JP2012249595A - Method for manufacturing tablet and tablet - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a method for manufacturing a tablet to obtain the tablet, which is the method for manufacturing the tablet containing powder of gramineous plant chloroplast of a barley young leaf, and the like, and amino sugar of glucosamine, and the like, can secure desired hardness, without applying a load on a tableting device in its tableting even when manufactured as a small tablet for suppressing total dose, and also obtain the tablet hard to occur discoloration in green color present with the powder of the gramineous plant chloroplast.SOLUTION: In the method for manufacturing the tablet containing the powder of the gramineous plant chloroplast and the amino sugar, the tablet is obtained by the tableting in which at least the amino sugar is granulated, at least the powder of the gramineous plant chloroplast remains as the powder without granulating it, and whole material is mixed. It is preferred that total mass per dose for the material is 200-350 mg, and the tableting pressure is 3.0-15.0 kN.

Description

  The present invention relates to a method for producing a tablet containing a powder of green leaves of grasses such as young barley leaves and an amino sugar such as glucosamine, and a tablet obtained by the method.

  Under the growing health orientation, it is widely practiced to take nutrition useful for health promotion as health foods or supplements for nutritional supplements. For example, green powder of grasses such as young barley leaves is rich in vitamins, minerals, dietary fiber, etc., and has attracted attention as a health food material that has effects such as adsorption of harmful substances, improvement of intestinal environment, and suppression of cholesterol absorption. (See Patent Document 1). In addition, amino sugars such as glucosamine are attracting attention as materials for health foods that are effective in improving arthritis (see Patent Document 2). On the other hand, Patent Document 3 below discloses an invention of a food composition characterized by containing barley young leaves and glucosamine, and describes that barley young leaves promote the anti-inflammatory effect of glucosamine. Further, it is described that the food composition is used in the form of a tablet.

JP 2002-65204 A JP 2003-325136 A JP 2011-55712 A

  However, in order to obtain tablets of appropriate hardness by compressing powdered green leaves of grasses such as young leaves of barley and amino sugars such as glucosamine as powders, it is manufactured by increasing the tableting pressure of the tableting device. In this case, there is a problem in that the heel portion of the tableting device is easily damaged and the maintenance of the tableting device is expensive. In addition, if a certain amount of tablet total is not maintained, it is difficult to produce a tablet having a small and easy-to-drink shape, since appropriate hardness as a tablet cannot be obtained.

  On the other hand, by granulating all the raw materials and then tableting, some of the problems described above can be improved. There was a problem that the green color of the color changed to brown during storage of the tablet, and the stability of the quality of the product could not be ensured.

  Accordingly, an object of the present invention is a method of producing a tablet containing green powder of grasses such as young barley leaves and amino sugars such as glucosamine, and does not impose a burden on the tableting device during the tableting. Provided is a method for producing a tablet, in which a desired tablet can be secured even if it is produced as a small tablet with a reduced total amount of tablet, and a green discoloration of green grass powder is obtained. There is. Moreover, it is providing the tablet obtained by the method.

  As a result of intensive studies to achieve the above object, the present inventors have completed an invention having the following configuration.

  That is, the present invention relates to a method for producing a tablet containing a grass green leaf powder and an amino sugar, wherein at least amino sugar is granulated, and at least the grass green leaf powder remains as a powder without granulation. A method for producing a tablet, wherein all raw materials are mixed and tableted.

  According to the present invention, since the powder of grass green leaves is not granulated, the raw material containing amino sugar is granulated, and all the raw materials containing these are mixed and tableted. Even if the tablet pressure is reduced or the total amount of tablets is reduced, a desired hardness can be ensured, and a tablet in which green discoloration caused by the powder of green grasses hardly occurs can be obtained.

  In the method for producing a tablet of the present invention, only the amino sugar is granulated, and other raw materials including the powder of grass plant green leaves are granulated without mixing, and all raw materials are mixed and tableted. It is preferable.

  Moreover, it is preferable that the powder of the grass family grass is a wheat leaf powder.

  The amino sugar is preferably glucosamine, a derivative thereof, and / or a salt thereof.

  Moreover, it is preferable that the raw material total mass per tablet shall be 200-350 mg, and the tableting pressure shall be 3.0-15.0 kN.

  On the other hand, another one of the present invention is a tablet obtained by the production method having the above-described structure.

  According to the present invention, at least the amino sugar is granulated, and at least the powder of the grass plant is not granulated, and all the raw materials are mixed and tableted, so the tableting pressure of the tableting device is It is possible to obtain a tablet that can secure a desired hardness even if the amount of the tablet is reduced or the total amount of the tablet is reduced, and that the green discoloration caused by the green leaves of the grass family plant hardly occurs.

It is a photograph which shows the result of the color tone stability of the tablet in Test Example 2.

  In the present invention, the gramineous plant includes all plants classified into the gramineous family and is not particularly limited. Specifically, barley such as barley, wheat, rye, and oats; rice, whey, persimmon, horse mackerel, acne, corn, sorghum, sugar cane, and Italian ryegrass. Among these, it is preferable to use barley, wheat, rye, oats and the like from the viewpoint of nutritional value.

  In the present invention, grass green leaves refers to harvested leaves and / or stems of gramineous plants. The green leaf is preferably a young leaf harvested before the maturity period. This is because the young leaves harvested before maturity are rich in nutrients such as vitamins, minerals and chlorophyll. In the case of green leaf of wheat, it is preferable that it is a wheat young leaf harvested before the maturation period, from the start of splitting to the first stage of heading (height is about 20 to 40 cm). Among these barley young leaves, barley young leaves having high nutritional value are more preferably used. The green leaves are preferably processed immediately after harvesting. When time is required for the treatment, it is preferably stored by a storage means such as low-temperature storage in order to prevent the green leaves from being altered.

  The powder of the grass family green leaf used in the present invention can be obtained by powdering the grass family green leaf. In general, a commercially available product may be used. Although it does not restrict | limit especially as a method of pulverization, For example, it can carry out by the method as disclosed by patent 3277181.

  That is, green leaves are harvested, washed with water, mud and the like are washed away, drained, and then cut to an appropriate length. Next, blanching treatment such as hot water treatment or steam heat treatment is performed as necessary. What is necessary is just to determine suitably the temperature and time of a process at this time according to the quantity of the green leaf to process, and the pH of hot water. The blanched green leaves are immediately cooled and dehydrated by centrifugation or the like. Next, drying is performed so that the water content is 5% by weight or less. Furthermore, a coarse pulverization process in which the major axis is roughly pulverized to a size of 0.1 to 20 mm by a cutter, a slicer, a dicer, etc., a heat sterilization process by high pressure sterilization, heat sterilization, pressurized steam sterilization, etc., crusher, mill, blender, stone mill, etc. The green leaf powder can be manufactured through a pulverization step of finely pulverizing. The particle size is preferably finely pulverized so that 90% by mass passes through 200 mesh (JIS standard).

  Examples of the amino sugar used in the present invention include glucosamine, N-acetylglucosamine, galactosamine, acetylgalactosamine, neuraminic acid, acetylneuraminic acid, hexosamine and the like. These may be in the form of salts such as hydrochloride and phosphate. Moreover, you may use the extract from the natural product which abundantly contains these, or what refine | purified it. In this case, it is preferable to use those prepared so that the purity as amino sugar is 1 to 99.9% by mass, preferably 70 to 99.9% by mass. According to this, it is easy to ensure the safety of taking.

  In the present invention, it is preferable to use glucosamine, N-acetylglucosamine which is a derivative thereof, or glucosamine hydrochloride. According to this, there are abundant resources derived from animals such as crabs and shrimps, and plants such as corn, which are generally commercially available and can be prepared or procured relatively inexpensively. Among them, it is preferable to use an amino sugar derived from a plant with less allergic problems, and it is particularly preferable to use glucosamine such as corn.

  Hereinafter, the manufacturing method of the tablet of this invention is demonstrated.

  The tablet production method of the present invention is a tablet production method comprising a grass green powder and an amino sugar. At least the amino sugar is granulated, and at least the grass green powder is not granulated. It is characterized in that all raw materials are mixed and tableted in the form of powder. That is, as shown in the examples described later, (1) in the method of tableting the entire raw material in powder form, the tableting pressure of the tableting device has to be increased, and a burden is placed on the heel portion of the tableting device. It is not preferable because it is applied. In addition, (2) in the method of mixing all the raw materials containing green grass powder and granulating it, the color stability is poor, and the green color of the grass green powder is It is not preferable because the tablet turns brown during storage and the stability of the product quality cannot be ensured. Furthermore, (3) Color tone stability is also obtained by mixing a raw material that contains green grass powder but excluding amino sugar and granulating it, and then mixing the amino sugar and then tableting. Is not preferable because of worsening.

  In the tablet production method of the present invention, the granulation may be carried out by a method and apparatus that meet the granulation principle of increasing the particle diameter of the powder, and there is no particular limitation. For example, it can be carried out with a fluidized bed granulator, a rolling granulator, a dry granulator, a stirring granulator, an extrusion granulator, or the like. Moreover, water, ethanol water, etc. can be used as a binder liquid at the time of granulation, and in order to assist granulation as needed, aqueous solution, such as pregelatinized starch, saccharides, and a polysaccharide thickener, is used as a binder. It can also be used as a liquid.

  In the tablet production method of the present invention, the tableting can be performed by a known method using an apparatus such as a rotary tableting machine. The tableting conditions may be determined as appropriate for the desired tablet, but from the viewpoint of hardness suitable for the tablet, the tableting condition may be set so that the hardness of the resulting tablet is 3 to 15 kP. Preferably, the tableting conditions are more preferably set to 5 to 12 kP. The hardness of the tablet can be measured by a hardness measuring device such as a Schleuniger hardness meter.

  Moreover, it is preferable to tablet so that the total mass of the raw material per tablet is 200 to 350 mg and the tableting pressure applied to the heel portion of the tableting device is 3.0 to 15.0 kN. If the total mass of the raw material is too small, there is a tendency that it is difficult to obtain an appropriate hardness, and if it is too large, it is difficult to obtain a small-sized tablet that is easy to drink. Also, if the tableting pressure is too small, there is a tendency that it is difficult to obtain an appropriate hardness, and if it is too large, a burden is placed on the heel portion of the tableting device and the maintenance is costly.

  In the manufacturing method of the tablet of this invention, you may mix | blend other raw materials other than the powder (or binder liquid required for granulation) of the said amino sugar or the said grass family green leaves.

  Other raw materials include tablet additives, lactose, dextrin, crystalline cellulose, starch, other monosaccharides, disaccharides, oligosaccharides and other excipients; calcium stearate, magnesium stearate, sucrose fatty acid esters, etc. Swelling agent: Dispersing agent such as silicon dioxide: In addition, fragrances, pigments and the like can be mentioned. Examples of physiologically active functional ingredients include vitamins such as vitamin B1, vitamin B6, and vitamin B12; hyaluronic acid, ginger powder, salmon cartilage extract, chicken cartilage extract, and the like. Furthermore, you may contain a pine bark extract, a potato extract, a kuzu flower extract, a sweet potato young leaf powder, a soybean extract, and an onion powder.

  In the tablet manufacturing method of the present invention, only the amino sugar may be granulated, and all the raw materials may be mixed and compressed into tablets without granulating other raw materials. According to this aspect, since the tablet can be produced with the amino sugar granulation conditions constant, even when there are variations in the composition of the raw materials, the preferred conditions for the amino sugar granulation are changed. It can respond without. Moreover, the occurrence of lumps caused by other raw materials to be blended during granulation can be suppressed.

  EXAMPLES Hereinafter, the present invention will be specifically described with reference to examples, but these examples do not limit the scope of the present invention.

  Using the barley young leaf powder and glucosamine hydrochloride, tablets having the composition shown in Table 1 below were produced.

  About the following Comparative Examples 1-3, the tablet was manufactured using the tableting apparatus of a laboratory (henceforth a "tablet prototype machine") (a test result is represented to the following FIG. 1B). As a result, as shown in Table 3 below, since Comparative Example 3 was an undesirable result in both tableting manufacturability and color tone stability, except for this, Example 1, Comparative Example 1, and Comparative Example About 2, tablet was manufactured using the tableting apparatus which manufactures an actual product (henceforth "tablet actual machine") (a test result is shown in following Table 2, FIG. 1A). Although the actual tableting machine is equipped with a pressure gauge, the tableting prototype machine is not equipped with a pressure gauge, so it is not possible to measure the exact tableting pressure in the test results of the tableting prototype machine. It was.

<Example 1>
Among the above raw materials, glucosamine hydrochloride is supplied to a fluidized bed granulator and sprayed with binder water containing 4% by mass of pregelatinized starch and 20% by mass of isomaltoligosaccharide, according to a conventional method at 20 to 40 ° C. The granulated product was granulated, and the other raw materials were mixed with the glucosamine hydrochloride granulated product in the form of powder. Tablets of about 250 to 280 mg per tablet were produced by tableting the mixture with a tableting device.

<Comparative Example 1>
All raw materials, including glucosamine hydrochloride, are mixed in powder form and used in a fluidized bed granulator for granulation while spraying binder water containing 4% by weight pregelatinized starch and 20% by weight isomaltoligosaccharide. Then, the granulated product was obtained, and tablets were produced in the same manner as in Example 1 except that the granulated product was subjected to a tableting device.

<Comparative example 2>
Tablets were produced in the same manner as in Example 1 except that all raw materials including glucosamine hydrochloride were mixed in powder form and the mixture was supplied to a tableting device.

<Comparative Example 3>
All raw materials other than glucosamine hydrochloride are mixed in the form of powder, and subjected to a fluidized bed granulator, granulated while spraying binder water containing 4% by weight of pregelatinized starch and 20% by weight of isomaltooligosaccharide. A tablet was produced in the same manner as in Example 1 except that the granulated product was obtained, mixed with glucosamine hydrochloride, and then subjected to a tableting device.

[Test Example 1] (Tabletting manufacturability)
Using a tableting machine, the tableting manufacturability of the tablets obtained by the production methods of Example 1, Comparative Example 1, and Comparative Example 2 was examined. Specifically, the weight of the tablet, the tableting pressure applied to the heel portion of the apparatus during tableting, and the hardness of the tablet were examined. The tableting pressure applied to the heel portion of the device was measured with a pressure gauge provided in the tableting device, and the hardness was measured using a “Schleuniger hardness meter”. The results are shown in Table 2. Each result is shown as an average of 10 tablets for weight and hardness, and an average of 65 tablets for tableting pressure.

  As a result, the tableting pressure applied to the heel portion of the device during tableting in the order of Example 1 <Comparative Example 1 <Comparative Example 2 in the state of maintaining the most suitable hardness of 9 kP as the tablet hardness. It was small. In particular, Example 1 only required a tableting pressure as small as 1.76 kN in comparison with Comparative Example 1, and a significant tableting pressure difference of 6.0 kN in comparison with Comparative Example 2.

  In general, it is known that the smaller the total tablet amount, the more difficult it is to obtain a suitable hardness as a tablet. Since Example 1 has a total tablet amount of about 20 mg less than Comparative Examples 1 and 2, if the total tablet amount of Example 1 is increased to the same level as Comparative Examples 1 and 2, the hardness is comparable even at a smaller tableting pressure. Can be estimated. Therefore, under the conditions of the same total amount of tablets, it is considered that Example 1 can produce tablets having a desired hardness even with a tableting pressure smaller than the above tableting pressure.

  On the other hand, in Comparative Example 3, since tablets were produced only with a tableting prototype without a pressure gauge, an accurate tableting pressure could not be measured, but a hardness of about 9 kP most suitable as the tablet hardness. The desired tablet could be produced with a smaller tableting pressure in Comparative Example 1 than in Comparative Example 3 under the condition that the above was maintained. From the results of Table 2, since the tableting pressure is small in the order of Example 1 <Comparative Example 1, even when Comparative Examples 1 to 3 and Example 1 are compared, Example 1 is desired with the smallest tableting pressure. It was clear that tablets of the same hardness could be produced.

  In addition, Comparative Example 1 in which all the raw materials were mixed and granulated in a powder form and then tableted, and all raw materials other than glucosamine hydrochloride were mixed and granulated in a powder form, and then mixed with glucosamine hydrochloride and compressed into tablets. Compared to Comparative Example 3, only the glucosamine hydrochloride was granulated and mixed with other raw materials, and tableting was performed in Example 1, with a smaller tableting pressure and a smaller total amount of tablets with the same degree of hardness. was gotten. Therefore, it became clear that tableting manufacturability is more improved than tableting after mixing and granulating all raw materials in powder form.

[Test Example 2] (Color tone stability)
The color stability of the tablets obtained by the production methods of Example 1 and Comparative Examples 1 to 3 was examined. Specifically, the tablets were stored in a dryer at a temperature of 60 ° C., and changes in the color tone of the tablets from day to day were observed visually. In addition, in FIG. 1, the photograph of the typical result is shown about the color tone change of the tablet obtained by each manufacturing method.

  As a result, in Comparative Example 1 in which all the raw materials were mixed in the form of powder and granulated and then tableted, the green color immediately after production gradually browned, and the color changed to dark brown after 5 days of storage at 60 ° C ( FIG. 1A, B). On the other hand, in Example 1 in which only glucosamine hydrochloride was granulated and mixed with other raw materials for tableting, and in Comparative Example 2 in which raw materials were mixed and tableted without being granulated, 60 Even after 7 to 8 days of storage at 0 ° C., the green color was maintained just after production (FIGS. 1A and 1B). On the other hand, in Comparative Example 3, in which raw materials other than glucosamine hydrochloride were mixed and granulated, and then mixed with glucosamine hydrochloride and tableted, discoloration from green to brown occurred as in Comparative Example 1 (Fig. 1B).

[Evaluation]
About the tablet obtained by each manufacturing method of Example 1 and Comparative Examples 1-3, the result of tableting manufacturability of Test Example 1 and the result of color tone stability of Test Example 2 are good: ◯, not preferable: Δ, The results are shown in Table 3 below when summarized in three stages of evaluation: bad.

  As shown in Table 3, a tablet with good tableting manufacturability and color tone stability was obtained because only glucosamine hydrochloride was granulated and mixed with other raw materials for tableting. It was a manufacturing method.

  Therefore, according to the production method of Example 1, it is possible to ensure the desired hardness even if the tableting device is manufactured as a small tablet by reducing the total amount of the tablet without burdening the tableting device at the time of tableting. A tablet that is less susceptible to green discoloration of the green leaf powder was obtained.

Claims (6)

  In a method for producing tablets containing grass green leaf powder and amino sugar, at least amino sugar is granulated, and at least green grass powder is mixed without mixing, and all raw materials are mixed. And tableting, wherein the tablet is compressed.   The method for producing a tablet according to claim 1, wherein only the amino sugar is granulated and all the raw materials are mixed and tableted while the other raw materials including the powder of green grass are not granulated.   The method for producing a tablet according to claim 1 or 2, wherein the powder of green grass is a wheat leaf powder.   The method for producing a tablet according to any one of claims 1 to 3, wherein the amino sugar is glucosamine, a derivative thereof, and / or a salt thereof.   The method for producing a tablet according to any one of claims 1 to 4, wherein the total raw material mass per tablet is 200 to 350 mg, and the tableting pressure is 3.0 to 15.0 kN.   The tablet obtained by the method as described in any one of Claims 1-5.