JP2010285429A - Disintegrator - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a disintegrator which is familiar to consuming public, can be taken with no sense of resistance, and exhibits intensive disintegrating actions after being taken. <P>SOLUTION: The inventors have found out that the disintegration actions of a disintegrator after being taken are remarkably improved by incorporating dried powder of barley leaves into the disintegrator, as a result of keen examinations to solve the problem, and have completed the invention. The disintegrator can be blended with e.g. tablets, granules, foods, nutritious supplements, medicinal preparations, detergents, bath agents, fertilizers, etc. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a disintegrant containing a dry powder of barley leaves.

  A disintegrant is a component mix | blended in order to make a tablet etc. easy to disintegrate. Examples of disintegrants include sodium carboxymethylcellulose (Patent Document 1), alanine (Patent Document 2), glycine (Patent Document 3), low-substituted hydroxypropylcellulose, carmellose calcium (carboxylmethylcellulose calcium), and croscarmellose. Sodium (cross-linked carboxymethyl cellulose sodium), sodium carboxymethyl starch, partially pregelatinized starch, crospovidone (cross-linked polyvinyl pyrrolidone) (Patent Document 4), starches (Patent Document 5) and the like are known. Such disintegrants are widely and generally used mainly for tablets for pharmaceutical use.

  On the other hand, the use of disintegrants in food applications (health foods, etc.) is not common compared to pharmaceutical applications. One reason for this is thought to be because many of the above disintegrants are unfamiliar to general consumers, and many people have resistance to being added to food. Here, starches are known as disintegrants that are familiar to general consumers and can be taken without resistance, but there is a problem that the disintegration action is not always sufficient. Thus, it has been desired to develop a disintegrant that is familiar to general consumers, can be taken without resistance, and has a strong disintegration effect after ingestion.

Japanese Patent No. 3310233 JP 2006-232680 A JP 2001-278812 A Japanese Patent No. 4158017 Japanese Patent Publication No. 6-88899

  An object of the present invention is to provide a disintegrant that is familiar to general consumers, can be ingested without a sense of resistance, and has a strong disintegration effect after ingestion.

As a result of earnestly examining the means for solving the above-mentioned problems, the inventors of the present invention can significantly improve the disintegrating action of the disintegrant after ingestion by including a dry powder of barley leaves in the disintegrant. As a result, the present invention has been completed. That is, the disintegrant according to claim 1 relates to a disintegrant characterized by containing a dry powder of barley leaves.

Further, the disintegrant according to claim 2 relates to the disintegrant according to claim 1, wherein the disintegrant is blended at a ratio of 1 to 60% by weight with respect to the tablet containing the disintegrant.

The disintegrant according to claim 3 further comprises an animal-derived cartilage extract, and relates to the disintegrant according to claim 1 or 2.

The disintegrant according to claim 4 relates to the disintegrant according to claim 3, wherein the cartilage extract is derived from pigs.

Since the disintegrant of the present invention is characterized by comprising a dry powder of barley leaves that is widely distributed in the market as health foods such as green juice, even a general consumer who does not like unfamiliar compounds is resistant. There is an effect that it can be taken without feeling.

Moreover, the disintegrant of this invention has the effect that the disintegration action after ingestion is excellent compared with the starch which is a conventional disintegrant.

Furthermore, the disintegrant of the present invention has the effect of further enhancing the disintegration action after ingestion by adding an animal-derived cartilage extract to the dry powder of barley leaves.

FIG. 1 is a photograph of Comparative Example 1 (left) and Example 1 (right) 420 seconds after the start of the disintegration test. FIG. 2 is a photograph of Comparative Example 1 (left) and Example 1 (right) 600 seconds after the start of the disintegration test. FIG. 3 is a photograph of Comparative Example 1 (left) and Example 1 (right) 810 seconds after the start of the disintegration test.

  Hereinafter, embodiments of the present invention will be described. The present invention is not construed as being limited by the description of the following embodiments, and various modifications can be made within the scope of the claims.

  The dry powder of barley leaves used in the present invention is not particularly limited, and commonly available dry powder of barley leaves (hereinafter referred to as “barley leaf dry powder”) is used. Further, a dried powder of barley leaf juice or a dried powder of barley leaf extract obtained by drying and pulverizing the juice or extract of barley leaves can also be used.

  Although it does not restrict | limit especially as a manufacturing method of the barley leaf dry powder used for this invention, For example, it manufactures by the method as disclosed by patent 3428956.

  The disintegrant of this invention is mix | blended in the ratio of 0.1 weight% or more with respect to a tablet etc. Preferably it mix | blends in the ratio of 1-60 weight%, More preferably, it is 20-60 weight%, Most preferably, it is 30-60 weight%.

  The disintegrant of the present invention can be blended in, for example, tablets, granulated products, foods, nutritional supplements (supplements), pharmaceutical preparations, detergents, bathing agents, fertilizers, etc., but preferably blended in tablets. Is desirable.

  The component added to the disintegrant of the present invention is not particularly limited, but it is desirable to add an animal-derived cartilage extract. It is preferable to add a cartilage extract derived from pigs.

  The animal-derived cartilage extract used in the present invention is not particularly limited, and normally available animal-derived cartilage extracts can be used.

  The method for producing an animal-derived cartilage extract used in the present invention is not particularly limited, and a production aid that can be used in the production of foods can be added.

  When the animal-derived cartilage extract is added to the disintegrant of the present invention, the animal-derived cartilage extract is preferably 0.1 to 1500 parts by weight, more preferably 100 parts by weight of the barley leaf dry powder. Is added in a proportion of 0.5 to 1000 parts by weight, most preferably 1 to 500 parts by weight.

  Examples of the present invention will be described below. The present invention is not construed as being limited to the following examples, and various modifications can be made within the scope of the claims.

(Test Example 1: Evaluation of disintegration action of dried barley leaf powder)
In Test Example 1, in order to evaluate the disintegrating action of the barley leaf dry powder, a tablet containing the barley leaf dry powder (Example 1), a tablet containing a starch conventionally known as a disintegrant (Comparative Example 1), and Tablets (Comparative Examples 2 to 4) in which other plant powders different from the barley leaf dry powder were blended were prepared, and the respective disintegration times were measured and compared. Furthermore, in order to evaluate the disintegration effect when the barley leaf dry powder and the animal-derived cartilage extract are combined, a tablet containing the barley leaf dry powder and the animal-derived cartilage extract (Example 1), barley Tablets containing no animal dry cartilage extract and animal derived cartilage extract (Comparative Example 1), and tablets containing no barley leaf dry powder and animal cartilage extract (Comparative Example 5) Then, the respective decay times were measured and compared.

Example 1
Glucosamine 46.9 wt%, starch 16.6 wt%, cellulose 15 wt%, chicken crown extract 5 wt%, calcium stearate 1 wt%, silicon dioxide 0.5 wt%, pork cartilage extract 10 wt%, After mixing powder so that dry powder of barley leaves (manufactured by Toyo Shinyaku Co., Ltd.) becomes 5% by weight as a disintegrant, the mixed powder is tableted with a tableting machine to make a tablet of 400 mg, and Examples It was set to 1.

(Comparative Example 1)
After replacing 5% by weight of the dry barley leaf powder contained in Example 1 with 5% by weight of starch and mixing the powder so that the blending ratio of starch was 21.6% by weight, the mixed powder was pressed with a tablet press. A tablet of 400 mg was made by tableting, and it was designated as Comparative Example 1.

(Comparative Example 2)
After mixing the powder obtained by replacing 5% by weight of dry barley leaf powder in Example 1 with 5% by weight of kale powder, a tablet of 400 mg was prepared by tableting the mixed powder with a tableting machine. 2.

(Comparative Example 3)
After mixing the powder obtained by replacing 5% by weight of barley leaf dry powder contained in Example 1 with 5% by weight of spinach powder, a tablet of 400 mg was prepared by tableting the mixed powder with a tableting machine. It was set to 3.

(Comparative Example 4)
After mixing the powder obtained by replacing 5% by weight of the dried barley leaf powder in Example 1 with 5% by weight of the pumpkin powder, a tablet of 400 mg was prepared by tableting the mixed powder with a tableting machine. It was set to 4.

(Comparative Example 5)
After mixing 5% by weight of barley leaf dry powder and 10% by weight of pork cartilage extract contained in Example 1 with 15% by weight of starch and mixing the powder prepared so that the blending ratio of starch was 31.6% by weight, A tablet of 400 mg was prepared by tableting the mixed powder with a tableting machine.

(Disintegration test)
According to the 15th revision Japanese Pharmacopoeia (March 31, 2006 Ministry of Health, Labor and Welfare Notification No. 285), using a disintegration tester (model number: NT-40H, manufactured by Toyama Sangyo Co., Ltd.), until the tablets disintegrate The decay time of was measured. “Disintegration of tablets” was determined according to the definition of the 15th revision Japanese Pharmacopoeia below.

(Definition of “disintegration of tablets”)
It is assumed that the tablet is disintegrated when there is no sample residue, or when it is a soft substance that does not clearly retain its original shape even when it is recognized, or when it is a fragment of the skin.

(Test results)
The disintegration time of the tablets of Example 1 and Comparative Examples 1 to 5 was measured by the above method. The results are shown in Table 1.

  Further, for Example 1 and Comparative Example 1, photographs were taken 420 seconds, 600 seconds, and 810 seconds after the start of the disintegration test. FIG. 1 shows a photograph 420 seconds after the start of the disintegration test, FIG. 2 shows a photograph 600 seconds after the start of the disintegration test, and FIG. 3 shows a photograph 810 seconds after the start of the disintegration test. In either case, the left is Comparative Example 1 and the right is Example 1.

From the results in Table 1, it was confirmed that the tablet containing the barley leaf dry powder (Example 1) disintegrated in a significantly shorter time than the tablet containing the starch that is a conventional disintegrant (Comparative Example 1). did it. This can also be confirmed from the photographs in FIGS. Moreover, the tablet (Example 1) which mix | blended the barley leaf dry powder disintegrates in a remarkably short time compared with the tablet (Comparative Examples 2-4) which mix | blended other plant powders different from barley leaf dry powder. I was able to confirm. From the above, it has been clarified that the dried barley leaf powder exhibits an excellent disintegrating action as compared with starch and other plant powders which are conventional disintegrants.

Furthermore, the tablet (Example 1) which mix | blended the barley leaf dry powder and the animal-derived cartilage extract was blended with the animal-derived cartilage extract without the barley leaf dry powder (Comparative Example 1), and It was confirmed that the tablet disintegrated in a significantly shorter time than the tablet (Comparative Example 5) in which neither the barley leaf dry powder nor the animal-derived cartilage extract was blended. From this, it became clear that the disintegration action is further enhanced by adding an animal-derived cartilage extract to the dried barley leaf powder.

(Test Example 2: Examination of appropriate blending ratio of barley leaf dry powder to tablet)
In Test Example 2, in order to examine an appropriate blending ratio of barley leaf dry powder to tablets, tablets having different barley leaf powder blending ratios were prepared, and the disintegration time was measured.

(Example 2)
Barley leaf dry powder 1%, starch 59%, calcium stearate 1%, silicon dioxide 2%, hydroxypropylcellulose 10%, maltose 27% by weight A tablet of 150 mg was prepared by tableting with a machine, and this was designated as Example 2.

(Example 3)
Barley leaf dry powder 3% by weight, starch 57% by weight, calcium stearate 1% by weight, silicon dioxide 2% by weight, hydroxypropylcellulose 10% by weight, malt sugar 27% by weight A tablet of 150 mg was prepared by tableting with a machine, and this was taken as Example 3.

Example 4
Barley leaf dry powder 5 wt%, starch 55 wt%, calcium stearate 1 wt%, silicon dioxide 2 wt%, hydroxypropylcellulose 10 wt%, maltose 27 wt% A tablet of 150 mg was prepared by tableting with a machine, and this was designated as Example 4.

(Example 5)
Barley leaf dry powder 15 wt%, starch 45 wt%, calcium stearate 1 wt%, silicon dioxide 2 wt%, hydroxypropylcellulose 10 wt%, maltose 27 wt% Tablets of 1 tablet 150 mg were prepared by tableting with a machine and used as Example 5.

(Example 6)
Barley leaf dry powder 20%, starch 40%, calcium stearate 1%, silicon dioxide 2%, hydroxypropylcellulose 10%, maltose 27% by weight A tablet of 150 mg was prepared by tableting with a machine, and this was designated as Example 6.

(Example 7)
Barley leaf dry powder 22%, starch 38%, calcium stearate 1%, silicon dioxide 2%, hydroxypropylcellulose 10%, maltose 27% by weight A tablet of 150 mg was prepared by tableting with a machine, and this was designated as Example 7.

(Example 8)
After mixing the powder so that the dry powder of barley leaves 25% by weight, starch 35% by weight, calcium stearate 1% by weight, silicon dioxide 2% by weight, hydroxypropylcellulose 10% by weight, maltose 27% by weight, the mixed powder is compressed into tablets. A tablet of 150 mg was prepared by tableting with a machine, and Example 8 was obtained.

Example 9
After mixing the powder so that the dry powder of barley leaves 30% by weight, starch 30% by weight, calcium stearate 1% by weight, silicon dioxide 2% by weight, hydroxypropylcellulose 10% by weight, maltose 27% by weight, the mixed powder is compressed into tablets. Tablets of 150 mg each were made by tableting with a machine, and this was designated as Example 9.

(Example 10)
After mixing the powder so that the dry powder of barley leaves 60% by weight, calcium stearate 1% by weight, silicon dioxide 2% by weight, hydroxypropylcellulose 10% by weight, and maltose 27% by weight, the mixed powder is compressed with a tablet press. Thus, one tablet of 150 mg was prepared and designated as Example 10.

(Comparative Example 6)
After mixing the powder so as to be 60 wt% starch, 1 wt% calcium stearate, 2 wt% silicon dioxide, 10 wt% hydroxypropylcellulose, and 27 wt% maltose, the mixed powder is compressed by tableting with a tableting machine. A 150 mg tablet was prepared and used as Comparative Example 6.

(Disintegration test)
Similar to Test Example 1, the disintegration time until the tablets disintegrated was measured according to the 15th revised Japanese Pharmacopoeia (March 31, 2006, Ministry of Health, Labor and Welfare Notification No. 285).

(Test results)
The disintegration times of the tablets of Examples 2 to 10 and Comparative Example 6 are shown in Table 2.

From the results of Table 2, the tablets (Examples 2 to 10) containing 1 to 60% by weight of barley leaf dry powder were compared with the tablets (Comparative Example 6) containing starch instead of the barley leaf dry powder. It was confirmed that it collapsed in a short time. Especially the tablet (Examples 6-10) which mix | blended the barley leaf dry powder in the ratio of 20 to 60 weight% disintegrated in a shorter time. Furthermore, the tablet (Examples 9-10) which mix | blended the barley leaf dry powder in the ratio of 30-60 weight% disintegrated in the remarkably short time.

  From the above, it has been clarified that the disintegration time of the tablet can be shortened by blending the barley leaf dry powder at a ratio of 1 to 60% by weight with respect to the tablet. Moreover, when barley leaf dry powder is blended at a rate of 20 to 60% by weight with respect to the tablet, the disintegration time can be further shortened, and barley leaf dry powder is blended at a rate of 30 to 60% by weight with respect to the tablet In this case, it was found that the disintegration time can be shortened remarkably.

The disintegrant of the present invention is characterized by comprising a dry powder of barley leaves that is widely distributed in the market as health foods such as green juice, so even a general consumer who does not like unfamiliar compounds is resistant. Can be taken without feeling. In addition, the disintegrant of the present invention exhibits an excellent disintegrating action when blended in a tablet, compared to starch, which is a conventional disintegrant. The disintegrant of this invention can be mix | blended with a tablet, a granulated material, a foodstuff, a nutritional supplement (supplement), a pharmaceutical formulation, a detergent, a bath agent, a fertilizer etc., for example.

Claims (4)

  A disintegrant characterized by containing a dry powder of barley leaves.   The disintegrant according to claim 1, wherein the disintegrant is blended at a ratio of 1 to 60% by weight with respect to the tablet containing the disintegrant.   The disintegrant according to claim 1 or 2, wherein the disintegrant further contains an animal-derived cartilage extract.   The disintegrant according to claim 3, wherein the cartilage extract is derived from pigs.