減する方法 |
| JP2015124437A Expired - Fee Related JP6109881B2 (ja) | 2008-08-27 | 2015-06-22 | 固体含有生物抽出物のウイルスおよび微生物含有量を低減する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015124437A Expired - Fee Related JP6109881B2 (ja) | 2008-08-27 | 2015-06-22 | 固体含有生物抽出物のウイルスおよび微生物含有量を低減する方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9107966B2 (https=) |
| EP (2) | EP2165717A1 (https=) |
| JP (2) | JP2012500636A (https=) |
| BR (1) | BRPI0917840B1 (https=) |
| ES (1) | ES2532637T3 (https=) |
| PL (1) | PL2328623T3 (https=) |
| WO (2) | WO2010022808A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2165717A1 (de) | 2008-08-27 | 2010-03-24 | Nordmark Arzneimittel GmbH & Co.KG | Verfahren zur Verringerung der viralen und mikrobiellen Belastung feststoffhaltiger biologischer Extrakte |
| ES2488407T3 (es) | 2009-01-29 | 2014-08-27 | Nordmark Arzneimittel Gmbh & Co. Kg | Preparación farmacéutica que contiene lipasa de origen bacteriano |
| PL2295039T5 (pl) * | 2009-08-28 | 2023-02-27 | Nordmark Pharma Gmbh | Sposób wytwarzania granulek zawierających pankreatynę, w szczególności mikrogranulek zawierających pankreatynę, oraz wytworzone tym sposobem granulki zawierające pankreatynę |
| EP2489349B1 (de) | 2011-02-17 | 2014-05-28 | Nordmark Arzneimittel GmbH & Co.KG | Pankreatin-Pellets, insbesondere Pankreatin-Mikropellets, und Verfahren zu deren Herstellung |
| MX380367B (es) | 2015-05-19 | 2025-03-12 | Scient Protein Laboratories Llc | Metodo para reducir o inactivar contenido viral o microbiano en los procesos para la fabricacion de pancreatina. |
| DE102015119006A1 (de) | 2015-11-05 | 2017-05-11 | Nordmark Arzneimittel Gmbh & Co. Kg | Verfahren zur Reduzierung der Belastung von Pankreatin mit Mikroorganismen |
| CN108795920B (zh) * | 2018-06-22 | 2022-04-08 | 苏州良辰生物医药科技有限公司 | 一种胰酶的制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA394981A (en) * | 1941-03-04 | The Griffith Laboratories | Pancreatin sterilization | |
| US2189948A (en) * | 1938-10-31 | 1940-02-13 | Griffith Laboratories | Sterilization of pancreatin |
| US3493399A (en) | 1967-04-11 | 1970-02-03 | Ezra Levin | Pancreatic food product |
| DE2923279C2 (de) | 1979-06-08 | 1987-07-09 | Kali-Chemie Pharma Gmbh, 3000 Hannover | Verfahren zur Herstellung von Pankreatin-Pellets und diese enthaltende Arzneimittel |
| DE3377506D1 (en) | 1982-12-30 | 1988-09-01 | Nordmark Arzneimittel Gmbh | Process for obtaining pancreatin |
| DE3248588A1 (de) | 1982-12-30 | 1984-07-12 | Nordmark-Werke Gmbh, 2000 Hamburg | Verfahren zur gewinnung von pankreatin von hohem schuettgewicht |
| CA2030581C (en) | 1989-11-24 | 2000-06-27 | Gunther Atzl | Pancreatin preparations |
| DE4227385A1 (de) | 1992-08-19 | 1994-02-24 | Kali Chemie Pharma Gmbh | Pankreatinmikropellets |
| US6696019B2 (en) † | 1998-06-15 | 2004-02-24 | Bbi Bioseq, Inc. | Rapid cryobaric sterilization and vaccine preparation |
| US6270723B1 (en) * | 1998-06-15 | 2001-08-07 | Bbi Bioseq, Inc. | Rapid cryobaric sterilization and vaccine preparation |
| FR2804326B1 (fr) * | 2000-01-27 | 2002-10-18 | Ellipse Pharmaceuticals | Procede de sterilisation par traitement sous hautes pressions de principes actifs sensibles |
| WO2002056824A2 (en) | 2000-08-10 | 2002-07-25 | Boston Biomedica, Inc. | Pressure cycling inactivation of pathogens in biological materials used for therapeutics or vaccines |
| CA2560613C (en) | 2004-03-22 | 2015-11-24 | Solvay Pharmaceuticals Gmbh | Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants |
| WO2006044529A1 (en) | 2004-10-14 | 2006-04-27 | Altus Pharmaceuticals Inc. | Compositions containing lipase; protease and amylase for treating pancreatic insufficiency |
| KR101555058B1 (ko) * | 2005-07-29 | 2015-09-22 | 애보트 래버러토리즈 게엠베하 | 살균된 판크레아틴 분말의 제조방법 |
| US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| WO2008127567A1 (en) | 2007-04-13 | 2008-10-23 | Beth Israel Deaconess Medical Center, Inc. | Novel nutritional food products for improved digestion and intestinal absorption |
| EP2165717A1 (de) | 2008-08-27 | 2010-03-24 | Nordmark Arzneimittel GmbH & Co.KG | Verfahren zur Verringerung der viralen und mikrobiellen Belastung feststoffhaltiger biologischer Extrakte |
| ES2488407T3 (es) | 2009-01-29 | 2014-08-27 | Nordmark Arzneimittel Gmbh & Co. Kg | Preparación farmacéutica que contiene lipasa de origen bacteriano |
| PL2295039T5 (pl) | 2009-08-28 | 2023-02-27 | Nordmark Pharma Gmbh | Sposób wytwarzania granulek zawierających pankreatynę, w szczególności mikrogranulek zawierających pankreatynę, oraz wytworzone tym sposobem granulki zawierające pankreatynę |
| EP2489349B1 (de) | 2011-02-17 | 2014-05-28 | Nordmark Arzneimittel GmbH & Co.KG | Pankreatin-Pellets, insbesondere Pankreatin-Mikropellets, und Verfahren zu deren Herstellung |
-
2009
- 2009-06-12 EP EP09007797A patent/EP2165717A1/de not_active Withdrawn
- 2009-06-16 WO PCT/EP2009/004318 patent/WO2010022808A1/de not_active Ceased
- 2009-08-27 ES ES09805986.8T patent/ES2532637T3/es active Active
- 2009-08-27 BR BRPI0917840-6A patent/BRPI0917840B1/pt not_active IP Right Cessation
- 2009-08-27 JP JP2011524251A patent/JP2012500636A/ja active Pending
- 2009-08-27 EP EP09805986.8A patent/EP2328623B2/de active Active
- 2009-08-27 WO PCT/EP2009/006216 patent/WO2010022946A1/de not_active Ceased
- 2009-08-27 US US13/060,712 patent/US9107966B2/en active Active
- 2009-08-27 PL PL09805986T patent/PL2328623T3/pl unknown
-
2015
- 2015-06-22 JP JP2015124437A patent/JP6109881B2/ja not_active Expired - Fee Related
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