JP2012191939A5 - - Google Patents
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- Publication number
- JP2012191939A5 JP2012191939A5 JP2012129374A JP2012129374A JP2012191939A5 JP 2012191939 A5 JP2012191939 A5 JP 2012191939A5 JP 2012129374 A JP2012129374 A JP 2012129374A JP 2012129374 A JP2012129374 A JP 2012129374A JP 2012191939 A5 JP2012191939 A5 JP 2012191939A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- oligonucleotide
- heg
- immune response
- ggttgt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091034117 Oligonucleotide Proteins 0.000 claims 24
- 230000028993 immune response Effects 0.000 claims 7
- 208000023275 Autoimmune disease Diseases 0.000 claims 4
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 2
- IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 1
- 229930024421 Adenine Natural products 0.000 claims 1
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims 1
- 102100039390 Toll-like receptor 7 Human genes 0.000 claims 1
- 229960000643 adenine Drugs 0.000 claims 1
- 208000037896 autoimmune cutaneous disease Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 229940104302 cytosine Drugs 0.000 claims 1
- 230000001934 delay Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 125000005642 phosphothioate group Chemical group 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 229940113082 thymine Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60683304P | 2004-09-01 | 2004-09-01 | |
| US60/606,833 | 2004-09-01 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530180A Division JP2008514187A (ja) | 2004-09-01 | 2005-08-24 | 先天性免疫応答及び自己免疫疾患の阻害法及び阻害用組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012191939A JP2012191939A (ja) | 2012-10-11 |
| JP2012191939A5 true JP2012191939A5 (cg-RX-API-DMAC7.html) | 2013-01-24 |
| JP5775024B2 JP5775024B2 (ja) | 2015-09-09 |
Family
ID=36036819
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530180A Pending JP2008514187A (ja) | 2004-09-01 | 2005-08-24 | 先天性免疫応答及び自己免疫疾患の阻害法及び阻害用組成物 |
| JP2012129374A Expired - Fee Related JP5775024B2 (ja) | 2004-09-01 | 2012-06-06 | 先天性免疫応答及び自己免疫疾患の阻害法及び阻害用組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530180A Pending JP2008514187A (ja) | 2004-09-01 | 2005-08-24 | 先天性免疫応答及び自己免疫疾患の阻害法及び阻害用組成物 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8759305B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2305693B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2008514187A (cg-RX-API-DMAC7.html) |
| KR (1) | KR101268877B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101052643B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2005282889B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2578775C (cg-RX-API-DMAC7.html) |
| DK (1) | DK1794174T3 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2385657T3 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ553581A (cg-RX-API-DMAC7.html) |
| PL (1) | PL1794174T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT1794174E (cg-RX-API-DMAC7.html) |
| SI (1) | SI1794174T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006028742A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005282889B2 (en) | 2004-09-01 | 2012-03-15 | Dynavax Technologies Corporation | Methods and conpositions for inhibition of innate immune responses and autoimmunity |
| CA2591582A1 (en) * | 2004-12-17 | 2006-06-22 | Dynavax Technologies Corporation | Methods and compositions for induction or promotion of immune tolerance |
| DE102005005642A1 (de) * | 2005-02-06 | 2006-08-10 | Phenion Gmbh & Co. Kg | Kosmetische oder pharmazeutische Zubereitungen enthaltend Nukleinsäuren, die zur Ausbildung von stem-loop-Sekundärstrukturen geeignete Sequenzen umfassen |
| SG160336A1 (en) | 2005-03-04 | 2010-04-29 | Dynavax Tech Corp | Vaccines comprising oligonucleotides having immunostimulatory sequences (iss) wherein the iss are conjugated to antigens and stabilized by buffer conditions and further excipients |
| PL2179737T3 (pl) | 2005-07-01 | 2014-01-31 | Index Pharmaceuticals Ab | Sposób do modulowania wrażliwości na steroidy |
| ES2450593T3 (es) | 2005-07-01 | 2014-03-25 | Index Pharmaceuticals Ab | Método inmunoestimulante |
| WO2007047396A2 (en) | 2005-10-12 | 2007-04-26 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
| US8895522B2 (en) | 2005-10-28 | 2014-11-25 | Index Pharmaceuticals Ab | Composition and method for the prevention, treatment and/or alleviation of an inflammatory disease |
| JP2010536787A (ja) * | 2007-08-15 | 2010-12-02 | イデラ ファーマシューティカルズ インコーポレイテッド | Ｔｏｌｌ様受容体モジュレータ |
| JP5749492B2 (ja) * | 2007-10-26 | 2015-07-15 | ダイナバックス テクノロジーズ コーポレイション | 免疫応答と自己免疫を阻害する方法及び組成物 |
| US8030289B2 (en) * | 2008-08-06 | 2011-10-04 | Changchun Huapu Biotechnology Co., Ltd. | Oligonucleotide and use thereof |
| PT2154144E (pt) * | 2008-08-06 | 2014-07-18 | Changchun Huapu Biotechnology Co Ltd | Oligonucleotídeos e utilização dos mesmos |
| CN102281880A (zh) * | 2008-10-06 | 2011-12-14 | 艾德拉药物股份有限公司 | 类Toll受体抑制剂在高胆固醇血症和高脂血症及相关疾病的预防和治疗中的用途 |
| EP2451974A2 (en) * | 2009-07-08 | 2012-05-16 | Idera Pharmaceuticals, Inc. | Oligonucleotide-based compounds as inhibitors of toll-like receptors |
| WO2011159328A1 (en) * | 2010-06-16 | 2011-12-22 | Dynavax Technologies Corporation | Methods of treatment using tlr7 and/or tlr9 inhibitors |
| BR112012032240A2 (pt) * | 2010-06-16 | 2019-09-24 | Dynavax Technologies Corporation | método de tratamento utilizando inibidores tlr7 e/ou tlr9 |
| WO2012040127A1 (en) | 2010-09-22 | 2012-03-29 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
| KR102100110B1 (ko) | 2010-11-19 | 2020-04-14 | 이데라 파마슈티칼즈, 인코포레이티드 | 톨-유사 수용체 기반 면역 반응을 조절하기 위한 면역 조절 올리고뉴클레오타이드(ｉｒｏ) 화합물 |
| CA2860234A1 (en) | 2011-12-22 | 2013-06-27 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
| HK1206362A1 (zh) | 2012-03-21 | 2016-01-08 | Alios Biopharma, Inc. | 硫代氨基磷酸酯核苷酸前藥的固體形式 |
| NZ630805A (en) | 2012-03-22 | 2016-01-29 | Alios Biopharma Inc | Pharmaceutical combinations comprising a thionucleotide analog |
| US9868955B2 (en) | 2012-09-29 | 2018-01-16 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
| US9228184B2 (en) | 2012-09-29 | 2016-01-05 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
| EP2754714A1 (en) * | 2013-01-14 | 2014-07-16 | Sarepta Therapeutics, Inc. | Inhibitory oligonucleotides and their use in therapy |
| JP6873052B2 (ja) | 2015-06-01 | 2021-05-19 | サレプタ セラピューティクス，インコーポレイテッド | Ｖｉｉ型コラーゲンにおけるアンチセンス誘導エクソン排除 |
| WO2017173334A1 (en) | 2016-04-01 | 2017-10-05 | Checkmate Pharmaceuticals, Inc. | Fc receptor-mediated drug delivery |
| WO2017214378A1 (en) | 2016-06-08 | 2017-12-14 | President And Fellows Of Harvard College | Engineered viral vector reduces induction of inflammatory and immune responses |
| WO2018089695A1 (en) | 2016-11-11 | 2018-05-17 | Dynavax Technologies Corporation | Toll-like receptor antagonist compounds and methods of use |
| JP6886854B2 (ja) * | 2017-04-13 | 2021-06-16 | シスメックス株式会社 | 被検物質の情報取得方法 |
| WO2019094548A1 (en) | 2017-11-08 | 2019-05-16 | President And Fellows Of Harvard College | Compositions and methods for inhibiting viral vector-induced inflammatory responses |
| EP3752194A4 (en) | 2018-02-13 | 2022-03-16 | Checkmate Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS FOR TUMOR IMMUNOTHERAPY |
| AU2019251421B2 (en) | 2018-04-09 | 2025-05-01 | Checkmate Pharmaceuticals | Packaging oligonucleotides into virus-like particles |
| US11863189B2 (en) * | 2021-03-05 | 2024-01-02 | Taiwan Semiconductor Manufacturing Company, Ltd. | Input buffer circuit |
| US12110324B2 (en) | 2022-07-22 | 2024-10-08 | Flagship Pioneering Innovations Vi, Llc | Antigen binding molecules targeting thymic stromal lymphopoietin (TSLP) |
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| AU2005282889B2 (en) | 2004-09-01 | 2012-03-15 | Dynavax Technologies Corporation | Methods and conpositions for inhibition of innate immune responses and autoimmunity |
| CA2591582A1 (en) * | 2004-12-17 | 2006-06-22 | Dynavax Technologies Corporation | Methods and compositions for induction or promotion of immune tolerance |
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| JP5749492B2 (ja) * | 2007-10-26 | 2015-07-15 | ダイナバックス テクノロジーズ コーポレイション | 免疫応答と自己免疫を阻害する方法及び組成物 |
-
2005
- 2005-08-24 AU AU2005282889A patent/AU2005282889B2/en not_active Ceased
- 2005-08-24 PT PT05792518T patent/PT1794174E/pt unknown
- 2005-08-24 US US11/212,297 patent/US8759305B2/en active Active
- 2005-08-24 EP EP10011096.4A patent/EP2305693B1/en not_active Expired - Lifetime
- 2005-08-24 NZ NZ553581A patent/NZ553581A/en not_active IP Right Cessation
- 2005-08-24 EP EP05792518A patent/EP1794174B1/en not_active Expired - Lifetime
- 2005-08-24 KR KR1020077006947A patent/KR101268877B1/ko not_active Expired - Fee Related
- 2005-08-24 ES ES05792518T patent/ES2385657T3/es not_active Expired - Lifetime
- 2005-08-24 CA CA2578775A patent/CA2578775C/en not_active Expired - Lifetime
- 2005-08-24 WO PCT/US2005/030494 patent/WO2006028742A2/en not_active Ceased
- 2005-08-24 PL PL05792518T patent/PL1794174T3/pl unknown
- 2005-08-24 SI SI200531556T patent/SI1794174T1/sl unknown
- 2005-08-24 CN CN200580037417.4A patent/CN101052643B/zh not_active Expired - Fee Related
- 2005-08-24 ES ES10011096.4T patent/ES2543207T3/es not_active Expired - Lifetime
- 2005-08-24 DK DK05792518.2T patent/DK1794174T3/da active
- 2005-08-24 JP JP2007530180A patent/JP2008514187A/ja active Pending
-
2012
- 2012-05-29 AU AU2012203156A patent/AU2012203156B2/en not_active Ceased
- 2012-06-06 JP JP2012129374A patent/JP5775024B2/ja not_active Expired - Fee Related
-
2014
- 2014-06-23 US US14/312,533 patent/US20150050296A1/en not_active Abandoned
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