JP2012191939A5 - - Google Patents
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- Publication number
- JP2012191939A5 JP2012191939A5 JP2012129374A JP2012129374A JP2012191939A5 JP 2012191939 A5 JP2012191939 A5 JP 2012191939A5 JP 2012129374 A JP2012129374 A JP 2012129374A JP 2012129374 A JP2012129374 A JP 2012129374A JP 2012191939 A5 JP2012191939 A5 JP 2012191939A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- oligonucleotide
- heg
- immune response
- ggttgt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091034117 Oligonucleotide Proteins 0.000 claims 24
- 230000028993 immune response Effects 0.000 claims 7
- 208000023275 Autoimmune disease Diseases 0.000 claims 4
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 2
- IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 1
- 229930024421 Adenine Natural products 0.000 claims 1
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims 1
- 102100039390 Toll-like receptor 7 Human genes 0.000 claims 1
- 229960000643 adenine Drugs 0.000 claims 1
- 208000037896 autoimmune cutaneous disease Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 229940104302 cytosine Drugs 0.000 claims 1
- 230000001934 delay Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 125000005642 phosphothioate group Chemical group 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 229940113082 thymine Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60683304P | 2004-09-01 | 2004-09-01 | |
| US60/606,833 | 2004-09-01 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530180A Division JP2008514187A (ja) | 2004-09-01 | 2005-08-24 | 先天性免疫応答及び自己免疫疾患の阻害法及び阻害用組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012191939A JP2012191939A (ja) | 2012-10-11 |
| JP2012191939A5 true JP2012191939A5 (https=) | 2013-01-24 |
| JP5775024B2 JP5775024B2 (ja) | 2015-09-09 |
Family
ID=36036819
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530180A Pending JP2008514187A (ja) | 2004-09-01 | 2005-08-24 | 先天性免疫応答及び自己免疫疾患の阻害法及び阻害用組成物 |
| JP2012129374A Expired - Fee Related JP5775024B2 (ja) | 2004-09-01 | 2012-06-06 | 先天性免疫応答及び自己免疫疾患の阻害法及び阻害用組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530180A Pending JP2008514187A (ja) | 2004-09-01 | 2005-08-24 | 先天性免疫応答及び自己免疫疾患の阻害法及び阻害用組成物 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8759305B2 (https=) |
| EP (2) | EP1794174B1 (https=) |
| JP (2) | JP2008514187A (https=) |
| KR (1) | KR101268877B1 (https=) |
| CN (1) | CN101052643B (https=) |
| AU (2) | AU2005282889B2 (https=) |
| CA (1) | CA2578775C (https=) |
| DK (1) | DK1794174T3 (https=) |
| ES (2) | ES2385657T3 (https=) |
| NZ (1) | NZ553581A (https=) |
| PL (1) | PL1794174T3 (https=) |
| PT (1) | PT1794174E (https=) |
| SI (1) | SI1794174T1 (https=) |
| WO (1) | WO2006028742A2 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008514187A (ja) | 2004-09-01 | 2008-05-08 | ダイナバックス テクノロジーズ コーポレイション | 先天性免疫応答及び自己免疫疾患の阻害法及び阻害用組成物 |
| EP1836218A2 (en) * | 2004-12-17 | 2007-09-26 | Dynavax Technologies Corporation | Methods and compositions for induction or promotion of immune tolerance |
| DE102005005642A1 (de) * | 2005-02-06 | 2006-08-10 | Phenion Gmbh & Co. Kg | Kosmetische oder pharmazeutische Zubereitungen enthaltend Nukleinsäuren, die zur Ausbildung von stem-loop-Sekundärstrukturen geeignete Sequenzen umfassen |
| AU2006220835B2 (en) | 2005-03-04 | 2012-01-19 | Dynavax Technologies Corporation | Vaccines comprising oligonucleotides having immunostimulatory sequences (ISS) wherein the ISS are conjugated to antigens and stabilized by buffer conditions and further excipients |
| WO2007004977A1 (en) | 2005-07-01 | 2007-01-11 | Index Pharmaceuticals Ab | Immunostimulatory method |
| PL2179737T3 (pl) | 2005-07-01 | 2014-01-31 | Index Pharmaceuticals Ab | Sposób do modulowania wrażliwości na steroidy |
| ES2544877T3 (es) | 2005-10-12 | 2015-09-04 | Idera Pharmaceuticals | Compuestos oligonucleótidos inmuno reguladores (IRO) para modular la respuesta inmune basada en receptor semejante a Toll |
| CA2625969A1 (en) | 2005-10-28 | 2007-05-03 | Index Pharmaceuticals Ab | Composition and method for the prevention, treatment and/or alleviation of an inflammatory disease |
| MX2010001785A (es) * | 2007-08-15 | 2010-03-10 | Idera Pharmaceuticals Inc | Moduladores de receptores tipo larga distancia. |
| CA2703931C (en) | 2007-10-26 | 2016-08-16 | Dynavax Technologies Corporation | Methods and compositions for inhibition of immune responses and autoimmunity |
| US8030289B2 (en) * | 2008-08-06 | 2011-10-04 | Changchun Huapu Biotechnology Co., Ltd. | Oligonucleotide and use thereof |
| PL2154144T3 (pl) * | 2008-08-06 | 2015-04-30 | Changchun Huapu Biotechnology Co Ltd | Oligonukleotydy i ich zastosowanie |
| AU2009302468A1 (en) * | 2008-10-06 | 2010-04-15 | Idera Pharmaceuticals, Inc. | Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto |
| WO2011005942A2 (en) * | 2009-07-08 | 2011-01-13 | Idera Pharmaceuticals, Inc. | Oligonucleotide-based compounds as inhibitors of toll-like receptors |
| CN103153346A (zh) * | 2010-06-16 | 2013-06-12 | 戴纳瓦克斯技术公司 | 使用tlr7和/或tlr9抑制剂的治疗方法 |
| JP5921535B2 (ja) * | 2010-06-16 | 2016-05-24 | ディナバックス テクノロジーズ コーポレイション | Ｔｌｒ７および／またはｔｌｒ９阻害剤を用いる治療の方法 |
| BR112013005872A2 (pt) | 2010-09-22 | 2019-09-24 | Alios Biopharma Inc | compostos, composição farmacêutica e respectivos usos |
| KR101985382B1 (ko) | 2010-11-19 | 2019-06-03 | 이데라 파마슈티칼즈, 인코포레이티드 | 톨-유사 수용체 기반 면역 반응을 조절하기 위한 면역 조절 올리고뉴클레오타이드(ｉｒｏ) 화합물 |
| EP2794630A4 (en) | 2011-12-22 | 2015-04-01 | Alios Biopharma Inc | SUBSTITUTED PHOSPHORTHIOAT NUCLEOTIDE ANALOGUE |
| WO2013142124A1 (en) | 2012-03-21 | 2013-09-26 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
| US9012427B2 (en) | 2012-03-22 | 2015-04-21 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
| US9228184B2 (en) * | 2012-09-29 | 2016-01-05 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
| US9868955B2 (en) | 2012-09-29 | 2018-01-16 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
| EP2754714A1 (en) * | 2013-01-14 | 2014-07-16 | Sarepta Therapeutics, Inc. | Inhibitory oligonucleotides and their use in therapy |
| US10849917B2 (en) | 2015-06-01 | 2020-12-01 | Sarepta Therapeutics, Inc. | Antisense-induced exon exclusion in type VII collagen |
| WO2017173334A1 (en) | 2016-04-01 | 2017-10-05 | Checkmate Pharmaceuticals, Inc. | Fc receptor-mediated drug delivery |
| US11339396B2 (en) | 2016-06-08 | 2022-05-24 | President And Fellows Of Harvard College | Engineered viral vector reduces induction of inflammatory and immune responses |
| US11370794B2 (en) | 2016-11-11 | 2022-06-28 | Dynavax Technologies Corporation | Toll-like receptor antagonist compounds and methods of use |
| JP6886854B2 (ja) * | 2017-04-13 | 2021-06-16 | シスメックス株式会社 | 被検物質の情報取得方法 |
| AU2018364542A1 (en) | 2017-11-08 | 2020-04-16 | President And Fellows Of Harvard College | Compositions and methods for inhibiting viral vector-induced inflammatory responses |
| US12246031B2 (en) | 2018-02-13 | 2025-03-11 | Checkmate Pharmaceuticals, Inc. | Compositions and methods for tumor immunotherapy |
| KR102890791B1 (ko) | 2018-04-09 | 2025-11-24 | 체크메이트 파마슈티칼스, 인크. | 바이러스-유사 입자 내로의 올리고뉴클레오타이드의 포장 |
| US11863189B2 (en) * | 2021-03-05 | 2024-01-02 | Taiwan Semiconductor Manufacturing Company, Ltd. | Input buffer circuit |
| US12110324B2 (en) | 2022-07-22 | 2024-10-08 | Flagship Pioneering Innovations Vi, Llc | Antigen binding molecules targeting thymic stromal lymphopoietin (TSLP) |
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| JP2008514187A (ja) | 2004-09-01 | 2008-05-08 | ダイナバックス テクノロジーズ コーポレイション | 先天性免疫応答及び自己免疫疾患の阻害法及び阻害用組成物 |
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-
2005
- 2005-08-24 JP JP2007530180A patent/JP2008514187A/ja active Pending
- 2005-08-24 SI SI200531556T patent/SI1794174T1/sl unknown
- 2005-08-24 ES ES05792518T patent/ES2385657T3/es not_active Expired - Lifetime
- 2005-08-24 EP EP05792518A patent/EP1794174B1/en not_active Expired - Lifetime
- 2005-08-24 PT PT05792518T patent/PT1794174E/pt unknown
- 2005-08-24 KR KR1020077006947A patent/KR101268877B1/ko not_active Expired - Fee Related
- 2005-08-24 WO PCT/US2005/030494 patent/WO2006028742A2/en not_active Ceased
- 2005-08-24 AU AU2005282889A patent/AU2005282889B2/en not_active Ceased
- 2005-08-24 CN CN200580037417.4A patent/CN101052643B/zh not_active Expired - Fee Related
- 2005-08-24 ES ES10011096.4T patent/ES2543207T3/es not_active Expired - Lifetime
- 2005-08-24 NZ NZ553581A patent/NZ553581A/en not_active IP Right Cessation
- 2005-08-24 CA CA2578775A patent/CA2578775C/en not_active Expired - Lifetime
- 2005-08-24 EP EP10011096.4A patent/EP2305693B1/en not_active Expired - Lifetime
- 2005-08-24 DK DK05792518.2T patent/DK1794174T3/da active
- 2005-08-24 US US11/212,297 patent/US8759305B2/en active Active
- 2005-08-24 PL PL05792518T patent/PL1794174T3/pl unknown
-
2012
- 2012-05-29 AU AU2012203156A patent/AU2012203156B2/en not_active Ceased
- 2012-06-06 JP JP2012129374A patent/JP5775024B2/ja not_active Expired - Fee Related
-
2014
- 2014-06-23 US US14/312,533 patent/US20150050296A1/en not_active Abandoned
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